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Dionex Application Improves Determination of Sulfate and Sulfamate in Topiramate Using Ion Chromatography

Dionex announces a new method for determination of sulfate and sulfamate in a pharmaceutical preparation using Ion Chromatography. Application Note 238: Determination of Sulfate and Sulfamate in Topiramate Using a Reagent-Free, released in September, describes a method that uses a Reagent-FreeTM ion chromatography (IC) system Ion Chromatography System with the IonPac® AS11 column and suppressed conductivity detection for the determination of sulfate and sulfamate in topiramate.

Topiramate is a second-generation antiepileptic drug used for the treatment of seizures and migraines. At elevated temperatures and humidity, the active pharmaceutical ingredient can degrade to produce organic degradation products, insoluble polymeric products, and the inorganic anions sulfamate and sulfate. Determination of sulfate and sulfamate (the inorganic degradation products) can be used to monitor and confirm topiramate degradation.

The method described in AN 238 demonstrates good linearity, precision, and accuracy for determining these inorganic degradation byproducts. This method also provides a simpler approach than the current and proposed USP methods for analysis of this drug product.

For more information visit or contact your local Dionex Representative.

Dionex (NASDAQ:DNEX) is a global leader in the manufacturing and marketing of liquid chromatography and sample preparation systems, consumables, and software for chemical analysis. The company's systems are used worldwide in environmental analysis and by the life sciences, chemical, petrochemical, food and beverage, power generation, and electronics industries. Our expertise in applications and instrumentation helps analytical scientists to evaluate and develop pharmaceuticals, establish environmental regulations, and produce better industrial products.

IonPac is a registered trademark and Reagent-Free is a trademark of Dionex Corporation


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