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YMC Europe GmbH

YMC Europe GmbH

YMC Europe GmbH


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All articles from YMC Europe GmbH

  How to improve your analysis of challenging compounds

Are you plagued with poor peak shapes, low sensitivities, sample carry over and/or low recoveries for challenging compounds. Several substances are able to interact with the usual inert column hardware materials such as stainless steel or titanium. The adsorption on metallic surfaces typically leads to peak tailing, loss of recovery and sample carry over. Critical substances are especially metal-coordinating compounds, such as fumonisins, sphingophospholipids or organophosphates in general....


  Bioinert YMC-Triart metal-free (U)HPLC columns are nominated for Wiley Analytical Science Award 2022

A number of analytes are able to interact with conventional inert column hardware materials such as stainless steel or titanium. The inert YMC-Triart metal-free (U)HPLC columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes and reliable recoveries for critical substances such as biomolecules. The prevention of carryover makes them an ideal choice for highly sensitive LC/MS analyses....


  Fast UHPLC Analysis of SARS-CoV-2 drug Remdesivir and its active metabolite GS-441524

As the COVID-19 pandemic continues, the worldwide search for an effective treatment is still ongoing. Remdesivir and GS-441524 are antiviral drugs that have been examined for the treatment of COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Remdesivir is a nucleotide analogue inhibitor that can inhibit the replication of animal and human coronaviruses...


  YMC SEC columns: The perfect match for light scattering detection

Method of choice: The combination of size exclusion chromatography (SEC) and light scattering detection (LS) determines molecular weight, especially for higher molecular species such as aggregates or oligomers. As an additional plus sample size and topology can also be revealed. Special attention needs to be turned to the quality of SEC columns in order to provide signals unaffected by spikes. YMC’s SEC columns support LS-detection perfectly due to a high level of inertness...


  Get your (U)HPLC methods back on track with YMC's new (U)HPLC Troubleshooting Guide

Have you ever experienced problems with a new method? Are your system suitability tests failing now for a method established years ago? Is is your HPLC column dying too fast? There are many possible reasons for these issues and their root cause can be hard to find. Our new (U)HPLC Troubleshooting Guide provides an easy breakdown of potential solutions for the most common issues in analytical liquid chromatography...


  Bioinert (U)HPLC columns for bio-separations and coordinating compounds

Are you dealing with demanding substances that tend to coordinate with metals? Are you looking for an inert solution for your peptide/protein, (oligo)nucleotide or sensitive small molecules? This is the solution for your problems! The bioinert YMC-Triart columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes for sensitive compounds. Check out YMC's new flyer to discover more about biocompatible YMC-Triart metal-free columns....


  New Application Note: Separation of 11 common cannabinoids using YMC-Triart C18

Do you analyse common cannabinoids? This application note shows how you can separate a mixture of 11 of the most common cannabinoids using the robust and reproducible YMC-Triart C18 column. Until recently, cannabis and its derivatives were widely restricted under legislation which stated they had no medical value and carried a substantial risk of misuse. Policy is rapidly changing, and cannabis can now be prescribed for medicinal use in many countries across Europe.


  New App Note: HIC-MS analysis of ADCs

In this application note the drug-to-antibody ratio (DAR) of a cys-linked ADC-mimic is determined using online native HIC-MS. Using the innovative BioPro HIC BF column and a direct coupling to the mass spectrometer even degraded payloads can be detected. The application also demonstrates how to overcome the high salt concentrations which are necessary for HIC methods....


  New application note: LC-MS/MS analysis of DSP toxins

Okadaic acid is diarrhetic toxin (DSP) which can be found in shellfish. Due to its inhibitory effects towards specific protein phosphatases it is a promising compound for various potential medical uses. This application note shows the LC-MS/MS analysis of okadaic acid and its derivates with different YMC-Triart phases. All phases are suitable for the separation of these compounds with high resolution....


  Improve peak shape and efficiency in your Ph. Eur. methods

In some methods derived from the Pharmacopoeia the stipulation of a specific injection solvent can lead to issues with peak shape and a reduced sensitivity for some or all compounds analysed. With a custom injection program, you can overcome this hurdle and still be conform to Pharmacopoeia guidelines. Your gain will be a higher chance to achieve your system suitability criterions and a more reproducible and robust analysis...


  Robust (U)HPLC columns for peptides and oligonucleotides

Are you looking for robust and reproducible columns to evaluate peptides? Do you want to separate oligonucleotides with high resolution? Robust YMC-Triart C18 columns are the perfect choice for reliable and reproducible (U)HPLC analyses of peptides and oligonucleotides with exceptional resolution. The wide temperature- (up to 90°C) and pH-range (1-12) provide increased flexibility....


  The best HIC column for each separation: BioPro HIC HT and BioPro HIC BF

In order to address separation requirements of different compounds, YMC offers two different HIC columns, BioPro HIC HT and BioPro HIC BF. They both have in common their non-porous polymethacrylate particle, while their properties and chromatographic behaviours are quite different. In this application note the retention behaviour of BioPro HIC HT and BioPro HIC BF columns is compared by separating two commercial monoclonal antibodies from each other.


  New Application Note from YMC - Fast and easy achiral and chiral analysis of cannabinoids

(U)HPLC analysis of original composition of cannabis plant material is necessary for such purposes as phenotype determination and quality control of medical cannabis used for therapeutic treatment. For fast and secure results YMC developed robust (U)HPLC methods for RP and chiral LC. Also, challenging distinction between cannabigerol (CBG) andcannabidiol (CBD) are easily achieved....


  Dedicated SEC columns for antibodies, their monomers, fragments and aggregates

If you are looking for a column to separate your antibodies from their fragments as well as from their aggregates, YMC-SEC MAB is your first choice! The column is designed to separate high and low molecular weight ranges, due to its 250 Å pore size. High column stability as well as excellent reproducibility is guaranteed!  The 2019 SCIENTISTS’ CHOICE AWARD NOMINEE is designed for...


  Quick and easy HPLC method for cannabidiol and melatonin separation

Are you working with cannabinoids in medicinal products? This application note describes how to obtain a fast separation of cannabidiol and melatonin which are compounds that can be used in medication for sleep disorders. Excellent peak shapes are achieved using YMC-Triart C18 in less than 7 min. Get your copy of the application note now....


  Analysis of commercial monoclonal antibodies by microLC-MS/MS

Are you required to analyse very small sample amounts? Or do you need to analyse very low concentrations of antibodies in different kinds of matrices? By using of microLC-MS/MS, only a very small amount of valuable samples, e.g. solutions prepared for patient application (usually a dilution of the dosage form), is required to identify and quantify. In addition, microLC-MS/MS can also be used to monitor residues on surfaces or materials in hospitals, pharmacies or laboratories that prepare solutions for patient application....


  HIC columns for reliable high throughput analyses

You are looking for a state-of-the-art hydrophobic interaction chromatography column? With high resolution at high throughput, but also with superior batch-to-batch reproducibility? Then BioPro HIC HT is the ideal choice for you! YMC’s HIC column, BioPro HIC HT, is especially designed for analysis of biopharmaceuticals such as antibody-drug-conjugates (ADCs). BioPro HIC HT columns are the ideal choice for drug-to-antibody ratio (DAR) determination due to a novel and optimised surface chemistry....


  New Glass Column Packing Service

Save time and order prepacked glass columns! Are you lacking the time to pack your column? Or don’t you have sufficient experience? Here is the solution! Rely on the experience of YMC and use prepacked ECO or ECOPLUS columns. Our packing expertise is your advantage. You may choose from the following packing services for ECO and ECOPLUS columns in standard and custom dimensions...


  Analysis of benzodiazepines and their metabolites by UHPLC-MS/MS

This application note shows a high-resolution UHPLC separation using a robust YMC-Triart C18 column including the previous sample preparation. The simultaneous analysis of etizolam, triazolam, and their metabolites 8-ethylhydroxyetizolam, alpha-hydroxyetizolam, 4-hydroxytriazolam and alpha-hydroxytriazolam in biological samples is performed by MS/MS detection....


  All new YMC Classics eCatalogue!

Are you working with YMC’s classic columns such as YMC-Pack Pro C18, YMC-Pack ODS-A/AQ or YMC-Pack Polyamine II? Are you looking for specific information such as phase specifications etc for these columns? In that case the new YMC Classics eCatalogue is your perfect resource for this kind of data....


  Versatile (U)HPLC-hybrid columns, now also in C8! YMC-TriArt C18 and C8With YMC-TriArt challenging pH-stability and high temperatures are no longer a limitation to your work. Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-TriArt a “First Choice” column in method development...


  The YMC Application Search is now available online YMC Application SearchThis collection encompasses the full spectrum of YMC HPLC applications into a single volume covering all RP, IEX, SEC, HILIC and NP separation mechanisms...


  Are you sure your column has been packed the best possible way? YMC-BioPro prep material in pre-packedUntil now the extremely efficient YMC-BioPro IEX phases have only been available as bulk media. Still it was introduced into many screening procedures in industry, because of its high quality. Now it is even easier to evaluate its extremely good cost-efficiency ratio: YMC announces the introduction of pre-packed IEX columns...


  The YMC HG-series: High Quality low price silica material The YMC HG-seriesIs it possible to get the best of both worlds? Better quality at better price? It is possible with the new YMC HG-grade series of silica based materials! These new phases combine the trusted selectivity of the YMC*gel materials with a new high performance silica base. The most obvious advantage of the new silica base is its extended mechanical stability which is due to an improved production process for the base silica...


  Easy handling with Kronlab Pilot columns Kronlab Pilot columnAs a long-time specialist in the field of glass Pilot columns for lab and production separations, Kronlab specialists are continuously in close dialogue with chromatography end-users from Pharma/Biotech as well as research and education fields. This leads to numerous technical and practical modifications which make your every-day work a lot easier.


  Preparative Chiral Purifications with YMC*Gel Chiral NEA YMC*Gel Chiral NEA - Fig. 1Chirality has become vitally important in the production of pharmaceuticals, agrochemicals and related products, due to the dramatically different pharmacology the various optical isomers can present, ranging from no activity through undesirable effects to having potentially catastrophic and sometimes life threatening adverse effects. This has led to the development of highly efficient chiral stationary phases (CSP) for analytical and preparative scale separations


  Pilot columns made to measure! It does not matter if it’s tall or short, fat or thin - Pilot columns are increasingly being manufactured to customers’ demands.


  YMC-Triart Prep - Application Note: Separation of structurally similar peptides at pH ≥ 7 Reversed phase chromatography is undoubtedly the most powerful method for peptide purification. In order to improve the cost effectiveness of industrial scale peptide purifications, YMC has developed a new hybrid silica base and a novel bonding technology to improve process efficiencies and inrease column life time.


  New brochure "YMC Phases for Biochromatography" New brochure The new HPLC brochure “YMC Phases for Biochromatography” is available now! It contains current applications for biomolecules using various separation mechanisms including IEX, SEC, RP and HILIC.


  Free Guide to HPLC formulae available from YMC A free guide to HPLC formulae from YMC is available to download.


  Regulatory Support File for YMC-BioPro now available A further milestone for YMC-BioPro IEX materials has been reached. The Regulatory Support File (RSF) for these high performance IEX resins has been finalized and is now available.


  Tricky syntheses in the micro-reactor YMC is a specialist in difficult, multistep syntheses in the micro-reactor. Higher yields, substances that are available more quickly and with extensive downstream processing guarantee substances up to the highest purity.


  Invitation to YMC’s free vendor lunch seminar at SPICA Every two years the leaders in preparative chromatography meet for the Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA). As a supplier strongly rooted in preparative chromatography, YMC will participate in two ways:


  Connectivity and Compatibility of Kronlab laboratory glass columns Sometimes one does not see the woods from the trees – or in other words: for some people it is evident, but not so for the others. With regards to Kronlab glass columns there are two questions still frequently asked..


  Glass columns – not only for biochromatography In the laboratory glass columns are favoured by many chromatographers because of their inertness towards proteins. Also the possibility to clean the packed columns with highly alkaline caustic soda solutions, a widely-used purification step, is a good argument for glass columns.


  Binary prep. HPLC-system for processing large volumes of ureacontaining protein solutions Often client specific requirements for multipurpose equipment can not be solved with “off the shelf“ solutions. In this specific case, the Kronlab custom build approach proved very useful: every component has been specifically approved for the application at hand and following a specified procedure it is integrated into an LC system. The result is a made-to-measure system.


  NEW: YMC-Triart Multi-layered hybrid material for HPLC


  YMC Europe GmbH at Analytica 2010 in Munich Analytica 2010 is taking place from the 23rd to 27th of March in Munich, Germany and YMC will be taking part.


  New YMC microreactor Systems – Microreaction technology got potential Microreactor technology, is currently one of the most innovative techniques in the field of chemical synthesis and similar fields. Now specific microreactors are coming to laboratories. Scientific advances throughout the world have demonstrated the many advantages which can be achieved through the use of microreactors for chemical reactions and processes.


  Binary Prep LC System for isolation of components from human blood serum Customised requirements for GMP-conforming extraction of substances are often not satisfied by “off-the-shelf” solutions. Every component in the well-established modular systems from Kronlab meets the requirements which will be demanded by the customers’ needs for an established procedure. The result: A made-to-measure system


  Workshop: Preparative liquid chromatography Run at our laboratory facilities in Dinslaken, Germany, this hands-on course is designed to introduce both theory and practical concepts of preparative liquid chromatography.


  Scalable and pH stable: New C8 and C18 hybrid phases from YMC


  HPLC-Tip: Degassing of the mobile phase A released gas in mobile phases during analysis causes noisy baselines and pressure fluctuations which affect sensitivity and reproducibility. It also severely compromises the use of fluorescence-, refractive-index- or UV-detectors (particularly at wavelengths below 210 nm). As a consequence effective mobile phase degassing must be employed for many analyses.


  The Bio-Chromatographers’ wish Simply high dynamic binding capacities (DBC’s) are no longer sufficient. High DBC, at high flow rates with close to 100% recovery, across a wide range of molecular weights, this is what chromatographers look for in modern ion exchange resins. “BioPro” YMC’s hugely successful ion exchange material offers exactly this. The growing user base confirms very good separation, high dynamic binding capacities and excellent recoveries for the anion as well as the cation exchanger material.


  New: YMC-Triart C18 With YMC-Triart challenging pH-Stability and high temperatures are no longer a limitation to your work.
Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-Triart a “First Choice” column in method development!


  Ion Exchange Media for High Resolution Purifications of Biomolecules YMC-BioPro Q30 and S30 are high performance ion exchange resins designed for the purification of proteins, peptides, antibodies and oligonucleotides in laboratory and industrial scale.


  Preheating of mobile phases - "nice-to-have" or "need-to-have"? Controlling the temperature of a column is a prerequisite for reproducible results in HPLC.
Column ovens are part of most HPLC systems and many of them offer space even for semi preparative columns. But with increasing inner diameter the heat transfer from the air surrounding the column to the whole cross section of the column (filled with the cold mobile phase) becomes more and more difficult. This may result in bad peak shapes, as the radial temperature gradientcauses different separation conditions for every part of the sample depending on its distance to the outer diameter.


  New method development tool for Bio-LC

As chromatographers, we all know the problems during method development - “Which phase is suitable and allows a simple and robust separation?” In the field of biochromatography, phase selection is a key to success!


  YMC-BioPro: IEX columns for peptides, proteins and biomolecules

Are you looking for a new ion exchange material?
Have you tried the new BioPro material from YMC - it will give you a significant alternative.


  Kronlab ECO glass columns Kronlab ECO glass columns meet highest quality demands. They are best suited for various chromatographic techniques like ion exchange, affinity and size exclusion chromatography.


  YMC-Actus for fast semi-preparative, high throughput HPLC separations. New Brochure out now! YMC-Actus is available in a range of C18phases including ODS-AQ with its hydrophilic endcapping, as well as a C8  phase to allow use of the full spectrum of RP-HPLC methods.


  Ultra Fast LC for Peptide mapping In order to succeed in developing protein-based drugs, a fast and easy detection of alteration within the protein structure is necessary. In many cases, peptide mapping is the method of choice, where proteins are analysed after digestion.


  New: YMC’s Applicationsbook for Ultra FastLC! The new YMC-UltraHT brochure from YMC includes information on how to transfer methods form existing, conventional methods to ultra fast LC, without generating excessive backpressure and without the need of specialised ultra high pressure chromatography equipment.


  Fast routine analysis of alkaloids

The method transfer from a conventional column to an ultra fast analysis for alkaloids has shown that the use of YMC-UltraHT 2 µm column and adjustment of flow parameters for the smaller column dimensions can reduce the analyses time by about 85% accompany with significant solvent savings and significant solvent savings whilst increasing the sample throughput in the laboratory.



  HPLC hint: The advantage of premixed solvents in HPLC For several reasons the storage of 100% pure solvents in the reservoir bottles of an HPLC system can be a problem. Pure acetonitrile, in particular, affects the system by adsorption of polymers from transmission lines resulting in sticky surfaces that inhibit the opening and closing of the valves


  Simultaneous separation of pesticides by LC/MS With the constantly rising population and frequent uncertain weather, the need for high yielding agriculture is paramount. This means that use of plant protection agents, such as herbicides and insecticides is necessary, in order to secure harvests.


  Normal Phase Chromatography – hints for an unloved technique Normal phase chromatography is not very popular with most analytical HPLC users. Poor reproducebility of the results is often cited as an argument against normal phase chromatography.


  Ion Exchange Material for Capture and Intermediate Purification Applications The Ion Exchange capture material is based on the same hydrophilic polymer matrix already used for the successful analytical phase. Analytical BioPro columns (particle size: 5 ÎĽm, pore size 100 nm) have proven to show low non specific binding and high dynamic binding capacity.


  Facing the challenge of efficiency in bio-pharmaceutical industry With continuously increasing volumetric productivity in fermentation processes, new stationary phases can help to overcome shortcomings in downstream processing. In order to address this YMC has developed a new Ion Exchange resin with high dynamic binding capacity and low nonspecific interaction. This helps to reduce “cost of goods” in the production process.


  FastLC Application for Curcumin The plant pigment curcumin, found in the popular Indian curry spice turmeric, is well known as an antioxidant for foods. However, researches have paid attention to another characteristic. Curcumin is highly active against the growth of certain cancers.


  YMC Exphere - Takes the Pressure off Preparative LC

YMC is pleased to introduce Exphere, a new family of bulk packing materials, specifically designed for preparative liquid chromatography. Exphere combines YMC's novel high strength silica with a special polymeric surface modification technique.


  Melamine in pet-food Melamine (sometimes confused with the plant and animal compound, melanine or another compound, melanin) is an industrial chemical used in the manufacture of plastic products. Despite that, tests showed that a number of milk companies have used it in processing milk to artificially increase the apparent protein content by addition of non-protein nitrogen and so allowing illegal dilution of the product with water with a corresponding increase in sales value.



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