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All articles from Wyatt Technology Corporation

  Wyatt Technology Publishes Whitepaper on Protein Quality Control in High-Throughput Screening Studies

Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, has published a new whitepaper outlining how to evaluate the solution quality of biotherapeutic candidates prior to screening via Surface Plasmon Resonance (SPR) or Bio Layer Interferometry (BLI).

ynaPro Plate Reader IIThe DynaPro® Plate Reader II. Analyte quality is critical to obtaining accurate and meaningful measurements in order to select the most promising therapeutic candidates, so ensuring the quality of samples is a vital step in the screening process. The DynaPro high- throughput dynamic light scattering (HT-DLS) system provides an effective method of assessing sample materials using a non-invasive, non-pertubative optical technique...

 

  Wyatt Technology’s 24th International Light Scattering Colloquium to Feature Recent Advances in the Characterization of Nanoparticles and Biomolecules

Wyatt Technology Corporation, the world leader in light scattering tools for nanoparticle and macromolecular characterization, is pleased to announce that this year’s International Light Scattering Colloquium (ILSC) will present a special symposium on the characterization of manufactured, environmental and therapeutic nanoparticles.

WyattSporting the theme of “Light Scattering in the Nano World”, ILSC 2015 will be held at the beautiful Four Seasons Biltmore Resort in Santa Barbara, CA on November 3-4. Online Registration is available. The full program includes additional presentations on the characterization of biomolecules and polymers in cutting-edge research. Satellite events planned include short courses and a focus meeting on method development...

 

  Wyatt Technology’s Calypso CG-MALS System Demonstrates Enhanced Capabilities for Characterization of Complex Protein-Protein Interactions

Study published in Nature outlines use of Wyatt’s Calypso II system to confirm the stoichiometry of αSNAP-SNARE complex

Calypso 11Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, is pleased to highlight a new study that describes the use of composition-gradient multi-angle light scattering (CG-MALS) for the characterization of complex protein-protein interactions. The study, entitled ‘Mechanistic insights into the recycling machine of the SNARE complex’, was published in the...

 

  Freeslate and Wyatt Technology to Present Automated Biologics Formulation and Stability Studies Incorporating Dynamic Light Scattering

Benefits of integrated formulation preparation and analytics for the development of biotherapeutics to be demonstrated in webinar sponsored by Freeslate

wyattWyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on...

 

  Wyatt Technology’s DynaPro Plate Reader Optimizes Screening Process for Biotherapeutic Candidates and Formulations

The High-Throughput DynaPro Plate Reader Utilizes Dynamic Light Scattering to Identify Most Promising mAb Buffer Conditions Prior to Extended Stability Testing

wyattWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation, is pleased to highlight a study recently authored by Martin Skov Neergaard from the Faculty of Health and Medical Sciences at the University of Copenhagen, “Protein-Protein Interactions Investigated by DLS: Determination at High and Low Protein Concentration.” This article outlines the benefits of quantifying protein-protein interactions (PPI) using...

 

  New Study from Wyatt Technology Showcases Automated Dual Measurement Capabilities of MP-PALS to Determine Charge and Diffusion Interaction Parameter

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation has published the results of a new study outlining the simultaneous measurement of protein charge and diffusion interaction parameter (kD) to determine the colloidal stability of two formulations with different long-term stability behavior.

Traditionally, wyattthese two properties are measured independently in laborious experiments requiring manual sample preparation and loading. The Möbius® from Wyatt Technology uses massively-parallel phase-analysis light scattering (MP-PALS) in conjunction with an autosampler to automate this combined measurement. The Möbius is therefore an ideal tool for protein characterization and is unique in its ability to provide a complete picture of...

 

  New Study Highlights Benefits of Combining Light Scattering and Refractive Index Detectors Designed Specifically for UHPLC Applications

Latest Application Note from Wyatt Technology Demonstrates How Absolute Molar Mass can be Measured Using UHPLC SEC-MALS

wyatt u dawnWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has announced the availability of a new application note which outlines the combined use of the Wyatt μDAWN™ multi-angle light scattering (MALS) detector and the Optilab® UT-rEX™ refractive index (RI) detector to measure the absolute molecular weight (or molar mass) and size of eluting species in ultra high performance liquid chromatography (UHPLC)....

 

  New Whitepaper from Wyatt Technology On Branching in Synthetic and Natural Polymers

Wyatt Technology has published a new whitepaper

An A4F-MALS system for characterizing branched polymers

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has published a new whitepaper on characterizing molecular structure in synthetic and natural polymers by multi-angle light scattering. Authored by Stepan Podzimek, Scientific Consultant for Wyatt Technology, the paper details the basic principles of the detection and characterization of branching by means of a multi-angle light scattering (MALS) detector and the various methods used...

 

  Wyatt Technology Specialists to Present Expert Seminar and Poster at WCBP 2014

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, will be presenting on innovative light scattering techniques at WCBP 2014.

CASSS logoThe 18th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products provides a forum for discussing the latest bioanalytical methods and their practical application to biotechnology, pharmaceuticals and other health-related products. Dr. Daniel Some, Director of Marketing and Principal Scientist at Wyatt Technology will be hosting a seminar entitled “Molar mass, size and interactions: light scattering tools for essential biophysical characterization.” From aggregates to conjugates, light scattering detectors combine with a variety of sample delivery systems to provide a comprehensive suite of biophysical characterization tools. This talk will include a detailed overview and examples of the tasks relevant to well-characterized biopharmaceuticals that may be accomplished with these tools...

 

  Wyatt Technology to Launch the First SEC-MALS Detector for UHPLC at Pittcon 2014

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, will be launching the µDAWN™ at Pittcon 2014

uDAWNThe µDAWN is the world’s first multi-angle light scattering (MALS) detector that can be coupled to any UHPLC system in order to determine absolute molecular weights and sizes of polymers, peptides, and proteins or other biopolymers directly, without resorting to column calibration or reference standards. Wyatt Technology’s µDAWN connects to the Optilab® UT-rEX™, the first refractive index detector for UHPLC....

 

  Wyatt Technology Announces San Francisco Bay Area Protein & Biotech Users Meeting February 20th 2014

Wyatt Technology San Francisco Bay Area Protein & Biotech Users Meeting

SF Airport Burlingame The meeting will host two to three expert speakers, ‘how-to’ sessions presented by Wyatt Application Scientists, updates on our latest products, and small group discussions covering topics such as:Biophysical characterization. Formulation and stability. Orthogonal techniques. Large aggregates and sub-visible particles. Biomolecular interactions...

 

 

  Wyatt Technology Recognized Among Top 15 Advances by The Analytical Scientist

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces that it has been ranked among the winners of The Analytical Scientist’s 2013 Innovation Awards (TASIAs). 

Optilab UT-rEXHonored is Wyatt’s Optilab UT-rEX, the first refractive index detector of its kind for UHPLC systems. The innovative Optilab UT-rEX uses a combination of miniaturized components, cutting-edge semiconductor photodiode technology and proprietary computer algorithms to enable it to be added to any UHPLC system. The TASIAs recognize products that enhance preparation, separation, identification or quantitation and contribute to making the world safer and the diagnosis of disease more effective...

 

  New Insights Published on Key Protein Interactions Involved in the Bacterial Flagellar Motor Complex

New Insights Published on Key Protein Interactions Involved in the Bacterial Flagellar Motor Complex Show Promise for Other Difficult Biomolecular Systems

Wyatt Technology Logo

New Application Note from Wyatt Technology Showcases the Ability of CG-MALS to Quantify Complex Proteins. Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has today published a new application note highlighting a study on the complex interactions between proteins and how they modulate the rotational direction of bacteria flagella....

 

  Wyatt Technology Instrumentation Used by Medical Research Council to Perform Breakthrough Research

Wyatt Technology Instrumentation Employed by the Medical Research Council to Perform Breakthrough Research into Human Health and Disease

Dr Chris Johnson Senior Investigator Scientist at the LMB

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that its technology is being used by the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) to make advancements in tackling specific problems in human health and disease such as understanding different biophysical processes, including mechanisms of viral diseases and immunity....

 

  Florida State University Demonstrates How Using Appropriate Buffer Conditions Improves Sample Preparation for Biophysical Studies - Such As Structural Analysis

New Customer Application Note Available from Wyatt Technology

DynaPro NanoStar from Wyatt

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, publishes new application note highlighting a study made by Florida State University. Authored by Tsz Kin Martin Tsui, Claudius Mundoma and Hong Li from Florida State University, the paper showcases how the Wyatt DynaPro dynamic light scattering (DLS) system can be used to characterize homogeneity and stability of a heterodimeric protein complex (HPC) under various buffer conditions. The results demonstrate that the pH of the buffer solutions influences the sample homogeneity and stability...

 

  Wyatt Calypso Succeeds in ABRF-MIRG Study

Wyatt Technology is pleased to report the success of the Calypso® composition-gradient multi-angle light scattering (CG-MALS) system in a study conducting by the Molecular Interactions Research Group (MIRG) of the Association of Biomolecular Research Facilities (ABRF). The conclusions of the 2012 MIRG study were announced at the ABRF 2013 annual meeting in Palm Springs earlier this month.

wyatt.In the study, a pair of unknown proteins, prepared and characterized by the ABRF, was sent out to multiple labs to determine binding affinity and stoichiometry. In a single afternoon consisting of 2 CG-MALS runs, the Wyatt Calypso system correctly determined that Protein Y (26.3 kDa) contains two binding sites for Protein X (11.9 kDa). The first X binds with KD of 10 nM and the second X binds with 14 μM. This analysis agreed perfectly with extensive analytical ultracentrifugation (AUC) and isothermal titration calorimetry (ITC) measurements performed by ABRF prior to distributing the samples....

 

  Wyatt Technology to Showcase First Refractive Index Detector for UHPLC at PITTCON 2013

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announces that it will be showcasing its innovative new RI detector, the Optilab UT-rEX, at PITTCON 2013

Refractive Index Detector for UHPLCThe Optilab UT-rEX is the first RI detector of its kind, specifically designed for use with UHPLC systems using columns packed with small beads. Wyatt Technology will exhibit the Optilab UT-rEX on booth #2133 at PITTCON 2013, Philadelphia, PA, March 17- 21, 2013...


 

  Wyatt Technology Celebrates its 30th Year of Macromolecular Characterization Expertise at the 2012 International Light Scattering Colloquium Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that it will be hosting its 23rd Annual International Light Scattering Colloquium (ILSC) on October 22-23, 2012.

Wyatt TechnologyAt this year's ILSC Wyatt plans to celebrate its 30th year with its valued customers and ILSC guests. Wyatt will showcase the latest instrumentation and applications across numerous industries such as biotechnology, pharmaceutical and chemical. The event, held at the exclusive Four Seasons Biltmore Resort in Santa Barbara, California, will feature a host of high-level academics and industry leaders and will be accompanied by the Dynamic Light Scattering Focus Meeting..

 

  Wyatt Technology Ranks as #4 in The Scientist’s 10th Annual Best Places to Work Survey Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces it has been ranked the fourth best place to work in the scientific industry.

Wyatt TechnologyThe accolade comes in the company's 30th anniversary year, when the company is celebrating its unique, family focused approach to business. The 10th Annual Best Places to Work in Industry survey by The Scientist has revealed that respondents ranked personal and scientific satisfaction as the most highly sought company trait, followed by high ethical standards...

 

  Wyatt Technology Instruments Employed to Develop Alternative Materials to Silicone Breast Implants Wyatt TechnologyWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that Professor Judit E. Puskas at the University of Akron has developed a system using its instrumentation that will also help to solve a prevalent and particularly controversial material science challenge. The researchers are employing the multi detector system to develop alternative materials to silicone breast implants. This development will be welcomed by many as faulty Poly Implant Prothèse (PIP) implants are causing global concern about implant safety, and as a result, alternative materials are sought...

 

  Wyatt Technology’s Möbius Mobility Instrument Facilitates Protein Net Charge Computation at Low Concentrations Wyatt Technology’s Möbius Mobility InstrumentWyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular characterization and software, announces that its Möbius electrophoretic mobility instrument can measure precise protein charges. The innovative optical design of the Möbius boosts the sensitivity of mobility measurements, enabling protein net charge characterization at much lower concentrations than previously possible. This unique capability is illustrated in a new application note, titled "Möbius Computation of Protein Net Charge from Electrophoretic Mobility", which is available to download free-of-charge...

 

  Wyatt Technology to Host the 22nd Annual International Light Scattering Colloquium Wyatt Technology Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced its 22nd Annual International Light Scattering Colloquium (ILSC) presenting the latest instrumentation and application developments in light scattering. The Colloquium is scheduled for Monday 31st October to Tuesday 1st November at the exclusive Four Seasons Biltmore Resort in Santa Barbara, California. This event will host a list of high-profile plenary speakers and light scattering instrument users...

 

  Wyatt Technology MALS Fulfils Latest European Pharmacopoeia Standard for HES Characterization Wyatt Technology CorporationWyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular characterization, announces that its Multi-Angle Light Scattering (MALS) instruments represent the latest European Pharmacopoeia (EP) requirements for hydroxyethyl starch (HES) characterization...

 

  WYATT TECHNOLOGY UNVEILS NEW BROCHURE FOR ITS NEWLY LAUNCHED MÖBIUζ MOBILITY INSTRUMENT Wyatt Möbiuζ™Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular characterization, has published a brochure in support of its new electrophophoretic mobility instrument, the MöbiuζTM. The 10 page brochure is a comprehensive document that outlines the unique capabilities of The MöbiuζTM, including an increased number of detectors at a variety of angles which produce a greater amount of data than any other "zeta-potential" instrument...

 

  Wyatt Technology Corporation Wins SBA’s Tibbetts Award for Advanced Technological Innovations Wyatt Technology Wyatt Technology Corporation today announced that it has received one of the prestigious Tibbetts Awards from the Small Business Administration (SBA) for its role as the world's leading provider of analytical light scattering instrumentation. The Small Business Administration presents the awards (also knows as "Tibbies") to companies and individuals that have advanced technological innovation and economic growth.

 

  Wyatt Technology MALS Detectors Used in Breakthrough Virus Research Wyatt TechnologyWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces that its instruments were used in a recent landmark study that transforms the previous scientific understanding of immunity to viral diseases like the common cold, 'winter vomiting' and gastroenteritis. The breakthrough research carried out by the United Kingdom's Medical Research Council Laboratory of Molecular Biology (MRC LMB) demonstrates the ability of tripartite motif-containing 21 (TRIM21) to neutralize viral infection. Wyatt Technology's Multi-Angle Light Scattering (MALS) detectors were used to monitor the interaction between TRIM21 and Immunoglobulin G (IgG).

 

  Wyatt Technology Instrumentation Used Against Bacteriophage Infections in Dairy Production new application note from Wyatt Technology demonstrates its instruments can be used to characterize lactococcus lactis in order to eliminate bacteriophage infections in dairy productionWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has been chosen by the Biological Macromolecules Joint Research Unit of the Université de Provence and Université de la Méditerranée in Marseille, France, for its instruments to characterize lactococcus lactis in order to eliminate bacteriophage infections in dairy production.

 

  Wyatt Technology MALS Detectors Enable Pharmaceutical Manufacturers to Perform Easy and Reliable Transmembrane Protein Characterization Wyatt Technology CorporationWyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announced today that the Université de Provence and Université de la Méditerranée in Marseille, France, have implemented the innovative Wyatt Multi-Angle Light Scattering (MALS) detectors for use in their Biological Macromolecules Joint Research Unit.

 

  WYATT TECHNOLOGY CONTINUES TO EVOLVE RI DETECTION WITH LAUNCH OF T-rEX Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces the launch of its brand new Refractive Index (RI) detection instrument - the Optilab® T-rEXTM.

 

  WYATT TECHNOLOGY WILL HOST 21st ANNUAL INTERNATIONAL LIGHT SCATTERING COLLOQUIUM Wyatt Technology, the world leader in instruments for absolute macromolecular characterization, is delighted to announce that it will host its 21st Annual International Light Scattering Colloquium (ILSC) October 18-19, 2010 at the exclusive Four Seasons Biltmore Resort in Santa Barbara, California. The event will welcome an array of high-profile Wyatt Technology light scattering customers including Nobel Prize winner, Professor Roger Yonchien Tsien.

 

  University of Navarra Implements Wyatt Technology Dynamic Light Scattering for Critical Micellization of Polymeric Systems with Temperature Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has been chosen by the University of Navarra for its instruments to characterize phase transitions and structures in micellar polymeric systems.