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All articles from Uniqsis Ltd

  Efficient Flow Chemistry Scale-up of Photoredox Coupling Reactions

The renowned Innovative Technology Centre (ITC) at the University of Cambridge, UK has used a Uniqsis PhotoSyn flow photoreactor to efficiently scale-up a radical mediated boronic acid coupling under photoredox conditions using a novel organic acridium-based photocatalyst. The acridium-based organic photocatalyst, developed by the University of Cambridge, is demonstrated to be an efficient replacement for iridium-based photocatalysts used to oxidise boronic acid derivatives by a single electron radical coupling process....

 

  Active Temperature Control for Flow Chemistry in Glass Chip Reactors

Polar Bear PlusUniqsis has introduced the Polar Bear Plus GSM™ - a versatile heating and cooling reactor module for flow chemistry applications using Glass Static Mixers / Reactor Chips (GSMs). To achieve high reproducibility and facilitate scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Uniqsis glass static mixer / reactor chips produce an efficient, turbulent mixed reagent stream...

 

  Flexible Modular Flow Chemistry System

Uniqsis productUniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. FlowLab Plus™ is a versatile flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry reactions....

 

  Highly Upgradeable Modular Flow Chemistry System

FlowLab PlusUniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. FlowLab Plus™ is a versatile flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry...

 

  Flow Synthesis of Novel Nanomaterials

FlowSyn continuous flow reactor with Flow-UV detectorUniqsis reports how the Institute of Physics at the University of Tartu (Estonia) has selected a FlowSyn™ continuous flow reactor with Flow-UV™ detector to assist them in development of novel nanomaterials for use in next generation applications. The material science research group of Dr Aile Tamm evaluated different technological approaches to synthesise nanomaterials before investing in the Uniqsis FlowSyn system...

 

  Variable Power LED Reactor for Flow Photochemistry

Polar Bear PlusThe Uniqsis PhotoSyn™ is a new high-power LED light unit enabling scalable flow photochemistry reactions yielding from milligrams to 100’s of grams per day. By eliminating the control, scale-up and safety problems associated with traditional batch photochemistry – the Uniqsis PhotoSyn™ enables synthetic chemists to routinely take full advantage of the many benefits offered by photochemistry...

 

  New Heater Module for Flow Chemistry Glass Static Mixer Chips

Flow Chemistry Glass Static Mixer ChipsUniqsis announces HotChip™ - a new standalone heater module that provides precise temperature control of flow chemistry glass static mixer (GSM) chip reactors. The Uniqsis range of chemically-resistant borosilicate glass chip reactor blocks can be used as static mixers to ensure effective mixing before a coil reactor or to perform fast exothermic experiments such as nitration’s or bromination’s where reaction times are often less than 1 minute...

 

  Uniqsis Reports on Expansion

Uniqsis,, a market leader in flow chemistry, reports following excellent business growth in 2017 that it has recruited a further sales / support specialist to be located at its office in Cambridge. Paul Pergande, Managing Director of Uniqsis commented "We are very pleased to welcome Steve Evans to Uniqsis. Steve's strong technical background as well as his in-depth knowledge of continuous flow reactor equipment and applications will be a major asset to both Uniqsis and its customers worldwide"....

 

  Low Cost 3D Printed Reactors for Continuous Flow Synthesis

flowsynUniqsis reports how chemists at the School of Pharmacy, University College London (UK) have been using a FlowSyn™ continuous flow reactor system.

Flow chemistry is an ideal approach to chemical synthesis where reactions can readily be optimised via simple iterations and can easily be scaled up. However, one of the challenges are the associated costs and fixed formats of the reactors themselves.....

 

  Automated Compound Library Production

Uniqsis has published an application note that describes an efficient 2-step synthesis of a library of pyrazoles under continuous flow-through conditions developed by chemists at GalChimia (Coruna, Spain) on a FlowSyn™ continuous flow reactor system.

Automated Compound LibraryPyrazoles are an important and well represented chemotype in drug discovery displaying wide ranging biological actions that include analgesic, anti-inflammatory, antipyretic, tranquilizing, muscle relaxing, anticonvulsant, antidiabetic and antibacterial activities....

 

  New Flow Chemistry System for Heterogeneous Catalysis

Uniqsis has introduced FlowLab Column™ – an optimised flow chemistry system for heterogeneous catalysis applications. 

FlowLab ColumnCatalysts can be divided into two main types - heterogeneous and homogeneous.  In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....

 

  Optimised Flow Chemistry System for Heterogeneous Catalysis

Uniqsis has introduced FlowLab Column™ – an optimised flow chemistry system for heterogeneous catalysis applications. 

FlowLab ColumnCatalysts can be divided into two main types - heterogeneous and homogeneous.  In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....

 

  Flow Reactor Enables Efficient Scale-Up of Challenging Batch Processes

A leading Contract Research and Development Organisation (CRDO) – Arcinova has invested in a Uniqsis FlowSyn™ continuous flow reactor enabling them to develop and simplify the scale-up of a challenging API batch process.

arcinovaFollowing a trial of the FlowSyn™ system – Arcinova could justify their investment based upon rapid synthetic method development and the considerable cost and time savings demonstrated versus using large scale reactor vessels for the selected process. Dr. Samuel Bourne, Continuous Manufacturing Lead at Arcinova commented...

 

  Uniqsis Describe Improved Olefin Metathesis Technique

Uniqsis has published details of a new flow-through protocol developed by the Lamaty Group at Universite de Montpellier (France) on a FlowSyn™ Multi-X system that provides efficient ring closing olefin metathesis.

FlowSynOlefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility....

 

  Efficient Ring-Closing Metathesis of Olefins under Flow-Through Conditions

Uniqsis has published details of a new flow-through protocol developed by the Lamaty Group at Universite de Montpellier (France) on a FlowSyn™ Multi-X system that provides efficient ring closing olefin metathesis.

Flow SynOlefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility. While several research groups have reported the development of olefin metathesis in continuous flow, most of them have focused on the use of a heterogeneous catalyst....

 

  Entry-Level Flow Chemistry Systems

Available in a choice of configurations the Uniqsis FlowLab™ range are affordable and easy-to-use flow chemistry systems ideal for use in research, education and for those wishing to try flow chemistry without the associated costs of a fully automatic system.

Uniqsis FlowLabBuilt around the same high quality components as used in the widely acclaimed Uniqsis  FlowSyn™ system, both the FlowLab™ and FlowLab Cold™ offer uncompromised performance at an entry-level price. The FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control computer...

 

  Affordable, Entry-level Flow Chemistry Systems

Available in a choice of configurations the Uniqsis FlowLab™ range are affordable and easy-to-use flow chemistry systems ideal for use in research, education and for those wishing to try flow chemistry without the associated costs of a fully automatic system.

Uniqsis FlowLabBuilt around the same high quality components as used in the widely acclaimed Uniqsis  FlowSyn™ system, both the FlowLab™ and FlowLab Cold™ offer uncompromised performance at an entry-level price....

 

  Novel UV-Visible Detector for In-Line Flow Chemistry

Uniqsis Ltd has introduced Flow-UV™ - an affordable in-line UV-Visible spectrophotometric detector for flow chemistry applications.

uniqsisDesigned for use with almost any commercial flow chemistry system - the compact Flow-UV™ detector (18 x18 x 17cm) fits conveniently into even crowded fume cupboards. Using the UV-visible absorbance data from a Flow-UV™ detector allows dispersion experiments to be monitored in real time and enables product collection to be controlled according to the onset and decline of steady state conditions....

 

  Uniqsis Reports Significant Growth in Flow Chemistry Market

Uniqsis Ltd., specialists in flow chemistry, has announced a 50% growth in sales and a significant increase in trading profit for their business year ending 31st January 2017. 

FlowSynDuring the year – Uniqsis achieved strongest growth in North America and Europe with a notable increase in sales of its high performance FlowSyn integrated continuous flow reactor systems for pharmaceutical, nanomaterials and academic research applications....

 

  FlowLab and FlowLab Cold - Affordable Entry-Level Flow Chemistry Systems from Uniqsis

FlowLab™ and FlowLab Cold™ are affordable and easy-to-use flow chemistry systems ideal for research, education and training and for those wishing to try flow chemistry without the associated costs of a sophisticated fully automatic system.

FlowlabThe FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be controlled remotely by Wi-Fi, allowing the control computer to be conveniently operated outside the fume hood....

 

  FlowStart - Affordable High Pressure Flow Chemistry from Uniqsis

FlowStart™ is an affordable and easy-to-use entry level flow chemistry system that is ideal for education, training and for those wishing to try flow chemistry without the associated costs of a sophisticated fully automatic system.

FlowStartThe system comprises two high pressure pumps, aHotCoil™ coil reactor station and FlowStart™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be operated by Wi-Fi allowing the control computer to be conveniently operated outside the fume hood. The FlowStart™ application provides control of the system via a step-through interface that is straightforward...

 

  An Affordable High Pressure Flow Chemistry System

FlowStart™ is an affordable, entry level flow chemistry system complete with everything necessary to run automated flow chemistry reactions easily and safely.   

  • Flowstart2 High pressure pumps: flow rates 0.01 to 10.0ml/min
  • Integrated pressure transducers: Pmax 100bar
  • HotCoil™ heated coil reactor station: Tmax 260°C with large visible display

 

  Introducing the HotCoil – The New Low-Cost Coil Reactor Heater from Uniqsis

Welcome to the HotCoil™, the latest addition to the Uniqsis range of flow chemistry systems and modules. 

FlowSynCompatible with all Uniqsis coil reactors and with an operating temperature range of ambient to +260°C, the HotCoil represents an excellent low-cost entry into flow chemistry. Simply add your own pumps to create a basic flow chemistry system. With its clear bright LED display and simple 'push-to-set' controller, the HotCoil is ideally suited to stand-alone operation. Alternatively, it can be controlled directly by the Uniqsis FlowSyn, Binary Pump Module, or the new FlowControl...

     

      Safe and High Yielding Flow Nitration Methodology

    Uniqsis has published details of a mild nitration method using its FlowSyn flow chemistry system that enables short reaction times and high conversion to be achieved whilst minimising the amount of corrosive (and potentially explosive) hot nitrating mixture present in the reactor at any one time.

    Uniqsis FlowSyn flow chemistry system

    Nitration is an important synthetic procedure that is often difficult to control. Under continuous flow-through conditions, however, exotherms are typically well controlled and nitration can be safely performed on a large scale. Using Uniqsis’s proprietary glass static mixer/reactor chip technology - nitration can be safely performed under accelerated conditions at elevated temperature and pressure without the associated problems typically encountered in batch reactors of controlling latency periods or controlling thermal run away...

     

      Mixer-Reactor Chip Improves Control of Rapid Highly Exothermic Reactions

    Uniqsis Ltd. has demonstrated how its proprietary glass static mixer-reactor chip technology can be used to perform highly exothermic reactions more conveniently at higher temperatures with useful throughputs under continuous flow-through conditions.

    Mixer-reactor chip technology

    To achieve high reproducibility and facilitate scale up, it is important to control both mixing and temperature, particularly for highly exothermic or rapid mixing-dependent reactions (‘Type A’ reactions). Where the diffusional mixing provided by simple ‘T’-piece mixers is too slow to afford good control and reproducible reaction outcomes, Uniqsis has introduced a range of ingenious glass static mixer blocks ('chips') that incorporate channels with active mixing geometries to provide efficient turbulent mixing throughout the reaction vessel whilst also functioning as very efficient heat exchangers...

     

      Promoting efficient gas dependent flow reactions

    Uniqsis Ltd has announced a new Gas Addition Module for its FlowSyn continuous flow reactor range. The new module enables fast, controllable pre-saturation of liquid reagents with a wide range of gases thereby promoting efficient gas-dependent reactions in flow, such as carbonylation, hydrogenation, ozonolysis and direct synthesis of carboxylic acids

    Gas Addition Module Mixing gas and liquids in a controllable and reliable manner has always posed a particular challenge for flow chemists, in particular the prevention of undissolved gas bubbles which have an adverse effect on the control of pressure and residence time in flow chemistry. The novel pressurised tube-in-tube design of the Gas Addition Module overcomes this problem by ensuring continuous interaction between the gas and liquid at every point along its length....

     

      Performing Gas Liquid Chemistries in a Controlled Manner

    Using a Uniqsis FlowSyn™ flow reactor system - Sygnature Discovery, a leading provider of integrated drug discovery services to the pharmaceutical industry, has reported results demonstrating how the system allows them to perform traditionally hazardous chemistries in a controlled manner

    Uniqsis FlowSyn™ flow reactor system For example, using the proprietary FlowSyn technology with a Uniqsis GAM IIgas-liquid reactor, laboratory scientists at Sygnature Discovery, in conjunction with Uniqsis, have developed high pressure reaction protocols that have enabled them to reproducibly perform carbonylation chemistries under continuous flow through conditions...

     

      Uniqsis announce new portfolio of modular flow systems

    Uniqsis has announced a new portfolio of modular flow systems, based around its Binary Pump Module (BPM) and FlowSyn™ flow reactor technology to provide users with greater flexibility and broader synthesis capabilities

    Modular Flow Reactor SystemsUniqsis developed the original two-channel FlowSyn™ flow reactor system as a fully integrated ‘one box’ solution to make the emerging technology of continuous flow chemistry easily accessible to anyone with an interest in exploring and exploiting this exciting field of research. This system, which handles simple homogeneous and heterogeneous reactions at the push of a button, represents an easy, hassle-free entry into continuous flow chemistry.,,,

     

      Advanced Cooling for Flow Chemistry

    Available from Uniqsis Ltd. the FlowSyn Polar Bear™ is a state-of-the-art chiller unit which, in combination with FlowSyn Continuous Flow Reactor, allows you to perform and control reactions down to -88°C


    the FlowSyn Polar BearThe FlowSyn Polar Bear™ provides faster and more efficient cooling than conventional chiller units and is ideal for pre-cooling reagents and controlling temperature in highly exothermic reactions. The system is compatible with the FlowSyn range of reactor modules and is designed to prevent ice formation so that you can clearly observe reactions as they occur.

     

      Uniqsis and WaveCraft collaborate on novel microwave-based flow chemistry solutions WavecraftUniqsis of Cambridge, UK, and WaveCraft of Uppsala, Sweden, have entered into a collaborative agreement to develop and market a new range of microwave-based flow chemistry systems that will radically improve efficiency when scaling up compound synthesis during drug development...

     

      Flow Chemistry Specialist Uniqsis Introduces New Gas Addition Module for Continuous Flow Reactors Gas Addition Module for the Uniqsis FlowSyn Flow chemistry specialist Uniqsis Ltd is introducing a new Gas Addition Module for the Uniqsis FlowSyn and other continuous flow reactors. The new module enables fast, controllable pre-saturation of liquid reagents with a wide range of gases and so promotes efficient gas-dependent reactions in flow, such as hydrogenation, ozonolysis, carbonylation, and direct synthesis of carboxylic acids...

     

      Cambridge Companies Collaborate in the Launch of New Products for Flow Chemistry FlowSyn Polar BearUniqsis Ltd and Cambridge Reactor Design Ltd (CRD), both based near Cambridge, England, are collaborating in the commercialisation of an advanced cooling system for continuous flow reactors used in flow chemistry. Known as the FlowSyn Polar Bear, the new system enables controlled mixing and cooling of reagents at temperatures down to -88°C...

     

      Cambridge Reactor Design and Uniqsis announce joint marketing agreement UniqsisCambridge Reactor Design and Uniqsis are pleased to announce that they have entered into a joint marketing agreement for the Gastropod gas introduction module and the Polar Bear low temperature reactor, for flow chemistry applications...

     

      Increasing the flow – see multi-kg outputs with FlowSyn MAXI FlowSyn MAXIUniqsis has launched the first instrument on the market for multi-kilogram flow chemistry. FlowSyn MAXI, allows users to safely perform larger-scale flow reactions, at up to 100ml/min between -90ÂşC and 260ÂşC, and at pressures up to 1400 psi.

     

      Versatile chilled reactor for sub-zero flow chemistry FlowSyn ‘Cold’ from UniqsisFlowSyn ‘Cold' from Uniqsis is a stand-alone reactor module which, when coupled with the FlowSyn integrated continuous flow reactor and a recirculating chiller/heater, allows reactions to be performed at precisely controlled temperatures between -70°C and +150°C.

     

      FlowSyn AUTO-LF – The automatic choice for Combinatorial Flow Chemistry FlowSyn AUTO-LF™ – The automatic choice for Combinatorial Flow ChemistryUniqsis (Cambridge, UK) has further enhanced the FlowSyn by launching an automated loop filling module (FlowSyn Auto-LF) that allows flow chemists to perform multiple experiments with multiple reagents automatically. With simultaneous loop filling and fraction collection this highly versatile research tool enables chemists to harness the power of flow to deliver more compounds even faster.

     

      FlowSyn - Your Perfect Match for Flow Chemistry The FlowSyn Continuous Flow Reactor from Uniqsis (Cambridge, UK) now gives chemists the freedom to choose the FlowSyn system with the appropriate flow path material best suited to their particular chemistry.

     

      Uniqsis appoints Paul Pergande as Commercial Director Uniqsis Ltd, the innovative continuous flow reactor manufacturer, has appointed Paul Pergande as the company's Commercial Director.

     

      Sub-Ambient Flow Chemistry A new interchangeable reactor tray is now available for the Uniqsis FlowSyn Continuous Flow Reactor that extends the system’s working temperature range down to -40°C.

     

      Flow Chemistry Scale Up for Microwave Reactions Three new Application Notes from Uniqsis Ltd, manufacturers of the FlowSyn™ Continuous Flow Reactor, describe how the system can reproduce and scale up reactions that have been developed using small scale batch reactions in a microwave reactor.