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YMC Europe GmbH

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All articles from YMC Europe GmbH

  New YMC Accura BioPro IEX columns - Robust bioinert columns for a new level of recovery

The columns provide very sharp peaks with high sensitivities due to an efficient bioinert surface coating of the column body and frits. YMC Accura BioPro IEX columns are the 1st choice for high resolution analysis of oligonucleotides, antibodies, and proteins – especially when coupled with mass spectrometry. Their non-porous hydrophilic polymer beads enable high efficiencies and high throughput analyses. The superior lot-to-lot reproducibility guarantees highly reliable results...


  Secure your place on the BioLC Workshop now!

Deepen your knowledge in this exciting workshop designed specifically for biochromatography users. Gain a comprehensive insight into the latest trends and methods in the chromatographic analysis of antibodies, proteins and peptides. You will receive important background information and valuable tips for practical application from experienced workers in biopharmaceutical research and development as well as experienced specialists in (U)HPLC separations and detectors...


  New Application Note - Separation of a complex carotenoid isomer mixture

An optimised separation of up to 48 carotenoids was successfully achieved using a reliable YMC Carotenoid column with C30 modification. This allowed a mixture of stereomutated carotenoid standards to be detected at different wavelengths. The success of this method was confirmed with a human plasma sample. 24h after the consumption of carotenoid-containing vegetables and fruits, several known carotenoids as well as three unidentified peaks were detected...


  Get your (U)HPLC methods back on track with YMC’s (U)HPLC Troubleshooting Guide

This handbook is the perfect companion on your way to trouble-free routine results. Its 40 pages are full of helpful tables, preventative measures and tips to eliminate unwanted effects on your analyses. The (U)HPLC Troubleshooting Guide provides an easy breakdown of possible solutions to the most common problems in analytical liquid chromatography. Take the first step towards a trouble-free routine and get your digital copy of this comprehensive guide...


  Determination of artificial sweeteners using LC-MS/MS

Artificial sweeteners are added to many foods and cosmetic products. As useful as they are in these areas, they pollute wastewater and groundwater. Therefore, powerful LC-MS/MS applications for the most common artificial sweeteners acesulfame, saccharin and cyclamateare essential. Find out more about how to implement an ultra-fast analysis routine in your lab by downloading the application note...


  New Tech Note: Guidelines for an effective purification method development

Chromatographic purification on a research scale is a must-have in many areas such as academia and pharmaceutical research. However, this can be very time consuming. Therefore, effective development of the purification method is essential. These guidelines from YMC demonstrate the main steps for an effective purification method development...


  How to choose the correct pore size for oligonucleotide analysis by SEC

SEC is a suitable method for the analysis of long chain oligonucleotides with length up to 200mer. The choice of the optimal pore size is crucial for the success of the method. In this Application Note, analyses of oligonucleotides of various lengths are described and a selection guide for columns for different DNA is discussed - a practical addition to your local application database...


  Permitted changes in HPLC methods from the 11th edition of the European Pharmacopoeia

On January 1st 2023 the 11th edition of the European Pharmacopoeia (Ph. Eur.) took effect. In course of revision, it was harmonised with the United States Pharmacopoeia (USP), British Pharmacopoeia (BP) and Japanese Pharmacopoeia (JP) so that the general chapter 2.2.46 on chromatographic separation techniques received an update. To keep you up to date on the permitted changes, YMC's technical experts have compiled for you these new rules in a helpful technical note, which lists all relevant allowed changes on one page...


  New App Note: RP analysis of RNA markers using bioinert YMC-Accura Triart Bio C4

This new application note describes the analysis of 7 RNA markers (100 – 1000 bases) using the recently introduced bioinert YMC-Accura Triart Bio C4 column at pH 7 and 80 °C. While conventional column hardware leads to peak tailing and loss of recovery when analysing oligonucleotides, the bioinert coated YMC-Accura Triart Bio C4 column shows excellent recoveries and peak shapes for all 7 well resolved markers...


  New Application Note: COVID-19 agent molnupiravir

Molnupiravir (Lagevrio®) is an antiviral medication to treat mild to medium COVID-19 infection. Molnupiravir is actually a prodrug of the active substrate N4-hydroxycytidine (NHC), a synthetic ribonucleoside analogue. The treatment leads to the introduction of copying errors during viral RNA replication and by this inhibits the viral reproduction. This new Application Note demonstrates how molnupiravir and its active agent β-d-N4-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column...


  Rapid Analysis of Tobacco Smoke Biomarkers

New Application note from YMC - Fast UHPLC Analysis of Biomarkers Related to Tobacco Smoke Exposure using YMC-Triart C18 and YMC-Triart Diol-HILIC. Both RP and HILIC allow for high resolution peaks and fast separation. In addition to nicotine, the metabolite cotinine is also determined. The challenge here is that this is only detectable for a short time. NNAL, a breakdown product of the lung carcinogen NNK, is also suitable. In addition, human cells are exposed to oxidative stress when smoking...


  New whitepaper: Your guide to cannabis testing

Hands-on cannabis testing! The market for cannabis products is expected to continue growing whilst requiring high quality equipment with excellent reproducibility for their complex analysis. In this whitepaper, the common challenges in cannabis testing by liquid chromatography are summarised. Numerous applications show how to select the ideal stationary phase for obtaining high resolution in cannabis potency testing excellent selectivity in pesticide analyses and sharp peak shapes in mycotoxin analyses...


  HPLC analysis of phosphoramidites using RP or NP conditions

Phosphoramidites are the essential part in the chemical synthesis of oligonucleotides, short fragments of nucleotides and analogues. During the synthesis, errors can occur which is why the phosphoramidites’ purity needs to be closely monitored. In this application note, it is shown how to analyse phosphoramidites using two different separation modes: reversed phase (RP) and normal phase (NP) chromatography. Due to the complexity of the analytes different interactions can be used in order to achieve acceptable retenetion and resolution...


  Application Note - Fast UHPLC analysis of cell penetrating peptides

Fast UHPLC Analysis of Cell Penetrating Peptides Using a YMC-Triart C18 column. Cell penetrating peptides (CPPs) are an interesting class of compounds since they are capable of transporting themselves across a cell membrane and also carry so-called “cargo” molecules with them. Due to their advantages over other transport mechanisms they are a focus for current research...


  How to select the ideal column for your separation

Do you want to know how to choose the right column for your separation? Then check out our new technical note focusing on how to select the perfect LC column! In this technical note, the differences in selectivity and resulting separation behaviour of various phases are shown. Primary and secondary interactions between the analyte and stationary phase are explained for each phase. Two application examples demonstrate how these interactions affect your analysis...


  New App Note: UHPLC analysis of cyclic peptides using LC/MS compatible conditions

Get to know the significant advantages of YMC-Triart Bio C4! This new application note shows why this stationary phase is the ideal choice for the analysis of cyclic peptides. These compounds are highly valuable drug candidates since their cyclic ring structure provides various advantages over their linear counterpart. This is the reason why they are increasingly becoming the focus in biopharmaceutical research...


  YMC Application Note - High sensitivity screening of antineoplastic drugs

YMC-Triart C18 UHPLC columns with an ID of 1 mm are the ideal choice for high sensitivity LC/MS analyses. In this new application note, the screening of 6 antineoplastic drugs is shown. This analysis requires the highest sensitivity since even the smallest amounts of these drugs need to be detected due to their adverse very serious, life-threatening effects. By choosing a high efficiency column with a small internal diameter of 1 mm and coupling it to mass spectrometry the benefit becomes clear: excellent peak shapes – also for low sensitivity compounds!


  Maximising the separation capacity by coupling two SEC columns

The use of only one SEC column brings a certain limitation due to its dedicated pore size and a limited column volume. By coupling two columns this hurdle can be overcome. Doubling the column length implies a doubled column volume which results in improved resolution of peaks. Additionally, if using two columns with different pore size, the applicable molecular weight range can be increased significantly....


  How to improve your analysis of challenging compounds

Are you plagued with poor peak shapes, low sensitivities, sample carry over and/or low recoveries for challenging compounds. Several substances are able to interact with the usual inert column hardware materials such as stainless steel or titanium. The adsorption on metallic surfaces typically leads to peak tailing, loss of recovery and sample carry over. Critical substances are especially metal-coordinating compounds, such as fumonisins, sphingophospholipids or organophosphates in general....


  Bioinert YMC-Triart metal-free (U)HPLC columns are nominated for Wiley Analytical Science Award 2022

A number of analytes are able to interact with conventional inert column hardware materials such as stainless steel or titanium. The inert YMC-Triart metal-free (U)HPLC columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes and reliable recoveries for critical substances such as biomolecules. The prevention of carryover makes them an ideal choice for highly sensitive LC/MS analyses....


  Fast UHPLC Analysis of SARS-CoV-2 drug Remdesivir and its active metabolite GS-441524

As the COVID-19 pandemic continues, the worldwide search for an effective treatment is still ongoing. Remdesivir and GS-441524 are antiviral drugs that have been examined for the treatment of COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Remdesivir is a nucleotide analogue inhibitor that can inhibit the replication of animal and human coronaviruses...


  YMC SEC columns: The perfect match for light scattering detection

Method of choice: The combination of size exclusion chromatography (SEC) and light scattering detection (LS) determines molecular weight, especially for higher molecular species such as aggregates or oligomers. As an additional plus sample size and topology can also be revealed. Special attention needs to be turned to the quality of SEC columns in order to provide signals unaffected by spikes. YMC’s SEC columns support LS-detection perfectly due to a high level of inertness...


  Get your (U)HPLC methods back on track with YMC's new (U)HPLC Troubleshooting Guide

Have you ever experienced problems with a new method? Are your system suitability tests failing now for a method established years ago? Is is your HPLC column dying too fast? There are many possible reasons for these issues and their root cause can be hard to find. Our new (U)HPLC Troubleshooting Guide provides an easy breakdown of potential solutions for the most common issues in analytical liquid chromatography...


  Bioinert (U)HPLC columns for bio-separations and coordinating compounds

Are you dealing with demanding substances that tend to coordinate with metals? Are you looking for an inert solution for your peptide/protein, (oligo)nucleotide or sensitive small molecules? This is the solution for your problems! The bioinert YMC-Triart columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes for sensitive compounds. Check out YMC's new flyer to discover more about biocompatible YMC-Triart metal-free columns....


  New Application Note: Separation of 11 common cannabinoids using YMC-Triart C18

Do you analyse common cannabinoids? This application note shows how you can separate a mixture of 11 of the most common cannabinoids using the robust and reproducible YMC-Triart C18 column. Until recently, cannabis and its derivatives were widely restricted under legislation which stated they had no medical value and carried a substantial risk of misuse. Policy is rapidly changing, and cannabis can now be prescribed for medicinal use in many countries across Europe.


  New App Note: HIC-MS analysis of ADCs

In this application note the drug-to-antibody ratio (DAR) of a cys-linked ADC-mimic is determined using online native HIC-MS. Using the innovative BioPro HIC BF column and a direct coupling to the mass spectrometer even degraded payloads can be detected. The application also demonstrates how to overcome the high salt concentrations which are necessary for HIC methods....


  New application note: LC-MS/MS analysis of DSP toxins

Okadaic acid is diarrhetic toxin (DSP) which can be found in shellfish. Due to its inhibitory effects towards specific protein phosphatases it is a promising compound for various potential medical uses. This application note shows the LC-MS/MS analysis of okadaic acid and its derivates with different YMC-Triart phases. All phases are suitable for the separation of these compounds with high resolution....


  Improve peak shape and efficiency in your Ph. Eur. methods

In some methods derived from the Pharmacopoeia the stipulation of a specific injection solvent can lead to issues with peak shape and a reduced sensitivity for some or all compounds analysed. With a custom injection program, you can overcome this hurdle and still be conform to Pharmacopoeia guidelines. Your gain will be a higher chance to achieve your system suitability criterions and a more reproducible and robust analysis...


  Robust (U)HPLC columns for peptides and oligonucleotides

Are you looking for robust and reproducible columns to evaluate peptides? Do you want to separate oligonucleotides with high resolution? Robust YMC-Triart C18 columns are the perfect choice for reliable and reproducible (U)HPLC analyses of peptides and oligonucleotides with exceptional resolution. The wide temperature- (up to 90°C) and pH-range (1-12) provide increased flexibility....


  The best HIC column for each separation: BioPro HIC HT and BioPro HIC BF

In order to address separation requirements of different compounds, YMC offers two different HIC columns, BioPro HIC HT and BioPro HIC BF. They both have in common their non-porous polymethacrylate particle, while their properties and chromatographic behaviours are quite different. In this application note the retention behaviour of BioPro HIC HT and BioPro HIC BF columns is compared by separating two commercial monoclonal antibodies from each other.


  New Application Note from YMC - Fast and easy achiral and chiral analysis of cannabinoids

(U)HPLC analysis of original composition of cannabis plant material is necessary for such purposes as phenotype determination and quality control of medical cannabis used for therapeutic treatment. For fast and secure results YMC developed robust (U)HPLC methods for RP and chiral LC. Also, challenging distinction between cannabigerol (CBG) andcannabidiol (CBD) are easily achieved....


  Dedicated SEC columns for antibodies, their monomers, fragments and aggregates

If you are looking for a column to separate your antibodies from their fragments as well as from their aggregates, YMC-SEC MAB is your first choice! The column is designed to separate high and low molecular weight ranges, due to its 250 Å pore size. High column stability as well as excellent reproducibility is guaranteed!  The 2019 SCIENTISTS’ CHOICE AWARD NOMINEE is designed for...


  Quick and easy HPLC method for cannabidiol and melatonin separation

Are you working with cannabinoids in medicinal products? This application note describes how to obtain a fast separation of cannabidiol and melatonin which are compounds that can be used in medication for sleep disorders. Excellent peak shapes are achieved using YMC-Triart C18 in less than 7 min. Get your copy of the application note now....


  Analysis of commercial monoclonal antibodies by microLC-MS/MS

Are you required to analyse very small sample amounts? Or do you need to analyse very low concentrations of antibodies in different kinds of matrices? By using of microLC-MS/MS, only a very small amount of valuable samples, e.g. solutions prepared for patient application (usually a dilution of the dosage form), is required to identify and quantify. In addition, microLC-MS/MS can also be used to monitor residues on surfaces or materials in hospitals, pharmacies or laboratories that prepare solutions for patient application....


  HIC columns for reliable high throughput analyses

You are looking for a state-of-the-art hydrophobic interaction chromatography column? With high resolution at high throughput, but also with superior batch-to-batch reproducibility? Then BioPro HIC HT is the ideal choice for you! YMC’s HIC column, BioPro HIC HT, is especially designed for analysis of biopharmaceuticals such as antibody-drug-conjugates (ADCs). BioPro HIC HT columns are the ideal choice for drug-to-antibody ratio (DAR) determination due to a novel and optimised surface chemistry....


  New Glass Column Packing Service

Save time and order prepacked glass columns! Are you lacking the time to pack your column? Or don’t you have sufficient experience? Here is the solution! Rely on the experience of YMC and use prepacked ECO or ECOPLUS columns. Our packing expertise is your advantage. You may choose from the following packing services for ECO and ECOPLUS columns in standard and custom dimensions...


  Analysis of benzodiazepines and their metabolites by UHPLC-MS/MS

This application note shows a high-resolution UHPLC separation using a robust YMC-Triart C18 column including the previous sample preparation. The simultaneous analysis of etizolam, triazolam, and their metabolites 8-ethylhydroxyetizolam, alpha-hydroxyetizolam, 4-hydroxytriazolam and alpha-hydroxytriazolam in biological samples is performed by MS/MS detection....


  All new YMC Classics eCatalogue!

Are you working with YMC’s classic columns such as YMC-Pack Pro C18, YMC-Pack ODS-A/AQ or YMC-Pack Polyamine II? Are you looking for specific information such as phase specifications etc for these columns? In that case the new YMC Classics eCatalogue is your perfect resource for this kind of data....


  Versatile (U)HPLC-hybrid columns, now also in C8! YMC-TriArt C18 and C8With YMC-TriArt challenging pH-stability and high temperatures are no longer a limitation to your work. Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-TriArt a “First Choice” column in method development...


  The YMC Application Search is now available online YMC Application SearchThis collection encompasses the full spectrum of YMC HPLC applications into a single volume covering all RP, IEX, SEC, HILIC and NP separation mechanisms...


  Are you sure your column has been packed the best possible way? YMC-BioPro prep material in pre-packedUntil now the extremely efficient YMC-BioPro IEX phases have only been available as bulk media. Still it was introduced into many screening procedures in industry, because of its high quality. Now it is even easier to evaluate its extremely good cost-efficiency ratio: YMC announces the introduction of pre-packed IEX columns...


  The YMC HG-series: High Quality low price silica material The YMC HG-seriesIs it possible to get the best of both worlds? Better quality at better price? It is possible with the new YMC HG-grade series of silica based materials! These new phases combine the trusted selectivity of the YMC*gel materials with a new high performance silica base. The most obvious advantage of the new silica base is its extended mechanical stability which is due to an improved production process for the base silica...


  Easy handling with Kronlab Pilot columns Kronlab Pilot columnAs a long-time specialist in the field of glass Pilot columns for lab and production separations, Kronlab specialists are continuously in close dialogue with chromatography end-users from Pharma/Biotech as well as research and education fields. This leads to numerous technical and practical modifications which make your every-day work a lot easier.


  Preparative Chiral Purifications with YMC*Gel Chiral NEA YMC*Gel Chiral NEA - Fig. 1Chirality has become vitally important in the production of pharmaceuticals, agrochemicals and related products, due to the dramatically different pharmacology the various optical isomers can present, ranging from no activity through undesirable effects to having potentially catastrophic and sometimes life threatening adverse effects. This has led to the development of highly efficient chiral stationary phases (CSP) for analytical and preparative scale separations


  Pilot columns made to measure! It does not matter if it’s tall or short, fat or thin - Pilot columns are increasingly being manufactured to customers’ demands.


  YMC-Triart Prep - Application Note: Separation of structurally similar peptides at pH ? 7 Reversed phase chromatography is undoubtedly the most powerful method for peptide purification. In order to improve the cost effectiveness of industrial scale peptide purifications, YMC has developed a new hybrid silica base and a novel bonding technology to improve process efficiencies and inrease column life time.


  New brochure "YMC Phases for Biochromatography" New brochure The new HPLC brochure “YMC Phases for Biochromatography” is available now! It contains current applications for biomolecules using various separation mechanisms including IEX, SEC, RP and HILIC.


  Free Guide to HPLC formulae available from YMC A free guide to HPLC formulae from YMC is available to download.


  Regulatory Support File for YMC-BioPro now available A further milestone for YMC-BioPro IEX materials has been reached. The Regulatory Support File (RSF) for these high performance IEX resins has been finalized and is now available.


  Tricky syntheses in the micro-reactor YMC is a specialist in difficult, multistep syntheses in the micro-reactor. Higher yields, substances that are available more quickly and with extensive downstream processing guarantee substances up to the highest purity.


  Invitation to YMC Every two years the leaders in preparative chromatography meet for the Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA). As a supplier strongly rooted in preparative chromatography, YMC will participate in two ways:


  Connectivity and Compatibility of Kronlab laboratory glass columns Sometimes one does not see the woods from the trees – or in other words: for some people it is evident, but not so for the others. With regards to Kronlab glass columns there are two questions still frequently asked..


  Glass columns In the laboratory glass columns are favoured by many chromatographers because of their inertness towards proteins. Also the possibility to clean the packed columns with highly alkaline caustic soda solutions, a widely-used purification step, is a good argument for glass columns.


  Binary prep. HPLC-system for processing large volumes of ureacontaining protein solutions Often client specific requirements for multipurpose equipment can not be solved with “off the shelf“ solutions. In this specific case, the Kronlab custom build approach proved very useful: every component has been specifically approved for the application at hand and following a specified procedure it is integrated into an LC system. The result is a made-to-measure system.


  NEW: YMC-Triart Multi-layered hybrid material for HPLC


  YMC Europe GmbH at Analytica 2010 in Munich Analytica 2010 is taking place from the 23rd to 27th of March in Munich, Germany and YMC will be taking part.


  New YMC microreactor Systems Microreactor technology, is currently one of the most innovative techniques in the field of chemical synthesis and similar fields. Now specific microreactors are coming to laboratories. Scientific advances throughout the world have demonstrated the many advantages which can be achieved through the use of microreactors for chemical reactions and processes.


  Binary Prep LC System for isolation of components from human blood serum Customised requirements for GMP-conforming extraction of substances are often not satisfied by “off-the-shelf” solutions. Every component in the well-established modular systems from Kronlab meets the requirements which will be demanded by the customers’ needs for an established procedure. The result: A made-to-measure system


  Workshop: Preparative liquid chromatography Run at our laboratory facilities in Dinslaken, Germany, this hands-on course is designed to introduce both theory and practical concepts of preparative liquid chromatography.


  Scalable and pH stable: New C8 and C18 hybrid phases from YMC


  HPLC-Tip: Degassing of the mobile phase A released gas in mobile phases during analysis causes noisy baselines and pressure fluctuations which affect sensitivity and reproducibility. It also severely compromises the use of fluorescence-, refractive-index- or UV-detectors (particularly at wavelengths below 210 nm). As a consequence effective mobile phase degassing must be employed for many analyses.


  The Bio-Chromatographers Simply high dynamic binding capacities (DBC’s) are no longer sufficient. High DBC, at high flow rates with close to 100% recovery, across a wide range of molecular weights, this is what chromatographers look for in modern ion exchange resins. “BioPro” YMC’s hugely successful ion exchange material offers exactly this. The growing user base confirms very good separation, high dynamic binding capacities and excellent recoveries for the anion as well as the cation exchanger material.


  New: YMC-Triart C18 With YMC-Triart challenging pH-Stability and high temperatures are no longer a limitation to your work.
Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-Triart a “First Choice” column in method development!


  Ion Exchange Media for High Resolution Purifications of Biomolecules YMC-BioPro Q30 and S30 are high performance ion exchange resins designed for the purification of proteins, peptides, antibodies and oligonucleotides in laboratory and industrial scale.


  Preheating of mobile phases - "nice-to-have" or "need-to-have"? Controlling the temperature of a column is a prerequisite for reproducible results in HPLC.
Column ovens are part of most HPLC systems and many of them offer space even for semi preparative columns. But with increasing inner diameter the heat transfer from the air surrounding the column to the whole cross section of the column (filled with the cold mobile phase) becomes more and more difficult. This may result in bad peak shapes, as the radial temperature gradientcauses different separation conditions for every part of the sample depending on its distance to the outer diameter.


  New method development tool for Bio-LC

As chromatographers, we all know the problems during method development - “Which phase is suitable and allows a simple and robust separation?” In the field of biochromatography, phase selection is a key to success!


  YMC-BioPro: IEX columns for peptides, proteins and biomolecules

Are you looking for a new ion exchange material?
Have you tried the new BioPro material from YMC - it will give you a significant alternative.


  Kronlab ECO glass columns Kronlab ECO glass columns meet highest quality demands. They are best suited for various chromatographic techniques like ion exchange, affinity and size exclusion chromatography.


  YMC-Actus for fast semi-preparative, high throughput HPLC separations. New Brochure out now! YMC-Actus is available in a range of C18phases including ODS-AQ with its hydrophilic endcapping, as well as a C8  phase to allow use of the full spectrum of RP-HPLC methods.


  Ultra Fast LC for Peptide mapping In order to succeed in developing protein-based drugs, a fast and easy detection of alteration within the protein structure is necessary. In many cases, peptide mapping is the method of choice, where proteins are analysed after digestion.


  New: YMC The new YMC-UltraHT brochure from YMC includes information on how to transfer methods form existing, conventional methods to ultra fast LC, without generating excessive backpressure and without the need of specialised ultra high pressure chromatography equipment.


  Fast routine analysis of alkaloids

The method transfer from a conventional column to an ultra fast analysis for alkaloids has shown that the use of YMC-UltraHT 2 µm column and adjustment of flow parameters for the smaller column dimensions can reduce the analyses time by about 85% accompany with significant solvent savings and significant solvent savings whilst increasing the sample throughput in the laboratory.



  HPLC hint: The advantage of premixed solvents in HPLC For several reasons the storage of 100% pure solvents in the reservoir bottles of an HPLC system can be a problem. Pure acetonitrile, in particular, affects the system by adsorption of polymers from transmission lines resulting in sticky surfaces that inhibit the opening and closing of the valves


  Simultaneous separation of pesticides by LC/MS With the constantly rising population and frequent uncertain weather, the need for high yielding agriculture is paramount. This means that use of plant protection agents, such as herbicides and insecticides is necessary, in order to secure harvests.


  Normal Phase Chromatography Normal phase chromatography is not very popular with most analytical HPLC users. Poor reproducebility of the results is often cited as an argument against normal phase chromatography.


  Ion Exchange Material for Capture and Intermediate Purification Applications The Ion Exchange capture material is based on the same hydrophilic polymer matrix already used for the successful analytical phase. Analytical BioPro columns (particle size: 5 μm, pore size 100 nm) have proven to show low non specific binding and high dynamic binding capacity.


  Facing the challenge of efficiency in bio-pharmaceutical industry With continuously increasing volumetric productivity in fermentation processes, new stationary phases can help to overcome shortcomings in downstream processing. In order to address this YMC has developed a new Ion Exchange resin with high dynamic binding capacity and low nonspecific interaction. This helps to reduce “cost of goods” in the production process.


  FastLC Application for Curcumin The plant pigment curcumin, found in the popular Indian curry spice turmeric, is well known as an antioxidant for foods. However, researches have paid attention to another characteristic. Curcumin is highly active against the growth of certain cancers.


  YMC Exphere - Takes the Pressure off Preparative LC

YMC is pleased to introduce Exphere, a new family of bulk packing materials, specifically designed for preparative liquid chromatography. Exphere combines YMC's novel high strength silica with a special polymeric surface modification technique.


  Melamine in pet-food Melamine (sometimes confused with the plant and animal compound, melanine or another compound, melanin) is an industrial chemical used in the manufacture of plastic products. Despite that, tests showed that a number of milk companies have used it in processing milk to artificially increase the apparent protein content by addition of non-protein nitrogen and so allowing illegal dilution of the product with water with a corresponding increase in sales value.



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