Search News Archives
Follow us on
Conferences | Events

Media Partners

 

New Method for Characterising Liposome Formulated Drugs

publication date: Nov 2, 2018
 | 
author/source: Postnova Analytics GmbH

Centrifugal Field-Flow Fractionation (CF3)Postnova Analytics has published an application study that describes a new method for quantification of liposome encapsulated drug using Centrifugal Field-Flow Fractionation (CF3).

Nanoparticles including liposomes are increasingly used for delivery of drug molecules. During formulation of a liposome around a drug particle, a relatively large amount of free drug may remain unencapsulated and therefore not available for drug delivery via the liposomal carrier. For formulation groups adopting this drug delivery methodology it is important to quantify the amount of free versus encapsulated drug in a product in order to accurately determine the delivered dose of drug to a patient.

In this study, Centrifugal Field-Flow Fractionation coupled with UV-Vis detection was shown to be able to separate and quantify the amount of free drug in a liposome-drug product. The separation data was verified using optical microscopy. The authors conclude that Centrifugal Field-Flow Fractionation shows great promise for separation and quantification of drug particles, as the field of nanomedicine and liposomal drug delivery grows.

The Postnova CF2000 Series system is based on the CF3 principle using a centrifugal field as driving force for the separation. Particles effected by this field are separated by dynamic diffusion based upon both their size and density. This unique feature allows researchers to separate different particle materials having the same particle size. The separation can be further optimized by the use of different eluents and rotation speed programs. The CF2000 has shown great utility for the separation of complex nanoparticle samples in application areas including pharmaceuticals, environmental research, food, cosmetics and agrochemicals.


more from postnova analytics



If you have not logged into the website then please enter your details below.



 


Popular this Month

 

Win a PIPETBOY from the new Integra summer collection!

 

Great Savings off Selected GC Columns

 

CytoSMART raises 5.2 million Euros for further product innovation and growth

 

High Volume Sample Storage in Space Efficient 96-Well Format

 

Cherwell Publishes Guide on Sterility Testing

 

Effective Removal of DMSO from Stored Samples

 

ATL Webcast: A Practical Guide to Selecting the Right LIMS

 

Genetic study reveals how gut bacteria work to keep us healthy

 

Lonza Establishes Custom Cell Biology Services to Offer Unique Manufacturing and Testing Capabilities

 

Thermo Fisher Scientific Opens Food Safety Customer Solution Center in India

 

 


 

 


 

Can't find what you are looking for?

Search by company or by product


Company Name:

Product:


 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd