Flexible automated image capture in bright-field and fluorescence

The Axio Scan.Z1, an automated microscope from Carl Zeiss Microscopy, allows researchers to digitalize fixed tissue sections and cytologic specimens in bright-field and fluorescence. Supporting scientists with recurring tasks in the capture of large sample contingents, for example tissue analysis in Alzheimer's and cancer research, the Axio Scan.Z1 is ideal for a range of applications from basic research to tasks in the pharmaceutical industry. As many as 100 microscope slides can be digitalized at one time.

Using an innovative tray design, the Axio Scan.Z1 captures the entire specimen area of the microscope slide, including the edge. The self-calibrating automated slide scanner presents specimens on high-quality virtual slides just minutes later. For fluorescence applications, filter wheels switch wavelengths in just 50 milliseconds.

Sensitive cameras and maximally corrected optics achieve optimal image quality. Maximum protection for the sample is ensured by the Colibri.2 UV-free LED light source, as well as a focus finder with oblique illumination, called the ring aperture contrast.

Axio Scan.Z1 is operated by ZEISS ZEN imaging software, which allows users to work with pre-defined recording parameters automatically or select all settings individually. The user interface is specially adapted to research workflow. Users decide at the outset how many microscope slides and which detection modes and camera they wish to use, and simply upgrade Axio Scan.Z1 as their tasks expand.

The virtual slides can be organized in the ZEN Browser database, which organizes data online and cross-platform via an intuitive web interface that keeps images filed together with metadata and supporting documents. With ZEN browser, users can also insert annotations and view images in transmitted light and multi-channel fluorescence virtual microscopy photos. The free ZEN browser mobile app for iPad and iPhone allows users to access, view, and share their images and data with colleagues independent of the operating system – even when traveling.

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