Merck Millipore, has launched Simpliconâ„˘ RNA Reprogramming Technology, which uses synthetic self-replicating RNA to create large numbers of human induced pluripotent stem cells (iPSCs) using a single transfection step.
This efficient reprogramming of somatic cells is accomplished without viral intermediates or host genome integration, offering a more defined and safer system for iPSC generation. "For stem cell researchers using iPSCs to study disease, differentiation and regenerative medicine, there's a real need for a reprogramming method that's as efficient as virus-based techniques yet as safe as non-viral methods," said Christophe Couturier, Head of Bioscience, Merck Millipore...
The project will be funded EUR 900K (USD 1.25 M) in total by the Belgian Walloon region and the Massachusetts Life Sciences Center (MLSC)
Promethera(R) Biosciences, a company that develops innovative therapies for the treatment of liver diseases, today announces a collaboration with EMD Millipore to develop an improved ready-to-use microfluidic perfusion liver assay. This new product is designed to perform more robust studies in pre-clinical toxicity and drug metabolism. Early availability of reliable human liver-based assays is critical to the pharmaceutical industry when deciding to bring a lead compound in clinical phase development....
Merck Millipore, the Life Science division ofÂ Merck KGaA, today announced that it will hold itsÂ 2014 Predictable Protein Performance Virtual ConferenceÂ on March 26 and 27, 2014.Â
The conference theme, "Predictable Protein Performance," will bring industry experts from around the world to discuss different aspects of this important topic. Conference speakers will explore why analyzing protein expression, structure, and function is key to any biological discovery and also outline strategies that researchers can take to ensure that the protein in their tubes accurately represents its native form, in its physiological context. Virtual Conference participants will learn how to maximize the information that can be obtained from each precious protein sample, no matter how complex or challenging it might be...
Merck Millipore, the Life Science division ofÂ Merck,Â today announced the expansion of its biomarker testing service capabilities with the launch of flow cytometry services at its North America facility.
The service supports exploratory and GLP-requiring studies, and includes full and flexible assay development, validation and sample testing services using clinically established flow cytometry instrumentation. The launch completes the significant investment Merck Millipore has made over the past two years to develop flow cytometry services globally, building on the existing industry-leading flow cytometry capabilities of the company's European testing site in Oxford, UK...
Merck Millipore offers a comprehensive portfolio of reliable and reproducible HPLC separation tools even for the most challenging analysis problems in research and development, quality control, environmental, clinical and biochemical analysis.
Join us at HPLC as Merck Millipore highlights its ChromolithÂ® High Resolution HPLC technology, which offers higher efficiency, improved peak shape, and more than two times lower back-pressure than any particulate packed column with the same dimensions.Â Additionally, the ChromolithÂ® columns have a more than 30% longer lifetime compared with particulate columns....
Merck Millipore highlights its new ZICÂ®-HILIC technology, a zwitterionic HILIC phase for LC-MS separation of polar compounds.
Merck Millipore offers a comprehensive portfolio of reliable and reproducible LC-MS separation tools even for the most challenging analysis problems in research and development, quality control, environmental, clinical and biochemical analysis.Merck Millipore will host a breakfast seminar on HILIC and analytical chromatography. Presentations include a discussion on how separation selectivity differs between HILIC columns; models will be shown to explain how to select columns....
In this new application note, Millipore describes how a Novel RNA detection reagent enables gene expression analysis in living cells.
This technology allows for carrier- free cellular endocytosis of the reagent, followed by detection and relative quantitative analysis of RNA levels. Because the reagent leaves the cell after the detection event, the same sample can be used for any downstream analysis, meaning you can assess multiple biomarkers or downstream functionalities in the same cells. Additionally, this reagent requires no upfront sample preparation, has no toxic effects on cellular fate and no known nonspecific, off-target effects....
Merck Millipore, the Life Science division of Merck, has announced availability of the MILLIPLEXÂ® map Human Stem Cell Pluripotency Magnetic Bead Kits, which enable the analysis of many different pluripotency biomarkers in a single measurement.
These kits are the first commercially available multiplexed protein biomarker assays based on the LuminexÂ® xMAPÂ® platform for this important research area. This new application of trusted bead-based multiplex technology gives researchers rapid feedback on the potency status of stem cell cultures and offers a significant advantage overÂ existing techniques, which detect a limited number of proteins with a semi-quantitative output for a single sample...
Merck Millipore, the Life Science division of Merck, has introduced AmiconÂ® Pro Purification System for Protein Purification
This centrifugal device streamlines the affinity purification workflow and minimizes protein loss. Users experience consistent, accurate sample preparation, resulting in more reliable recovery, uncompromised purity and easier data generation.
Centrifugal device streamlines the affinity purification workflow and minimizes protein loss
Combines the bind, wash, elute, buffer exchange and concentration steps into one device
Supports additional applications including depletion of abundant proteins, protein enrichment and clean-up of antibody labeling reactions
Merck Millipore, the Life Science division of Merck, today announced the publication of a white paper, "Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal Antibodies", Â which describes both regulatory and technical aspects of comparability studies for the development of biosimilars
Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
Details use of flow cytometry and surface plasmon resonance to quantify binding of therapeutic monoclonal antibodies to molecules mediating cytotoxicity
Assays provide valuable preclinical data about drug properties and their physiological interactions without the need for animal experiments
Merck Millipore's Discovery and Development Solutions business, part of the Life Science division of Merck, today announced it will now offer genomic biomarker services to aid drug companies in targeting patient sub-groups for improved clinical outcomes, understanding drug safety and efficacy, and characterizing tumors
Genetic and epigenetic technologies added to established CRO services for biomarker development, validation and testing
Consolidated protein, genomic and cell-based bioanalysis services enable multiple biomarker analysis for better pipeline decisions
Genomic biomarkers advance "Precision Medicine," helping identify patients most likely to respond to a drug or experience side effects
Merck Millipore, the life science division of Merck, today announced that Merck Millipore has entered into an agreement with an academic consortium funded by the NIH, to distribute more than 140 peer-validated neuroscience-specific monoclonal antibodies through its worldwide network
Adds more than 140 peer-validated neuroscience-specific monoclonal antibodies to portfolio
Includes antibodies for neurotransmitters and neurodegeneration
All antibodies independently peer-reviewed and validated
Merck Millipore, the life science division of Merck,has announced the launch of Vegetable Contact Agar + LTHTh - ICRplus, a ready-to-use plate ideal for environmental monitoring of isolators and clean rooms
The plate is designed to determine the microbial count present on a surface, and because its agar is of non-animal origin, the device minimizes the risk of animal spongiform encephalopathy (TSE/BSE) transmission.
Ready-to-use plate determines a surface's microbial count
Minimizes the risk of TSE/BSE contamination during environmental monitoring
Provides superior growth promoting properties and neutralization of disinfectants
MobiusÂ® CellReady bioreactor provides a disposable, single-use platform for industrial production of stem cells
Facilitates consistent, reproducible large scale expansion of adult stem cells
Merck Millipore Introduces Magna ChIP HT96 Kits for High-Throughput Chromatin Immunoprecipitation
Apr 24, 2012Merck Millipore, the Life Science division of Merck, has introduced the Magna ChIPTM HT96 kit for high-throughput chromatin immunoprecipitation (ChIP).Â Using the kit, ChIP can be performed on up to 96 samples in a single experiment using as few as 10,000 cells per well.Â Â The optimized protocol uses a single, proprietary buffer for sonication, immunoprecipitation and washing which yields excellent sensitivity and lower backgrounds than conventional ChIP methods...
Merck Millipore Launches Direct Detect Biomolecular Quantitation System, Offering Significant Advantages over Bradford and Lowry Assays
Mar 16, 2012Merck Millipore, the Life Science division of Merck KGaA of Darmstadt, Germany, today launched the Direct DetectTM system for rapid, simplified protein quantitation.Â The Direct DetectTM system exploits Merck Millipore's membrane expertise to enable infrared-based measurement of amide bonds in protein chains, an intrinsic component of every protein, without relying on amino acid composition, dye-binding properties, or redox potential. Conventional assays based on UV-Vis spectroscopy rely on absorbance by a protein's aromatic amino acids and therefore have limited utility.
EMD Millipore Introduces High-Throughput Sample Preparation System
Apr 18, 2011EMD Millipore, the Life Science division of Merck KGaA of Germany, today announced the introduction of the SamplicityTM Filtration System, an innovative new technology that provides a convenient, high throughput alternative to syringe-tip filters when preparing samples for chromatography...