Isotope Ratio Measurement Can Now Go to the Sample Site

New Insights Published on Key Protein Interactions Involved in the Bacterial Flagellar Motor Complex Show Promise for Other Difficult Biomolecular Systems

New Application Note from Wyatt Technology Showcases the Ability of CG-MALS to Quantify Complex Proteins. Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has today published a new application note highlighting a study on the complex interactions between proteins and how they modulate the rotational direction of bacteria flagella....

Evolving Applications for Sintered Porous Plastics

Porvair Filtration Group has written a technical article that documents the evolution of how sintered porous plastics have been used in industrial applications to their incorporation today in novel Chromatin Immunoprepitation (ChIP) assay kits used by scientists at the forefront of epigenetics research. Sintered porous plastics are produced by heat sintering together porous polymers such as polyethylene and polypropylene...

Thermo Fisher Scientific is pleased to announce a new technical note which demonstrates high resolution chromatographic separations of organic acids in beer samples.

Organic acids are end products of yeast fermentation critical to the flavor of beer, but are also products of bacterial fermentation that introduce a sour flavor, either purposely or unintentionally due to spoilage. Technical Note 126: Determination of Organic Acids in Beer Samples Using a High-Pressure Ion Chromatography System specifically discusses the separation of organic acids in beer samples using a Thermo Scientific™ Dionex™ IonPac™ AS11-HC-4μm anion-exchange column....

VICI Metronics’ Dynacalibrator® Model 150  is a constant temperature system designed to generate precise ppm or ppb concentrations of chemical compounds in a gas stream, using permeation devices as the trace gas source.

It is used as a reference for the calibration of gas chromatography instruments and in other instruments that measure gas concentrations. This light-weight unit is a compact calibrator capable of delivering the precise concentrations required. A passivated Inertium® coated stainless steel permeation chamber houses the permeation device(s), with measured inert carrier gas sweeping the calibration gas/vapor from the chamber.....

Thermo Fisher Scientific is pleased to announce new membrane options in its family of Thermo Scientific Titan3 syringe filters.

They complement existing solvent and sample compatibility choices by accommodating a wider range of application requirements. The new options include 0.22µm and 0.45µm hydrophilic PTFE membranes in 17mm and 30mm syringe filter formats. They allow use of both organic and aqueous solvents without pre-wetting the membrane. This removes the need for multiple membranes and can reduce processing steps, helping users to simplify workflows. Titan3 syringe filters are designed for clean, fast, robust and cost-effective sample extractions, resulting from low extractible membranes combined with an easy-to-use format and high burst pressures....

Porvair Filtration Group has introduced four and five layer composite mesh filters, produced at its US facility in Ashland Virginia, that provide extremely high efficiency filtration in both gas and liquid applications.

The new four and five layer composite meshes are produced as self-supporting cylinders that, when incorporated into dedicated filtration systems, enable routine filtration down to sub-micron levels. Suitable for use in a wide range of applications such as critical chemical filtration duties and for high challenge backwash refinery slurry oil filters, the multi-layer composite mesh filters are designed to be cleaned in situ....

Dates and Agenda Set, Registration Now Open for Quantitative Proteomics and ProteoMMX 3.0 Events

Waters Corporation (NYSE:WAT) and the Biochemical Society announced today the opening of registration for the Biochemical Society’s Quantitative Proteomics Training Day and the ProteoMMX 3.0 Symposium, consecutive events taking place March 24 - 27, 2014 in Chester, England. The Quantitative Proteomics Training Day is aimed at researchers seeking to gain familiarity with the field of quantitative proteomics. ProteoMMX 3.0, following immediately after the Training Day, is dedicated to current thinking and state of the art research in quantitative proteomics...

Featuring NEW 4 liter capacity in a traditional 3 liter footprint

New enhanced general purpose centrifuge product line offers clinical and life science researchers the ability to spin more samples in a single run while maximizing critical lab space. The Thermo Scientific general purpose centrifuges feature increased capacity and flexibility with rotor innovations including the new Thermo Scientific TX-1000 rotor, which is the only rotor on the market that employs a 4-liter capacity in a traditional 3-liter footprint....

Malvern Instruments has posted a new application note demonstrating the use of the company’s Viscotek SEC-MALS 20 multi angle light scattering (MALS) detector for size exclusion chromatography (SEC) in the analysis of monoclonal antibodies.

The application note, ‘Molecular weight measurements of an antibody using Viscotek SEC-MALS 20’, reports experimental data for the analysis of aggregates within monoclonal antibody formulations and can be freely downloaded. Monoclonal antibodies are being targeted for use in a growing range of therapeutic applications. Measuring the molecular weight of the protein, monomer, oligomers and aggregates within the sample and in formulations is an important part of assessing their safety and efficacy as drugs.....

Kinesis has launched the new TELOS MicroPlate™, a versatile 96-well plate for the extraction of drug molecules from small volume biological fluid samples.

Available as either loose wells or populated plates, the TELOS MicroPlate is available in 5 and 10mg sorbent masses and allows analyte elution in as little as 50µl. The full range of TELOS neo Generic SPE Sorbents (PRP, PCX, WCX, PAX and WAX) are available in this novel format. The TELOS MicroPlate supports both high throughput assays (populated plate) and also those assays with varying sample numbers (loose wells), where the user can populate a plate to individual needs...

Thermo Fisher has developed a multianalyte-targeted technique that uses a spectro-electro array platform to resolve and quantify phenols, phenolic acids, and polyphenolsin a variety of natural products, supplements, herbs, spices, and beverages.

Application Note 1063: Targeted Analyses of Secondary Metabolites in Herbs, Spices, and Beverages Using a Novel Spectro-Electro Array Platformdemonstrates that this approach extends the range of compounds that can be simultaneously detected and enables the separation and quantitation of 49 different phytochemicals commonly found in a number of herbs, spices, and beverages...

Thermo Fisher Scientific has developed an ion chromatography (IC) method for determining low concentrations of morpholine in linezolid using an eluent generation system with suppressed conductivity detection.

Morpholine is used in the synthesis of linezolid and may be present in the drug product. This approach achieves efficient separation using a high-performance cation-exchange column with a high-purity electrolytically generated methanesulfonic acid eluent. Application Note 1062: Determination of Morpholine in Linezolid by Ion Chromatography demonstrates that this IC method also allows simultaneous determination of sodium, ammonium, potassium, and other cations present in the sample...

Organomation announces the newly redesigned MICROVAP product line

These evaporation systems are designed for controlled concentration of small samples.  All four models in the product line are light, compact and digitally controlled for ease of use. The MICROVAP blowdown evaporators are offered in four different models, each providing flexibility for sample preparation applications of different kinds. The single and triple position MICROVAP microplate evaporators, formerly referred to as MICRO-TITERS, concentrate samples held within 96 well plates.  These microplate evaporators can accommodate both deep well and micro well plates.....

Bruker has released an application note on the evaluation of matrix effects on the analysis of carbendazim in orange juice and wine using the EVOQ Elite liquid chromatography mass spectrometer (LC-MS/MS).

Carbendazim is a fungicide and a known endocrine with potentially harmful effects on human health. The US Food and Drug Administration (FDA) has limited the concentration of carbendazim in imports to 10 ppb. Using the EVOQ, Bruker has developed a quantitative Multiple Reaction Monitoring (MRM) method for carbendazim analysis in orange juice and wine matrices. The EVOQ’s sensitivity was demonstrated as detections of 0.005 ppb were made, far below the FDA limit. The application note is available to download...

Genevac has developed a protocol using its SuperCool 75 condenser

Genevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...

Dri-Pure® technology from Genevac offers significant benefits to scientists, especially those working in synthesis and purification. 

This innovative technology enables scientists to rapidly dry their samples without cross-contamination or loss of sample due to solvent bumping. Other methods of solvent removal tend to be very laborious or lead to unacceptable cross-contamination, Dri-Pure® running on a Genevac evaporator gives smooth, controlled solvent removal in optimum time. The patented Dri-Pure® technology is available for all current models of Genevac centrifugal evaporators, from the affordable EZ-2 through to the production-scale HT-24...

Thermo Fisher Scientific has developed a reliable method for determining levels of dithiocarbamate fungicides (DTCs) with high precision using gas chromatography-mass spectrometry (GC-MS).

The complex extraction and identification of DTCs is performed on various food samples after a thorough method validation. Application Note 10333, Analysis of Dithocarbamate Pesticides by GC-MS, compares DTC levels in various food samples to matrix-matched calibration standards. SIM mode analysis provides high selectivity with easy-to-integrate chromatograms. The analysis uses a Thermo Scientific™ TRACE GC Ultra™ gas chromatograph equipped with a Thermo Scientific™ TriPlus™ RSH liquid autosampler coupled to a Thermo Scientific™ ITQ™ 900 ion trap mass spectrometer...

Jenway’s 67 series spectrophotometers offer high quality split-beam optics and a cutting-edge user interface for fast, intuitive operation.

Excellent data portability and secure multi-user operation add to the versatility of these advanced instruments. The 67 series spectrophotometers are covered by a three year warranty which includes the xenon lamp. Both models 6705 and 6715 facilitate measurements from 190nm to 1100nm using a pulsed xenon light source. Model 6715 has an ultra narrow bandwidth of 1.5nm providing even better scanning resolution

Now available, J.G. Finneran Associates manufactures 20mL Clear and Amber Headspace Vials with ceramic write-on spots with graduated marks for easier labeling and identification. 

The graduated marks provide the ability to fill the vial to a desired level and facilitates viewing the sample volumes.  The marking spots can be written on with a #2 pencil.  Our line of headspace vials, are made from only Type I borosilicate glass for durability, heat resistance and low extraction.  The Finneran headspace vials are designed for high pressure strength during the heating process thus reducing the possibility of cracking or strain lines.

Merck Millipore Launches CpGenome™ Direct Prep Bisulfite Modification Kit for Simplified One-Step Conversion of Unmethylated Cytosines

The launch of Malvern Instruments’ Viscotek SEC-MALS 20 chromatography detector has triggered record downloads of one of the supporting white papers ‘Static light scattering technologies for GPC/SEC explained’, underlining the enthusiasm amongst users for straightforward information on GPC/SEC analysis.

The recent addition of Viscotek SEC-MALS 20 to Malvern’s range of detectors puts the company in the unique position of being the sole provider of every commercially available light scattering technology for GPC/SEC. Customers can therefore be assured of a truly unbiased choice of detector solutions. The popular white paper is just one of a suite of educational information and application notes provided by Malvern’s specialist team to help users select the right detector for their application...