New Zetasizer Nano ZSP offers emerging rheology technique for weakly structured fluids
With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
As science evolves, new technologies and methods are continuously created that supplant older, outdated methods. The main reasons to replace outdated applications are: to save money, to save time, and to be safer. If a new application can do all three, its chance of successfully replacing an older technology greatly increases
In the last decade, the microplate reader has become a multi-mode, multi-functional instrument that is used routinely in most laboratories. As such, the number and type of microplate based applications have grown tremendously. A number of these applications use the Fluorescence Intensity, Fluorescence Polarization or Time-Resolved Fluorescence detection mode in a microplate reader....
Read More'Ethanol Production by Dry Milling' - New Case Study from Cole ParmerAug 20, 2012 Cole-Parmer's Masterflex® provides accurate and repeatable pumping solution for ethanol production process, enabling precise volume of enzymes to be added continuously.
Ethanol is a versatile alcohol that is used in fuel, beverages and thermometers. Two processes utilized to produce ethanol from grain are dry milling and wet milling. Dry milling plants generate ethanol, carbon dioxide, and distillers' grain, which is used as a high-protein livestock feed supplement. Wet milling plants create these and additional valuable byproducts such as corn syrup, dextrose, and fructose, however they cost substantially more to build and operate than a dry milling plant...
Read MoreMalvern Spraytec used in characterizing agricultural spray nozzlesAug 20, 2012A new application note from Malvern Instruments discusses the importance of droplet size in agricultural spraying and describes the use of the company's Spraytec system in defining the performance of agrochemical application systems.
‘Characterization of agricultural spray nozzles using the Malvern Spraytec' provides insight into the way this laser diffraction droplet size analyzer helps in understanding the performance of spray nozzles used for the application of herbicides, fungicides and insecticides.
Read MoreImproved cryopreservation of human hepatocytesAug 13, 2012A recently published article from researchers at the Karolinska Institute details an improved protocol for cryopreservation of primary human hepatocyte using STEM-CELLBANKER® cryopreservation solution from AMSBIO.
In the article the authors compare cryopreservation of liver hepatocytes using STEM-CELLBANKER with the frequently used DMSO-University of Wisconsin (DMSO-UW) medium protocol. Both protocols yielded hepatocytes with good P450 function, however, the STEM-CELLBANKER protocol gave a higher viability than the DMSO-UW cryoprotectant. The researchers concluded that STEM-CELLBANKER beneficially is also xeno-free and will be applicable to cryopreservation of clinical-grade primary human hepatocytes...
Read MoreOn-demand webinar discusses latest advances in 3D Cell Culture technologyJul 17, 2012AMSBIO, a supplier of advanced 3D tools to the life science community, recently participated in a '3D Cell Culture in Drug Discovery and Disease Modeling' webinar. Due to huge demand, the webinar which aired on 22nd May, has been reproduced in an on-demand version.
Driven by the limitations of 2D cell cultures - scientists search for alternative solutions that mirror the environment experienced by normal cells in the body and replicate complex tissue structures and in vivo-like morphology. The '3D Cell Culture in Drug Discovery and Disease Modeling' webinar focuses on discussing the latest advances in 3D technology and its contribution to conducting more realistic research...
Read MoreDelivering Pump Solutions for Chemical Process DevelopmentJul 9, 2012New Case Study from Cole Parmer
HEL Group chooses Masterflex® pumps for bespoke phase separation automated reactor system
International company HEL specialises in process safety and development and provides pre-pilot scale chemical reactors and systems to the pharmaceutical, fine chemical, petrochemical industries and academia. HEL's project team prepared three automated reactor systems for a process chemistry application in which the client required phase separation. The client needed an automated system and HEL project leaders turned to Cole-Parmer for help in outfitting the system with the correct pumping technology...
Read MoreNew advice from Malvern Instruments for implementing on-line particle size analysisJun 26, 2012A new white paper from Malvern Instruments examines the different strategies open to anyone adopting on-line particle size analysis, providing guidance on its design and implementation and highlighting the economic and practical benefits of selecting an approach best suited to the project in hand.
The white paper discusses the choices around project implementation, advises on how to take best advantage of in-house expertise and suggests when to draw on outside help. ‘Strategies for success: How will you implement on-line particle sizing? Choosing the right approach' is available for download...
Read MoreNew white paper - Quantifying the impact of humidity on powder propertiesJun 22, 2012New experimental data from Freeman Technology demonstrate how dynamic, shear and bulk powder testing can be applied to quantify the impact of humidity on powder behaviour, supporting the need to develop effective strategies for moisture control and process optimisation.
Quantifying the impact of humidity on powder properties' by Brian Armstrong (Powder Technologist) and Jamie Clayton (Operations Manager), Freeman Technology, is now available for download...
The researchers demonstrate how SMARTTM Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments. SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles... Read MoreNew application note explores the optimisation of targeted DNA sequencingJun 14, 2012Improving custom bait design to increase accuracy, sensitivity and coverage depth
Oxford Gene Technology (OGT), provider of innovative clinical genetics and diagnostic solutions to advance molecular medicine, has released a new application note exploring the optimisation of targeted DNA sequencing. Entitled, "Fishing for variants in the deep end of the gene pool", the document discusses how the intelligent design of custom bait probes can significantly improve data quality by decreasing off-target noise...
Read MoreChoosing the Right Oligonucleotide Modification for Your NeedsJun 13, 2012Latest issue of IDT's DECODED newsletter offers informative oligonucleotide selection guide
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a guide to choosing the right oligonucleotide modification in this quarter's edition of the company's DECODEDnewsletter. As IDT offers hundreds of useful modifications for oligonucleotides, choosing the appropriate one for your work can be confusing. The article provides insightful information to help when choosing the right modification, including a detailed list of the modification categories...
Read MoreBack to basics with Malvern Instruments particle characterization white paperJun 1, 2012From a starting point of ‘what is a particle?', Malvern Instruments' new ‘A basic guide to particle characterization' white paper takes the reader through descriptions of a range of particle properties and then goes on to introduce a variety of different particle characterization techniques. Designed both as a primer for those new to particle characterization and as a refresher for the more experienced...
Read MoreMalvernMay 29, 2012A performance-defining parameter in products from paint and coatings to personal care
A new white paper from Malvern Instruments is aimed at helping product developers and formulators get to grips with the measurement of yield stress. Yield stress is a rheological parameter that is industrially important in defining the performance of food, paint, personal care and many other products. In order to obtain relevant, robust and reproducible yield stress data for a particular material, it is essential to make an assessment of both the test type, and the measurement protocol used to perform the test. The white paper ‘Understanding yield stress measurements' provides a valuable introduction to the topic... Read MoreMalvern team presents May 22, 2012Malvern Instruments light scattering specialists Dr Ana Morfesis and Dr Ulf Nobbmann, will present a poster on ‘Nanoparticle characterization by light scattering' as part of the 86th ACS Colloid and Surface Science Symposium being held at the University of Baltimore in Maryland, USA, June 10-13, 2012. Their poster will be displayed from 5.30 until 7.30 pm on Monday June 11 in a session held in the exhibition area, where delegates will also be able to visit the Malvern booth to find out more about the company's full range of systems for nanoparticle characterization, including the market leading Zetasizer Nano.
Read MoreNew Applications Resource from BMG LABTECHMay 15, 2012A perfectly engineered microplate reader is only part of the solution. Knowing how to effectively perform all of the leading applications on that instrument is the final piece of the puzzle. This is why BMG LABTECH has created an application notes binder, which combines all of the current application notes into one resource. The application notes detailed in our Application Notes Binder were all performed on BMG LABTECH's wide range of microplate readers and they outline a variety of experiments...
Read MoreNew Malvern download with detailed Zetasizer specifications helps users match system with applicationMay 9, 2012In line with a policy of continuous improvement, Malvern Instruments has reviewed, verified and published updated specifications for the Zetasizer series of dynamic light scattering (DLS) particle characterization systems, all fully backed by measurements on real samples. Full updated specification details are available online...
Read MoreMetrohm publishes new Application Notes (ANs) about photometric titrationMay 2, 2012Accompanying the introduction of the new Optrode photometric sensor, Metrohm presents a range of titrimetric applications using the advantages of photometric detection of the equivalence point. The new applications cover a number of industries including the pharmaceutical industry, the petrochemical industry, and water analysis. The new ANs are available for free from the homepage of Metrohm International Headquarters...
Read MorePermanganate index: fully automatic determination according to DIN EN ISO 8467 (DIN 38409-5)Apr 17, 2012Metrohm presents a method for completely automated determination of the permanganate index according to DIN EN ISO 8467 (DIN 38409-5). The new method not only saves time, but is robust and, because of the tiamoTM titration software, very easy to use. The permanganate index is used to evaluate the quality of different types of water, e.g. drinking water, mineral water, spring water, and table water. It is determined in accordance with DIN EN ISO 8467 (DIN 38409-5)...
Read MoreReliable method for characterising PFC'sApr 16, 2012Exeter Analytical has developed a reliable analytical method for accurately determining the percentage Carbon (C), Hydrogen (H) and Nitrogen (N) content of polyfluorinated compounds (PFCs). Polyfluorinated compounds are extremely thermally and chemically stable and have soil, water and fat-repellent properties. They are nearly non-biodegradable and accumulate in the environment and the food chain...
Read MoreGas Analyzers Meet Stringent Requirements of Respiration CalorimetersApr 13, 2012MEI Research is an engineering firm based in St. Louis Park, MN, that develops technologies to support research in nutrition and weight management.One of MEI's goals is to improve the design and construction of whole-body respiration calorimeters. These instrumented systems calculate energy expenditure by precisely measuring the amount of oxygen that the body converts by metabolism to carbon dioxide during periods from minutes up to several days. Calorimeters comprise sealed living areas, atmosphere controls and gas analyzers. Because the living areas contain thousands of times more air than respiratory volume the accuracy of the analytical systems that measure carbon dioxide (CO2) and oxygen (O2) concentrations is critical to overall performance... Read MoreCheese aromas pinpointed by innovative techniqueApr 5, 2012Food scientists working in the dairy industry are set to benefit from the development of a powerful new technique for analysing the aroma profile of cheese. The innovative method, which uses technology developed by Markes International to analyse vapours emitted by a sample, will enable analysts to identify the specific chemical compounds released by different cheeses, even when they are present at trace levels and have low odour thresholds...
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With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
In the last decade, the microplate reader has become a multi-mode, multi-functional instrument that is used routinely in most laboratories. As such, the number and type of microplate based applications have grown tremendously. A number of these applications use the Fluorescence Intensity, Fluorescence Polarization or Time-Resolved Fluorescence detection mode in a microplate reader....
Ethanol is a versatile alcohol that is used in fuel, beverages and thermometers. Two processes utilized to produce ethanol from grain are dry milling and wet milling. Dry milling plants generate ethanol, carbon dioxide, and distillers' grain, which is used as a high-protein livestock feed supplement. Wet milling plants create these and additional valuable byproducts such as corn syrup, dextrose, and fructose, however they cost substantially more to build and operate than a dry milling plant...
‘Characterization of agricultural spray nozzles using the Malvern Spraytec' provides insight into the way this laser diffraction droplet size analyzer helps in understanding the performance of spray nozzles used for the application of herbicides, fungicides and insecticides.
In the article the authors compare cryopreservation of liver hepatocytes using STEM-CELLBANKER with the frequently used DMSO-University of Wisconsin (DMSO-UW) medium protocol. Both protocols yielded hepatocytes with good P450 function, however, the STEM-CELLBANKER protocol gave a higher viability than the DMSO-UW cryoprotectant. The researchers concluded that STEM-CELLBANKER beneficially is also xeno-free and will be applicable to cryopreservation of clinical-grade primary human hepatocytes...
Driven by the limitations of 2D cell cultures - scientists search for alternative solutions that mirror the environment experienced by normal cells in the body and replicate complex tissue structures and in vivo-like morphology. The '3D Cell Culture in Drug Discovery and Disease Modeling' webinar focuses on discussing the latest advances in 3D technology and its contribution to conducting more realistic research...
International company HEL specialises in process safety and development and provides pre-pilot scale chemical reactors and systems to the pharmaceutical, fine chemical, petrochemical industries and academia. HEL's project team prepared three automated reactor systems for a process chemistry application in which the client required phase separation. The client needed an automated system and HEL project leaders turned to Cole-Parmer for help in outfitting the system with the correct pumping technology...
The white paper discusses the choices around project implementation, advises on how to take best advantage of in-house expertise and suggests when to draw on outside help. ‘Strategies for success: How will you implement on-line particle sizing? Choosing the right approach' is available for download...
Quantifying the impact of humidity on powder properties' by Brian Armstrong (Powder Technologist) and Jamie Clayton (Operations Manager), Freeman Technology, is now available for download...
The researchers demonstrate how SMARTTM Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments. SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles...
Oxford Gene Technology (OGT), provider of innovative clinical genetics and diagnostic solutions to advance molecular medicine, has released a new application note exploring the optimisation of targeted DNA sequencing. Entitled, "Fishing for variants in the deep end of the gene pool", the document discusses how the intelligent design of custom bait probes can significantly improve data quality by decreasing off-target noise...
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a guide to choosing the right oligonucleotide modification in this quarter's edition of the company's DECODED newsletter. As IDT offers hundreds of useful modifications for oligonucleotides, choosing the appropriate one for your work can be confusing. The article provides insightful information to help when choosing the right modification, including a detailed list of the modification categories...
From a starting point of ‘what is a particle?', Malvern Instruments' new ‘A basic guide to particle characterization' white paper takes the reader through descriptions of a range of particle properties and then goes on to introduce a variety of different particle characterization techniques. Designed both as a primer for those new to particle characterization and as a refresher for the more experienced...
A new white paper from Malvern Instruments is aimed at helping product developers and formulators get to grips with the measurement of yield stress. Yield stress is a rheological parameter that is industrially important in defining the performance of food, paint, personal care and many other products. In order to obtain relevant, robust and reproducible yield stress data for a particular material, it is essential to make an assessment of both the test type, and the measurement protocol used to perform the test. The white paper ‘Understanding yield stress measurements' provides a valuable introduction to the topic...
Malvern Instruments light scattering specialists Dr Ana Morfesis and Dr Ulf Nobbmann, will present a poster on ‘Nanoparticle characterization by light scattering' as part of the 86th ACS Colloid and Surface Science Symposium being held at the University of Baltimore in Maryland, USA, June 10-13, 2012. Their poster will be displayed from 5.30 until 7.30 pm on Monday June 11 in a session held in the exhibition area, where delegates will also be able to visit the Malvern booth to find out more about the company's full range of systems for nanoparticle characterization, including the market leading Zetasizer Nano.
A perfectly engineered microplate reader is only part of the solution. Knowing how to effectively perform all of the leading applications on that instrument is the final piece of the puzzle. This is why BMG LABTECH has created an application notes binder, which combines all of the current application notes into one resource. The application notes detailed in our Application Notes Binder were all performed on BMG LABTECH's wide range of microplate readers and they outline a variety of experiments...
In line with a policy of continuous improvement, Malvern Instruments has reviewed, verified and published updated specifications for the Zetasizer series of dynamic light scattering (DLS) particle characterization systems, all fully backed by measurements on real samples. Full updated specification details are available online...
Accompanying the introduction of the new Optrode photometric sensor, Metrohm presents a range of titrimetric applications using the advantages of photometric detection of the equivalence point. The new applications cover a number of industries including the pharmaceutical industry, the petrochemical industry, and water analysis. The new ANs are available for free from the homepage of Metrohm International Headquarters...
Metrohm presents a method for completely automated determination of the permanganate index according to DIN EN ISO 8467 (DIN 38409-5). The new method not only saves time, but is robust and, because of the tiamoTM titration software, very easy to use. The permanganate index is used to evaluate the quality of different types of water, e.g. drinking water, mineral water, spring water, and table water. It is determined in accordance with DIN EN ISO 8467 (DIN 38409-5)...
Exeter Analytical has developed a reliable analytical method for accurately determining the percentage Carbon (C), Hydrogen (H) and Nitrogen (N) content of polyfluorinated compounds (PFCs). Polyfluorinated compounds are extremely thermally and chemically stable and have soil, water and fat-repellent properties. They are nearly non-biodegradable and accumulate in the environment and the food chain...
MEI Research is an engineering firm based in St. Louis Park, MN, that develops technologies to support research in nutrition and weight management. One of MEI's goals is to improve the design and construction of whole-body respiration calorimeters. These instrumented systems calculate energy expenditure by precisely measuring the amount of oxygen that the body converts by metabolism to carbon dioxide during periods from minutes up to several days. Calorimeters comprise sealed living areas, atmosphere controls and gas analyzers. Because the living areas contain thousands of times more air than respiratory volume the accuracy of the analytical systems that measure carbon dioxide (CO2) and oxygen (O2) concentrations is critical to overall performance...
Food scientists working in the dairy industry are set to benefit from the development of a powerful new technique for analysing the aroma profile of cheese. The innovative method, which uses technology developed by Markes International to analyse vapours emitted by a sample, will enable analysts to identify the specific chemical compounds released by different cheeses, even when they are present at trace levels and have low odour thresholds...