Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Efficient Flow Chemistry Scale-up of Photoredox Coupling Reactions

publication date: Dec 5, 2018
 | 
author/source: Uniqsis Ltd

Polar Bear Plus


The renowned Innovative Technology Centre (ITC) at the University of Cambridge, UK has used a Uniqsis PhotoSyn flow photoreactor to efficiently scale-up a radical mediated boronic acid coupling under photoredox conditions using a novel organic acridium-based photocatalyst.

The acridium-based organic photocatalyst, developed by the University of Cambridge, is demonstrated to be an efficient replacement for iridium-based photocatalysts used to oxidise boronic acid derivatives by a single electron radical coupling process.

By eliminating the control, scale-up and safety problems associated with traditional batch photoreactors – the Uniqsis PhotoSyn LED photochemical flow reactor enabled synthetic chemists at the University of Cambridge to straightforwardly scale a photoredox cross-coupling of boronic acids in 81% yield with gram per hour throughput. In the described work, the researchers also used a Uniqsis Flow-UV inline UV-Vis spectrometer to conveniently monitor steady state.

Using a pair of enclosed large format LED arrays to concentrate the light inwards onto a central coil reactor, the Photosyn is able to provide sufficient light to facilitate reactions in coil reactors (up to 50 ml) enabling efficient photochemical synthetic work at larger scales.

Since 2007, Uniqsis has specialised in the design and supply of mesoscale continuous flow chemistry systems for a wide range of applications in chemical and pharmaceutical research. The company’s aim is to make flow chemistry easily accessible to both novices and experienced users.

 

Why FlowSyn?

more from Uniqsis



If you have not logged into the website then please enter your details below.



 

News Channels

 

 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 

 

 

 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events