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New Knockout and Knockdown Validated Antibodies Are Launched by Creative Diagnostics for Bio-researchers

publication date: Feb 12, 2018
author/source: Creative Diagnostics

Knockout and Knockdown Validated Antibodies

Creative Diagnostics recently announces that it has added new Knockout and Knockdown Validated Antibodies to its existing antibodies portfolio.

As a leading supplier of high quality antibodies validated for use in multiplexed assays, Creative Diagnostics recently announces that it has added new Knockout and Knockdown Validated Antibodies to its existing antibodies portfolio, which are designed according to the scientific needs of global research institutes, universities and biotech and pharmaceutical companies, etc.

Knockout validation has been developed as a part of Creative Diagnostics’ standard antibody validation, and knockout validated antibodies are available at Creative Diagnostics. Validating an antibody's specificity is crucial to ensure the absence of nonspecific binding. One approach to address this is through knockout or knockdown of the target protein by CRISPR- or RNAi-mediated technologies.

Western blot using knockout (KO) cell lysate has become a new practice for antibody validation. In KO validation, a knockout cell line was paired with the parental cell line in western blot analysis. A truly specific antibody recognizes the target protein of right molecular weight in the WT cell lysate, but not in the KO cell lysate.

"With the increasing need for highly specific antibodies, Creative Diagnostics is committed to providing the best antibodies available. We are currently retesting the entire portfolio of Creative Diagnostics antibodies to verify that they are specific to the indicated targets. Antibodies that have passed the KO/KD test will be labeled with the KO/KD validated icon. We’re pleased that we can offer our customers an increased selection and enable them to perform multiple experiments." said Dr. Jessica Waldorf, chief scientific officer of R&D department of Creative Diagnostics.

"Creative Diagnostics has rich experience on the precision knockout validation technology. We’ll make sure that our antibodies are highly specific to the intended protein target, so that we can provide researchers with trusted data and enable them to confidently select the right product and ensure the accuracy of their experiment results. Along with our variable quality antigens and the latest knockout validated technology, we believe our clients can get achievable results with Creative Diagnostics.” added Dr. Randy S. Vaughn, senior researcher, Creative Diagnostics.

If you want to share your knockout/knockdown validation data using Creative Diagnostics antibodies, please feel free to contact Creative Diagnostics at 1-631-619-7922 or email to

About Creative Diagnostics

Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components and critical assay reagents. It also provides contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. It aims to provide a trusted source for all researchers’ assay development and manufacturing needs.


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