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Simplified and Reproducible Separation of Ethyl Sulfate Impurity in Indinavir Sulfate

Thermo Fisher ScientificThermo Fisher Scientific Inc. is pleased to announce a new method that uses ion chromatography (IC) to separate ethyl sulfate in an indinavir sulfate drug sample. Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS. Application Note 284: Determination of Ethyl Sulfate Impurity in Indinavir Sulfate Drug Using Ion Chromatography demonstrates that only the addition of deionized water to the IC system is required to deliver reproducible chromatography while avoiding the time, labor, and potential error of manual eluent preparation. This method uses an electrolytic suppressor in recycle mode, and therefore, does not require the analyst to prepare sulfuric acid solutions for eluent suppression.

Pharmaceutical companies can use the method described in AN 284 to monitor process-related and degradation impurities before commercial release to prove the consistency of their manufacturing process.

This application note and many others can be found at under the Documents tab.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit


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