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Sensitive and Simple Determination of Monochloroacetic Acid in Carbocisteine

publication date: Apr 10, 2014
 | 
author/source: Thermo Fisher Scientific

Thermo Fisher Scientific has developed a reproducible and accurate ion chromatography (IC) method for determining monochloroacetic acid (MCAA) in carbocisteine drug substance and two monochloroacetic acid drug products, thus enabling efficient quality control of the carbocmanufacturing processisteine.

Thermo Fisher ScientificApplication Note 1076: Determination of Monochloroacetic Acid in Carbocisteine demonstrates that this IC method is easily executed using a reagent-free IC system controlled by data management software. The analyst simply adds water and samples to separate and accurately determine MCAA using a hydroxide-selective anion-exchange column (Thermo Scientific Dionex IonPac AS11-HC column).

Carbocisteine is a mucolytic drug frequently prescribed to improve the breathing of patients with chronic bronchitis and bronchial asthma. During the carbocisteine production process, the substrate MCAA—which is cardio- and hematotoxic—is used and is inevitably present in the carbocisteine drug substance and hence products. Therefore, the determination of MCAA is important for the quality control of carbocisteine production. This new approach is sensitive and easier to use than other commonly used methods available to date.


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 About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of $12 billion, we have approximately 39,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through three premier brands, Thermo Scientific, Fisher Scientific and Unity™ Lab Services, which offer a unique combination of innovative technologies, convenient purchasing options and a single solution for laboratory operations management. Our products and services help our customers solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. 

All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries



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