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All articles from Postnova Analytics GmbH

  New Method for Characterising Liposome Formulated Drugs

Centrifugal Field-Flow Fractionation (CF3)Postnova Analytics has published an application study that describes a new method for quantification of liposome encapsulated drug using Centrifugal Field-Flow Fractionation (CF3). Nanoparticles including liposomes are increasingly used for delivery of drug molecules. During formulation of a liposome around a drug particle, a relatively large amount of free drug may remain unencapsulated and therefore not available for drug delivery via the liposomal carrier...

 

  Fast Measurement of Nanocrystal Length & Thickness

Asymmetrical Flow Field Flow FractionationPostnova Analytics reports on how Asymmetrical Flow Field Flow Fractionation coupled to Multi Angle Light Scattering (AF4-MALS) has been successfully used to characterise a polydisperse cellulose nanocrystal for size and thickness in just 40 minutes analysis time. Nanocrystals research has been an area of significant interest lately, due to a growing range of applications....

 

  Separation & Characterisation of Self Assembling Block Copolymers

postnovaPostnova Analytics reports on how Thermal Field Flow Fractionation has been successfully used to elucidate the core microstructure, morphology and chain arrangement of self-assembling block copolymers. This pioneering study was undertaken by the renowned research group under Professor H Pasch at the Department of Chemistry and Polymer Science, University of Stellenbosch...

 

  Thermal Field Flow Fractionation Copolymer Case Study

Thermal Field Flow FractionationPostnova Analytics reports on how Thermal Field Flow Fractionation has been successfully used to elucidate the core microstructure, morphology and chain arrangement of self-assembling block copolymers. This pioneering study was undertaken by the renowned research group under Professor H Pasch at the Department of Chemistry and Polymer Science, University of Stellenbosch (South Africa)...

 

  Analysis of Nanoparticles in Commercial Sunscreens

Postnova Analytics has published a new application note that describes a new approach for analysis of titanium dioxide nanoparticles in commercial sunscreens. The technique, which combines Inverse Supercritical Fluid Extraction (I-SFE) and Miniaturized Asymmetrical Flow Field-Flow Fractionation hyphenated with UV-Vis and MultiAngle Light Scattering...

 

  Determining the Physicochemical and Biophysical Attributes of Monoclonal Antibodies

EAF2000 system

Postnova Analytics has published a new poster that compares the suitability of Electrical Asymmetrical Flow Field Flow Fractionation (EAF4) and Size Exclusion Chromatography (SEC) for determining the physicochemical and biophysical attributes of monoclonal antibodies. In the described work, a reference monoclonal antibody (RM 8671 mAb), from the U.S. National Institute of Standards and Technology...

 

  Comparative Analysis of a Complex Monoclonal Antibody

EAF4 modulePostnova Analytics has published a new poster that compares the suitability of Electrical Asymmetrical Flow Field Flow Fractionation (EAF4) and Size Exclusion Chromatography (SEC) for determining the physicochemical and biophysical attributes of monoclonal antibodies. In the described work, a reference monoclonal antibody (RM 8671 mAb), from the U.S. National Institute of Standards and...

 

  Characterising Nanomaterials in Food by FFF-ICP-MS Postnova Analytics

Postnova Analytics reports on how the inorganic analysis team within LGC (Teddington, UK) has been using the AF2000 Field Flow Fractionation system coupled to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to characterise nanomaterials in complex food sample matrices. Nanomaterials are known to be present in over 1300 foods and commercial products....

 

  Postnova Analytics Announces 2018 Seminar on Advanced Separation Techniques

Postnova Analytics has announced its second annual 1-day seminar exploring how advanced separation techniques are extending the frontiers of characterisation of nanoparticles, polymers and proteins. Following the popularity of the first Postnova first seminar, held at the company’s UK headquarters in Malvern, an informative program of talks from eminent guest speakers, plus presentations from Postnova scientists has been assembled.....

 

  Unlocking the Puzzle of Neurodegenerative Diseases

Postnova Analytics reports that the Department of Molecular Biology & Biotechnology at the University of Sheffield (UK) is using their AF2000 Field Flow Fractionation system to investigate the mechanism of amyloid formation, a protein mis-folding process implicated to be the cause of Alzheimer’s and other neurodegenerative diseases.

Molecular Biology Biotechnology at the University of SheffieldUnderstanding the causes of neurodegenerative diseases is a huge challenge. Outbreaks of BSE (commonly known as mad cow disease) and the rise of Alzheimer’s as a leading cause of death has meant that there is increasing pressure to find a cure....

 

  Separation & Characterisation of Complex Charged Molecules

Postnova Analytics announces the launch of the EAF2000 - an innovative new simultaneous Electrical and Asymmetrical Flow Field Flow Fractionation system designed to enhance separation and characterisation of biopharmaceutical, environmental and nanomaterials.

Electrical and Asymmetrical Flow FFFEAF4 technology uniquely combines the principle of Electrical and Asymmetrical Flow FFF in just one system. In an EAF2000 system - Electrical and Cross Flow Fields are applied simultaneously across the FFF channel enabling separations by particle size and particle charge based on electrophoretic mobility....

 

  Orthogonal Platform Enhances Protein Separation & Characterisation

Postnova Analytics reports on the extended data available through integrating its AF2000 MultiFlow Flow Field-Flow Fractionation (FFF) platform with its SC2000 modular multi-detector Size Exclusion chromatography (SEC) system.

AF2000Drawing on over three decades of cutting-edge separations leadership, Postnova has designed an advanced orthogonal system that allows both SEC and FFF separations to be carried out on the same sample within one instrument platform. The result is enabling labs around the world to generate more useful information from even complex proteins, antibodies, polypeptides and polysaccharides....

 

  Postnova FFF/SEC Platform Advances Protein Separation And Characterisation

Postnova Analytics reports on the extended data available through integrating its AF2000 MultiFlow Flow Field-Flow Fractionation (FFF) platform with its SC2000 modular multi-detector Size Exclusion chromatography (SEC) system.

AF2000Drawing on over three decades of cutting-edge separations leadership, Postnova has designed an advanced orthogonal system that allows both SEC and FFF separations to be carried out on the same sample within one instrument platform. The result is enabling labs around the world to generate more useful information from even complex proteins, antibodies, polypeptides and polysaccharides.....

 

  Analytical Protein Aggregate Separation without a Column

Postnova Analytics announces the AF2000 MALS - a new temperature controlled Flow Field-Flow Fractionation - MALS system developed to provided unmatched separation, characterization and fractionation of biopharmaceutical proteins.

Postnova AF2000 MultiFlowThe AF2000 MALS employs a similar setup to a traditional GPC-MALS system but avoids the limitations of column-based chromatographic separations. In the AF2000 MALS system the liquid chromatography column is replaced by a proprietary separation channel technology that retains molecules based only on size and by the influence of a cross flow as a separation force....

 

  MALS Detector for Size Exclusion Chromatography and Field Flow Fractionation

Postnova Analytics PN3621 MALS detector sets a new standard for sensitive, precise and flexible Multi-Angle Light Scattering detection for Size Exclusion Chromatography (SEC) and Field Flow Fractionation (FFF) systems.

PN3621 MALSThe detector simultaneously measures the intensity of scattering at 21 angles which enables the precise calculation of the absolute molecular weight of proteins, natural and synthetic polymers, and also molecular size expressed as the radius of gyration, Rg. Incorporating the broadest range of working angles (7° - 164°) in a commercially available light scattering detector....

 

  Sensitive & Precise Multi-Angle Light Scattering Detector

The PN3621 MALS from Postnova Analytics sets a new standard for sensitive, precise and flexible Multi-Angle Light Scattering detection for Size Exclusion Chromatography (SEC) and Field Flow Fractionation (FFF) systems.

PN3621 MALS from Postnova AnalyticsThe detector simultaneously measures the intensity of scattering at 21 angles which enables the precise calculation of the absolute molecular weight of proteins, natural and synthetic polymers, and also molecular size expressed as the radius of gyration, Rg....

 

  Characterisation of Nanomaterials in Commercial Products

Postnova Analytics reports on how the inorganic analysis team within LGC (Teddington, UK) has been using the AF2000 Field Flow Fractionation system coupled to Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to characterise nanomaterials in complex sample matrices for clinical, cosmetic and food use.

Postnova AF2000Nanomaterials are known to be present in over 1300 commercial products. As a result of the European Union (EU) recently providing a precise definition of a nanomaterial for regulatory purposes, it has become important to be able to characterise nanomaterials reliably to understand their behaviour in contact with humans and the environment....

 

  Postnova AF2000 Assists UCL in Developing Nanoscale Vehicles for Drug Delivery

Postnova Analytics reports on the recent investment by the Department of Chemistry at University College London (UCL) in an AF2000 Field Flow Fractionation (FFF) System to assist them in their development of novel nanoscale vehicles for drug delivery.

Postnova AF2000 is a high performance Field Flow FractionationUCL has pioneered the engineering of novel nanoscale drug delivery vehicles which can be tuned to release a range of cargos. The drug delivery system is based upon the synthesis of self-assembled spherical polymer vesicles known as polymersomes. Polymersomes are biocompatible and stable making them ideal for the development of drug delivery systems...

 

  Novel Nanoscale Vehicles for Drug Delivery

Postnova Analytics reports on the recent investment by the Department of Chemistry at University College London (UCL) in an AF2000 Field Flow Fractionation System to assist them in their development of novel nanoscale vehicles for drug delivery.

AF2000 Field FlowUCL has pioneered the engineering of novel nanoscale drug delivery vehicles which can be tuned to release a range of cargos. The drug delivery system is based upon the synthesis of self-assembled spherical polymer vesicles known as polymersomes. Polymersomes are biocompatible and stable making them ideal for the development of drug delivery systems....

 

  Lecture on Characterisation of Natural & Synthetic Rubbers

At the recent International Symposium on GPC/SEC and Related Techniques in Amsterdam, Postnova Analytics presented a well-received lecture entitled 'Comprehensive Characterization of Natural Rubber Samples using Thermal Field-Flow-Fractionation coupled with MALS and Triple Detection'.

TF3The presentation by Dr Gerhard Heinzmann included an informative introduction to the Thermal Field Flow Fractionation (TF3) technique, a comparison of the technique versus using GPC/SEC and application examples including data from a complex natural rubber sample....

 

  Advanced Characterisation of Natural & Synthetic Rubbers

At the recent International Symposium on GPC/SEC and Related Techniques in Amsterdam, Postnova Analytics presented a well-received lecture entitled 'Comprehensive Characterization of Natural Rubber Samples using Thermal Field-Flow-Fractionation coupled with MALS and Triple Detection'.

Thermal Field Flow FractionationThe presentation by Dr Gerhard Heinzmann included an informative introduction to the Thermal Field Flow Fractionation (TF3) technique, a comparison of the technique versus using GPC/SEC and application examples including data from a complex natural rubber sample. The speaker explained how advantageously TF3 is able to separate samples by both particle size and chemical composition at the same time....

 

  Advanced Separation Techniques Seminar

Postnova Analytics has announced a 1-day seminar examining the latest advanced separation techniques for the characterisation of nanoparticles, polymers and proteins.

postnova UK headquarters in MalvernThis free seminar, due to be held on November 17th 2016 at the company's new UK headquarters in Malvern, has been designed to advance the attendees knowledge of applications and techniques in nanoscale characterisation. The meeting will be particularly useful to those using Field-Flow Fractionation (FFF), Size Exclusion Chromatography (SEC/GPC) and Light Scattering as well as scientists interested in how these techniques may be useful in their research...

 

  Determining the Size & Chemical Composition of Tattoo Ink Nanoparticles

Postnova Analytics have published an application study detailing how the technique of Field-Flow Fractionation-ICP-MS can be used to study the size and chemical composition of tattoo ink nanoparticles. 

Field-Flow Fractionation-ICP-MSAccording to a recent report from the European Commission Joint Research Centre, whilst some 12% of Europeans have tattoos, little is known about the long term effects of the chemicals in the inks. Commonly tattoo inks contain metallic impurities that can result in adverse skin reactions, including infections and allergies, right after tattooing or even years later....

 

  Thermal Separation of Complex Polymers

The Postnova TF2000 is an advanced thermal field flow fractionation (TF3) system that provides a highly efficient method of separating and characterising complex polymer samples such as natural or synthetic rubbers, starches and paints from approximately 10 kDa up to 100 MDa and more in organic and aqueous solvents. 

Postnova TF2000The TF2000 uses a temperature gradient as the driving force for its separation of polymers and particles. Molecules affected by the thermal gradient undergo diffusion which enables separation by both their molar mass and chemical composition. This unique feature allows the separation of different materials having the same molar mass....

 

  Study Reports on New Technique for Analysing Plasma Proteins

Postnova Analytics reports on exciting advances in the analysis of plasma proteins using a hyphenated system that couples asymmetric flow Field-Flow Fractionation (AF4) and inductively coupled plasma-mass spectrometry (ICP-MS).

postnovaprIn a new application study researchers show how an AF4-ICP-MS system is able to obtain valuable information on the multi-element speciation and absolute molecular mass of human plasma proteins such as Albumin and Transferrin. Human Serum Albumin (HSA) and Transferrin are the two main plasma proteins that are known to bind and transfer metal ions in biological fluids....

 

  Hyphenated Technique Reveals Valuable Information About Plasma Proteins

Postnova Analytics reports on exciting advances in the analysis of plasma proteins using a hyphenated system that couples asymmetric flow Field-Flow Fractionation (AF4) and inductively coupled plasma-mass spectrometry (ICP-MS). 

AF4-ICP-MS systemIn a new application study researchers show how an AF4-ICP-MS system is able to obtain valuable information on the multi-element speciation and absolute molecular mass of human plasma proteins such as Albumin and Transferrin. Human Serum Albumin (HSA) and Transferrin are the two main plasma proteins that are known to bind and transfer metal ions in biological fluids....

 

  Speciation Analysis of Plasma Proteins Using Asymmetric Flow FFF-ICP-MS

Postnova Analytics reports on exciting advances in the analysis of plasma proteins using a hyphenated system that couples asymmetric flow Field-Flow Fractionation (AF4) and inductively coupled plasma-mass spectrometry (ICP-MS). 

 Asymmetric Flow FFF-ICP-MSIn a new application study researchers show how an AF4-ICP-MS system is able to obtain valuable information on the multi-element speciation and absolute molecular mass of human plasma proteins such as Albumin and Transferrin. Human Serum Albumin (HSA) and Transferrin are the two main plasma proteins that are known to bind and transfer metal ions in biological fluids. Metal-protein complexes are involved...

 

  Centrifugal Field Flow Fractionation System

The CF2000 Centrifugal Field Flow Fractionation (CF3) system from Postnova Analytics sets a new standard for high resolution separation and fractionation of nanoparticles. 

CF2000 Centrifugal Field Flow FractionationBased on the CF3 principle, the Postnova CF2000 employs a centrifugal field as the driving force for separations. Particles affected by this field are separated by dynamic diffusion on the basis of both particle size and density. This unique feature of the CF2000 allows the separation of different particulate materials having the same particle size. Separations on the CF2000 can be further optimized by using different eluents and temperature...

 

  High Resolution Separation and Fractionation of Nanoparticles

The CF2000 Centrifugal Field Flow Fractionation (CF3) system from Postnova Analytics sets a new standard for high resolution separation and fractionation of nanoparticles.

CF2000 Centrifugal Field Flow FractionationBased on the CF3 principle, the Postnova CF2000 employs a centrifugal field as the driving force for separations. Particles affected by this field are separated by dynamic diffusion on the basis of both particle size and density. This unique feature of the CF2000 allows the separation of different particulate materials having the same particle size. Separations on the CF2000 can be further optimized by using different eluents...

 

  High Performance Separation of Particles & Molecules

Postnova Analytics, the leading international supplier of Field-Flow Fractionation (FFF) systems, has announced that it will be launching a series of exciting new products at the forthcoming Analytica 2016 in Munich, Germany.

PN3310 Viscometer DetectorVisitors to Analytica Hall 1 Booth 329 will be able to see the official launch of Postnova’s innovative, new Size Exclusion Chromatography (SEC) option, together with its new powerful NovaSEC software. The new Postnova SC2000 Modular SEC option offers unrivalled flexibility in Advanced SEC/GPC analysis. It is the first truly modular multi-detector SEC system available allowing flexible access to a wide range...

 

  Field Flow Fractionation of Proteins, Macromolecules and Nanoparticles

The Postnova AF2000 MultiFlow is a high performance Flow Field-Flow Fractionation (FFF) platform for separation of proteins, macromolecules and nanoparticles.

postnovaModular in design, the AF2000 MultiFlow incorporates the combined experience, expertise and technological advances from Postnova Analytics' nearly two decades of leadership in FFF. Incorporating a range of FFF modules in a single integrated system to provide universal separation, the AF2000 MultiFlow offers more flexibility, better performance and more robust results than any system before. The AF2000 MultiFlow platform is...

 

  Field Flow Fractionation of Proteins, Macromolecules and Nanoparticles

The Postnova AF2000 MultiFlow is a high performance Flow Field-Flow Fractionation (FFF) platform for separation of proteins, macromolecules and nanoparticles.

Postnova AF2000 MultiFlowModular in design, the AF2000 MultiFlow incorporates the combined experience, expertise and technological advances from Postnova Analytics' nearly two decades of leadership in FFF. Incorporating a range of FFF modules in a single integrated system to provide universal separation, the AF2000 MultiFlow offers more flexibility, better performance and more robust results than any system before. The AF2000 MultiFlow platform is...