Vyon® porous plastics from Porvair Sciences are the perfect material for filtration applications in the healthcare and medical device market. The tortuous path of Vyon® porous plastics make these materials particularly effective at bacterial filtration and preventing microbial ingress. Employing a standard procedure, based upon ASTM F2101, Porvair Sciences can manufacture Vyon® porous plastic filters for incorporation into a medical device that offer greater than 99% Bacterial Filtration Efficiency (BFE)...

Offering complete disruption of cytoplasmic and nuclear membranes, Porvair Sciences Chromatrap® buffer chemistries are optimised for sonication and enzymatic shearing. The success of a ChIP assay is highly dependent on the quality of chromatin prepared. Chromatrap® lysis and hypotonic buffers are high performance reagents you can trust in this critical first step in isolating chromatin from your sample...

Vyon® porous plastics from Porvair Sciences are the perfect material for filtration applications in the healthcare and medical device market The tortuous path of Vyon® porous plastics make these materials particularly effective at bacterial filtration and preventing microbial ingress. Manufactured to a variety of pore sizes and thickness, Vyon® porous plastic materials can also be used to filter out a wide variety of different contaminating particles...

Unlike traditional loose-packed Solid Phase Extraction (SPE) methods, Microlute CP SPE 96-well microplates and cartridges are based upon a solid interconnected network of evenly distributed pores combined with novel retentive media. This unique design enhances the flow-through of samples to maximise interactions between analytes and the solid phase to deliver unmatched reproducible SPE products that excel in terms of performance, cleanliness, and sensitivity...

Manufactured to the ANSI/SLAS standard, the range of reagent reservoirs from Porvair Sciences are designed for simple integration into any automated liquid handling system. Moulded from high-purity polypropylene, in a Class 10,0000 cleanroom environment, Porvair reagent reservoirs offer chemical compatibility with most organic solvents, acids and bases. High heat resistance allows the reagent reservoirs to be autoclaved clean...

Specialists in innovative porous plastics technologies – Porvair Sciences has introduced a new range of Vyon® PTFE porous plastic materials for applications where temperature or chemical resistance is important. Vyon® PTFE is a unique, high-performance porous plastic material manufactured from 100% pure polytetrafluoroethylene. Through sintering, Porvair produce porous PTFE structures composed of tortuous interconnected pathways with minimal dead-end pores...

Porvair Sciences has developed a 2 ml 96-well microplate whose design is optimised for labs processing cannabis samples for analysis of Tetrahydrocannabinol (THC) and Cannabidiol (CBD). Sample processing is the second step in testing cannabis strains. This is carried out after collecting leaf, bud, and flower samples from cannabis plants, ready for accurate determination of the THC/CBD ratio by HPLC...

Porvair Sciences has introduced a 96-well deep well microplate designed for labs using magnetic beads for nucleic acid purification, clean up and protein purifications. The 96-well magnetic bead separation plate has a reinforced base that can be routinely centrifuged at up to 6,000x g enabling faster magnetic bead separation protocols and improved sample quality. Manufactured in a class 10,000 cleanroom facility from ultra-pure grade polypropylene, the magnetic bead separation plate contains the lowest possible level of leachable...

Porvair Sciences announce eGecko² – an automated barcode application system that provides the ideal high throughput solution for precisely applying barcode labels onto racks of plates and Petri dishes. Based upon a robust and proven label printer and print engine, the eGecko² is a completely integrated printer and application unit in one, requiring only an electrical supply for operation. A choice of easily exchangeable operating heads allows you to apply labels on both flat and curved surfaces....

Designed to be simple to operate, the Ultraseal Lite semi-automatic microplate sealer from Porvair Sciences is the perfect device for labs with low to medium throughput (6 plates / minute) processing needs. Compact in design, the Ultraseal Lite will fit just about anywhere you need to use it - be it on a lab bench or inside a fume hood. Combining a powerful 400W heater with a strong sealing action, the Ultraseal Lite will deliver high integrity sealing of almost any type of microplate...

The Ultravap® family of blowdown evaporators from Porvair Sciences is proven to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from 12-, 24-, 48-, 96- and 384- well microplates and glass tubes. Designed with a flat front profile and platform shuttle enables easy interfacing with liquid-handling robots for high automation efficiency. Able to operate up to 80°C - Ultravap® evaporators can remove all chromatography solvents cleanly and efficiently without risk of cross-contamination....

Porvair Sciences has added a new 1.2 ml Deep Well microplate, with round well bottoms for maximum sample recovery, to its family of 96-well square storage plates. Manufactured from ultra-pure medical grade polypropylene, in a class 10,000 DNase/RNase-free cleanroom environment, the new plate offers high integrity storage of your samples at -80?C even over extended periods of time...

The Chromatrap® Homogeniser Spin Column from Porvair Sciences maximises the yield and quality of viral RNA extracted from nasal and throat swab samples. The easy-to-use spin column offers a fast and efficient ‘one-stop’ alternative to using traditional syringe and needle homogenisation techniques. Employing a novel dual frit extraction design the Chromatrap® Homogeniser Spin Column reduces lysate viscosity and captures insoluble debris by centrifugation....

The Sero Krystal™ PDL range of coated microplates from Porvair Sciences set a new benchmark for reproducible cell culture even with challenging cell types. Many scientists would prefer to grow cells in a serum-free environment to more accurately mimic physiological conditions. However, this often presents challenges as cell lines often struggle to attach to traditional tissue culture plastics in the absence of serum....

Designed to provide dry down of samples in microplates and glass tubes up to 150 mm in length - the Ultravap® Mistral XT150 blowdown evaporator from Porvair Sciences offers a low maintenance, sample-safe alternative to using water bath-based evaporators. Able to operate at temperatures up to 80°C - nearly all common chromatography solvents including acetonitrile, dichloromethane, hexane, methanol and water can be evaporated with ease by the Ultravap® Mistral XT150...

Porvair Sciences low profile microplates offer the highly efficient use of stacking space that is essential to achieving efficient automation workflows. Designed to deliver a sample volume of 0.5ml / well in a plate height of just 27mm, these low-profile 96-well microplates are ideal for a wide range of pharmaceutical, biotechnology and healthcare storage applications...

Developed for automated applications - Porvair Sciences 96-well polypropylene microplates provide the perfect vessel for Biobanks and Biorepositories looking to store and maintain the integrity of their valuable specimens over prolonged periods of time. Biobanking is the process by which samples of body fluids or tissue are collected for research use to improve our understanding of health and disease. However, keeping these biological specimens in long-term sample storage conditions comes with a key challenge...

A new 'Guide to Dry Down Solvent Evaporators' from Porvair Sciences offers an informative insight into traditional bottlenecks in chromatography sample preparation workflows and describes how blowdown evaporators work. Further the guide looks at factors that can enhance the speed and efficiency of sample dry down in microplates and vials and provides advice on how to choose the right evaporator for your laboratory....

Precision manufactured to SBS / SLAS dimensions - Porvair Sciences range of reservoir trays are designed for simple integration with any robotic liquid handling system.  When pipetting higher value reagent - it is an advantage to reduce the waste or dead volume in your reservoir tray.  Incorporating a low plate profile and a novel 'pyramid bottom' design - Porvair reservoir trays provide easy access to all liquid contents as well as ensuring a low reagent dead volume for 96- and 384-well filling applications...

Drawing upon its expertise in polymer moulding, surface treatment, specialist assembly and knowledge of analytical, healthcare and life science applications has enabled Porvair Sciences to become a market leading supplier of private label and custom manufactured microplates. Krzysztof Kielmann, Microplates Product Manager at Porvair Sciences said "Many instrument suppliers today recognise that 'off-the-shelf' microplates will not always enable them to fulfil new application opportunities or gain a competitive edge...

The Ultravap® Mistral family of microplate evaporators from Porvair Sciences are used in labs worldwide to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from 12- to 384-well microplates and vials up to 15cm tall. The latest generation of Ultravap® Mistral evaporators are designed with new flat front profile and platform shuttle enabling easy interfacing with liquid-handling robots for increased automation efficiency...

Porvair Sciences has published an in-depth application report demonstrating how their Microlute® CP Reverse Phase Solid Phase Extraction (SPE) microplates provide a robust and highly reproducible SPE LC-MS sample preparation methodology for a range of neutral, acidic, and basic analytes. As a sample preparation method - Solid Phase Extraction is widely acknowledged as a 'go to' tool for the clean-up of samples before analysis by hyphenated techniques such as LC/MS or GC/MS...

At Lab Innovations 2021, Porvair Sciences will showcase its extensive range of consumables and instruments for improving workflow in life science laboratories. To assist lab scientists tasked with overcoming workflow bottlenecks associated with sample handling / storage, sample preparation, sample processing and sample analysis - Porvair Sciences technical specialists will be available on Stand B22 to answer your questions.

Porvair Sciences announce a new range of fast to apply and highly effective microplate adhesive seals for labs that are short on time and may not have access to automated sealing instruments. Adhesive seals offer an inexpensive and easy way to seal microplates for transport or to prevent contamination and evaporation. Porvair Sciences adhesive films come in a variety of formats to suit most applications...

Porvair Sciences has introduced a new and improved version of its Microlute® PLR phospholipid removal microplate designed to enhance the flow of samples through a proprietary filter to maximise the recovery of analytes with unmatched reproducibility. Benefiting from the naturally hydrophobic PFTE filter - the new second generation Microlute® PLR plate can be manufactured faster and more reproducibly than ever before....

Porvair Sciences has installed new automated precision die-cutting equipment that has enabled a five-fold increase in its production capacity for porous plastic components. This major investment by the company is in response to a significant rise in demand from customers for precision components made from its high performance Vyon® porous plastics. Installed in Porvair's cGMP compliant cleanroom production facility the new equipment is able to produce porous plastic components...

Porvair Sciences announces that its Ultravap® Mistral XT 150 blowdown evaporator is now able to operate at temperatures up to 80°C thereby significantly increasing the rate of evaporation of both organic solvents and aqueous solutions. Designed to provide dry down of samples in microplates and glass tubes up to 150 mm in length - the Ultravap® Mistral XT150 offers a low maintenance, sample-safe alternative to using water bath-based evaporators...

Designed to be simple to operate, the new Ultraseal LITE semi-automatic microplate sealer from Porvair Sciences is the perfect device for labs with low to medium throughput (6 plates / minute) processing needs. Compact in design, the Ultraseal LITE will fit just about anywhere you need to use it - be it on a lab bench or inside a fumehood...

Porvair Sciences has further expanded its range of high-performance microplate products for SARS-CoV-2 nucleic acid purification. The new KF deep well plate and tip comb plate combo are specifically designed to enhance the performance and productivity of the market-leading Thermo Scientific™ KingFisher™ range of nucleic acid purification systems....

Porvair Sciences reports investment in a dedicated clean area for manufacturing Vyon^® porous plastic components for healthcare, pharmaceutical and life science products. With the global market searching for high performance solutions for critical filtration, laboratory liquid handling and separation applications - Porvair has experienced a doubling in demand for components and products such as pipette filter tips based upon its Vyon® porous plastics....

Removal of gDNA from RNA samples is of particular important to scientists undertaking RT-PCR, RNA-seq and microarray-based applications where the high purity and accurate measurement of RNA is vital. Employing a simple load and spin method the new columns efficiently capture gDNA on the membrane allowing efficient flow through of DNA-free cell lysatesfor downstream RNA purification....

Porvair Sciences has announced its next generation AutoCapper electronic sealer - a versatile device designed to take the strain out of applying friction sealing caps to a wide range of microplates. Built to quickly and securely seal 96-well deep well microplates as standard, the AutoCapper is also compatible with shallow well and 24- and 48-well deep well plate formats using a range of supplied adapter blocks....

The Microlute™ CP range of Solid Phase Extraction (SPE) 96-well microplates and cartridges from Porvair Sciences takes SPE to a new level of performance by enhancing the reproducibility of analyte extraction and recovery from biological, environmental and chemical samples. Unlike traditional loose-packed SPE methods, Microlute CP uses a hybrid structure, a solid interconnected network of evenly distributed pores combined with the retentive media....

Porvair Sciences Ultraseal Pro is the new fully automated heat-sealing instrument designed to consistently seal and protect a wide range of microplates and tubes. Protecting precious samples during storage and transportation is an essential final step for a wide range of laboratory and clinical applications. Of the various methods for sealing microplates, heat sealing has become the preferred option....

The Microlute™ PLR from Porvair Sciences is a benchmark product for phospholipid removal. The 96-well microplate provides effective removal (>99%) of phospholipids and proteins with higher levels of reproducibility from plasma and serum samples while maintaining maximum recovery of target analytes. Proven in comparative tests with competitive products to provide the most efficient removal of the widest range of phospholipids from plasma and serum samples...

Porvair Sciences has launched new kits for rapid extraction of total RNA from a wide range of biological samples. These proprietary kits enable extraction of up to 1000 µg of application-ready pure RNA in as little as 10 minutes. Extraction and purification of  RNA is required for numerous downstream molecular biology applications such as RT-PCR, qPCR, Western blotting and RNA amplification. The global COVID-19 pandemic has resulted in a huge increase in the demand for testing and detection of viral nucleic acids...

Porvair Sciences has launched its new generation Ultravap® Levante nitrogen blowdown sample evaporator. The second generation system offers the many benefits associated with Porvair's flagship evaporator, the Ultravap® Mistral, in an affordable, easy-to-use package. This state-of-the-art single microplate evaporator is designed to meet the current needs of most chromatography laboratories...

Porvair Sciences new Krystal™ Glass Bottom microplate with high quality specialty glass from Schott provides unmatched performance for whole-plate CCD imaging and laser detection applications. Krystal™ Glass Bottom plates combine the advantageous optical properties of glass, low background and low birefringence, with the versatility of a microplate...

Porvair Sciences announce the availability of a new guide that makes selection of the optimum Solid Phase Extraction (SPE) microplate for your application both quick and easy. SPE is a widely used method of sample preparation that concentrates and purifies analytes from a solution by means of absorption, followed by the elution of the analyte with a solvent appropriate for instrumental analysis, with techniques such as LC-MS...

Porvair Sciences has launched a new second generation model of its Ultravap^® Mistral - an automation-ready sample evaporator that offers throughput advantages to laboratories looking to optimise and accelerate sample preparation. Designed to remove the traditional laboratory ‘bottleneck’ of solvent evaporation, industry-leading sample drying reproducibility has been achieved by recent advancements in gas injection technology....

Porvair Sciences provides a complete design and manufacture service to help customers develop new and innovative custom microplates for specialist applications. Porvair Sciences is widely recognised as a leader in the field of moulding ultra-pure plastic materials such as polystyrene, polypropylene and polycarbonate. With decades of experience and expertise in ultrasonic welding, surface treatment techniques, co-sintering of polymers / silicas, specialist assembly and a strong understanding of analytical applications...

Finneran Porvair has introduced new Convenience Kits for Per- and Polyfluoroalkyl substances (PFAS) testing. Because Per- and Polyfluoroalkyl substances don't break down they can accumulate over time in the environment and in the human body. There is increasing evidence that exposure to PFAS can adversely affect human health. As a result, regulatory bodies are increasingly legislating that many materials should be tested to ensure that they contain no traces of PFAS or that the traces are below allowed legal limits....

Porvair Sciences will exhibit its latest specialist microplates and microplate instrumentation at the forthcoming SLAS 2021 Digital International Conference and Exhibition (January 25-27th 2021). Microplates product manager - Krzysztof Kielmann commented "A particular focus of our virtual exhibit will be specialist microplates and instrumentation for labs supporting the global COVID-19 testing effort....

Porvair Sciences reports, due to promising results, it has agreed with its collaborative partners to make additional investment in the CEAT project which aims to dramatically improve the diagnosis and treatment of ovarian cancer. In the initial stage of the CEAT (Cluster for Epigenomic and Antibody Drug Conjugate Therapeutics) project - Porvair Sciences supplied its proprietary Chromatrap^®....

Porvair Sciences has introduced a new 2.2ml 96 deep well plate specifically designed to be fully compatible with the Thermo Scientific™ KingFisher™ range of nucleic acid purification systems. For many labs, up-front sample preparation and handling represents a major bottleneck in their research workflow, as it is largely done manually. Widely used for the nucleic acid purification step in SARS-CoV-2 testing, the KingFisher™ Flex instrument can process 96 samples per run when paired with 96 deep-well microplates....

Porvair Sciences reports on testing that demonstrates how its hydrophilic Vyon® porous plastics exhibit outstanding performance in drug discovery applications due to the high hydrophilic void volume conversion of the materials’ pore structure after a special treatment process. Vyon® manufactured from HDPE (High Density Polyethylene) and & UHMWPE (Ultra-High Molecular Weight Polyethylene) is naturally hydrophobic...

Porvair Sciences offers an extensive range of sterile deep well microplates for sensitive biological and drug discovery applications. Deep well microplates are an important class of functional plasticware used for sample preparation, compound storage, mixing, transport and fraction collection. They are widely used in life science laboratories and are available in different sizes and plate formats, the most commonly used being 96 well and 384 well plates made from virgin polypropylene...

Porvair Sciences announces a special version of its popular Homogeniser Spin Column optimised for RNA extraction from buccal swabs. A large number of current COVID-19 diagnostic tests are reliant on detection of viral RNA from buccal swabs by PCR. The Chromatrap® Homogeniser Spin Column from Porvair Sciences has been adapted to ensure that it can routinely improve yield and quality of viral RNA from nasal and throat swab samples.,,

Leading microplate technology specialists - Porvair Sciences has expanded its range of high integrity heat sealing films. Choosing the correct combination of seal and closure device for different types of microplate is important to achieving good laboratory practice and to avoid unnecessary work further downstream....

Porvair Sciences reports on the Vyon® porous plastic filters it is supplying to University of Cambridge spinout company - Diagnostics for the Real World for their game-changing SAMBA II machine that provides diagnosis of COVID-19 infection in under 90 minutes. SAMBA II provides a simple and accurate system for the diagnosis of infection with SARS-CoV-2, the virus that causes the disease COVID-19....

Porvair Sciences announce Microlute™ CP - a new generation of Solid Phase Extraction (SPE) 96-well microplates and cartridges that take SPE to a new level of performance by enhancing the reproducibility of analyte extraction and recovery from biological, environmental and chemical samples. Unlike traditional loose-packed SPE methods, Microlute CP uses a hybrid structure...

Porvair Sciences has introduced Microlute™ SLE 96-well plates and cartridges to enable you to quickly and easily extract a wide range of acidic, basic and neutral analytes from samples with greater reproducibility. Designed to provide a superior method of liquid extraction, Microlute™ SLE products use selectively sourced diatomaceous earth (DE) as the solid support to maximise absorption...

Porvair Sciences announce Microluteä PLR - a new benchmark product for phospholipid removal. The 96-well microplate provides effective removal (>99%) of phospholipids and proteins with higher levels of reproducibility from plasma and serum samples while maintaining maximum recovery of target analytes. Phospholipid-based matrix effects are a major source of variability and inaccuracy in bioanalytical mass spectrometry (MS) analysis....

Porvair Sciences has expanded its range of high quality, black microplates that minimise sample degradation by exposure to light, even over long storage periods. Available in a choice of 48-, 96- and 384-well formats – Porvair Sciences black plates are precisely manufactured to applicable ANSI / SLAS dimensions ensuring complete compatibility with almost all readers and automated equipment.

The MiniVap® Nitrogen Blowdown evaporator from Porvair Sciences is purpose designed for research and development departments where low numbers of individual microplates or vials need drying. The MiniVap® is simple to operate and maintain. Installation requires only connection to a gas supply and standard mains socket. With manual control of the needle depth, gas temperature and flow rate, it allows fine control and quicker drying times than other standard methods....

The Chromatrap® Protein Extraction kit from Porvair Sciences offers a fast and efficient method of extracting cytoplasmic, nuclear or total protein from mammalian cells. Combining the optimised protocol with proprietary reagents, the kit is able to provide high yields of purified active protein with low cross-fraction contamination in less than 90 minutes. Avoiding the need for ultracentrifugation steps in its protocol, the Chromatrap® Protein Extraction kit...

Porvair Sciences has expanded its range of high-performance microplates to now offer an optimized product to suit a wide range of filtration applications. The main application of filtration microplates in scientific research is the removal of particulate matter and debris from liquids. Once the two have been separated using a filter plate, assays can then examine either the filtrate or the particular matter itself, depending on the application....

Porvair Sciences has developed a new range of filters for pipette tips for a leading separation science supplier who was looking to bring control of supply and manufacture of these components in house. Initially Porvair Sciences undertook testing to fully characterise (air flow, pore size, material make-up) the outsourced pipette tip filters the customer sought to replace. Then working closely with an injection moulding company who were reverse engineering the pipette tip itself...

Porvair Sciences will showcase its recently extended ranges of ultra-clean deep well and assay microplates for the first time in Europe at the forthcoming Lab Innovations 2019 exhibition. Krzysztof Kielmann, Microplates Product Manager at Porvair Sciences commented "We offer ultra-clean deep well plates in an unmatched range of formats, well shapes and volumes. Researchers can now work with volumes as low as 1ml and as high as 2.2ml, each with different well and bottom shapes....

Porvair Sciences has launched a new range of Liquid Handling Pipette Tip Filters that provide unmatched capabilities to block out aerosol and liquid contaminants. Hilary Bishop, Product Manager for Porous Products commented “Using our proprietary Vyon® porous plastics, the new pipette tip filters are fully compliant with FDA, USP Class VI and European Pharmacopoeia statutory regulations as well as being free from heavy metals....

Porvair Sciences announce the new Chromatrap^® Homogeniser Spin Column which provides a quick, cost effective way to homogenize cells and tissues lysates in a single step. Developed as a quick, clean and efficient alternative to syringe and needle homogenization techniques - the Chromatrap® Homogeniser Spin Column offers labs an easy-to-use downstream sample processing...

Porvair Sciences announces its complete range of Krystal (TM) clear bottomed assay microplates is now available individually packed and sterilised for optimised tissue culture cell growth or non-sterile for assay development. Available in a choice of 24-, 96- and 384-well formats, Krystal™ series clear bottom assay plates are widely recognised as industry-leading cell culture tools...

Porvair Sciences has extended its sample storage and collection range with the introduction of 5 new deep well microplates. Deep well microplates are an important class of functional labware used for sample preparation, compound storage, mixing, transport and fraction collection. They are widely used in life science laboratories and are available in different sizes and plate formats....

Porvair Sciences has published data that demonstrates how optimising protein orientation for maximum chromatin-antibody binding and capture is enabling its Chromatrap® ChIP-seq kits to offer market leading sensitivity. Lindsay Parkes, Senior Research Scientist at Porvair Sciences explained "We have developed our bead-free technology to enable maximum capture of antibody....

Porvair Sciences has introduced the first commercial ChIP kit range dedicated to Drosophila (fruit fly). Benefiting from proprietary bead-free ChIP technology, these new kits deliver high-quality ChIP-ready chromatin from as little as 5 Drosophila specimens and from a range of Drosophila tissues....

Porvair Sciences has published data that demonstrates how optimising protein orientation for maximum chromatin-antibody binding and capture is enabling its Chromatrap® ChIP-seq kits to offer market leading sensitivity. Lindsay Parkes, Senior Research Scientist at Porvair Sciences explained "We have developed our bead-free technology to enable maximum capture of antibody....

Porvair Sciences, global specialists in the manufacture of microplates and microplate equipment, offer an extensive range of sample preparation products for mass spectrometry techniques including LC/MS and GC/MS. Together with sister company J.G. Finneran Associates, Porvair Sciences is able to offer an unmatched selection of innovative glass vials, seals, closures, and microplates....

The family of ultra-flat Krystal™ glass bottom microplates from Porvair Sciences provide unmatched performance for high-throughput screening and tissue culture applications. The automation-compatible Krystal™ plates combine the advantageous optical properties of glass, low background and low birefringence, with the versatility of a microplate....

The Protein Crash technique used by the Porvair Sciences P3 microplate is highly effective at removing proteins from biological samples prior to analysis. The P3 microplate works by denaturing the protein upon addition of solvents such as acetonitrile or methanol. The proteins “crash” or precipitate out of solution to forms large sticky globules.....

Porvair Sciences has launched a reinforced base version of its 96-well deep round microplate (P/N 219020).The plate has been designed with a working volume of 2ml per well (double that of most round well reinforced storage plates) and can be routinely centrifuged at up to 6000g. Manufactured from ultra-pure grade polypropylene, Porvair’s new reinforced base 96-well deep round plates are certified as RNase / DNase free and contain the...

This project will involve collaboration with 5 key industrial partners - Porvair Sciences, Bruker UK, GE Healthcare UK, Axis Bio and GlaxoSmithKline (GSK).  A new Antibody Drug Conjugates company will join the project in its second year. Antibody Drug Conjugates (ADC’s) are a powerful new class of therapeutics in medical oncology, where antibodies that target specific cancers are coupled with cytotoxic agents....

Porvair Sciences has announced that its industry standard 96-well sample storage plate - the round bottom 1ml deep well microplate is now available manufactured in the USA. Produced from ultra-pure grade polypropylene, Porvair's round bottom 1ml deep well plates are certified as RNase / DNase free and contain no measurable contaminants that can leach out and contaminate your stored samples.  In an independent study*, despite...

Chromatrap®  has entered into a partnership with Covaris to offer a highly scalable and simple ChIP workflow enabling researchers to easily isolate protein-DNA complexes for downstream applications, such as ChIP-Seq, ChIP-qPCR, Next-generation sequencing (NGS), and Mass Spectrometry (MS). Preparing samples for Chromatin Immunoprecipitation (ChIP) has traditionally been a multi-step, time-consuming, and error-prone workflow....

Porvair Sciences reports on a highly effective protocol, using its Plant Genomics microplate, for preparing cannabis samples for analysis of Tetrahydrocannabinol (THC) and Cannabidiol (CBD). With increasing legalization of cannabis for medicinal and research purposes, demand for accurate and high throughtput analysis of its active ingredients has dramatically risen. Cannabis plant material contains several cannabinoids for which the human brain has evolved receptors....

Porvair Sciences announce how its Chromatrap® Lysis and Hypotonic buffers play a crucial role in enabling researchers to better explore and understand the underlying processes and mechanisms that drive biological organisms. There are many benefits to using Chromatrap® buffer reagents for lysing cells. These buffers have been formulated to act  rapidly, gently and efficiently, ensuring reproducible results with high...

Porvair Sciences unique Krystal 2000 microplate range sets a new standard for luminescence and fluorescence assays. Incorporating individual clear cups moulded into either a black or white polypropylene matrix using a patented `two-shot` manufacturing process totally eliminates the well-to-well optical crosstalk inherent with other clear-bottomed microplate designs. As a result - Krystal 2000 plates enable you to achieve unmatched luminescence...

Porvair Sciences announce Autocapper – a new affordable microplate sealing system designed to work with reusable mat caps (friction seals) from all the major manufacturers. Set-up to quickly and securely seal 96-well deep well microplates as standard, the Autocapper is compatible with shallow well and several other plate formats (24-well, 48-well) using a range of supplied adapter blocks. Designed to meet the needs of laboratories for low to medium throughput microplate sealing, the Autocapper is compact and easy-to-use....

Porvair Sciences has introduced new 8- and 12-channel reservoir troughs to help improve multichannel pipetting convenience and productivity in high-throughput laboratories. The reservoir troughs are designed to hold liquid reagents in precise rows that align with 8-channel and 12-channel pipettes allowing researchers to simultaneously aspirate or dispense fluids in all channels.  These reservoir troughs help laboratories improve productivity by increasing the speed and...

Porvair Sciences, original manufacturers of porous plastics, will be showcasing its advanced materials for the medical and life science markets at this year’s COMPAMED exhibition in Dusseldorf, Germany. Visitors to Booth F08 in COMPAMED Hall 8a, will be able to learn how Porvair's BioVyon™ range of high-performance porous materials have been incorporated into products to achieve more sensitive analysis, better healthcare, improved medical...

Porvair Sciences new UltraVap Mistral XT 100 allows for the first time, full automated dry down of organic solvent-based samples in tubes up to 100mm in length. The UltraVap Mistral XT 100 is Porvair Sciences latest fully robot compatible nitrogen blow-down evaporator, suitable for integration adjacent to most leading laboratory liquid handling robots. Designed with the demands of linear robots very much in mind, the UltraVap Mistral XT 100...

Porvair has chosen Lab Innovations 2018 to bring together, for the first time on a single exhibition stand (G16), all the latest products and application solutions from its fast-growing Laboratory Division. The Laboratory Division designs and manufactures instruments and consumables for use in environmental and bioscience laboratories with a particular focus on water analysis instruments and sample preparation...

Beginning October 1st through December 31st, a portion of each sale of our Pink promotional products will be donated to Gilda’s Club. Our donation will be made in the memory of our company founder and Mom – Josephine Finneran. Gilda’s Club is a community organization for people living with cancer, their families and friends....

Porvair Sciences reports how its P3 microplate can be used to accelerate removal of interfering proteins from serum, plasma or even whole blood samples prior to analysis by Liquid Chromatography / Mass Spectrometry (LC/MS). Biological samples commonly contain proteins that interfere with downstream applications. Traditionally scientists have used the CRASH method....

Compact in size, the UltraJet electronic pipette filler from Porvair Sciences is perfect for use even in confined spaces such as safety cabinets and fume hoods. The UltraJet pipette filler is quick and simple to operate. Its lightweight, ergonomic design ensures you can use it for extended periods of time without discomfort.....

Porvair Sciences has extended its BactiGrowth range of specially packaged plates designed to enable high yield growth of bacteria, yeast, mammalian or insect cell lines. Precisely manufactured to conform to the automation-friendly ANSI/SBS format, BactiGrowth plates are available in plate formats from 24- through to 384-well and well volumes from 300 µl to 10 ml per well to....

Porvair Sciences announces its JG Finneran range of high strength rounded or flat-bottomed headspace vials which are available in 6mL, 10mL, 20mL, and 27mL capacities. Available in either clear glass, or amber glass for light sensitive samples, each vial's wide opening allows samples to be simply and quickly added....

Porvair Sciences has produced an informative catalogue that describes its growing range of easy-to-use kits for DNA extraction, purification and size selection. Obtaining DNA from biological samples is the first and most crucial step in molecular biology. Eluting both high quality and high yield of DNA from a wide range of biological samples can be challenging...

Porvair Sciences has introduced the JG Finneran 50-position stackable rack for 12mm vials and tubes. This new stackable rack is designed to hold 12mm vials and tubes in the optimum orientation for pipetting tasks. Available in blue, black and white as standard, the 50-position rack is securely stackable saving valuable bench space....

Available in 96- and 384-well configurations - Porvair Sciences reagent reservoirs are designed for simple integration into any automated liquid handling system. Reagent reservoirs provide an economical way to divide up reagents and wash stations on the deck of automated liquid handling systems. Made to the ANSI/SLAS standard, Porvair reagent reservoirs can be used with most liquid handlers and are fully...

Porvair Sciences has collaborated with Persomics Inc. to develop and supply ANSI/SLAS format Arrays as an OEM product for their ImagineArray™ platform. On the Persomics ImagineArray™ platform, traditional microplate wells are replaced with contact-printed spots on a slide which is mounted into an SLAS/ANSI format frame. Each spot is a...

Porvair Sciences introduces new black Krystal UV Quartz bottomed microplates that offer excellent optical transmission in the wavelength range 185nm to 1100nm making them ideal for labs looking to make Circular Dichroism (CD) measurements....

The patented 96-well Multi-Tier Microplate System (MTP) from Porvair Sciences and sister company - JG Finneran is a unique device providing analysts with the convenience of an ANSI/SLAS microplate footprint but loaded with inert glass vials. Minimising the risk of extractables leaching out into samples to be analysed, the MTP accommodates a wide range of vial volumes enabling it to be...

J.G. Finneran the industry leader in quality chromatography vials and accessories introduces the new Stackable Vial Rack for 12x32mm vials. Unique chromatography sample vials, closures and accessories manufactured by J.G. Finneran Associates are available internationally from a network of laboratory dealers. J. G. Finneran along with Porvair Sciences will be exhibiting at analytica 2018 – Hall A.1 Stand 523. Please come by and visit us to see what the Finneran Porvair team has to offer....

Porvair Sciences, in conjunction with sister company – JG Finneran Associates Inc., has produced a new informative guide to assist lab scientists select the optimum seal and closure device for different types of microplate. Choosing the correct combination of seal and closure device for each type of microplate is important to achieving best laboratory practice and to avoid unnecessary work further downstream. Microplates are a convenient method...

Porvair Sciences announces the launch of UniqSeq - a new ChIP-Seq library preparation kit. High quality library preparation is key to a successful ChIP-Seq experiment. Obtaining complex libraries with good coverage and low bias are just some of the features that depend on high quality DNA after performing ChIP assays. As a new or occasional user, creating these libraries can seem like a daunting task.....

Porvair Sciences is a leader in bespoke and speciality microplate design and manufacture. Closely examining the needs of clients for special microplate designs, assembly techniques and plate structure, Porvair can deploy more than 30 years’ experience in the design, assembly and testing of microplates to deliver a world-class final product that can meet or exceed the most exacting specifications....

Porvair Sciences announces a new and improved Chromatrap® ChIP-Seq kit (v.1.5) that is optimised to work from fresh and frozen extracted tissue as well as cell lines. This latest version of the popular Chromatrap® ChIP-Seq kit enables ChIP to be performed from as little as 50mg of a wide range of extracted tissue samples. The new protocol incorporates optimised lysis and hypotonic buffers and guidelines on how to achieve maximum...

Porvair Sciences has extended its range of silicone impact support mats to protect deep well microplates when they are being centrifuged. Designed to fit into the skirt of the deep well plates, silicone impact support mats allow plates to be used in a centrifuge without risking plate distortion, cracking or breaking, resulting in well leakage and loss of valuable samples. Impact support mats are now available for Porvair Sciences square deep well plates (2ml, 1ml and 350ul), round well plates (2ml & 1ml) and range of large volume deep well plates....

Porvair Sciences has announced that it will showcase its latest microplate and chromatography products at the forthcoming Analytica 2018 exhibition in Munich, Germany. Designed for high recovery extraction of analytes from biological fluids, the 96-well Supported Liquid Extraction (SLE) microplate operates without the need for offline steps such as protein precipitation. The large pore size and high pore volume of...

Porvair Sciences Ltd, a leading supplier of separation and filtration technology for life science and healthcare applications, is hitting the small screen in a special showcase of its healthcare expertise.

Porvair Sciences are teaming up with Suzhou Tianlong Bio Technology Co Ltd (China), together with Swansea University and Xi'an Jiaotong University in a collaborative project

The project will integrate Porvair's innovative solid-state chromatin immunoprecipitation platform, Chromatrap® with Tianlong's expertise in automated robotic technologies and diagnostic multiplex PCR kits to develop innovative technologies in epigenetic characterisation for patient stratification in renowned precision medicine.

Porvair Sciences has posted a new online video demonstrating how nitrogen blowdown evaporators offer a useful tool for removing the solvent dry-down bottleneck in LC/MS sample preparation.

In the new video the presenter demonstrates how nitrogen blowdown evaporators can quickly and easily remove most chromatographic solvents, enabling fast recovery of dry compounds and allowing re-suspension of unknown mixtures in optimised solvents for LC/MS analysis. Additionally, the video introduces Porvair Sciences complete range of MiniVap and UltraVap blowdown evaporators. Blowdown evaporators give significant throughput advantages...

Chromatrap, a leading developer of cutting-edge life science products, has launched an affordable, easy-to-use range of DNA kits for routine molecular biology applications. 

Leveraging proprietary buffer chemistry and unique spin column design, Chromatrap® DNA kits are all free from salts, contaminants and inhibitors, providing you with the high recovery of top quality DNA perfect for downstream applications....

Porvair Sciences has published an informative video demonstrating how to use a solid-state filter microplate to remove interfering proteins from serum, plasma or even whole blood samples prior to analysis by LC/MS

Porvair Sciences has introduced a new range of pierceable cap mats from sister company, JG Finneran Associates Inc.

These new cap mats ensure the integrity of samples in Porvair 96-well Deep well microplate with glass inserts used in high throughput chromatography. Manufactured from chemically resistant PTFE with a silicone lining, the new JG Finneran pierceable cap mats come with a specially weakened area....

Porvair Sciences reports on the revolutionary “FlowerPlate” microplate developed and manufactured as an OEM product with and for m2p-labs in Germany.

Based in Baesweiler, Germany, m2p-labs was founded in 2005 as a spin-off of RWTH Aachen University. The company focuses on development and supply of systems for microreaction and automated solutions for screening and bioprocess development.....

Chromatrap has demonstrated that its unique solid state patented technology allows for ChIP-seq assays to be routinely performed from as little as 500ng of chromatin.

Traditionally availability of starting material has been a major problem for epigenetics researchers. The available techniques for tackling small samples which provide low yields of chromatin are usually long and complex, and involve pooling or the spiking of samples with chromatin from another source....

The 96-well Supported Liquid Extraction (SLE) microplate from Porvair Sciences is designed for routine, high recovery extraction of analytes from biological fluids.  

Porvair Sciences reports that the National Center for Biological Sciences (NCBS) in Bangalore, India is using its Krystal 384 black microplate to produce a standard drug testing assay for Plasmodium vivax infection.

The NCBS is a leading national institute whose faculty members undertake research in the frontier areas of biology. Scientists at the NCBS use experimental and computational approaches to study molecules, cells and organisms creating an understanding of the biology at each of these levels to advance an integrated view of life processes....

Porvair Sciences reports that the National Center for Biological Sciences (NCBS) in Bangalore, India is using its Krystal 384 black microplate to produce a standard drug testing assay for Plasmodium vivax infection.

The NCBS is a leading national institute whose faculty members undertake research in the frontier areas of biology. Scientists at the NCBS use experimental and computational approaches to study molecules, cells and organisms creating an understanding of the biology at each of these levels to advance an integrated view of life processes....

Porvair Sciences announces the availability of a new guide that improves your background knowledge and makes selection of the optimum deep-well microplate for your application both quick and easy.

Deep-well plates are used in a wide variety of applications including compound storage, fraction collection, sample mixing and preparation. Choosing the correct deep-well plate for your application can mean the difference between indifferent and great results. The easy-to-use guide provides....

Porvair Sciences announces a new easy-to-use 96-well Supported Liquid Extraction (SLE) microplate designed for high recovery extraction of analytes from biological fluids.   

Using the Porvair SLE plate high analyte recovery, free of proteins and phospholipids, is routinely obtainable without the need for offline steps such as protein precipitation. Supported Liquid Extraction is a separation technique similar to traditional liquid-liquid extraction....

Chromatrap announces that its popular Native ChIP kit is now fully compatible for mass spectrometry (MS) as a downstream process.

Combining Chromatrap®’s unique solid-state ChIP technology with MS enables researchers to obtain high quality data sets for chromatin proteomic profiling and mapping of histone modification patterns....

Chromatrap® announces that BioLegend, a major US-based manufacturer and supplier of reagents and kits for biomedical research, has chosen their novel solid-state ChIP technology to power a new range of faster and more efficient chromatin immunoprecipitation kits. 

These new kits will combine BioLegend's expertise in developing the Go-ChIP-Grade™ antibodies that are validated for ChIP assays with the patented solid-state immunocapture surface at the heart of every Chromatrap® product....

Porvair Sciences new Glass Vial Deep-well plate is designed to ensure that absolutely no extractables or leachates are present in a withdrawn sample, thereby removing the risk of false peaks in sensitive uHPLC and MS applications.

This high-quality product combines 96 x 1ml tapered or flat bottomed glass vials held firmly in each well of a 2ml 96 Deep-well plate.  Porvair Glass Vial Deep-well plates are less costly than solid glass plates and are precisely manufactured to comply with ANSI/SLAS dimensions to ensure complete compatibility with automated equipment....

The new Glass Vial Deep-well plate from Porvair Sciences is designed to ensure that absolutely no extractables or leachates are present in a withdrawn sample, thereby removing the risk of false peaks in sensitive uHPLC and MS applications.

This high-quality product combines 96 x 1ml tapered or flat bottomed glass vials held firmly in each well of a 2ml 96 Deep-well plate.  Porvair Glass Vial Deep-well plates are less costly than solid glass plates and are precisely manufactured to comply with ANSI/SLAS dimensions....

Porvair Sciences announces a new range of 384-well filtration plates with a unique drip geometry which provides unmatched sample recovery.

By cleverly re-shaping the drip director, and giving it a compound curve structure, the new filtration plates virtually eliminate the traditional “hanging filtrate” effect where excess filtrate clings by surface tension to the outside of the structure. In addition to improving total sample recovery, the new filtration plate design helps to minimise work surface and sample contamination as well as improving productivity...

Chromatrap® has introduced a new and improved version of it’s popular solid phase chromatin immunoprecipitation (ChIP) assay kit for chromatin extracted from Formalin Fixed Paraffin Embedded (FFPE) tissue.

Ideal for tissue samples, biopsies and difficult to lyse samples, the Chromatrap® FFPE ChIP-seq kit has overcome the issues often associated with FFPE ChIP, by offering a streamlined protocol which provides the user with excellent quality isolated chromatin....

Chromatrap® has published a new article that describes a detailed genome wide comparison of native and crosslinked chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) using the company's patented solid state spin column technology.

Chromatrap® supply high quality N-ChIP-seq and X-ChIP-seq kits. This article compares the enrichment of the histone H3K4me3 modification signal across the whole genome, from chromatin prepared by both methods (native vs cross link)....

Porvair Sciences is pleased to welcome J. G. Finneran Associates into the Porvair family following its acquisition by Porvair plc. 

J.G. Finneran designs, manufactures and distributes specialist laboratory consumables including vials, filters, microplates, closures and ancillary products. Finneran products clearly complement the biotechnology and chromatography product lines of Porvair Sciences and the combined product ranges will provide an enhanced offering to all customers....

Chromatrap® has published a new article that describes a detailed genome wide comparison of native and crosslinked chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) using the company's patented solid state spin column technology.

Chromatrap® supply high quality N-ChIP-seq and X-ChIP-seq kits. This article compares the enrichment of the histone H3K4me3 modification signal across the whole genome, from chromatin prepared by both methods (native vs cross link). The histone mark H3K4me3 was chosen for this study to highlight the sensitivity and efficiency of the Chromatrap...

Porvair Sciences has introduced a new version of its popular Ultravap Mistral automatic dry down station - the Mistral Ex.

With an adapted sample platform the automation-friendly Mistral Ex is able to productively remove solvent from a wide range of sample formats including 24 to 384-well format deep and shallow well plates, vials and now test tubes up to 100mm high. The Mistral Ex uses warm nitrogen gas blown down into the microplate wells, vials or tubes, just above the liquid level....

Porvair Sciences launched their new Seed Genomics microplate at the recent Plant & Animal Genomics 2017 conference in San Diego (USA) and received an enthusiastic response from the assembled scientists. 

Visiting genomic researchers were particularly impressed by the strong reinforced polypropylene deep well plate with its matching polypropylene cap mats. The extra ribbing underneath the plate to support its use in a GenoGrinder® bead beater system* was a feature welcomed by many visitors who saw the plate....

Chromatrap® has published a new application note that demonstrates how its unique solid state patented technology provides unrivalled sensitivity allowing users to perform ChIP assays using as few as 1000 cells per immunoprecipitation.

Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples with chromatin from another source. In the application note, the authors demonstrate how...

Chromatrap® reports on the excellent results achieved by customers using their 96 well high throughput plates for ultra-pure DNA purification. 

Using proprietary filtration media that offer much higher loadings of active material, assay times of less than 5 minutes are routinely achievable. Customers report that using Chromatrap® DNA purification kit that DNA samples ranging from 50 bp up to 23 kb can be purified with up to 98% recovery.....

Chromatrap® has published a new application note that demonstrates how its unique solid state patented technology provides unrivalled sensitivity allowing users to perform ChIP assays using as few as 1000 cells per immunoprecipitation.

Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples...

Porvair Sciences announces the introduction of Autocapper - a versatile electronic applicator that enables friction sample seals to be quickly and securely applied to both microplates and microtube racks.

The simplicity of the Autocapper design, which features a drawer to hold your microplate and cap mat, ensures highly reliable, high integrity sample sealing over many years’ service. Incorporating a powerful motor the Autocapper is able to apply sufficient force to fit cap mats of varying materials to most commercial available deep well plates....

Porvair Sciences announces the introduction of Autocapper - a versatile electronic applicator that enables friction sample seals to be quickly and securely applied to both microplates and microtube racks.

The simplicity of the Autocapper design, which features a drawer to hold your microplate and cap mat, ensures highly reliable, high integrity sample sealing over many years’ service. Incorporating a powerful motor the Autocapper is able to apply sufficient force to fit cap mats of varying materials to most commercial available deep well plates....

Chromatrap®  offers an optimised unique buffer chemistry that provides the leading solution for the isolation of high quality and high yield chromatin.

The success of any ChIP assay is dependent upon the quality of your chromatin. The unique buffer system for chromatin extraction developed by Chromatrap® has been cited in a growing number of recent publications investigations into G-quadruplex structures in human regulatory chromatin and receptor signals in natural killer cells....

Porvair Sciences will showcase two important technical breakthroughs at PAG XXV in San Diego (USA) from January 14-18, 2017.

Their brand-new 96-well Seed Genomics plate sets a new standard for high throughput plant genomics sample preparation. Unlike most commercially available deep well plates, the Seed Genomics plate has been proven to withstand demanding applications using steel ball bearings in the wells shaken at up to 1500rpm used to homogenise seeds, leaves or tissue ready for DNA extraction...

Porvair Sciences announces a new range of 96-well (square and round) capmats made from 100% pure silicone that has been conditioned for low bleed and ease of needle penetration when used with autosamplers.

Advantageously these silicone capmats reseal after each piercing and may be re-pierced many times without loss of function. Specially treated with a PTFE coating, Porvair silicone capmats offer increased chemical resistance thereby maintaining high sample integrity even over extended periods of time. Resistant to organic solvents including ethanol, methanol, DMSO and DMF, these flexible silicone capmats individually seal the top of each microplate well reducing the chance of...

The Chromatrap® Enzymatic Shearing Kit provides an excellent method for the preparation of high quality, ideally fragmented chromatin for ChIP analysis.

The success of a ChIP assay is highly dependent on the quality of chromatin prepared. The Enzymatic shearing kit provides buffers to optimise the shearing conditions of your chromatin by enzymatic digestion. Chromatin prepared using this kit demonstrates excellent enrichment, independent of starting cell number...

Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.

Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding....

Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.

Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding.....

Porvair Sciences has confirmed that 2016 will see record sales of its Ultravap and Minivap ranges of blowdown evaporators to laboratories worldwide. 

The company first began selling nitrogen blowdown evaporators for microplate sample drying in 1999. Offering unmatched ease of integration into robotic liquid handling workflows, the latest Porvair microprocessor controlled evaporators, the Ultravap Mistral and Ultravap Levante, has consolidated their position as a leading international supplier of microplate evaporators....

Chromatrap® announces that seven further popular antibodies have been validated for use in chromatin immunoprecipitation (ChIP) assays by their UK-based research team.

The new crop of antibodies represents some of the most frequently-cited antibodies in mammalian epigenetic research including H3K4me1, H4K5ac, H4K12ac, H2Az, H3, H4, H3K9me1 and H3K9me2. In addition the new ChIP validated antibodies are now available from Chromatrap® with matching primers....

Chromatrap® reports on the advantages of using its Chromatin Immunoprecipitation Sequencing (ChIP-seq) assay kits for histone methylation applications.

Chromatrap’s® ChIP-seq kit uses solid state technology in parallel with high throughput sequencing to deliver a streamlined ChIP-seq protocol from small cell numbers and low chromatin concentrations to investigate the epigenetic landscape. Specifically adapted for broader chromatin concentrations, Chromatrap® ChIP-seq combines the dynamic range of Chromatrap® with the downstream analysis power of deep sequencing...

Proven in labs around the world, the Porvair Sciences Microlute SPE sample preparation system provides a fast, trouble-free alternative to cartridges for high productivity sample clean-up.

The Microlute SPE sample preparation system also enables you to increase your assay sensitivity by providing reliable pre-injection clean-up and concentration on samples as small as 150µl. Supplied as a package including filter plate, collection plate, waste tray and manifold, the Microlute SPE sample preparation system contains all the elements to deliver the advantages of high productivity SPE sample preparation in a convenient microplate format. Microlute SPE plates are available...

Chromatrap is a pioneer in the development of solid-state filter-based technology that significantly enhances and accelerates the important epigenetic research tool of chromatin immunoprecipitation (ChIP). 

The company has developed a range of optimised ChIP assay kits for use in many areas of genome research including classical qPCR, DNA sequencing and from formaldehyde fixed paraffin embedded samples (FFPE) using either discrete spin columns or dedicated 96-well filter plates. The simplicity and efficacy of Chromatrap ChIP assays, enabling more IPs from less material, more quickly than traditional methods...

The Ultravap Levante from Porvair Sciences is a next generation nitrogen blowdown evaporator designed to meet the needs of the modern automated laboratory.

The Ultravap Levante comes with an RS232 connection and a remote command set enabling it to connect to and be operated from most commercially available robotic liquid handling systems. Porvair have positioned this automation-ready microplate evaporator to appeal to the budget-conscious laboratory who may wish to automate their sample dry-down bottleneck in the future....

Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.

The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed....

Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.

The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....

Porvair Sciences range of high performance PCR plates are made from polypropylene for extra rigidity.

These plates are compatible with the majority of 96- and 384-well block PCR and sequencing instruments, including fast sequencers and the (TM) RT-PCR machine. Manufactured under Class 10,000 clean room conditions the complete range of 13 microplates is certified free of pyrogens as well as DNAse and RNAse enzyme activity enabling optimised PCR results....

Porvair Sciences range of high performance PCR plates are made from polypropylene for extra rigidity.

These plates are compatible with the majority of 96- and 384-well block PCR and sequencing instruments, including fast sequencers and the Roche Light Cycler (TM) RT-PCR machine. Manufactured under Class 10,000 clean room conditions the complete range of 13 microplates is certified free of pyrogens as well as DNAse and RNAse enzyme activity enabling optimised PCR results....

Porvair Sciences range of 384-well plates are produced in class 10,000 cleanroom conditions from superior grade, ultra-clean polypropylene to strict quality control guidelines.

Available both sterile and non-sterile, Porvair 384-well plates provide a perfect solution for sample storage and assay set-up, allowing dilutions and aliquots to be simply handled, stored, or transported. Manufactured extra flat to ensure effective sealing, Porvair 384-well plates maintain your sample integrity over extended periods down to –80ºC....

Porvair Sciences range of 384-well plates are produced in class 10,000 cleanroom conditions from superior grade, ultra-clean polypropylene to strict quality control guidelines.

Available both sterile and non-sterile, Porvair 384-well plates provide a perfect solution for sample storage and assay set-up, allowing dilutions and aliquots to be simply handled, stored, or transported. Manufactured extra flat to ensure effective sealing, Porvair 384-well plates maintain your sample integrity over extended periods down to –80ºC. Manufactured to conform to ANSI/SLAS plate dimensions all Porvair...

Chromatrap reports on 3 further customer papers published in different prestigious peer reviewed journals, which cite how its proprietary solid state Chromatin Immunoprecipitation (ChIP) technology has enabled ground breaking research.

A recent study published in Drug Metabolism & Deposition [1] looks at " The role of Chromatin structural changes in regulating human CYP3A ontogeny. Variability in drug metabolizing enzyme developmental trajectories contributes to inter-individual differences in susceptibility to chemical toxicity and adverse drug reactions, particularly in the first years of life. Factors linked to these inter-individual differences are largely unknown...

Chromatrap® has announced a new 96-well high throughput purification plate for production of ultra-pure DNA.

Using proprietary filtration media that allow much higher loadings of active material than has been previously possible, typical assay times using the Chromatrap® DNA Purification Plate are less than 5 minutes. Buffers are optimised to remove any unwanted impurities while providing efficient DNA recovery from samples. The Chromatrap® DNA Purification Kit is designed for the purification and concentration of samples from PCR...

Chromatrap® has announced a new 96-well high throughput purification plate for production of ultra-pure DNA.

Using proprietary filtration media that allow much higher loadings of active material than has been previously possible, typical assay times using the Chromatrap® DNA Purification Plate are less than 5 minutes. Buffers are optimised to remove any unwanted impurities while providing efficient DNA recovery from samples. The Chromatrap® DNA Purification Kit is designed for the purification and concentration of samples from PCR...

Following extensive customer research, Chromatrap® has re-designed its website to better serve the needs of end users.

With an expanding product range, new families of ChIP validated antibodies and a suite of useful new support information including articles, application notes, video tutorials and guides a new site was required. The bright, fresh new website layout makes it easier and quicker to find the ideal Chromatrap ChIP kit for your immunoassay. “We wanted a fresh approach” said Chromatrap Marketing Director...

Porvair Sciences has announced that it will launch an exciting new microplate for genomics sample preparation at the forthcoming Analytica 2016 exhibition in Munich, Germany.

Designed with thickened walls and strengthened ribs underneath to stop cracking or leaking when used in Geno/Grinder or Tissulyser machines the robust 96-well 2ml deep well Genomics Sample Preparation Plate sets a new standard for high throughput genomics sample preparation. Unlike most commercially available deep well plates, the Genomics Sample Preparation Plate has been proven to...

Porvair Sciences reports that a major Pharmaceutical company based in France has integrated its Ultravap Mistral blowdown evaporation system with a Hamilton Star robotic liquid handling system to enhance new drug candidate processing in its medicinal chemistry department.

Using the Ultravap Mistral the pharmaceutical scientists have been able to remove the traditional ‘bottleneck’ of solvent evaporation from microplates by automated this time consuming step.  Set-up for unattended operation the Ultravap Mistral performs an evaporation every 20 minutes, and after each cycle, the level of liquid is checked by the robot and the needle depth is automatically modified to be about...

Porvair Sciences has announced it has chosen the ELRIG Symposium in Rennes, France (3-4th May 2016) to demonstrate its latest products that enable Lab Automation facilities to optimise sample preparation and improve productivity.

Visitors to the ELRIG Symposium will be able to see the Ultravap Mistral - a product designed to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates. Designed to be automation-friendly, the Ultravap Mistral gives significant throughput advantages to laboratories looking to optimise microplate sample preparation. Faster than centrifugal evaporation for single plates, significant increases in sample throughput are...

Chromatrap announces that its high quality ChIP-validated antibodies can now be supplied with optimised matching primer sets.

Using this out-of-box solution there is now no need to waste your valuable time searching databases and designing your own forward and reverse primers. Purchasing Chromatrap ChIP-validated antibodies with their matching high-quality primers, saves you time and gives you the confidence of using primers tested with the exact antibody and gene target with which you work. Many common epigenetic targets of interest...

Chromatrap announces that its high quality ChIP-validated antibodies can now be supplied with optimised matching primer sets.

Using this out-of-box solution there is now no need to waste your valuable time searching databases and designing your own forward and reverse primers. Purchasing Chromatrap ChIP-validated antibodies with their matching high-quality primers, saves you time and gives you the confidence of using primers tested with the exact antibody and gene target with which you work.
 Many common epigenetic targets of...

Available from Porvair Sciences is a black 96-well deep well plate, offering a working volume of 1ml per well, that in conjunction with black sealing films ensures that light sensitive assays and samples are not degraded by exposure to light, even over long-term storage periods.

Manufactured from polypropylene, Porvair's black deep well microplate has excellent heat and solvent resistant qualities. Using only ultra-pure grade polymer means that the black deep well plate has near zero leachates ensuring long-term sample integrity.  The black plate is fully validated RNase and DNase free allowing it to be used with even the most sensitive biological samples. Benefiting from a cylindrical well...

Krystal UV quartz bottomed microplates from Porvair Sciences Ltd. are designed for high throughput applications which require excitation or detection wavelengths in the far UV region below 350nm.

Made from highly polished fused quartz - Krystal UV plates are suitable for the most demanding cell-based assay requiring monitoring in the UV region down to 200nm. Direct quantitation of DNA/Protein rations at 260, 280 and 240nm is possible through use of these plates. Designed to exhibit low auto fluorescence, Krystal UV plates are available in 96- and 384-well plate designs, both compliant with ANSI/SLAS standards...

Chromatrap, a business unit of Porvair Sciences, announces a new patented protocol that is able to simply, quickly and efficiently enrich transcription factors from Native Chromatin.

Native Chromatin Immunoprecipitation (N-ChIP) is an alternative to traditional cross-linked (X-ChIP), which removes the need for fixing cells with formaldehyde prior to extraction. As a consequence the cells remain in a more natural 'native state'. The DNA/protein fragments are selectively immunoprecipitated using antibodies directed against the protein of interest and the resulting fractions treated to separate the DNA and...

Porvair Sciences offer a range of sample evaporators and microplate products optimised for use in conjunction with LC/MS and LC/MS/MS instrumentation.

To facilitate better analysis of very dilute samples by LC/MS, Porvair Sciences nitrogen blowdown evaporators can assist by evaporating solvent to increase concentration thereby increasing sensitivity. In applications where serum or plasma samples have been de-proteinated using a protein precipitation microplate, such as the Porvair P3 plate, the sample is typically left in acetonitrile. Porvair evaporators provide a quick and...

Chromatrap®, a business unit of Porvair Sciences, has announced that it will be the Lead Sponsor at the prestigious “Epigenetics in Drug Discovery” conference to be held in Cambridge, UK from 26th-27th January 2016.

Viewed as a new frontier in drug discovery, rapid progress has been made in enhancing understanding of epigenetic mechanisms of both new and existing drugs. With the processes that control epigenomic function providing new opportunities, epigenetics targets are enabling the discovery of novel drugs. At the conference - Dr Amy Beynon will deliver a presentation highlighting the use of new Chromatrap solid state ChIP...

Porvair Sciences offer a range of sample evaporators and microplate products optimised for use in conjunction with LC/MS and LC/MS/MS instrumentation.

To facilitate better analysis of very dilute samples by LC/MS, Porvair Sciences nitrogen blowdown evaporators can assist by evaporating solvent to increase concentration thereby increasing sensitivity. In applications where serum or plasma samples have been de-proteinated using a protein precipitation microplate, such as the Porvair P3 plate, the sample is typically left in acetonitrile. Porvair evaporators provide a quick and easy-to-use method of removing the acetonitrile...

Porvair Sciences has announced the MiniVap™ Gemini - an all new entry-level product designed to remove the solvent from two microplates simultaneously.

Using a highly efficient evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each well of two 96-well microplate simultaneously, the MiniVap Gemini enables researchers to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates prior to analysis or reconstitution in buffer. The productive MiniVap™ Gemini has been designed to accommodate any ANSI / SLAS footprint 96-well...

Chromatrap, a business unit of Porvair Sciences Ltd, has announced the launch of its own range of Chromatin Immunoprecipitation (ChIP)-validated antibodies.  

Building on the company’s success in the solid-state ChIP market, which underpins modern epigenetic research, the addition of ChIP-validated antibodies further enhances the high performance application solutions that Chromatrap can provide researchers. Chromatrap Product Development Manager, Dr Amy Beynon commented “The use of high quality and specific ChIP-validated antibodies is essential for the success of a ChIP assay...

Chromatrap®, a business unit of Porvair Sciences, has developed a new protocol that further extends the many advantages of its popular Chromatin Immunoprecipitation Sequencing (ChIP-seq) assay kits.

Key developments for the Chromatrap® ChIP-seq kit (version 1.2) include high quality chromatin can now be achieved via sonication or enzymatic digestion ; high and low abundant enrichment is possible from small chromatin samples ; improved antibody binding ; greater chromatin loading flexibility and the ability to use increased slurry volumes for difficult samples. Chromatrap’s® ChIP-seq kit uses solid state technology...

Chromatrap®, a business unit of Porvair Sciences, has produced an informative new guide entitled ‘Top 10 Tips for ChIP-seq Library Preparation'.

ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...

Chromatrap®, a business unit of Porvair Sciences, has produced an informative new guide entitled ‘Top 10 Tips for ChIP-seq Library Preparation'.

ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...

Correct assay plate selection is vital for successful research, whether you are performing absorbance, fluorescence or luminescence assays.

Porvair Sciences offers a wide range of assay plates which are recognized as industry-leading tools for Pharma drug discovery and screening.
A new guide, contained within an updated assay plates mini catalogue, has been produced by Porvair to provide information and guidance on how to choose the correct assay plate for your research. By carefully selecting the correct plate type for your assay, it is possible to significantly improve results. By following the simple instructions set out in the...

The unique Krystal 2000 microplate range from Porvair Sciences has been optimised for luminescence and fluorescence assays.

A patented manufacturing process, using a ‘two-shot’ mould, provides clear, individual wells in an opaque matrix. The special design of the plate totally eliminates the well-to-well optical crosstalk inherent with other clear bottomed microplate designs, giving unmatched accuracy, sensitivity and repeatability of photometric readings. Very high signal-to-noise ratio and low detection limits can be achieved with this superb plate. All tissue-culture treated plates are supplied...

Chromatrap®, a business unit of Porvair Sciences, has produced a new 10-page brochure that provides an informative introduction to chromatin immunoprecipitation (ChIP) technology and a detailed comparison of traditional bead based and Chromatrap® solid state ChIP technologies.

Chromatrap® ChIP kits use revolutionary spin columns or microplates which contain discs of an inert, porous polymer to which protein A or G has been covalently attached. This patented format is unique. During an assay, the chromatin/antibody complex is selectively retained by the disc. Flushing with three buffers and an elution step are all that is required to obtain the selectively enriched DNA, making Chromatrap® more efficient in the laboratory. With a fast processing time of...

The Ultravap Levante™ is a new introduction to Porvair Sciences’ popular series of nitrogen blow-down sample concentrators and evaporators. 

Using technology from the successful Ultravap Mistral™ series of robot-ready, integration compatible evaporators Porvair have re-designed the classic single plate evaporator to meet the needs of the modern laboratory. The Ultravap Levante makes it even easier to integrate an automatic dry down step into your biological sample preparation protocol. With the needs of LC/MS users very much in mind, the Ultravap Levante offers rapid programmable dry down of samples dissolved in...

Chromatrap®, a business unit of Porvair Sciences, has published a new application note that describes how Chromatrap® ChIP-seq assays now enable unbiased, genome-wide understanding of protein-DNA regulatory networks. 

Genome-wide mapping of protein-DNA interactions is essential for a complete understanding of gene regulation. A detailed map of epigenetic marks and transcription factor binding is necessary for deducing the regulatory networks that underpin gene expression in a variety of biological systems. The most widely used tool for examining these interactions is ChIP followed by massively parallel sequencing (ChIP-seq). The new application note reports on how the Chromatrap...

Chromatrap®, a business unit of Porvair Sciences, has announced a new web page that brings together protocols developed using their proprietary solid state chromatin immunoprecipitation (ChIP) technology.

The new web page provides scientists with optimised ChIP methodologies for qPCR, high throughput qPCR, sequencing, high throughput sequencing and enzymatic chromatin shearing using Chromatrap®  kits. Chromatrap® is a ground breaking technology that offers a quicker, easier and more efficient way of undertaking ChIP assays. Chromatrap® kits for qPCR use revolutionary Chromatrap®Protein-A or Protein-G spin columns which contain...

Chromatrap®, a business unit of Porvair Sciences, has introduced a new Formaldehyde Fixed Paraffin-Embedded (FFPE) ChIP Kit which overcomes the widely acknowledged shortfalls of the technique.

Due to the cross-linking of proteins by formaldehyde, FFPE tissues have traditionally presented a particular challenge for ChIP analysis. In addition, the small size and delicate nature of the tissue, and the difficulty in extracting samples from paraffin, used to provide tissue support after preservation, can damage complex cellular complexes such as chromatin. ChIP assays from these samples until now have therefore proved time consuming and difficult...

Porvair Sciences offers a range of products that enable optimised Solid Phase Extraction (SPE) of polar compounds. 

This includes a new C18 silica packed Microlute™ plate, vacuum manifolds, collection plates and solvent evaporators all designed to streamline your sample preparation. The new C18 Microlute plate offers good separation of a wide range of polar compounds which are not attracted to the C18 tail. MicroLute™ is the original 96-well format SPE plate proven in labs worldwide. The plate provides all the advantages of automated and...

Chromatrap®, a business unit of Porvair Sciences, has published a new application note that describes how Chromatrap® ChIP-seq assays now enable unbiased, genome-wide understanding of protein-DNA regulatory networks. 

Genome-wide mapping of protein-DNA interactions is essential for a complete understanding of gene regulation. A detailed map of epigenetic marks and transcription factor binding is necessary for deducing the regulatory networks that underpin gene expression in a variety of biological systems. The most widely used tool for examining these interactions is ChIP followed by massively parallel sequencing (ChIP-seq). The new application note reports on how...

Chromatrap®, a business unit of Porvair Sciences, has announced a major product launch at the European Human Genetics Conference (Glasgow, UK) and the Festival of Genomics (Boston, USA) on the 6th June 2015 and 22nd-24th June 2015 respectively.

Visitors to ESHG Stand 268 and Festival of Genomics Booth 18 will be able to see a new high-throughput ChIP Sequencing product and learn about Chromatrap's latest developments in solid state Chromatin Immunoprecipitation (ChIP) technology. Chromatrap’s® new ChIP-seq kit utilises the company's proprietary solid state technology in parallel with high throughput sequencing to deliver a streamlined ChIP-seq protocol from small cell...

Visitors to ACHEMA 2015 have been invited by Porvair Sciences to Stand F44 in Halle 4.2 to see their expansive range of application optimised microplates and microplate equipment.

For labs involved with fraction collecting, compound storage, plate replication and mixing applications - Porvair has developed a genuine 2.00 ml 96 round well deep well plate that enables scientists to use the full 2.00 ml well capacity. Manufactured under class 10,000 conditions from ultra-pure grade polypropylene the 2.00ml 96 ROUND well deep well plates are certified as RNase / DNase free and contain no measurable contaminants that could otherwise leach out and affect the sample...

Porvair Sciences glass vial storage plate combines 96 borosilicate glass vials of 700µl into a rigid polypropylene carrier microplate to provide a superior product for storage and transportation applications.

This extremely hard wearing plate provides a zero-leachates solution for UHPLC and also for storage scenarios such as combinatorial chemistry where broad chemical resistance and thermal stability is vital. Porvair glass vial storage plates are less costly than solid glass plates and are precisely manufactured to comply with ANSI/SLAS dimensions to ensure complete compatibility with automated equipment. To prevent evaporation or...

Porvair Sciences glass vial storage plate combines 96 borosilicate glass vials of 700µl into a rigid polypropylene carrier microplate to provide a superior product for storage and transportation applications.

This extremely hard wearing plate provides a zero-leachates solution for UHPLC and also for storage scenarios such as combinatorial chemistry where broad chemical resistance and thermal stability is vital. Porvair glass vial storage plates are less costly than solid glass plates and are precisely manufactured to comply with ANSI/SLAS dimensions to ensure complete compatibility with automated equipment. To prevent evaporation...

To ensure full compatibility with robotic systems, DNase / RNase- and pyrogen-free PCR plates from Porvair Sciences feature high rigidity to minimise distortion before and after thermal cycling.

Produced in Class 10,000 clean room conditions – Porvair range of PCR plates are certified free of pyrogens as well as DNAse and RNAse enzyme activity enabling routine achievement of excellent PCR results. Porvair PCR plates are based upon a well design where the liquid meniscus comes below the plate surface eliminating sample carryover problems when using a plate lid.
Summarised in an easy-to-use selection guide...

The MiniVap™ blowdown evaporator from Porvair Sciences takes just minutes to remove volatile organic solvents from your 96-well microplates.

The MiniVap™ is the perfect tool for labs where smaller numbers of individual plates need drying. Incorporating advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each well of a 96-well microplate simultaneously, the MiniVap enables researchers to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates prior to analysis or reconstitution in buffer...

Chromatrap®, a business unit of Porvair Sciences, has an announced solid state ChIP kits which rapidly improve chromatin immunoprecipitation (ChIP) through a unique patented technology that streamlines the process, ensuring chromatin preparation to qPCR analysis can be performed in under five hours.

Chromatrap® is a ground breaking technology that offers a quicker, easier and more efficient way of undertaking ChIP assays. Chromatrap® kits for qPCR use revolutionary Chromatrap®Protein-A or Protein-G spin columns which contain discs of an inert, porous polymer to which protein A/G has been covalently attached. During an assay, the chromatin/antibody complex is retained by the disc. Flushing with three buffers and an elution step are...

Porvair Sciences low profile 96-well deep well plate achieves a storage volume of 1.1ml / well in a height of just 27 mm enabling more plates to be stacked or stored in a given space.

Manufactured from extractables-free polypropylene in an ISO 10,000 approved clean room environment - Porvair low profile plates undergo extensive quality testing to ensure they are of the highest quality, certified free from DNase, RNase and endotoxin contamination. Combining an affordable price with uncompromising high quality, Porvair low profile 96-well deep well plates are precisely manufactured to comply with...

Porvair Sciences has released a new 2015 catalogue that describes its popular range of high quality tissue culture treated plastics and consumable products for Epigenetics.

Porvair Tissue Culture plastics are made to the highest international standards for material quality, surface optical polish, tissue culture treatment, sterility and pack integrity. All products are certified to be free from DNA/RNA, DNase/RNase and Pyrogen contamination. Investment in UK based laboratory testing ensures that you receive consistently high quality products. Complementing its tissue culture treated flasks...

The Development Microlute™ from Porvair Sciences is a Solid Phase Extraction (SPE) microplate which provides a wide assortment of phase chemistries and sorbent loadings in a single plate making it ideally suited for method development.

Offering scientists a choice of up to 12 different phases and sorbent loadings (10 -100mg) in a standard format 96-well plate the Development Microlute™ allows you to simply and rapidly screen for the optimal retention and selectivity required to achieve your sample preparation objectives. By providing a complete SPE methods development solution that does not need to be constructed by the user, the Development Microlute™ delivers...

£1000 trade-in value on any evaporator system against the purchase of a new UltraVap Mistral

The UltraVap Mistral from Porvair Sciences makes it easy to integrate an automatic dry down step into your automated liquid handling protocol. Optimised to work with most commercial robotic liquid handling systems the UltraVap Mistral represents the leading edge in automated microplate drying technology.  Until 30th November 2014 - Porvair Science is offering a £1000 trade-in value on any evaporator system against the purchase of a new UltraVap Mistral....

Porvair Sciences has developed a new ChIP sequencing assay kit extending the benefits of their proprietary Chromatrap® solid state ChIP technology to preparation of purified Chromatin for the generation of sequencing libraries.

Chromatin immunoprecipitation (ChIP) is a technique used to detect interactions between proteins and DNA, and is based on the enrichment of DNA associated with a specific protein of interest. Combining ChIP with massively parallel sequencing (ChIP-seq) allows the accurate survey of interactions between proteins and DNA, enabling the study of epigenetic marks which is essential for a full understanding of...

An informative video interview with Professor Steve Conlan of the College of Medicine at Swansea University (UK) highlights the latest research developments in women’s reproductive health using unique molecular biology tools.

Porvair Sciences 24-well deep well plates permit  users to simply undertake multiple, high volume (10ml / well) experiments in a single unit maximising both productivity and  operational flexibility. 

The 24-well plates are constructed of high grade, low extractable polypropylene, which imparts excellent temperature and  chemical resistance making them the perfect tool for applications including  serial dilution, mixing, reaction chemistry and cell culture growth. The  wells are square with a conical base to optimise sample concentration and  recovery...

Porvair Sciences 24-well deep well plates permit users to simply undertake multiple, high volume (10ml / well) experiments in a single unit maximising both productivity and operational flexibility.

The 24-well plates are constructed of high grade, low extractable polypropylene, which imparts excellent temperature and chemical resistance making them the perfect tool for applications including serial dilution, mixing, reaction chemistry and cell culture growth. The wells are square with a conical base to optimise sample concentration and recovery. The plate dimensions are precisely manufactured to SLAS/ANSI specifications making them... 

A new instructional video from Porvair Sciences explains exactly how to conduct a ChIP assay for epigenetic research starting from a confluent monolayer of human cells.

This live demonstration of the Chromatin Immunoprecipitation (ChIP) assay uses Porvair’s innovative solid-state ChIP kit – Chromatrap 96. The video was prepared to inform researchers of an optimised protocol for preparing fresh chromatin from a dish of growing cells and how to verify the quality of the chromatin recovered...

Porvair Sciences has announced a new 5-layer cell culture flask developed to fulfil the need of the growing number of applications that require large numbers of cells. 

While single layer flasks are well proven for small-scale cell culture scale up, their use can become laborious and time-consuming when large numbers of cells are required. Offering a sterile growth area of 870cm2 in a compact footprint - Porvair's new 5-layer cell culture flask offers a high performance solution to this application need...

Chromatrap®, the novel solid-based matrix for chromatin immunoprecipitation (ChIP) assays, available from Porvair Sciences, has been successfully used to isolate high quality chromatin from difficult biopsy material.

Focusing on the precipitation of epigenetic marks from primary endometrial stromal cells, researchers have produced excellent enrichment of high abundant epigenetic marks from 1 million cells isolated from a tissue biopsy. The selective enrichment using Chromatrap was highlighted by the selective amplification of both positive and negative gene targets relative to negative IgG. Further the work described demonstrates how the Chromatrap ChIP Assay Kit is able to delineate the balance between active and repressive associated marks and also is compatible with human tissue...

Porvair Sciences has announced a new video that provides an informative introduction to the Ultravap Mistral - a next generation robot-compatible dry down station designed to remove the 'bottleneck' of solvent evaporation from microplates.

Porvair Sciences reports on positive commentary by researchers in published papers citing how using the fast, sensitive ChromaTrap™ Chromatin Immunoprecipitation (ChIP) technology has benefited their research.

In a paper by C.R Williams et al (Am J Physiol Cell Physiol 303: C213–C223, 2012) - Chromatrap was used to assess the occupation of NFkB p65 onto the Nox4 promoter in human aortic endothelial cells which had been treated with normal and high glucose. ChIP data using Chromatrap pro A spin columns demonstrated that in high glucose concentrations NfkB binding to the Nox4 promoter was increased when compared to normal glucose concentrations and rosiglitazone attenuated NfkB binding to the promoter. Their findings illustrated that NFkB/p65-Nox4 axis as an important target of rosigliatzone in vascular endothelial cells following hyperglycemia...

Porvair Sciences' has produced an informative new guide entitled ‘Top 10 tips for positive ChIP results’.

The success of a Chromatin immunoprecipitation (ChIP) assay is highly dependent on the quality of chromatin prepared.  Written by scientists with many years experience of ChIP, the new 8-page document provides an informative 10-point illustrated guide to help you improve your ChIP assay results. ChIP is a commonly used immunprecipitation technique for mapping the DNA-protein interactions in cells which are crucial for correct gene regulation. In a ChIP assay  DNA-protein complexes (Chromatin) are selectively immunoprecipitated using....

Porvair Sciences has introduced new silicone cap mats for its range of 2ml deep well storage blocks.

Porvair Sciences' product catalogue for 2013-2014 is packed with vital information on the company's wide range of microplates, plate sealers and microplate evaporators to help you get the best from your separations, assays and storage applications.

Porvair Sciences has announced that it will be showing its latest specialist microplates and microplate equipment at the forthcoming Pittcon 2014 (Chicago), Analytica 2014 (Munich) and Genomics Research 2014 (San Francisco) exhibitions.

Visitors to Pittcon Booth 4021 and Analytica Stand B2.320A will be able to see Porvair’s complete range of automation friendly microplates and equipment. On display will be the Ultravap Mistral - Porvair's new generation robot-compatible nitrogen blow down station. For many years, Porvair Sciences has led the field in nitrogen blow down evaporation. The UltraVap Mistral makes it even easier to integrate an automatic dry down step into your automated liquid handling protocol. Combining uncompromising high quality with an affordable price...

Porvair Sciences has announced a new Chromatrap Enzymatic Shearing Kit that contains all the necessary reagents and buffers for up to 10 chromatin preparations.

The success of a ChIP assay is highly dependent on the quality of chromatin prepared.  The Chromatrap® enzymatic shearing kit  - allows you to determine optimal shearing conditions for your chromatin preparations and can supply you with enough chromatin to perform up to 24 ChIPs if using standard Chromatrap® ChIP spin column kit or up to 96 IP’s if using Chromatrap®  ChIP 96 High throughput microplate. Chromatin immunoprecipitation (ChIP) is a technique used to study the association of specific proteins,or their modified isoforms, with defined genomic regions...

Porvair Sciences reports strong growing demand for their Chromatrap® chromatin immunoprecipitation (ChIP) assay technology from academic groups and biopharmaceutical organisations involved with epigenetic research.

Stephen Knight, Sales and Marketing Director commented "An expanding number of proven application solutions and the introduction of the Chromatrap® 96 HT solid-state ChIP high throughput platform has enabled us to more than double the number of research groups using ChromaTrap assay technology during the last 12 months".  He added "We are particularly pleased by the very positive feedback from early adopters of the technology"...

The MiniSeal II semi-automatic microplate sealer from Porvair Sciences comes complete with adapters enabling it to process deep well, shallow well, low profile deep well, filter and assay plates that conform to the ANSI / SLAS standard format.

MiniSeal II plate adaptors not currently in use are ingeniously designed to stack on top of the unit to keep them readily available. The MiniSeal II heat sealer operates with a very high force, this together with a powerful 450W heater ensures high integrity sealing of almost any type of microplate. With so much available power, sealing times for most polypropylene plates with Porvair seals are less than 3 seconds each....

Porvair Sciences has introduced the Co-Mix - an accurate, reliable, compact and simple-to-use multi-format mixer.

Operated via an intuitive touchscreen the Co-Mix offers effortless changing between mixing of 96- and 384-well microplates in skirted, semi-skirted and unskirted variants plus deep-well plates and PCR tubes / strips.  An innovative plate holding mechanism ensures smooth manipulation of microplates eliminating sample spillage and cross-contamination problems. A vortex module enables mixing of numerous tube formats including micro test tubes...

Porvair Sciences has announced new additions to its popular range of high quality tissue culture (TC) treated laboratory plasticware.

Complementing its tissue culture treated flasks, dishes, syringe filters, centrifuge tubes and microplates – Porvair has added new ranges of affordably priced, top quality pipettes, micro-pipettes, pipette fillers, filter tips and cell scrapers. Porvair TC-plastics are made to the highest international standards for material quality, surface optical polish, tissue culture treatment, sterility and pack integrity. All products are certified to be free from DNA/RNA, DNase/RNase and Pyrogen contamination. Investment in UK based laboratory testing ensures that you receive consistently high quality products...

Porvair Sciences has announced that it will officially launch Chromatrap®96 HT – an innovative 96-well chromatin immunoprecipitation (ChIP) assay plate at Epigenomics of Common Diseases (Wellcome Trust, Cambridge, UK) from 7th-10th November 2013.

The Chromatrap®96 HT is a new high throughput ChIP microplate based on the novel spin-column ChIP technology. It is essentially 96 separate Chromatrap spin-columns in one device designed to enable researchers to perform up to 96 ChIP experiments in parallel. Assays can be performed either by using hand-held multichannel pipette or by using automated liquid handling robots for even higher throughputs...

Porvair Sciences new generation Krystal™ glass bottom plates are precision manufactured using a proprietary process resulting in excellent light transmission and an ultra-flat optical plane (+/- 15µm) making them perfect for imaging growing cells.

The complete range of 24-, 96- and 384-well Krystal glass bottom microplates is available sterilised for tissue culture to optimise cell growth or non-sterile for assay development. Deep black plates for fluorescent studies are available, together with brilliant white plates which increase sensitivity for luminescence and absorbance work. The high optical clarity base of each plate in the range offers the advantage of easy positioning and crisp images when used with confocal microscopes....

Porvair Sciences has announced the Microlute SPE sample preparation starter kit.

This kit contains everything needed to begin productive SPE sample preparation in a 96 well plate format, including two development filter plates and a popular C18 sorbent filter plate, 2ml collection plates, disposable waste trays and, most importantly, the Microlute Acrylic Vacuum Manifold. The new starter kit offers all the advantages of SPE sample preparation in a convenient microplate format, capable of rapidly processing 96 samples in one run, repeatedly and precisely. All that is required for full operation is a suitable laboratory vacuum connection or pump...

Porvair Sciences has developed the first 96-well round deep well plate that genuinely delivers 2.00 ml liquid capacity / well in an automation compatible SLAS / ANSI footprint.

The revolutionary "common wall" design provides a full 2ml round well, round bottom well within a 45mm height limit, thus ensuring full compatibility with most plate handling equipment. Unlike other '2ml' deep well plates that typically offer just 1.80-1.90ml / well,  the new Porvair plate enables labs involved with fraction collecting, compound storage, plate replication and mixing applications the chance to use the full 2.00 ml well capacity without compromise. Manufactured under class 10,000 conditions from ultra-pure grade polypropylene, Porvair's new 2.00ml 96-well deep well plates are certified as RNase / DNase free and contain no measurable contaminants that could otherwise leach out and affect the sample...

Porvair Sciences has launched a new online service providing organisations with easy access to next day delivery on competitively priced, high performance microplate thermal seals.  For laboratories in the UK choosing to use the new service all microplate seals are also delivered free-of-charge.

Available in a wide choice of colour-coded designs - Porvair microplate thermal seals are available optimised for use with all brands of assay plates. These easy to use thermal seals work with all commercially available heat sealers that take pre-cut strip seals. They are printed in five different colours and marked “This way up” to ensure easy selection of the right gauge of seal and correct positioning on the microplate.  Seals are compatible with most heat sealers...

Porvair Sciences offers a range of high quality, large volume microplates (5ml, 7ml and 10ml) to meet the special requirements of storage / transport applications in combinatorial chemistry, environmental and food technology markets.

Produced under class 10,000 clean room conditions from virgin polypropylene, each 24-well (10ml) and 48-well (5ml and 7ml) plate contains no contaminants that may leach out and affect the samples being stored or transported. All these large volume plates can be heat sealed or capped with flexible polymer “cap mats” to enable high integrity storage of samples for prolonged periods at -80°C....

Porvair will officially launch the UltraVap Mistral robot-compatible automatic dry down station at Drug  Discovery 2013 (Manchester, UK) and Biotechnica 2013 (Hannover, Germany)

Drawing upon Porvair’s market leading position in nitrogen blow down evaporation – the UltraVap Mistral offers a simple, turnkey solution for integrating an automatic dry downstep into your automated liquid handling protocol.  The UltraVap Mistral is fully optimised to work with robotic liquid handling systems from suppliers including Beckman, Hamilton and Tecan and features a new “shuttle” design capable of serving and retrieving microplates to and from the robot deck without further need for off-deck handling.

Porvair Sciences has announced a new version of its Chemical Compatibility Chart that provides an easy-touse reference guide detailing the chemical resistance of membranes and matrices used in microplates to a wide range of common laboratory chemicals.

Employing tests performed at room temperature (25°C) - Porvair has compiled data as to the compatibility of different microplate matrices and membranes to a wide range of acids, alcohols, bases, esters, hydrocarbons /chlorinated hydrocarbons, ketones and other chemicals. In the tabulated chart - chemical compatibility data for each microplate material is listed as ‘suitable’, ‘ok for medium term use’ or ‘unsuitable’ thereby offering lab scientists the information to enable selection of just microplates constructed from materials optimised for their application...

Porvair Sciences has announced the first North American edition* of its internationally trusted ‘Catalog of Microplates and Microplate Equipment’.

Many scientists around the world have come to rely upon the Porvair Sciences catalog as a trusted source of information that enables them to choose the optimum microplate, microplate evaporator or sealer for their application. This new2013 edition brings together information on Porvair Sciences comprehensive microplate and microplate equipment product range that is available and supported by knowledgable local agents** through the USA and Canada. Reflecting Porvair's continuing commitment to continuous technological innovation, the North American catalog introduces a suite of exciting new products..

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Porvair Sciences has announced an application note describing the excellent results achievable from a new 96-well format version of its ChromaTrap chromatin immunoprecipitation (ChIP) assay technology.

Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...

To address performance limiting well-to-well crosstalk inherent in most assay plates – Porvair Sciences has developed the Krystal 2000 microplate range. 

Incorporating unique individual clear cups molded into either a black or white polypropylene matrix – crosstalk is eliminated and the sensitivity, photometric accuracy and repeatability of your bottom reading absorbance, fluorescence and luminescence measurements markedly improved. Maintaining industry standard 96-well microplate dimensions the Krystal 2000 range is fully compatible with all commercially available plate readers, robotic sample processors and automated liquid handling systems...

A new application note from Porvair Sciences details a protocol for its Chromatrap® ChIP assay kit that has been developed to enrich epigenetic marks from primary human tissue cells.

Chromatrap® Pro-A, the novel solid-based matrix for chromatin immunoprecipitation assays (ChIP) has been successfully used for isolation of high quality chromatin from difficult biopsy material. Focusing on an application to precipitate epigenetic marks from primary endometrial stromal cells - results show high abundant epigenetic marks from 1 million cells isolated from a tissue biopsy, with selective amplification of positive gene targets relative to negative IgG and negative gene loci....

Porvair Sciences has announced that its latest applications focused microplates and microplate equipment will be exhibited at Forum LABO, European Lab Automation  ASMS and HPLC 2013

Porvair Sciences has announced an online video demonstrating its MicroShake™ orbital shaker and how it can be used to accelerate sample preparation when using the company's popular p3 protein precipitation plates

Porvair Sciences announces new versions of its MiniVap and UltraVap blowdown evaporators that use warm air or nitrogen to speed up the evaporation of common HPLC solvents such as dichloromethane, methanol and acetonitrile from sample vials, significantly improving throughput and removing this common laboratory bottleneck

Porvair Sciences has announced the addition of the novel Chromatrap chromatin immunoprecipitation (ChIP) assay range to its portfolio of products for epigenetics

Porvair Sciences has announced a new range of 12-, 24-, 48- and 96 well format untreated polystyrene culture microplates for growing cells in stationary suspension or other applications where reduced cell attachment is desired

Porvair Sciences has chosen the forthcoming Pittcon 2013 exhibition to showcase its latest applications focused microplates and microplate equipment to scientists visiting the event in Philadelphia

Porvair Sciences has announced a new version of its MiniVap™ Blowdown Evaporator able to quickly and safely remove solvent from up to 48 vials in parallel

For organizations looking to commercialise technology innovations or companies looking to develop a high quality product with a competitive edge - Porvair Sciences has a long history of successfully helping customers develop new and innovative microplates and microplate equipment

Porvair Sciences, specialist manufacturer of high quality microplates, microplate equipment and tissue culture plastics, has launched a new website to provide visitors with in-depth information relating to its comprehensive range of products and custom design service

To protect light sensitive samples - Porvair Sciences offers a selection of high quality, black microplates and seals that eliminate sample degradation, even over long storage periods

The Microlute™ SPE sample preparation system from Porvair Sciences provides a faster, trouble-free alternative to cartridges for high throughput sample clean-up

The Combipack™ is Porvair Sciences economic response to the growing use of protein precipitation separation techniques in chromatography labs

Porvair Sciences announces the introduction of the 500120 series gas permeable adhesive microplate seals. These unique gas permeable adhesive seals allow uniform air and carbon dioxide (CO2) exchange, but prevent moisture evaporation making them perfect for Eukaryotic cell culture and long-term live cell assays...

The TriSeal Pro from Porvair Sciences Ltd. is a new budget-priced continuous roll microplate heat sealer optimised for medium to high throughput plate sealing applications