Search News Archives
Follow us on
Conferences | Events
Media Partners
Integrated DNA Technologies

Integrated DNA Technologies

Integrated DNA Technologies

Products

Contact Integrated DNA Technologies


If you have not logged into the website then please enter your details below.

All articles from Integrated DNA Technologies

  Correcting Sickle Cell–Causing Mutation with Efficient CRISPR-Cas9 Genome Editing

IDTResearch published in Nature Medicine describes collaborative effort to reduce off-target CRISPR-Cas9 genome editing – removing barriers for human therapeutic applications. Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to...

 

  IDT Supports Genomics Research with Enhanced Website

IDTNew website increases accessibility to leading-edge product range and latest information. As advocates for the genomics age, Integrated DNA Technologies (IDT), has launched a new version of its website designed to enhance support to researchers across the globe. The updated website features easy-to-find product information arranged by application and fast navigation - saving valuable time and...

 

  IDT Provides Optimized Conditions for HDR in CRISPR Editing

New application note gives researchers insights and guidance on maximizing HDR-mediated insertion of short fragments in CRISPR genome editing

IDTAs an advocate for the genomics age, Integrated DNA Technologies (IDT), has published a new application note on optimization of CRISPR-Cas9 for homology-directed repair (HDR) applications. Available as part of the IDT collection of CRISPR application notes and protocols, this article supports researchers using CRISPR...

 

  IDT’s 2017 Sustainability Award Funding to Exceed $50K

Support and recognition for biodiversity research with potential for global impact

Award Funding to Exceed 50kDemonstrating its ongoing commitment to science advocacy and sustainability, Integrated DNA Technologies (IDT), is inviting applications for its 2017 Sustainability Award program. Open to researchers working on biodiversity projects in academic, non-profit, and government labs, this year IDT has extended the program to...

 

  IDT Launches First Cas9 Enzyme that Drastically Reduces CRISPR Off-Target Effects without Significant Loss of On-Target Activity

Integrated DNA Technologies (IDT) today announced the launch of the first Cas9 enzyme variant that extensively reduces off-target effects in CRISPR genome editing without compromising on-target activity.

IDT launches first Cas9 enzyme that drastically reduces CRISPR off-targetThe Alt-R® S.p. HiFi Cas9 Nuclease 3NLS enzyme is a recombinant S. pyogenes Cas9 mutant that improves specificity while maintaining a high editing efficiency similar to wild-type Cas9. The launch represents a major step towards therapeutic use of CRISPR, which has previously borne the risk of the unwanted off-target editing events observed with wild-type Cas9....

 

  IDT Raises the Bar for PCR-Based Genotyping with Novel rhAmp SNP Solution

Innovative method delivers simple, accurate and cost-effective SNP analysis

IDTReflecting its mission to provide innovative solutions to the genomics community, Integrated DNA Technologies (IDT) introduces its unique rhAmp™ SNP Genotyping System, enabling researchers to make accurate and confident SNP calls both quickly and cost-effectively....

 

  IDT Partners with Illumina for NGS Library Preparation Multiplexing and Target Enrichment

Leaders in NGS tools collaborate to deliver robust multiplexing capabilities and streamline target enrichment methods

IDTIntegrated DNA Technologies (IDT) have announced a broad partnership with Illumina, Inc. to provide improved library preparation multiplexing and target enrichment solutions for the next generation sequencing (NGS) market....

 

  Integrated DNA Technologies Appoints LubioScience as Distributors in Switzerland

Researchers in Switzerland no longer need to import IDT products; local expertise facilitates ordering

IDTIntegrated DNA Technologies (IDT), has signed a distributor agreement with LubioScience GmbH (LubioScience), based in Lucerne, Switzerland. Through LubioScience, researchers in Switzerland will benefit from local access to IDT’s full range of high quality reagents for genomics research...

 

  Integrated DNA Technologies Acquires Oligo Manufacturing Business of GeneWorks (Australia)

IDT expands its capacity for direct sales of genomic products in Asia-Pacific region

IDTIntegrated DNA Technologies (IDT), through its Singapore subsidiary, today completed the acquisition of the oligonucleotide manufacturing business of GeneWorks Pty Ltd. (GeneWorks) in Australia. This acquisition sees IDT expand its reach in the Asia-Pacific region, following its recent establishment of sales offices in Japan and Korea.....

 

  IDT First to Market with Complete Cpf1-based CRISPR Genome Editing System

Expanded CRISPR toolkit includes Cpf1 and range of Alt-R™ support products, increasing the options available to molecular biology researchers

Cpf1Reflecting its drive to provide innovative solutions to the genomics community, Integrated DNA Technologies (IDT) is the first genomics company to develop and bring to market a complete ribonucleoprotein-based Cpf1 CRISPR system. The Alt-R™ A.s. Cpf1 CRISPR System inherits the optimized, efficient, and cost-effective traits of IDT’s innovative Cas9-based system while taking advantage of Cpf1’s natural AT-rich target sequence preference....

 

  IDT Sustainability Award Supports Biodiversity Research for Second Year

Integrated DNA Technologies (IDT), the world leader in custom oligonucleotide synthesis, announces the winners of its 2016 Sustainability Award contest.

IDTThis award recognizes innovative research that has the potential to make a global impact in the area of biodiversity. This year’s winning projects highlight the importance of sustaining biodiversity in groundwater, seed banks, and the microbiome of birds....

 

  Integrated DNA Technologies Ships qPCR Master Mix at Ambient Temperature

Innovative product development exemplifies commitment to sustainability—reduces waste and saves costs

IDT imageIntegrated DNA Technologies, has developed a unique master mix for probe-based qPCR assays that is stable for ambient shipping. The company’s PrimeTime® Gene Expression Master Mix is the only widely distributed commercial master mix shipped in solution at ambient temperature. Under these conditions, the master mix, which is compatible with a wide range of real-time PCR instruments....

 

  Integrated DNA Technologies Supports Brazilian Research Team’s Biocontrol Method for Zika Virus

Natural method also is proving effective against dengue and chikungunya

IDTIntegrated DNA Technologies, is donating reagents to Eliminate Dengue Brazil to help combat the spread of Zika virus (ZIKV) in Brazil. The Eliminate Dengue Program is an international, non-profit research collaboration led by Prof Scott O’Neill of Monash University, Australia....

 

  Integrated DNA Technologies Acquires Oligonucleotide Synthesis Company ValueGene, Inc.

Company welcomes new customers with promise to provide seamless support for genomics research

Longze Cui of ValueGene Dan DernbachIntegrated DNA Technologies, the global leader in custom nucleic acid synthesis, has announced the acquisition of ValueGene, Inc. (“ValueGene”), an oligonucleotide synthesis services company based in San Diego, California. ValueGene offers custom DNA and RNA oligonucleotide synthesis products, including PAGE and HPLC purification and modification services. Dr Joseph A Walder, IDT founder and chief executive officer...

 

  Integrated DNA Technologies Expands Global Sales Network

Company now selling directly to customers in South Korea

IDTIntegrated DNA Technologies , the global leader in custom nucleic acid synthesis, has acquired MBiotech, Inc. (“MBiotech”), headquartered in Seoul, South Korea. MBiotech has been a distributor of IDT products for more than a decade. In its promotion of IDT products, MBiotech has successfully made IDT’s brand well-known throughout the South Korean peninsula....

 

  Takara Bio USA, Inc. and Integrated DNA Technologies Announce Collaboration to Support Targeted RNA Sequencing

Life science companies combine expertise to enhance transcriptome research 

IDTTakara Bio USA, Inc. (TBUSA, formerly Clontech Laboratories, Inc.), a wholly owned subsidiary of Takara Bio Inc., and Integrated DNA Technologies (IDT) today announced a new collaboration to support targeted RNA sequencing. This relationship will leverage IDT’s unrivalled proficiency in the manufacture and quality control of long oligonucleotides and TBUSA’s expertise in developing low-input solutions for...

 

  Integrated DNA Technologies (IDT) Announces Platinum Sponsorship of International Genetically Engineered Machine (iGEM) Competition

Integrated DNA Technologies (IDT), the global leader in nucleic acid synthesis, announces its 2016 Platinum Level sponsorship of the International Genetically Engineered Machine (iGEM) competition.

IDT iGemThe iGEM Foundation conducts a yearly international competition for students interested in synthetic biology. Last year, more than 280 teams from 39 countries participated in the competition. IDT also will provide each registered team with up to 20KB of its market leading gBlocks® Gene Fragments synthetic DNA products—for a total value of almost US$1M. “We are very proud to continue our support of iGEM teams that enable...

 

  Caribou Biosciences and Integrated DNA Technologies (IDT) Announce Non-Exclusive License Agreement for CRISPR-Cas9 Reagents

Caribou has granted IDT worldwide rights to commercialize CRISPR-Cas9 reagents under Caribou™s intellectual property.

Caribou BiosciencesThe license is subject to a research use limited label. "We are proud to partner with Integrated DNA Technologies, a prominent leader in the field of nucleic acid based technologies", said Rachel Haurwitz, Ph.D., President and Chief Executive Officer of Caribou. This partnership will help provide researchers with the tools they need to conduct effective CRISPR-Cas9 research. Joseph Walder, M.D., Ph.D., President and...

 

  Sophia Genetics and Integrated DNA Technologies (IDT) Partner to Create NGS Solutions in Routine Clinical Diagnostics

Sophia Genetics announces a strategic partnership with Integrated DNA Technologies to accelerate the adoption of next generation sequencing (NGS) in routine clinical diagnostics.

Sophia GeneticsThe Sophia DDM™ advanced analytical platform will be paired with IDT’s xGen® hybridization-based target enrichment panels to provide hospitals with excellent analytical performance, unrivalled flexibility for gene panel composition, and high sample throughput. The NGS bundles will be available immediately to more than 120 hospitals currently using the Sophia DDM™ platform.  As additional hospitals add this platform to...

 

  IDT Delivers a Complete Solution for Probe-Based qPCR Assays

PrimeTime® qPCR Assays and Master Mix from IDT provide superior efficiencies and reliability for gene expression studies

Singleplex and duplex PrimeTime® qPCR Assays using the PrimeTime Master MixIntegrated DNA Technologies (IDT) has introduced its latest addition to an expanding genomic applications portfolio: PrimeTime® Gene Expression Master Mix, an optimized enzyme mix for probe-based qPCR. IDT continues to provide higher value qPCR products by delivering superior assay performance at a lower price per reaction, while empowering customers with access to assay sequences. This newest product enhances the...

 

  IDT’s xGen Exome Research Panel Delivers Deep and Uniform Coverage in a Single Day

IDT enables insightful NGS results in clinical and companion diagnostics research, every time

xGen Exome Panel Coverage Depth Integrated DNA Technologies (IDT), introduces its new xGen® Exome Research Panel v1.0 for insightful analysis of the human exome via next generation sequencing. A total of 429,826 probes span 39 Mb of the human genome, providing deep and uniform coverage of 19,396 genes. This leads scientists directly to relevant mutations, aiding advances in clinical and companion diagnostics research. By using the xGen Exome Research Panel with xGen...

 

  Dr Patricia Tavormina Named Winner of First IDT ISO 14001 Sustainability Award

Biodiversity research on methane sinks and global warming earns $14,001 in oligo credit

Dr Patricia TavorminaIntegrated DNA Technologies (IDT), the world leader in custom oligonucleotide synthesis, awarded the inaugural IDT ISO 14001 Sustainability Award to Dr Patricia Tavormina of the Division of Geological and Planetary Sciences at the California Institute of Technology. Dr Tavormina's research focuses on naturally occurring methane-oxidizing bacteria, (MOB), and the role they play in limiting greenhouse gases, which contribute to global warming. IDT introduced...

 

  Get the Most Out of Your qPCR

New IDT Webinar: ‘High throughput qPCR: tips for analysis across multiple plates’

Dr Mikael KubistaIntegrated DNA Technologies (IDT) will be hosting a webinar to help researchers get the most out of gene expression studies that analyze large numbers of samples. Entitled ‘High throughput qPCR: tips for analysis across multiple plates’, the webinar will be presented by Dr Mikael Kubista, founder and CEO of the TATAA Biocenter and head of the Department of Gene Expression at the Institute of Biotechnology of the Czech Academy of Sciences. The webinar will be...

 

  Point-of-Care Diagnostics for Ebola

IDT’s Ebola PrimeTime® qPCR Assay Validated

scientists Kristin Beltz and Dr Scott RoseIn a recent DECODED research profile, Integrated DNA Technologies (IDT), details how IDT scientists Kristin Beltz and Dr Scott Rose are collaborating with Dr Brian Taylor’s research team at Battelle (Aberdeen, MD, USA) to design and validate a RT-qPCR assay that can detect the Ebola virus in the field. The IDT PrimeTime® Ebola qPCR Assay detects Zaire ebolavirus, the species involved in the 2013–2015 West African Ebola outbreak. Initial sensitivity...

 

  Get Your Groove Online – GMP Probes for IVD Manufacturing

IDT first to offer easy online ordering of MGB Eclipse® qPCR probes licensed for human in vitro diagnostics use

MGB Eclipse probesIntegrated DNA Technologies (IDT), has become the only company to add fully licensed Minor Groove Binder (MGB) Eclipse® GMP probes to its online service, enabling quick and efficient ordering. GMP-produced and supplied under license for use as components in human in vitro diagnostic tests, these robust and economical qPCR probes join the company’s wider product portfolio of GMP probes and primers available to order through the...

 

  Untangling the Web of Gene Expression

IDT facilitates a unique, scalable method for analyzing hundreds of enhancer:promoter interactions in a single assay

Untangling the Web of Gene ExpressionAdvancing the development of novel methods for understanding gene expression, Integrated DNA Technologies (IDT) has enabled Dr Jim Hughes, Associate Professor at the Weatherall Institute of Molecular Medicine, Oxford, UK, to optimize his unique Capture-C method, based on Chromosomal Conformational Capture (3C). As outlined in the recent DECODED Online article, Understanding How Distal Regulatory Elements Control Gene...

 

  IDT Opens Molecular Biology R&D Facility in Redwood City

Dr Caifu Chen to lead new product development at California site

IDT Opens Molecular Biology FacilityAlready the world’s leader in custom nucleic acid synthesis, Integrated DNA Technologies (IDT) is capitalizing on its expertise to deliver a broader range of validated molecular biology products. Research and development for these products will now be performed in a newly built facility in Redwood City, California. The 8,000 square foot building houses state-of-the-art labs that will allow IDT scientists to maximize the company’s world-class...

 

  A Beginner’s Guide to CRISPR Genome Editing

In a recent DECODED Online entry, Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides an overview of the CRISPR/Cas9 system to scientists looking to enhance their genome modification strategy in model organisms or cell lines.

CRISPR/Cas9The CRISPR/Cas9 system has rapidly become a leading method for genome editing. Faster and more efficient than other methods, the system is continually being improved. This entry informs researchers on the latest developments and highlight the potential of this evolving technology. Bringing together the latest information on CRISPR/Cas9, the piece links through to resources that cover the many advantages over other methods such as...

 

  Bringing Biotechnology to the Public

IDT supports bioengineering educational initiative that will provide color-changing flowers

color-changing PetuniaTo help the general public understand how bioengineering is changing the world for the better, Integrated DNA Technologies (IDT) is supporting a unique public outreach program led by expert plant synthetic biologists at Revolution Bioengineering. Detailed in a recent DECODED article, “Color-Changing Flowers—Biotechnology for Everyone”, Revolution Biotechnology is creating bioengineered Petunia flowers that change color on...

 

  IDT’s CRISPR/Cas9 Online Resource for all Your Genome Editing Needs

Comprehensive resource pools the latest in the field for newcomers and experts

genome pictureIntegrated DNA Technologies (IDT) has pooled its expertise in genome editing into a free web resource dedicated to providing researchers a hub of information on the very latest in using the CRISPR/Cas9 system. On the webpage, researchers can find a range of educational and practical resources suited to those both experienced and new to genome editing. These include a recent highly successful and comprehensive IDT webinar...

 

  Breaking Barriers in siRNA Delivery

To accelerate the understanding of disease and the development of gene knockdown therapies, Integrated DNA Technologies (IDT) is facilitating the advancement of a new transfection technique.

This nanoparticle-based method is explored in a recent DECODED article contributed by Precision NanoSystems Inc. (PNI). By combining IDT’s highly potent Dicer-substrate RNAs (DsiRNAs) and PNI’s unique nanoparticle delivery system for hard-to-transfect cells, the IDT-PNI partnership presents a successful solution for challenging gene silencing applications, achieving >95% transfection efficiency. The novel NanoAssemblr™ system and...


 

  IDT and Ubiquitome Partner to Develop Mobile Ebola Test

Integrated DNA Technologies (IDT), and Ubiquitome today announced a partnership to develop the Ubiquitome Freedom4 Real-Time RT-PCR Ebola Virus Assay for easy use in the field.

IDT logoThis rapid test is designed to be run on Ubiquitome’s hand-held, battery powered real-time PCR device, the Freedom4. IDT, a market leader in the manufacture of GMP quality products for use in molecular diagnostic tests, is leveraging its PrimeTime qPCR Assay platform to develop an assay that will provide accurate and consistent test results for Ebola virus disease. Fitting in the palm of a hand, Ubiquitome’s Freedom4...

 

  IDT Launches GMP MGB Eclipse Probes for In Vitro Diagnostic Use

Integrated DNA Technologies (IDT) has acquired a license from ELITech Group (Bothell, WA) to manufacture and supply MGB Eclipse® Probes for use as a component in human in vitro diagnostic tests.

Integrated DNA Technologies As a result of improved knowledge and understanding of the human genome, quantitative real-time PCR (qPCR) has become an increasingly important tool for in vitro diagnostics and patient management. The gold standard 5′ nuclease qPCR assay uses oligonucleotide probes that have three critical features: fluorescent reporter dyes, quenchers for these dyes, and a minor groove binder. qPCR is a sensitive method for detecting abnorma...

 

  IDT Shares Tips for Optimizing Target Capture

In a recent DECODED Online article,  scientists at Geneseeq Technology, Inc., a cancer diagnostics company, demonstrate improved target capture methods for increasing reliability of next generation sequencing data, particularly important for clinical diagnostics.

IDT Shares TipsThe scientists’ insights cover use of blocking oligos, optimizing hybridization conditions, and getting the most out of formalin-fixed and paraffin embedded (FFPE) samples. Geneseeq provides clinicians with guided treatment solutions for cancer, based on comprehensive, systematic analysis of patients’ genomic mutations. The company was an early adopter of IDT’s xGen® Lockdown® Probes and uses these with xGen® Blocking Oligos to...

 

  IDT Launches Modular NGS Gene Capture Pools

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, today announced the introduction of xGen® Predesigned Gene Capture Pools and Plates.

IDT Launches ModularThese modular gene capture probes are the latest addition to IDT’s growing portfolio of high quality, customizable next generation sequencing products. xGen Predesigned Gene Capture Pools and Plates are ideal for creating customized target capture panels for enrichment of 10 or more genes or for enhancing the performance of existing panels. Predesigned Gene Capture Pools and Plates are ideal for scientists who need to reduce the cost of...

 

  IDT’s Novel rhPCR Unravels Gene Expression

In DECODED Online, Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, looks at how its novel RNase H2–dependent polymerase chain reaction (rhPCR) method has helped researchers to detect differential amplification of alternatively spliced latrophilin (Lphn) transcripts in mice.

IDT imageLatrophilins are cell adhesion molecules that have been linked with synaptic function, development, and maintenance. The three Lphn genes are very similar, which complicates the use of standard qRT-PCR to distinguish the various transcripts. The rhPCR method developed by IDT overcomes this problem by simultaneously increasing PCR specificity and eliminating primer-dimer formation. This is achieved by using blocked primers, which require cleavage by...

 

  IDT Shares Comprehensive qPCR Resources

IDT decoded
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, is sharing its wealth of qPCR expertise and knowledge in a special qPCR compendium edition of the DECODED newsletter, available free of charge online.

In this issue, number 4.2, researchers can read an interview with internationally recognized expert on quantitative PCR, Dr Jo Vandesompele. Discussing the common issues researchers face when using qPCR, and the future direction of the technology, Dr Vandesompele notes a trend towards digital PCR (dPCR). For those who want to discover dPCR in more depth there is a special article dedicated to the topic – ‘Digital PCR (dPCR) – what is it and...

 

  Integrated DNA Technologies Advances Human Health and Clinical Research

Two new xGen® next generation sequencing panels to be launched

IDT

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, is extending its portfolio of NGS panels with the addition of the xGen® Inherited Disease and Pan-Cancer Panels. Adding these to the xGen AML Panel which was launched at the end of last year, IDT now offers a range of panels for deep sequencing that can be supplemented to cover a comprehensive range of diseases....

 

  Summit Partners Makes Growth Equity Investment in IDT

Integrated DNA Technologies (IDT) announced today a minority investment by growth equity investor Summit Partners. IDT’s founder, Dr. Joseph Walder, will remain the company’s majority owner. Additional terms of the investment were not disclosed.

Integrated DNA Technologies LogoIDT is the world’s largest manufacturer of custom nucleic acid products. The company supplies scientists with synthetic DNA and RNA sequences, serving the academic research, biotechnology, clinical diagnostics, and pharmaceutical sectors. IDT develops innovative products while providing unmatched product value, excellent delivery times, and personalized customer service....

 

  Advancing CRISPR Research with gBlocks Gene Fragments

Sequence and application flexibility allow for the exploration of CRISPR and Cas9 function

Integrated DNA Technologies

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, advances CRISPR research with the use of its gBlocks Gene Fragments. Detailed online in the latest issue of DECODED, CRISPRs can be used in conjunction with CRISPR associated (Cas) proteins, for example Cas9 has been well documented, to recognize and cleave complementary DNA. This mechanism, which is found naturally within bacteria and archaea to protect cells from foreign sequence, has been harnessed for use in genome editing.

 

  Enhanced Molecular Inversion Probes for NGS Target Enrichment

IDT presents latest developments at AGBT

Integrated DNA Technologies LogoIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, will present its findings on the use of molecular inversion probes (MIPs) for next generation sequencing (NGS) target enrichment at the 15th annual Advances in Genome Biology and Technology (AGBT) meeting in Marco Island, Florida, Feb 12-15. John Havens PhD, Vice-President of Business Development at IDT, will talk about MIPs and their proven effectiveness in the enrichment of genomic content of biological samples for specific regions of interest...

 

  Providing a Rapid and Reliable Method of Gene Cloning

Integrated DNA Technologies Presents at Antibody Engineering and Therapeutics 

Michel Cannieux holds a PhD in Plant Molecular Biology

Michel Cannieux, PhD, MBA, Director of Product Commercialization, Synthetic Biology at IDT discussed a novel, rapid and reliable method to build and clone genes of interest at a fraction of the cost of full gene synthesis. The talk, entitled “Rapid and Reliable Gene Construction with gBlocks™ Gene Fragments and Gibson Assembly™ Method” took place at 12.00 on December 11. As double stranded, sequence verified DNA blocks up to 750 base pairs, gBlocks Gene Fragments have high sequence fidelity. As a result, they are ideal for use in a broad range of biological applications....

 

  Building 3D Nanostructures with Synthetic DNA

Harvard professor explains how to programme complex oligo structures for new applications 

Decoded Magazine

The quarterly newsletter DECODED, from Integrated DNA Technologies (IDT) explores the work of Dr Pen Yin, assistant professor of systems biology at Harvard Medical School, who is harnessing the base pairing properties of DNA to create 3D structures of “DNA bricks”. This new nano-construction technique is based on short DNA oligos, which assemble at right-angles to interlocking sequences, forming 3D units. With such a heavy dependency on oligonucleotide quality, Dr Yin has relied on IDT. These DNA bricks are inspiring many future applications, such as catalysts and drug compounds, and can eventually be used to create electrical circuit boards on the nanometer scale...

 

  Integrated DNA Technologies Launches xGen Universal Blocking Oligos

Enhancing the performance of target capture experiments

xGen Universal Blocking Oligos

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has launched the latest addition to its portfolio of next generation sequencing (NGS) products, xGen® Universal Blocking Oligos. By incorporating these oligos into target capture experiments, users can decrease the complexity and increase throughput of their target capture experiment without degradation of performance. Blocking oligos are commonly used to enhance the performance of capture experiments, through the prevention of cross-hybridization between adapter sequences...

 

  Integrated DNA Technologies Launches its First Cancer Panel

Fast and accurate screening for mutations identified in acute myeloid lymphoma using the xGen® Acute Myeloid Lymphoma Panel v1.0

Excellent coverage uniformity obtained with xGen lockdown AML cancer panel.png

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, is enabling cancer research with its latest next generation sequencing (NGS) product, the xGen® Acute Myeloid Leukemia Cancer Panel v1.0. Consisting of 11,743 xGen Lockdown® Probes, this cancer panel targets over 260 clinically relevant genes that were found to be mutated in a study of 200 patients with acute myeloid leukemia (AML), and published by The Cancer Genome Atlas consortium. The AML Cancer Panel is used for enriching the genome for regions of interest before performing NGS. It can, therefore, be used to study disease occurrence and progression, and help with the development of better targeted therapies...

 

  Providing cost-effective capture of defined genomic regions

IDT xGEN® Lockdown® Probes advance research at the University of Texas at Austin, USA

xGen Lockdown Probes yield high coverage

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides researchers in Prof Jeffrey Barrick’s laboratory (University of Texas at Austin, USA) with its xGEN® Lockdown® Probes for target enrichment of specific gene regions. Detailed in the DECODED quarterly newsletter from IDT, Prof Barrick’s research team is developing methods to track rare mutations in evolving populations to assess effects on fitness from sequence alone...

 

  Integrated DNA Technologies Enhances its qPCR Probe Portfolio

The perfect choice for qPCR, on any scale

PrimeTime qPCR Assays

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has further expanded its portfolio of PrimeTime® qPCR products with the launch of two new probes. The PrimeTime Eco Probe and PrimeTime Mini LNA Probe complete the existing offering, providing new options for customers performing gene expression and genotyping experiments...

 

  Are SNPs Impacting Your PCR Efficiency

IDT helps users to safeguard their experiments

PrimeTime qPCR Assays page print

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides an overview in the latest issue of its quarterly newsletter, DECODED, of the importance of checking for single nucleotide polymorphisms (SNPs) when designing PCR assays. If PCR is performed using primers that overlap a SNP, the SNP can impact the progress of the PCR, and thus the accuracy of resulting data...

 

  miRNA Regulated Networks Identified in Cystic Fibrosis

The IDT newsletter DECODED features the latest research to rescue the CFTR functionality

IDT DECODED newsletter

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers insight into recent research that has unearthed an miRNA-regulated network implicated in the pathogenesis of Cystic Fibrosis (CF). Described in the April edition of DECODED, the international IDT customer newsletter, optimized DIG-labeled DsiRNAs (IDT) were used to develop a novel, enhanced approach for oligonucleotide delivery....

 

  IDT opens SGD 6 million manufacturing facility in Singapore

World’s largest supplier of custom nucleic acids opens SGD 6 million manufacturing facility in Singapore

Integrated DNA Technologies Logo

Already the world’s leader in custom nucleic acid synthesis, Integrated DNA Technologies (IDT) has expanded its manufacturing capabilities to Singapore. IDT is now able to provide locally-manufactured oligonucleotides to researchers in Singapore and throughout the region from the company’s first synthesis facility in Asia. In January of 2012, IDT acquired the oligo business of Singapore’s top supplier, 1st BASE Pte. Ltd. Shortly thereafter, IDT began work to create a state-of-the art hub for oligo manufacturing and support dedicated to the Asian market. IDT completed the nearly SGD 6 million project in spring of 2013, and the Singapore company’s synthesis and other processes are now fully integrated with IDT’s operations in the US and Europe...

 

  PrimeTime qPCR Assay Plates Streamlines High Throughput qPCR Analysis

PrimeTime® qPCR Assay Plates with online tool for ordering primers and probes in 96 well format

PrimeTime qPCR Assays page print

Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has announced the launch of PrimeTime® qPCR Assay Plates, for high throughput qPCR analysis. Primers and probes for 5’-nuclease and intercalating dye assays (e.g., SYBR®) can now be directly ordered online in a 96 well plate format, eliminating the time-consuming transfer of primers and probes from reagent stocks, and streamlining the reaction set-up. PrimeTime qPCR Assay Plates offer an ideal solution for many applications that generate large quantities of data, such as validation of NGS and microarray data, as well as high throughput gene expression screening...

 

  IDT and SGI-DNA Broaden Their Collaboration to Provide Synthetic DNA Products up to 2 Mbp

Integrated DNA Technologies, Inc. (IDT) and SGI-DNA announce an expanded partnership to develop, manufacture, and market a variety of synthetic DNA products

idtIDT is the world’s leader in custom oligonucleotide synthesis and SGI-DNA is a newly formed subsidiary of Synthetic Genomics, Inc. (SGI), which focuses on genomic-driven solutions to a variety of global needs. In February of 2012, IDT and SGI began to co-manufacture, commercialize, and market small synthetic gene products of up to 5 kb....

 

  New England Biolabs Reports Significant Process Improvements Using IDT’s gBlocks

Providing fast and accurate gene assembly

decodedThe latest issue of Integrated DNA Technologies' (IDT's) DECODED newsletter highlights how New England Biolabs (NEB) researchers were able to expe­dite the cloning of a 2.1 kb gene into a linearized pET21-a bacterial expression vector using 5 gBlocksTM Gene Fragments that spanned the entire 2.1 kb sequence. Cloning, sequencing, and characteriza­tion of protein activity took less than 4 days, shorter than necessary for a third party to synthesize the complete gene and provide a finished construct.

 

  IDT Supports the qPCR Community Recent qPCR webinar and application guide advance end-user knowledge 
Integrated DNA Technologies (IDT)
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, continues to provide support for life science applications with its latest successful webinar. Over 1300 researchers registered for the live webinar entitled ‘State-of-the-art normalization of RT-qPCR data', presented by Dr Jo Vandesompele, professor of functional genomics and applied bioinformatics at Ghent University and co-founder of real-time PCR company Biogazelle. His expertise in the qPCR area includes numerous ground-breaking publications on normalization of gene expression and real-time PCR data analysis...

 

  Choosing the Right Oligonucleotide Modification for Your Needs Latest issue of IDT's DECODED newsletter offers informative oligonucleotide selection guide

Integrated DNA Technologies (IDT)Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a guide to choosing the right oligonucleotide modification in this quarter's edition of the company's DECODED newsletter. As IDT offers hundreds of useful modifications for oligonucleotides, choosing the appropriate one for your work can be confusing. The article provides insightful information to help when choosing the right modification, including a detailed list of the modification categories...

 

  IDT sponsors undergraduate iGEM teams for the second year running Integrated DNA Technologies (IDT)The International Genetically Engineered Machine (iGEM) competition provides undergraduate students with the opportunity to get involved in the advancement of synthetic biology. As one of the sponsoring partners, Integrated DNA Technologies (IDT) is offering to support individual iGEM student teams. Last year, the 11 teams sponsored by IDT were provided with credit which they could use to obtain IDT products, including oligonucleotide primers and synthetic GENEs for use in their research project...

 

  Integrated DNA Technologies Acquires 1st BASE Oligonucleotide Business in Singapore Integrated DNA Technologies (IDT) Integrated DNA Technologies (IDT) has acquired the oligonucleotide business of Singapore's top supplier in the field, 1st BASE Pte. Ltd (1st BASE).  Already the world leader in custom nucleic acid synthesis, IDT will now offer locally-manufactured oligos to researchers in Singapore and throughout the region from the company's first synthesis facility in Asia...

 

  IDT further optimizes ZEN probes for qPCR Integrated DNA Technologies (IDT)Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has expanded its ZENTM double-quencher probe portfolio to offer a new range of quencher/dye combinations. The probes are now available with a choice of five fluorescent dyes, FAM, HEX, TET, MAX or JOE, providing additional experimental flexibility. Part of the PrimeTime® qPCR range, ZENTM double-quenched probes generate less background while...

 

  IDT Launches its RxnReady Oligo Service Integrated DNA Technologies (IDT)Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, now offers its customers the ability to order RxnReady oligonucleotides. Users can specify the premixing of 2 - 6 standard desalted DNA oligos, in a single tube, according to the individual specifications provided. An additional level of flexibility is provided by the ability to incorporate a range of modifications, including 5' amino, 5' biotin, 5' or internal deoxyInosine, 5' or internal deoxyUridine, and 5' phosphorylation...

 

  IDT Newsletter Helps You ‘Find Out First’ Integrated DNA Technologies (IDT)Each quarter, Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, releases the latest version of its DECODED newsletter. Each issue contains everything from interesting summaries and interviews about the latest academic research findings, to applications overviews, laboratory tips, and the latest product news. A column entitled ‘Find Out First' provides users with an exclusive first look at a new IDT product or update...

 

  IDT offers pre-designed and custom assays, primers and probes for qPCR Integrated DNA Technologies (IDT), Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a broad range of custom qPCR assays, primers, and probes. PrimeTime® qPCR Assays are available in three different sizes (Mini, Standard, and XL) and provide the forward and reverse primers, as well as a hydrolysis probe in a single tube. Primers and probes are also available separately, including the new Double-Quenched Probe which increases accuracy and sensitivity through the incorporation of an internal ZEN quencher. As such, users are provided with an option to meet any experimental requirements.

 

  Decode the world of oligos IDT DECODED NewsletterIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has recently launched its quarterly newsletter: Decoded. Structured in an educational format, the newsletter features regular sections such as ‘your research', where readers can learn about research applications and findings. With additional sections dedicated to explaining fundamental scientific principles, tips and ideas to streamline your research, as well as a light hearted science-humor feature...

 

  IDT offers a complete range of gene silencing products Integrated DNA Technologies Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers a comprehensive range of customizable products for RNA interference (RNAi) applications. The Screening Dicer-substrate siRNA (DsiRNA) provides researchers with a cost-effective and quick solution for their RNAi requirements. IDT's DsiRNAs are chemically synthesised 27-mer RNA duplexes optimised for Dicer processing and incorporation into the RISC complex, resulting in an increase in potency...

 

  IDT’s SciTools provide intelligent oligonucleotide design Integrated DNA Technologies (IDT)Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides SciTools, a free oligo design and analysis suite for the in-depth characterization of oligonucleotides. The applications provided can determine the properties and optimal assay conditions of any sequence entered, all at the click of a button...

 

  IDT increases qPCR sensitivity and specificity with its double-quenched probes Dual-quenched probeIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers its double-quenched probe, to increase the accuracy and reliability of 5' nuclease qPCR experiments. This novel proprietary probe design positions an internal ZENTM quencher 9 bases from the 5' fluorophore, which when combined with the standard 3' quencher, significantly decreases background fluorescence and increases sensitivity...

 

  IDT offers GMP production of oligos for diagnostic use IDT offers GMP production of oligos for diagnostic useIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has extended its proven expertise in oligo research, development and production to clinical and commercial OEM customers. Its Clinical and Commercial Manufacturing (CCM) facility is dedicated to the GMP production of oligos for diagnostic use. With the need for fully compliant oligos in the clinical sector, the production facility is fully ISO 13485:2003 certified, and registered with the US Food and Drug Administration (FDA)...

 

  IDT’s free SciTools suite for easy oligonucleotide design and analysis IDT’s free SciTools suite for easy oligonucleotide design and analysis Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a number of free oligo design and analysis tools via its online SciTools suite (www.idtdna.com/scitools). These software applications determine the properties of any oligo sequence entered, as well as mediating the intelligent design of assay conditions, all at the click of a button. The suite is easy to use and makes it simple to add each optimized oligo to an ongoing order list ready for purchase...

 

  IDT PrimeTime Pre-designed Assays increase qPCR accuracy and efficiency IDT PrimeTime Pre-designed Assays increase qPCR accuracy and efficiencyIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, now offers PrimeTime Pre-designed qPCR Assays which are guaranteed to work for human, mouse, and rat transcriptomes. Users can search and select from the online database that contains thousands of assays. All assays are designed to span exons, protect against non-specific amplifications, avoid known SNPs, and minimize the impact of secondary structure...

 

  Quanta Biosciences and IDT partner to develop and produce microRNA PCR Integrated DNA Technologies Quanta Biosciences (Gaithersburg, MD) has developed hundreds of assays for quantifying microRNAs, and has entered into a partnership with Integrated DNA Technologies (Coralville, IA) to custom manufacture them...

 

  IDT offers complete synthetic biology capabilities Integrated DNA Technologies Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers a completely confidential custom gene synthesis service. By manufacturing any genes, including hard-to-clone sequences, IDT provides a cost-effective service, eliminating the outlay for construction, cloning, and sequencing. In addition, each gene undergoes design, review and consultation, codon optimization, and sequence verification to provide guaranteed yields of 2 µg of purified DNA...

 

  IDT offers oligonucleotides to suit all applications Integrated DNA TechnologiesIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, offers a comprehensive oligo manufacturing service with rapid turnaround times. All oligos are provided deprotected, desalted, quantified using UV spectrophotometry and checked for quality using mass spectrometry as standard, to provide the highest quality and yield accuracy currently available.

 

  IDT introduces downloadable qPCR user guide IDT introduces downloadable qPCR user guideIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has developed an extensive quantitative real-time polymerase chain reaction (qPCR) user guide, which is available to download for free.

 

  IDT Launches Michael Zuker’s UNAFold Page Integrated DNA TechnologiesIntegrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, and Rensselaer Polytechnic Institute (RPI) today announced the launch of the UNAFold secondary structure prediction software at IDT. The software will be used to more accurately detect secondary structures within sequences submitted by customers, and will be made freely available through a web-based interface on IDT's SciTools website.

 

  IDT enters exclusive agreement with 454 Life Sciences to provide custom primers for GS FLX Titanium Chemistry Integrated DNA Technologies (IDT), the custom biology company, has signed an exclusive agreement with 454 Life Sciences, a Roche company, to provide researchers with custom primers for the GS FLX Titanium Chemistry, used on the company's GS FLX System and GS Junior System.

 

  IDT Presents at Presidential Commission for the Study of Bioethical Issues Appearing on behalf of the International Gene Synthesis Consortium (IGSC) member companies, Integrated DNA Technologies (IDT), a world leader in custom nucleic acid synthesis, yesterday spoke at the Presidential Commission for the Study of Bioethical Issues, in Philadelphia, PA

 

  IDT is awarded further funding for gene silencing research Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, recently received a Phase II SIBR grant, which will fund the ongoing ‘Gene Silencing with U1 Adapter Oligonucleotides' research project. As a new class of synthetic nucleic acids, the U1 adapters are capable of down-regulating the expression of genes of interest at the pre-mRNA stage, via a mechanism of action distinct from antisense or siRNA.

 

  IDT signs contract to supply Research Councils UK with custom oligonucleotides Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has signed a three year contract with Research Councils UK (RCUK) for the supply of synthetic oligonucleotides. RCUK coordinates the UK's seven research councils, enhancing the overall impact and effectiveness of the research they fund.

 

  IDT rises to 6th in ‘Best Places to Work’ Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has been named one of the top 10 ‘Best Places to Work in Industry', in a poll of research staff conducted by a leading magazine. Published in the May issue of ‘The Scientist', the poll put IDT 6th in the small company category, exceeding its 2009 placement of 8th.

 

  IDT launches Double-Quenched ProbesTM to increase qPCR sensitivity and precision Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, has introduced a new double-quenched probe, which increases the accuracy and reliability of 5' nuclease qPCR experiments. While traditional probes have 20-30 bases between the dye and quencher, this novel proprietary probe design positions an internal ZEN quencher only 9 bases from the 5' fluorophore.

 

  IDT earns ISO 9001:2008 certification at its European oligonucleotide production headquarters and adds GMP service for oligo drug development Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, today announced that the production processes for synthetic oligonucleotides at its European headquarters in Leuven, Belgium have achieved ISO 9001:2008 certification.

 

  Integrated DNA Technologies and Glycon Partner in Australia Integrated DNA Technologies (IDT) and Glycon Pty Ltd of New South Wales, Australia, are partnering to bring IDT's market leading products and services to researchers in Australia.

 

  IDT shares its expertise at qPCR 2010 in Vienna Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, will be presenting at the upcoming qPCR 2010 International Symposium, 7 - 9 April, in Vienna.

 

 

Media Partners