Special Offers & Promotions



Latest News



View Channel

New Products



View Channel

Video Presentations



View Channel

Separation Science



View Channel

Microscopy & Image Analysis



View Channel

Laboratory Automation & IT Solutions



View Channel


Mixer-Reactor Chip Improves Control of Rapid Highly Exothermic Reactions

Uniqsis Ltd. has demonstrated how its proprietary glass static mixer-reactor chip technology can be used to perform highly exothermic reactions more conveniently at higher temperatures with useful throughputs under continuous flow-through conditions.

Mixer-reactor chip technologyTo achieve high reproducibility and facilitate scale up, it is important to control both mixing and temperature, particularly for highly exothermic or rapid mixing-dependent reactions (‘Type A’ reactions). 

Where the diffusional mixing provided by simple ‘T’-piece mixers is too slow to afford good control and reproducible reaction outcomes, Uniqsis has introduced a range of ingenious glass static mixer blocks ('chips') that incorporate channels with active mixing geometries to provide efficient turbulent mixing throughout the reaction vessel whilst also functioning as very efficient heat exchangers.

Uniqsis offers both conventional 2 input 1 output static glass mixer/reactor chips for combining 2 reagent streams, useful in nitration chemistry for example, and a 3 input 1 output chip which is particularly useful for reactions requiring a ‘quench’ input. The chips are easy to incorporate into the reaction flow path and use conventional threaded connectors that require no tools to attach and achieve leak-free seals over a wide temperature range. Precision machined from chemically inert borosilicate glass, these chip are tested to operate efficiently at up to 40 bar pressure and from -80°C to +150°C.

Metalations are typically performed at very low temperature (often -78°C) in batch with slow addition of the organometallic base in order to control the highly exothermic nature of such reactions. In Application Note 25** - Uniqsis demonstrate how a low temperature metalation-quench reaction can be performed at higher temperature in flow using the mixer-reactor chip in combination with a FlowSyn Cold Coil is able to reproducibly perform a high yield metalation-quench reaction.

Uniqsis mixer-reactor chips in combination with a FlowSyn column module, Cold Coil or Polar Bear reaction station offer a convenient and reliable solution to the control of mixing and temperature in chemical synthesis. 

Uniqsis specialises in the design of meso-scale continuous flow chemistry systems for a wide range of applications in chemical and pharmaceutical research. The company’s aim is to make flow chemistry easily accessible to both novices and experienced users.

more about mixer-reactor chip technology

more about Uniqsis

more news from Uniqsis


If you have not logged into the website then please enter your details below.


Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin


Request your free copies HERE




Popular this Month

Top 10 most popular articles this month



Today's Picks



Looking for a Supplier?

Search by company or by product


Company Name:






Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


Media Partners


Exhibitions & Events