Follow us...

 

Search News Archives

Channels

News

 

 

View Channel

Laboratory Products

 

 

View Channel

Special Offers and Promotions

 

Microscopy | Image Analysis

 

 

View Channel

Separation Science

 

 

View Channel

Coronavirus (COVID-19)

 

 

View Channel

Research & Case Studies

 

 

View Channel

Brochures & Literature

 

 

View Channel

 

Conferences | Events

New App Note - Characterization of lactose powders for DPI applications

publication date: Jun 15, 2021
 | 
author/source: GranuTools

new-app-note-characterization-lactose-powders-dpi
 

Lactose clearly meets the criteria for an ideal carrier for inhalation applications. It is chemically and physically inert to other excipients and active ingredients.

Widely available worldwide, lactose is well characterized, easy to store, cost-effective and typically has low lot-to-lot variability. Dry powder inhaler (DPI) products are designed to deliver a dry powder active ingredient to a patient’s lungs using an inhaler device. The formulation typically consists of a homogenous blend of the active ingredient and an excipient (typically lactose), which is contained within a reservoir, capsule, or blister. Such formulations are produced by physically mixing micronised drug particles and the larger-sized excipient ‘carrier’ particles.

Contrary to many conventional tableting formulations, the excipient is an important functional ingredient in a DPI formulation. The excipient carrier plays at least two roles in the formulation. Since the active ingredient is used in very small quantities, blending with the excipient is necessary to enable delivery of such a small quantity.  Second, the excipient must separate from the drug during inhalation so that the drug can be inhaled into the patient’s lungs. The excipient physical properties and interfacial forces affect the blend uniformity and drug release of the DPI formulation. It is important that these characteristics are controlled during manufacture and storage of the excipient.

The main challenges in DPI development are producing a uniform blend for accurate dosing and then proper drug separation during inhalation. In the present article, packing dynamics, flowability and tribocharging properties of six lactose powders have been investigated. We show how these methods can help to gather important information on powder behaviour helping the design of new products with improved performances.

 

 

View Application Note

View Company Profile | Recent news

  


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners