Shimadzu, a global leader in analytical instrumentation and testing equipment, announces the release of several new features for the compact Brevis GC-2050 gas chromatograph. These enhancements offer flexible configurations, enabling the Brevis GC-2050 to cover a wide range of applications. It is the world’s first gas chromatograph (GC) system with CO2 reduction visualization function...

This Application Note presents an optimised SEC-MS method for the high-performance separation and characterisation of a single-chain variable fragment (scFv) and its drug conjugates (FDC). Using a bioinert PEEK-lined YMC-Pack Diol-120 metal-free column combined with MS compatible conditions delivers sharp peaks & precise resolution, enhanced signal response and reliable results. Boost your analytical expertise – download the Application Note now!...

TESTA Analytical reports a major polymer manufacturer is using their COMBO-ONE detector, as part of a GPC/SEC system, to characterize the structure of macromolecules that offer desirable performance properties. The client is a leading European manufacturer of high-performance water-soluble polymers for industrial applications. These polymers, although presenting a similar molecular weight and molecular weight distribution, have different physical structures which influence their performance in the target application...

Thermo Fisher Scientific Inc., the world leader in serving science, introduced today new lines of floor-model centrifuges to provide more sustainable solutions without compromising performance and sample security. The Thermo Scientific™ Cryofuge™, Thermo Scientific™ BIOS and Thermo Scientific™ LYNX centrifuges are the first floor-model centrifuges that feature natural refrigerant cooling systems compliant with European Union (E.U.) and U.S. Environmental Protection Agency (EPA) F-gas regulations...

Scientists at the Technical University of Munich (TUM) have developed a method that relies on physics rather than conventional chemistry to obtain the proteins that are needed for this purpose. Using short-wave, UV light invisible to humans, they have succeeded in purifying proteins from cell extracts or cultures. This technique is more efficient and gentler than previous methods...

Waters Corporation has announced the expansion of the Alliance™ iS Bio HPLC product line with integrated photodiode array (PDA) detection, advancing the capabilities of the next-generation intelligent HPLC platform designed for development and Quality Control (QC) laboratories. "The addition of the Alliance iS Bio HPLC System with PDA detection allows biopharmaceutical laboratories to perform enhanced spectral analysis, including impurity detection, peak purity analysis, multi-wavelength detection, and method validation...

TESTA Analytical has released an updated version of its HPLC Pump Qualification Pack designed for regulated labs looking to qualify the operation and performance of their HPLC systems. Version 1.4 of the popular HPLC Pump Qualification Pack includes a series of updates that make the tool more flexible and audit ready. Improvements include a new Pump Validation Checklist to guide users through the validation process step by step, ensuring a structured workflow thereby reducing the chance of errors...

Aston Institute for Membrane Excellence (AIME) and Aston University College of Health and Life Sciences have installed a cutting-edge mass spectrometer to study biological membranes, following a grant of £1.5m from the Biotechnology and Biological Sciences Research Council (BBSRC). The research team is led by Dr Ivana Milic, a lecturer in Aston University School of Biosciences and part of the multidisciplinary AIME. The new Orbitrap Ascend Tribrid mass spectrometer from Thermo Fisher Scientific...

The demand for faster and more reliable cannabinoid analysis is growing with the expanding use of medicinal cannabis. Traditional HPLC methods often fall short in resolution due to the similar structures of cannabinoids. This application note presents a rapid UHPLC method using the YMC-Triart C18 ExRS column, delivering high-resolution separation of 11 cannabinoids in less than 6 minutes. Optimised for challenging separations, this column ensures efficiency without compromising accuracy...

SepSolve Analytical Ltd has launched Smart Subtract®, a powerful new tool that transforms how chromatographic data is compared. Identifying differences between ‘good’ and ‘bad’ batches has long been a time-consuming and labour-intensive process, often taking days or even weeks to yield meaningful insights. Smart Subtract reduces this to minutes while delivering more accurate results...

TESTA Analytical reports that its Differential Refractometer improves the precision of dn/dc determination using light scattering techniques. An accurate dn/dc value is essential in molecular weight determination of biopolymers and polymers by light scattering. Backed by decades of experience of Gel Permeation Chromatography (GPC) and Light Scattering techniques, Testa Analytical has created a differential refractometer accessory for light scattering instruments that deliver exceptional performance and is easy-to-use...

The world’s number one laboratory gas generator manufacturer¹, PEAK Scientific, has announced that its’ best-selling Genius range of nitrogen gas generators for LC-MS are now the first laboratory nitrogen generators to be certified with an Accountability, Consistency and Transparency (ACT®) Ecolabel from My Green Lab®. With this certification, laboratories with an active Genius product can access independently verified environmental impact data, covering key sustainability metrics related to manufacturing, energy and water use, packaging, and end-of-life considerations...

The requirements for quality assurance of biologics are increasing. Danish contract laboratory now opens for access to a database that - combined with the company’s measurement tools - can shorten the development time and heighten the quality of novel biological products. Since 2007, the contract laboratory Alphalyse A/S has developed and refined a new method of impurity analysis in biological pharmaceuticals based on mass spectrometry (MS)...

Bio-Rad Laboratories, Inc. a global leader in life science research and clinical diagnostics products, has announced the launch of Nuvia wPrime 2A Media, a scalable weak anion exchange and hydrophobic interaction (AEX-HIC) mixed-mode chromatography resin for small- to large-scale biomolecule purification. Bio-Rad's partners in the resin’s development successfully used the resin to remove host cell proteins, high and low molecular weight aggregates and impurities, and DNA from monoclonal and bispecific antibodies, and adeno-associated virus...

Labomatic Instruments AG and KNAUER Wissenschaftliche Geräte GmbH are pleased to announce a strategic cooperation aimed at combining their complementary strengths to offer a larger portfolio to their respective customer bases. Customers in the liquid chromatography segment in particular are likely to benefit from the complementary expertise, especially in terms of flow rate and pressure ranges...

Using the HPLC Pump Qualification Pack from TESTA Analytical considerably reduces the time required for HPLC pump qualification, while improving traceability of results. Comprising a calibrated non-invasive, realtime LC flowmeter, data validation tool and tablet-computer with pre-installed software – the pack automatically performs all necessary flow data calculations plus operational and performance qualification checks...

Advances in nanoparticle and protein development have introduced complex solutions with a narrow window for achieving optimal efficacy and safety. Addressing these challenges requires precise control over charge, size and distribution. The ZetaStar™️ instrument integrates dynamic, static and electrophoretic light scattering (DLS/SLS/ELS) measurements into a single system...

YMC Accura columns are the solution for researchers working with challenging phosphate-rich molecules or metal-coordinating compounds. These bioinert columns feature an advanced inert coating, designed to prevent peak tailing and carry-over, while delivering optimal recovery rates. Their seamless compatibility with MS detectors, as demonstrated in this technical note, ensures enhanced workflow accuracy, making them an indispensable tool for high-sensitivity applications...

Flow rate is one of the most important parameters in any liquid chromatography system, it determines retention time or volume and therefore has a major influence on reproducibility. In this new study, the TESTA Analytical Liquid Chromatography Flowmeter is shown to provide a valuable tool for continuous, non-invasive measurement of flow rate in GPC/SEC systems...