Recent Articles in Separation science - Articles and Application notes
Determination of Lanthanides by Ion ChromatographyMay 12, 2011Lanthanides are of increasing technological importance. However, the techniques commonly used to determine them require equipment well beyond the means of small budgets. Ion chromatography applying non-suppressed conductivity or UV/VIS detection is a straightforward, much less expensive alternative...
Read MoreThermo Fisher Scientific Introduces Flexible, Adaptable Column for Nanoscale HPLCApr 8, 2011Thermo Fisher Scientific Inc., the world leader in serving science, has announced the release of the Thermo Scientific EASY-Column for nanoscale HPLC applications. Nanoscale HPLC is primarily used in combination with high performance mass spectrometry for the analysis of complex biological samples, such as applications in proteomics and disease biomarker discovery. The EASY-ColumnTM operates effectively on any nano LC system, including the Thermo Scientific EASY-nLC, and it is optimized for online LC-MS...
Read MoreMass Based Purification Simplified with Gilson LC/MS Purification SystemMar 28, 2011Presenting the first practical mass-based purification system from Gilson. Developed for chemists to provide a simple, fast and flexible solution, this unique and usable purification system combines world class MS technology with existing industry leading preparative HPLC solutions...
Read MoreTrace Determination of Heavy Metals in Pharma ProductsMar 23, 2011Warwick Analytical Services has published a technical article that describes a new standard ICP methodology that has been developed to determine trace heavy metals in pharmaceutical products...
Read MoreBiotage Introduces New SNAP XL Flash PurificationMar 22, 2011Biotage® (STO: BIOT), a leading supplier of tools and technology for analytical and medicinal chemistry, announced 2 new additions to its SNAP XL family of cartridges for large scale and development purification. Released in both 750g and 1500g sizes, the new cartridges offer powerful solutions for reverse phase chromatography (KP-C18-HS) and also optimized silica for the separation of amines (KP-NH)...
Read MoreSage-N Research and Nonlinear Dynamics Sign Co-Marketing Agreement to provide Complete Workflow Solutions to High End Proteomics LabsMar 17, 2011Sage-N Research Inc. (Sage-N), the world leader in computational proteomics, have announced a co-marketing agreement with Nonlinear Dynamics who are renowned developers of proteomics software. The collaboration will see Sage-N Research co-market Nonlinear Dynamics' Progenesis LC-MS label-free quantification software alongside its SORCERER proteomics platform. The scientific capabilities of both companies are a natural compliment and the combined offering will facilitate continued progression in the global field of proteomics...
Read MoreATAS GL Introduces 4th Generation of OPTIC Multimode Inlet for Gas ChromatographyMar 14, 2011
After the worldwide success of three generations of OPTIC™ multimode inlet for gas chromatography (GC), ATAS GL International B.V. has developed a new instrument, the OPTIC-4. Broadest range of capabilities of the previous generations is expanded with new features and solutions that cannot be found in any other GC inlet.
Read MoreNitrogen Mustard Hydrolysis Products: Quantitative Analysis ImprovedFeb 28, 2011Dionex is proud to announce a rapid separation liquid chromatography (RSLC) tandem mass spectrometric (MS/MS) method for quantitative analysis of ethanolamines in environmental water samples. Application Note 271:Quantitative Analysis of Nitrogen Mustard Hydrolysis Products as Ethanolamines demonstrates use of the Dionex Acclaim® TrinityTM P1 Mixed-Mode column, featuring reversed-phase, anion-exchange, and cation-exchange retention mechanisms, to provide retention and resolution for five target analytes within 5 minutes.
Read MoreUsing GPC/SEC to accurately characterise complex biopolymers in foodFeb 22, 2011Published work, now freely available on the Malvern Instruments website, shows that the Viscotek TDAmax gel permeation/size exclusion chromatography (GPC/SEC) system is an information-rich, time-efficient analytical solution for the comprehensive characterization of complex food ingredients and additives based on polysaccharides. The work by Dr Gerhard Heinzmann and Dr Bernd Tartsch is detailed in a paper "Alginates, Chitosanes and Xanthans - Characterisation of Food Ingredients by GPC/SEC with Triple Detection".
Read MoreMalvernFeb 14, 2011Malvern Instruments has launched the Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS (size exclusion chromatography - light scattering) detector package dedicated to protein analysis. The proven Zetasizer µV offers dual DLS (dynamic light scattering) and SLS (static light scattering) capabilities. It can be used as a stand-alone detector, analyzing samples in a cuvette, and now as a fully-featured modular chromatography detector. For protein applications, this makes the Zetasizer µV an ideal tool
Read MoreA Highly Versatile Workflow Solution for Quantitative Protein AnalysisFeb 11, 2011Agilent Automation Solutions has announced a new white paper entitled 'An introduction to High-throughput Microchromatography' which introduces a highly versatile quantitative sample preparation technique for protein analysis.
Read MoreEnhanced Method for Monitoring Hydroxymethylfurfural Levels in Food and BiomassFeb 10, 2011Dionex is proud to announce a new high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD)-based method for the determination of hydroxymethylfurfural (HMF) in samples ranging from food (honey and pancake syrup) to treated biomass (corn stover and wood hydrolysate). Application Note 270: Determination of Hydroxymethylfurfural in Honey and Biomass demonstrates that this method has a broad linear range, high precisions, and low detection limits. This system configuration requires only addition of deionized water for continuous operation
Read MoreCommon Cations and Amines Identification and Quantification Improved Using IC-MSFeb 4, 2011Dionex announces a new method that combines ion chromatography (IC) and mass spectrometry (MS) detection for the determination of six commonly occurring cations and four amines at part per billion (ppb) levels. With MS detection, confirmation of the analyte identity can be achieved from full-scan spectra, and quantification can be achieved at low ppb levels with greater confidence by using selected ion monitoring (SIM) scans. Application Note 269: Identification and Quantification at ppb Levels of Common Cations and Amines by IC-MS demonstrates successful application of this method with analysis of water samples.
Read MoreNew Kanamycin and Amikacin Method Exceeds US Pharmacopeia Analysis RequirementsFeb 2, 2011Dionex is proud to announce a new method using high-performance anion-exchange chromatography in combination with pulsed amperometric detection (HPAE-PAD) for the analysis of kanamycin and amikacin, two closely related aminoglycoside antibiotics.
Read MoreThermo Fisher Scientific Launches New LC/MS Compendium to Share Environmental and Food Safety Testing KnowledgeJan 28, 2011Thermo Fisher Scientific Inc., the world leader in serving science, today announced a new, comprehensive and searchable compendium entitled "LC-MS Applications for Food, Beverage and Water Testing." The compendium designed as a knowledge transfer tool, provides customers with access to the wealth of application expertise developed by Thermo Fisher. Containing a variety of testing methods and technical applications for environmental and food testing laboratories, the free digital compendium is available free of charge
Read MoreThermo Fisher Scientific Method Uses GC-MS/MS to Significantly Increase the Number of Pesticides Detectable in a Single InjectionJan 25, 2011Thermo Fisher Scientific Inc., the world leader in serving science today announced it has developed a faster screening method for pesticides, enabling labs to simultaneously screen and confirm the presence of more than 1000 pesticides, at low levels, using a single injection. Other commonly used techniques require multiple injections in order to comply with increasingly stringent regulations.
Read MoreFaster Separation and Quantification of Metabolites in Brassica napus RapeseedsJan 12, 2011Dionex is proud to announce a new platform developed by a customer to measure various metabolites in Brassica napus seeds. In cooperation with the Leibniz Institute of Plant Genetics and Crop Plant Research, the company has released Customer Application Note 109: Primary Metabolite Analysis of Plant Material Using a Triple Quadrupole MS Coupled to a Monolith Anion-Exchange Column. This method combines separation using the 1 mm IonSwiftTM MAX-100 anion-exchange column and ICS-3000 system and detection with the API 4000TM electrospray ionization (ESI) tandem mass spectrometry (MS/MS) system from AB SCIEX, providing a simple, rapid, specific, and sensitive method for the simultaneous detection and quantification of several primary metabolites involved in the tricarboxylic acid (TCA) cycle and glycolysis pathway.
Read MoreBiotage Announces New Methods for the Extraction of Key Compounds for Clinical, Environmental and Forensic ApplicationsJan 11, 2011Biotage® (STO: BIOT), a leading supplier of tools and technology for analytical and medicinal chemistry, introduced a new series of application notes utilizing the industry-standard RapidTrace® SPE Workstation. These methods are now available at www.biotage.com. New applications include extractions from plasma, urine and whole blood, typically assayed in clinical and forensic protocols. Additionally, a new soil analysis method for dioxins and furans joins the presently available EPH protocols from Biotage.
Read MoreThermo Fisher Scientific Develops Method to Detect Dangerous Carbonyl CompoundsJan 10, 2011Thermo Fisher Scientific Inc., the world leader in serving science, today announced that it has developed a powerful method for the trace-level analysis of carbonyl compounds in a wide range of matrices. Carbonyl compounds, hazardous pollutants released from diverse sources including motor vehicles and industrial emissions, have been shown to have adverse effects on human health. This new UHPLC/UV method enables the separation, detection and quantitation of parts per billion (ppb) concentrations of low molecular weight carbonyls in complex samples, safeguarding human health and ensuring compliance with industry regulations
Read MorePhenomenex Publishes Guides for Medicinal Chemistry Sample Cleanup with Strata SorbentsJan 7, 2011Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the publication of a new medicinal chemistry methods brochure and companion wall poster guide to sample cleanup using the company's line of StrataTM-XL polymeric solid phase extraction (SPE) sorbents. The 12-page guide provides methods for large-volume reaction cleanup of synthetic organic compounds, while the wall poster is a convenient laboratory reference showing the steps for fast cleanup of basic, acidic and neutral compounds using the Phenomenex Strata-XL sorbents in pre-packed GigaTM tubes
Read MoreDionex Releases Technical Note for Determination of Water and Fat-Soluble VitaminsJan 4, 2011Dionex is pleased to announce the release of a new, key document entitled, Technical Note 89:Determination of Water- and Fat-Soluble Vitamins by HPLC. This technical note provides the physical-chemical properties including solubility, stability, and absorbance behavior of a large collection of vitamins. The document also describes a method that allows for the determination of fat- and water-soluble vitamins in one analysis with a run time of 25 minutes using the Dionex UltiMate® 3000 dual system and Acclaim® reversed-phase columns
Read MorePolyaromatic Hydrocarbons Now Quantifiable by Electrochemical Detection Using a Boron-Doped Diamond ElectrodeDec 24, 2010Dionex is proud to announce a powerful new method that extends the usefulness of electrochemical detection (ECD) to polyaromatic hydrocarbon (PAH) compounds that do not respond to ECD using typical carbonbased electrodes. Application Note 265: Quantification of Polyaromatic Hydrocarbons with a Boron-Doped Diamond Electrode uses the Coulochem® III detector and gradient high-performance liquid chromatography (HPLC) with a boron-doped diamond (BDD) electrode to detect and quantify aromatic, genotoxic compounds down to tens of pg on column
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Lanthanides are of increasing technological importance. However, the techniques commonly used to determine them require equipment well beyond the means of small budgets. Ion chromatography applying non-suppressed conductivity or UV/VIS detection is a straightforward, much less expensive alternative...
Thermo Fisher Scientific Inc., the world leader in serving science, has announced the release of the Thermo Scientific EASY-Column for nanoscale HPLC applications. Nanoscale HPLC is primarily used in combination with high performance mass spectrometry for the analysis of complex biological samples, such as applications in proteomics and disease biomarker discovery. The EASY-ColumnTM operates effectively on any nano LC system, including the Thermo Scientific EASY-nLC, and it is optimized for online LC-MS...
Presenting the first practical mass-based purification system from Gilson. Developed for chemists to provide a simple, fast and flexible solution, this unique and usable purification system combines world class MS technology with existing industry leading preparative HPLC solutions...
Warwick Analytical Services has published a technical article that describes a new standard ICP methodology that has been developed to determine trace heavy metals in pharmaceutical products...
Biotage® (STO: BIOT), a leading supplier of tools and technology for analytical and medicinal chemistry, announced 2 new additions to its SNAP XL family of cartridges for large scale and development purification. Released in both 750g and 1500g sizes, the new cartridges offer powerful solutions for reverse phase chromatography (KP-C18-HS) and also optimized silica for the separation of amines (KP-NH)...
Sage-N Research Inc. (Sage-N), the world leader in computational proteomics, have announced a co-marketing agreement with Nonlinear Dynamics who are renowned developers of proteomics software. The collaboration will see Sage-N Research co-market Nonlinear Dynamics' Progenesis LC-MS label-free quantification software alongside its SORCERER proteomics platform. The scientific capabilities of both companies are a natural compliment and the combined offering will facilitate continued progression in the global field of proteomics...
After the worldwide success of three generations of OPTIC™ multimode inlet for gas chromatography (GC), ATAS GL International B.V. has developed a new instrument, the OPTIC-4. Broadest range of capabilities of the previous generations is expanded with new features and solutions that cannot be found in any other GC inlet.
Dionex is proud to announce a rapid separation liquid chromatography (RSLC) tandem mass spectrometric (MS/MS) method for quantitative analysis of ethanolamines in environmental water samples. Application Note 271:Quantitative Analysis of Nitrogen Mustard Hydrolysis Products as Ethanolamines demonstrates use of the Dionex Acclaim® TrinityTM P1 Mixed-Mode column, featuring reversed-phase, anion-exchange, and cation-exchange retention mechanisms, to provide retention and resolution for five target analytes within 5 minutes.
Published work, now freely available on the Malvern Instruments website, shows that the Viscotek TDAmax gel permeation/size exclusion chromatography (GPC/SEC) system is an information-rich, time-efficient analytical solution for the comprehensive characterization of complex food ingredients and additives based on polysaccharides. The work by Dr Gerhard Heinzmann and Dr Bernd Tartsch is detailed in a paper "Alginates, Chitosanes and Xanthans - Characterisation of Food Ingredients by GPC/SEC with Triple Detection".
Malvern Instruments has launched the Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS (size exclusion chromatography - light scattering) detector package dedicated to protein analysis. The proven Zetasizer µV offers dual DLS (dynamic light scattering) and SLS (static light scattering) capabilities. It can be used as a stand-alone detector, analyzing samples in a cuvette, and now as a fully-featured modular chromatography detector. For protein applications, this makes the Zetasizer µV an ideal tool
Agilent Automation Solutions has announced a new white paper entitled 'An introduction to High-throughput Microchromatography' which introduces a highly versatile quantitative sample preparation technique for protein analysis.
Thermo Fisher Scientific Inc., the world leader in serving science today announced it has developed a faster screening method for pesticides, enabling labs to simultaneously screen and confirm the presence of more than 1000 pesticides, at low levels, using a single injection. Other commonly used techniques require multiple injections in order to comply with increasingly stringent regulations.
Thermo Fisher Scientific Inc., the world leader in serving science, today announced that it has developed a powerful method for the trace-level analysis of carbonyl compounds in a wide range of matrices. Carbonyl compounds, hazardous pollutants released from diverse sources including motor vehicles and industrial emissions, have been shown to have adverse effects on human health. This new UHPLC/UV method enables the separation, detection and quantitation of parts per billion (ppb) concentrations of low molecular weight carbonyls in complex samples, safeguarding human health and ensuring compliance with industry regulations
Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the publication of a new medicinal chemistry methods brochure and companion wall poster guide to sample cleanup using the company's line of StrataTM-XL polymeric solid phase extraction (SPE) sorbents. The 12-page guide provides methods for large-volume reaction cleanup of synthetic organic compounds, while the wall poster is a convenient laboratory reference showing the steps for fast cleanup of basic, acidic and neutral compounds using the Phenomenex Strata-XL sorbents in pre-packed GigaTM tubes