EFFICENT SEPARATION 

Alongside monoclonal antibodies (mAbs) and antibody-drug-conjugates (ADCs) antibody fragments and their drug conjugates find application in therapeutic treatments. These fragments bind selectively to specific antigens, mirroring the function of intact antibodies. Due to their significantly
smaller size, antibody fragments require dedicated analytical methods for precise characterisation and quality control.

This Application Note presents an optimised SEC-MS method for the high-performance separation and characterisation of a single-chain variable fragment (scFv) and its drug conjugates (FDC). Using a bioinert PEEK-lined YMC-Pack Diol-120 metal-free column combined with MS compatible conditions delivers:

✔ Sharp peaks & precise resolution
✔ Enhanced signal response
✔ Reliable results

Boost your analytical expertise – download the Application Note now!

View Application Note

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