Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, has published a new whitepaper outlining how to evaluate the solution quality of biotherapeutic candidates prior to screening via Surface Plasmon Resonance (SPR) or Bio Layer Interferometry (BLI).

The DynaPro® Plate Reader II. Analyte quality is critical to obtaining accurate and meaningful measurements in order to select the most promising therapeutic candidates, so ensuring the quality of samples is a vital step in the screening process. The DynaPro high- throughput dynamic light scattering (HT-DLS) system provides an effective method of assessing sample materials using a non-invasive, non-pertubative optical technique...

Wyatt Technology Corporation, the world leader in light scattering tools for nanoparticle and macromolecular characterization, is pleased to announce that this year’s International Light Scattering Colloquium (ILSC) will present a special symposium on the characterization of manufactured, environmental and therapeutic nanoparticles.

Sporting the theme of “Light Scattering in the Nano World”, ILSC 2015 will be held at the beautiful Four Seasons Biltmore Resort in Santa Barbara, CA on November 3-4. Online Registration is available. The full program includes additional presentations on the characterization of biomolecules and polymers in cutting-edge research. Satellite events planned include short courses and a focus meeting on method development...

Study published in Nature outlines use of Wyatt’s Calypso II system to confirm the stoichiometry of αSNAP-SNARE complex

Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, is pleased to highlight a new study that describes the use of composition-gradient multi-angle light scattering (CG-MALS) for the characterization of complex protein-protein interactions. The study, entitled ‘Mechanistic insights into the recycling machine of the SNARE complex’, was published in the...

Benefits of integrated formulation preparation and analytics for the development of biotherapeutics to be demonstrated in webinar sponsored by Freeslate

Wyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on...

The High-Throughput DynaPro Plate Reader Utilizes Dynamic Light Scattering to Identify Most Promising mAb Buffer Conditions Prior to Extended Stability Testing

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation, is pleased to highlight a study recently authored by Martin Skov Neergaard from the Faculty of Health and Medical Sciences at the University of Copenhagen, “Protein-Protein Interactions Investigated by DLS: Determination at High and Low Protein Concentration.” This article outlines the benefits of quantifying protein-protein interactions (PPI) using...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation has published the results of a new study outlining the simultaneous measurement of protein charge and diffusion interaction parameter (k_D) to determine the colloidal stability of two formulations with different long-term stability behavior.

Traditionally, these two properties are measured independently in laborious experiments requiring manual sample preparation and loading. The Möbius^® from Wyatt Technology uses massively-parallel phase-analysis light scattering (MP-PALS) in conjunction with an autosampler to automate this combined measurement. The Möbius is therefore an ideal tool for protein characterization and is unique in its ability to provide a complete picture of...

Latest Application Note from Wyatt Technology Demonstrates How Absolute Molar Mass can be Measured Using UHPLC SEC-MALS

Wyatt Technology has published a new whitepaper

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has published a new whitepaper on characterizing molecular structure in synthetic and natural polymers by multi-angle light scattering. Authored by Stepan Podzimek, Scientific Consultant for Wyatt Technology, the paper details the basic principles of the detection and characterization of branching by means of a multi-angle light scattering (MALS) detector and the various methods used...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, will be presenting on innovative light scattering techniques at WCBP 2014.

The 18th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products provides a forum for discussing the latest bioanalytical methods and their practical application to biotechnology, pharmaceuticals and other health-related products. Dr. Daniel Some, Director of Marketing and Principal Scientist at Wyatt Technology will be hosting a seminar entitled “Molar mass, size and interactions: light scattering tools for essential biophysical characterization.” From aggregates to conjugates, light scattering detectors combine with a variety of sample delivery systems to provide a comprehensive suite of biophysical characterization tools. This talk will include a detailed overview and examples of the tasks relevant to well-characterized biopharmaceuticals that may be accomplished with these tools...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, will be launching the µDAWN™ at Pittcon 2014

The µDAWN is the world’s first multi-angle light scattering (MALS) detector that can be coupled to any UHPLC system in order to determine absolute molecular weights and sizes of polymers, peptides, and proteins or other biopolymers directly, without resorting to column calibration or reference standards. Wyatt Technology’s µDAWN connects to the Optilab® UT-rEX™, the first refractive index detector for UHPLC....

Wyatt Technology San Francisco Bay Area Protein & Biotech Users Meeting

The meeting will host two to three expert speakers, ‘how-to’ sessions presented by Wyatt Application Scientists, updates on our latest products, and small group discussions covering topics such as:Biophysical characterization. Formulation and stability. Orthogonal techniques. Large aggregates and sub-visible particles. Biomolecular interactions...

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces that it has been ranked among the winners of The Analytical Scientist’s 2013 Innovation Awards (TASIAs). 

Honored is Wyatt’s Optilab UT-rEX, the first refractive index detector of its kind for UHPLC systems. The innovative Optilab UT-rEX uses a combination of miniaturized components, cutting-edge semiconductor photodiode technology and proprietary computer algorithms to enable it to be added to any UHPLC system. The TASIAs recognize products that enhance preparation, separation, identification or quantitation and contribute to making the world safer and the diagnosis of disease more effective...

New Insights Published on Key Protein Interactions Involved in the Bacterial Flagellar Motor Complex Show Promise for Other Difficult Biomolecular Systems

New Application Note from Wyatt Technology Showcases the Ability of CG-MALS to Quantify Complex Proteins. Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has today published a new application note highlighting a study on the complex interactions between proteins and how they modulate the rotational direction of bacteria flagella....

Wyatt Technology Instrumentation Employed by the Medical Research Council to Perform Breakthrough Research into Human Health and Disease

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announced that its technology is being used by the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) to make advancements in tackling specific problems in human health and disease such as understanding different biophysical processes, including mechanisms of viral diseases and immunity....

New Customer Application Note Available from Wyatt Technology

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, publishes new application note highlighting a study made by Florida State University. Authored by Tsz Kin Martin Tsui, Claudius Mundoma and Hong Li from Florida State University, the paper showcases how the Wyatt DynaPro dynamic light scattering (DLS) system can be used to characterize homogeneity and stability of a heterodimeric protein complex (HPC) under various buffer conditions. The results demonstrate that the pH of the buffer solutions influences the sample homogeneity and stability...

Wyatt Technology is pleased to report the success of the Calypso® composition-gradient multi-angle light scattering (CG-MALS) system in a study conducting by the Molecular Interactions Research Group (MIRG) of the Association of Biomolecular Research Facilities (ABRF). The conclusions of the 2012 MIRG study were announced at the ABRF 2013 annual meeting in Palm Springs earlier this month.

In the study, a pair of unknown proteins, prepared and characterized by the ABRF, was sent out to multiple labs to determine binding affinity and stoichiometry. In a single afternoon consisting of 2 CG-MALS runs, the Wyatt Calypso system correctly determined that Protein Y (26.3 kDa) contains two binding sites for Protein X (11.9 kDa). The first X binds with KD of 10 nM and the second X binds with 14 μM. This analysis agreed perfectly with extensive analytical ultracentrifugation (AUC) and isothermal titration calorimetry (ITC) measurements performed by ABRF prior to distributing the samples....

Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, today announces that it will be showcasing its innovative new RI detector, the Optilab UT-rEX, at PITTCON 2013

The Optilab UT-rEX is the first RI detector of its kind, specifically designed for use with UHPLC systems using columns packed with small beads. Wyatt Technology will exhibit the Optilab UT-rEX on booth #2133 at PITTCON 2013, Philadelphia, PA, March 17- 21, 2013...

Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular characterization, has published a brochure in support of its new electrophophoretic mobility instrument, the MöbiuζTM. The 10 page brochure is a comprehensive document that outlines the unique capabilities of The MöbiuζTM, including an increased number of detectors at a variety of angles which produce a greater amount of data than any other "zeta-potential" instrument...