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New Tech Note: Guidelines for an effective purification method development
Chromatographic purification on a research scale is a must-have in many areas such as academia and pharmaceutical research. However, this can be very time consuming. Therefore, effective development of the purification method is essential.
These guidelines from YMC demonstrate the main steps for an effective purification method development:
- Developing a well-optimised separation on analytical scale
- Loading study on analytical scale
- Scale-up to semi-preparative column dimensions
- Quality control/proof of concept
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