Follow us...

 

Search News Archives

Channels

News

 

 

View Channel

Laboratory Products

 

 

View Channel

Special Offers and Promotions

 

Microscopy | Image Analysis

 

 

View Channel

Separation Science

 

 

View Channel

Coronavirus (COVID-19)

 

 

View Channel

Research & Case Studies

 

 

View Channel

Conferences | Events

Rapid LC-MS Analysis for TDM - Shimadzu and UMG Göttingen test faster delivery of vital lab results to doctors

publication date: Nov 7, 2022
 | 
author/source: Shimadzu
rapid-lcms-analysis-tdm-shimadzu-and-umg-gttingen-test
Dr. rer. nat. Frank Streit, Head of Clinical Research, University Medical Center Göttingen

 

Shimadzu and UMG (University Medical Center Göttingen) team up to develop new clinical LC-MS methods for more rapid and flexible TDM analysis

Shimadzu, a global thought leader in innovative laboratory instrumentation, is embarking on a new collaboration with the University Medical Center Göttingen (UMG). UMG is one of Germany's leading university medical facilities. The collaboration will focus on the development of new clinical laboratory methods using liquid chromatography - mass spectrometry (LC-MS) for therapeutic drug monitoring (TDM) analysis.

 

TDM in healthcare

TDM plays a vital role in providing precision medical care. TDM analysis measures the concentration of drugs currently in the blood to determine the required next dosage of a drug, e.g., antibiotics, antiepileptics, antidepressants, etc. That means that it is especially important for a clinical laboratory to test a sample and return the result to the doctor as swiftly as possible.

This is especially true for emergency patients who demand a special treatment. Because the standard dosage may not meet their needs in Intensive Care Unit (ICU), fast test results are crucial for doctors to properly treat patients and save lives.

 

Looking beyond conventional solutions

The conventional method for conducting TDM tests has been to use an immunoassay.

More recently, however, clinical laboratories have been turning to LC-MS systems for this purpose. Among the advantages of LC-MS are greater accuracy and flexibility.

Despite this overall superiority, methods using LC-MS have previously been difficult to apply in emergency cases because of the complexity of sample preparation. For instance, the high flexibility of the LC-MS system also means that each target group of drugs requires its own column, mobile phase, and analysis conditions such as temperature. This means that it can take time to switch methods to start a new sample analysis. And that can make it difficult for a clinical laboratory to quickly return analysis results to the doctors who need them.

 

Making a good method faster

But Shimadzu's CLAM-2030 has shown enormous potential in simplifying, streamlining and speeding up LC-MS testing. CLAM-2030 is a fully automated sample preparation module for LC-MS. Lab technicians simply place blood collection tubes in position and the module automatically performs sample pretreatment steps up to LC/MS/MS analysis.

 

Good news for emergency patients everywhere

Further developing and testing this potential will form the core of the new collaboration between Shimadzu and UMG. Working together with Prof. Andreas Fischer, Dr. Frank Streit and other leading experts at University Medical Center Göttingen, new methods for multiple target groups of drugs will be developed. The team will also use CLAM-2030 to optimize these new methods so that clinical laboratories can switch methods easily and flexibly – and most importantly quickly. This will mean that the more accurate results of LC-MS testing can be used by doctors more rapidly than ever before.

 

Working together leads to greater innovation

The collaboration with UMG takes place under the auspices of Shimadzu’s ambitious European Innovation Center (EUIC) program. Shimadzu’s EUIC puts our cutting-edge analytical technologies to work with top-level expertise in science, technology and society in order to create new and better solutions for tomorrow.

 

Video - CLAM-2030, a game changer for university hospitals

 

 

 

Recent news from Shimadzu

 


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

Today's Picks

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners