In the ever-evolving world of powder processing, understanding the permeability of powders is absolutely critical across numerous industries. Whether it's pharmaceuticals, food production, or additive manufacturing, having a deep understanding of how powders behave under various packing conditions can dramatically impact product quality and production efficiency. Today, we're excited to introduce the GranuPack Permeability Unit, a cutting-edge breakthrough in powder permeability analysis...

Powders are used in all production processes of solid dosage forms like tablet or dry powder inhaler (DPI) manufacturing processes. Among all the powder properties, permeability, which is the capacity of a fluid (air) to pass through a powder bed, plays a crucial factor in different pharmaceutical processes. In the die filling of tablet manufacturing, the permeability determines the powder flowability during the displacement of the powder within the die and the capacity of the powder to pack in the die...

Discrete Element Method (DEM) simulations provide detailed representations of particulate processes, considering all particle-particle and particle-geometry interactions. DEM has been used to model different industrial process, from blending, powder conveying and tabletting. To have detailed and accurate representation of the real material, a proper calibration of the DEM model parameters is essential. Join GranuTools on 18 April at 4 PM CET and learn how the use of digital twins allows you to have a proper calibration of the DEM model parameters...

New Virtual Powder Flow Course happening in February 2023 focusing on the properties of powders! Understanding the flow of powders is essential in many industrial applications. Anyone working with powdered materials has once experienced processability problems like a lack of flowability, heavy sticking on pipes and machine surfaces, or variability in dosage among many other examples...

In this Virtual Powder Flow Course, Granutools explore the properties of powders at different scales, from the interactions between the particles at the micro scale to the consequence on the powder processability. Then, you will learn how this new knowledge can be used to better understand the processability of powders through detailed case studies...

In the pharmaceutical industry, the current trend is to move from conventional batch manufacturing to Continuous Manufacturing processes. The challenges for this shift are many: quality control of the blend (homogeneity), inter- and intra-lot variability, suitability of excipients (flow, density, compactability), build-up of electrostatic charges. The 3rd APV Continuous Manufacturing Conference in Rome (organized by Janssen Pharmaceutical) was the perfect stage to discuss these critical points with renowned representatives of the Pharma sector....

The first Pharma User Club meeting organized by Granutools was successfully held on January 26th, 2022. More than 200 attendees joined this virtual meeting, which was the perfect occasion to hear renowned speakers, join a large and diverse community, and network. The talks covered a wide range of subjects and aspects of the pharmaceutical industry and academy: from lactose excipients to APIs, from flowability to electrostatics, from feedstock to production lines, from process simulation to model calibration...

Powders are widely used as excipients or APIs in pharmaceutical products and formulations. Several production processes are dealing with powders: tableting, wet and dry granulation, blending, caps filling, etc. Therefore, understanding powder flow behaviour is needed to avoid inappropriate properties and serious complications in production lines (clogging, agglomeration, segregation, etc.)....

With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques exist but only a few can mimic the die filling process successfully. One of the challenges in mimicking the die filling process is understanding the rheological powder behaviour and the differences in flow field in the feeding frame...

In the pharmaceutical industry, the trend is to move from conventional batch manufacturing to continuous manufacturing processes. The challenges for such change are numerous, but many papers are published to solve those issues and improve production. This is the case of the paper published by Carl Allenspach from Bristol-Myers Squibb (International Journal of Pharmaceutics 596 (2021)....

In this article, the characterization of lactose powders for use in DPI applications is discussed. We present new results obtained from state-of-the-art characterization methods allowing us to gather insightful information on the powder behavior. Moreover, electrostatic properties which are of great interest for DPI applications in particular with respect to drug release from the lactose carrier are investigated....

It is well known that flow properties of powders are governed by the intrinsic grain properties and forces acting on and between the grains. It is no surprise that the amount of API present in a blend impacts powder processability. To this end, GranuTools has developed, over the past years, a whole range of state-of-the-art equipments to allow characterizing the flow properties of powders and granular materials in many different geometries to match process conditions....

GranuTools now offering its expertise and extended range of instruments to characterize powders and granular materials in various conditions/geometries. It is well known that flow properties of powders are governed by the intrinsic grain properties and forces acting on and between the grains. However, what one often forgets is the dramatic influence of the conditions under which powders are processed (stress state, flow field, relative humidity, and temperature)....

The new website of Granutools is now online. On this brand-new website, you can now navigate through the solutions designed especially for your business. Industries such as Additive Manufacturing, Pharmaceuticals, Food, Ceramic, or Minerals are represented through a series of our user cases and application notes that can be accessed freely, without prior login. Visit the new website to discover our line of leading-edge instruments for powder flow characterization...

Webinars presented cover many subjects and aspects of the pharmaceutical industry: from lactose to API, from their flowability to their electrostatics, from the feedstock to the production lines, Granutools’ webinars covered a wide range of subjects. Their expertise in the field is recognized by prestigious clients of the pharma world such as DFE Pharma or the RCPE....

The Granupack is helping many industries to understand better their powder behavior! A new instrument is now available in the Granutools products, the Granupack High Temperature which does everything the Granupack does but also enable you to control the temperature of the cell with precision (up to 200°C). You will be surprised to discover how even slight changes in temperature can affect the flowing properties of your powders...

In this new webinar, Granutools will join forces with the RCPE to give you new insight on the importance of electrostatics for pharmaceuticals powders. Together they will explain how the material properties, particle properties, and formulation properties will affect the tribo-charging and how it is possible to use the GranuCharge as a proxy of industrial processes like a twin screw feeder....