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All articles from Genevac Ltd

  Safe Evaporative Sample Preparation of High Potency APIs

EZ-2 centrifugal evaporatorGenevac, an SP Scientific brand, recently provided a leading pharmaceutical company with a glovebox-enclosed version of its EZ-2 centrifugal evaporator to safely remove solvents from cytotoxic drug preparations. Cytotoxic drugs are used widely in the treatment of cancers as well as other diseases. Antibody drug conjugates are a class of highly potent therapeutic drugs used for treating targeted cancerous tumors. These chemotherapeutic drugs can be 100...

 

  Benchtop Evaporator Aids Forensic Science

Benchtop Evaporator Aids Forensic ScienceGenevac’s EZ-2 Series centrifugal evaporator is being used by a growing number of forensic science labs as a preferred sample preparation tool for applications including drug and alcohol testing as well as toxicological screening. Forensic investigations often use the sensitivity and identifying power of Mass Spectrometry (MS), typically with solid phase extraction and evaporation as part of the sample preparation process. Blood and urine analysis are widely used for forensic...

 

  Intuitive Benchtop Centrifugal Evaporator

third generation EZ-2 Series centrifugal evaporatorThe third generation EZ-2 Series centrifugal evaporator from Genevac is the latest version of this popular evaporation system that combines great performance, ease of use, wide sample format compatibility and can be used with all commonly used solvents and acids. To enable all users to achieve excellent results every time, the EZ-2 has been made easier to use than a conventional rotary evaporator. In addition to accommodating many more samples, it can operate entirely unattended....

 

  Doubling the Speed of Microplate Sample Evaporation

Speed of Microplate Sample EvaporationGenevac has published data which shows how Heat Transfer Plates improve evaporation results when drying microplate samples, by improving the flow of heat to the product. A major factor in determining the speed of evaporation is the rate at which heat enters the sample. As well as the temperature of the heat lamps or thermal medium, the thermal conductivity of any materials in between must also be taken into consideration....

 

  Evaporative Sample Preparation Protocol Improves Natural Product Extraction

Genevac has published a technical article that describes how its Rocket™ Evaporator has been used by the Technical University of Munich (Germany) as a sample preparation tool for extraction of active phytochemicals from the leaves of Gymnema sylvestre. A Genevac Rocket Evaporator was chosen to dry the samples because of its high-volume sample capacity, unique technology that eliminates cross contamination due...

 

  Safe Evaporation Under Inert Atmosphere

HT-12Genevac announce HT Series 3 evaporators with Inert Gas Purge (IGP) option enable safe operation even when removing highly explosive solvents such as diethyl ether. To eliminate these risks, the IGP system purges the air from the HT Series 3 evaporator using an inert gas prior to commencing the evaporation process....

 

  Improving Clinical Pathology Sample Preparation Productivity

mivacGenevac reports on how Eurofins Biomnis has, using a miVac Quattro concentrator and SpeedTrap frost-free cold trap, considerably improved sample preparation productivity in its specialised clinical pathology laboratory....

 

  Removal of Solvents from Oil and Fat Samples

oil and nutsGenevac reports on special evaporative techniques for removal of solvents from oil and fat samples. Working with oils and fats can be difficult.  Whether extracting and recovering additives, evaluating lipid content of foods or characterising reclaimed cooking oils before reprocessing or conversion to biofuels, oils and fats can be difficult to dry. Extraction and separation techniques...

 

  Leading French Clinical Pathology Lab Improves Productivity

miVacGenevac reports on how Eurofins Biomnis (Lyon, France) has, using a miVac Quattro concentrator and SpeedTrap frost-free cold trap, considerably improved sample preparation productivity in its specialised clinical pathology laboratory. Sébastien Chanlon, Production Manager of the Eurofins Biomnis Analytical Chemistry Business Unit, commented “My department employs a wide range of...

 

  Reliable Sample Preparation for Neonatal Screening

baby footGenevac reports on how its hydrochloric acid (HCl) resistant EZ-2 evaporator offers significant benefits to clinical labs tasked with analysing plasma, blood or urine samples for neonatal disorders. In new born infants, tandem Liquid Chromatography Mass Spectrometry (LC/MS/MS) is a widely used analytical technique to identify metabolic neonatal disorders which include aminoacidemia’s, urea cycle disorders...

 

  Desktop Centrifugal Concentrator for Nucleic Acids

The miVac DNA centrifugal sample concentrator from Genevac is purpose designed to efficiently remove water and organic solvents from biological samples containing nucleic acids. The compact benchtop system includes a built-in high-performance vacuum pump, concentration chamber with electromagnetic drive for quiet, maintenance-free operation, and a fixed aluminium rotor for microcentrifuge tubes. To use your miVac DNA – simply position the system on your lab bench, connect the power lead and exhaust tube and then start benefiting from fast, trouble-free nucleic acid concentration....

 

  EZ Solvent Removal From Genevac

EZ-2 SeriesThe compact benchtop EZ-2 Series evaporator from Genevac has been designed to meet or exceed the solvent removal needs of most laboratory scientists.

Using the most advanced proven technology in evaporation science, the EZ-2 Series has been designed specifically for solvent removal in many areas of scientific research, whether concentration of samples or complete drying is required. For many applications an optimised EZ-2 evaporator is available to suit your solvent removal needs...

 

  Rapid Sample-Safe Evaporation of Large Solvent Volumes

Designed for laboratories tasked with handling larger sample volumes - Rocket™ evaporators from Genevac set the standard for productive, sample-safe operation.

Rocket evaporatorsRocket technology enables the rapid evaporation of larger volumes of solvent in parallel and without supervision.  The system controls the whole process, temperature, duration, prevention of bumping and foaming as well as stopping the method at a defined volume of concentrate .....

 

  Improve Your Sample Lyophilisation

Genevac announces that state-of-the-art condenser technology enables its HT Series 3 evaporator, using FastLyo™ methodology, to set a new benchmark for fast and efficient sample lyophilisation.

HT Series 3 evaporatorA series of technical and applications articles are available demonstrating this technological advance. When working with certain HPLC solvents, such as acetonitrile / water or methanol / water, a fully dried result can be hard to achieve due to interactions with the dissolved sample - resulting in the formation of a gum or oil....

 

  Single System Replaces Multiple Rotary Evaporators

Genevac reports that its Rocket Synergy centrifugal evaporator is being adopted by laboratories looking to replace multiple rotary evaporators, from benchtop to production capacity, saving them valuable bench space and improving productivity.

batch processingRocket Synergy evaporator controls are very easy to use - simply load your samples, select the correct method, press start and walk away. The evaporator is equipped with high performance features that prevent foaming, bumping and cross contamination.....

 

  Lab Tools for Concentrating Samples Safely & Quickly

Genevac Rocket Synergy, HT and EZ-2 series evaporators are designed to be very useful tools for lab scientists wishing to concentrate a sample safely and quickly.

HT and EZ-2 series evaporatorsGenevac has remained an industry leader by partnering with customers to understand the obstacles involved in using centrifugal evaporation/concentration systems. This partnership has led to the development of a range of innovations including Dri-Pure®, SampleGenie™...

 

  Sample Concentration Prior to Analysis

Genevac Rocket Synergy, HT and EZ-2 series evaporators are designed to be very useful tools for lab scientists wishing to concentrate a sample safely and quickly.

HT and EZ-2 series evaporatorsGenevac has remained an industry leader by partnering with customers to understand the obstacles involved in using centrifugal evaporation/concentration systems. This partnership has led to the development of a range of innovations including Dri-Pure®, SampleGenie™....

 

  Evaporative Sample Preparation for Mass Spectrometry

Genevac has established a new web page that brings together customer technical articles that illustrate how centrifugal evaporation has become a sample preparation technique of choice for laboratories that seek to analyse complex samples using hyphenated mass spectrometry [MS] techniques.

centrifugal evaporationMany laboratories still rely upon the use of a rotary evaporator to perform the evaporation part of their sample preparation protocol prior to LC-MS or GC-MS analysis. While rotary evaporator methods often give good recoveries, they can only handle a single sample, require continuous monitoring to control the process and to ensure that no foaming or bumping occurs....

 

  Genevac Reports on Determining Antibiotic Residues in Foodstuffs

Genevac has published a customer report that describes an evaporative sample preparation protocol for highly sensitive analytical methods used to test foodstuffs, principally meat, fish and shellfish, for the presence of antibiotics. 

Genevac EZ-2 evaporatorThe analytical method calls for good upstream sample preparation to eliminate the effects of the matrix, and can be manual and time consuming, particularly where evaporation is concerned. The authors describe how the installation of the Genevac EZ-2 evaporator in their laboratory is estimated to save the laboratory 2-3 hours per day....

 

  Determining Antibiotic Residues in Foodstuffs

Genevac has published a customer report that describes an evaporative sample preparation protocol for highly sensitive analytical methods used to test foodstuffs, principally meat, fish and shellfish, for the presence of antibiotics. 

Genevac evaporatorThe analytical method calls for good upstream sample preparation to eliminate the effects of the matrix, and can be manual and time consuming, particularly where evaporation is concerned. The authors describe how the installation of the Genevac EZ-2 evaporator in their laboratory is estimated to save the laboratory 2-3 hours per day that previously was spent on evaporation tasks...

 

  Short Videos Offer Informative Tips on Sample Evaporation

Genevac announces a major new online video resource for any lab tasked with removing solvent from its samples.

genevac new videoThe new Tips and Tricks series of short videos (www.youtube.com/user/spscientific/playlists), presented by Genevac applications specialists, highlights some of ways to get the best out of your evaporation system....

 

  Safe Evaporation of Solutions Containing Hydrochloric Acid

Genevac has published a technical paper that reviews a selection of organic synthesis / purification reactions widely used by chemists in the drug discovery process where hydrochloric acid (HCl) has to be removed post reaction. 

EZ-2In addition the paper discusses solutions to the problems which routine evaporation of concentrated HCl can create. When synthesising and purifying organic molecules, hydrochloric acid (HCl) can be a very useful reagent for instance for t-BOC deprotection of amines, preparing acid chlorides and re-salt formation....

 

  Sample Preparation Protocol Speeds Determination of Water Toxins

Genevac has published an informative customer article that reviews the development of a new sample preparation method using its EZ-2 centrifugal evaporator to help simplify and accelerate the detection and quantitation of algal toxins in surface water.

EZ-2-EliteDue to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have...

 

  Accelerating Sample Preparation for Determination of Water Toxins

Genevac has published an informative customer article that reviews the development of a new sample preparation method using its EZ-2 centrifugal evaporator to help simplify and accelerate the detection and quantitation of algal toxins in surface water.

 EZ-2 centrifugal evaporatorDue to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have been able to...

 

  Genevac Updates Biological Sample Concentrator Range

Genevac announces the second generation version of its popular miVac centrifugal sample concentrator range that features a sleek new look.

MiVacIncorporating an improved pressure controller with intuitive programming and graphical display - miVac concentrators are now even easier to use.  Featuring solid aluminium JetRotors - second generation miVac concentrators offer unmatched speed of evaporation in an affordable entry level system....

 

  Low Temperature Condenser Enhances Evaporation & Lyophilisation Results

Benefiting from a state-of-the-art -75°C condenser - the Series 3 HT Evaporator from Genevac sets a new benchmark for enhanced evaporation and lyophilisation results.

the Series 3 HT EvaporatorDrying HPLC purification fractions, such as water and acetonitrile, is a routine yet essential task in many pharmaceutical laboratories.  Typically labs require HPLC fractions to be dried to a powder form, such that samples can be accurately weighed, easily sub-sampled and re-dissolved.  To provide a rapid, high-throughput alternative to freeze drying of such samples...

 

  Safeguarding Samples from Potential Thermal Degradation

Genevac, market leader in solvent removal, has announced the latest version of its proprietary autostop when dry control software which allows it’s EZ-2, Rocket and HT-Series evaporators to automatically detect when the samples are dry and then shut it down - safeguarding valuable samples from potential thermal degradation. 

EZ-2 Rocket and HT-Series evaporatorsCombined with Genevac's continuous running condensers, autostop when dry control software allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs. Until the introduction of autostop when dry control software - evaporators users had to constantly monitor or estimate the drying time for a given sample....

 

  Benchtop Concentrator Enhances Forensic Sample Preparation

Genevac report on a paper by UK researchers describing use of its miVac DNA concentrator to provide reliable and efficient sample preparation in the development of a novel forensic method to detect diclofenac residues in vultures and livestock animals.

miVac DNADiclofenac is a non-steroidal anti-inflammatory drug that is extensively used to treat pain and reduce inflammation in humans and animals.  Traditionally, livestock carcasses on the Indian subcontinent and in Africa have been left out by the millions for scavengers, particularly vultures, to consume....

 

  Eliminating Solvent Bumping & Foaming during Evaporation

Genevac reports that its proprietary Dri-Pure® technology, available as standard on Series 3 HT, EZ-2 and Rocket Synergy evaporators, enables scientists to rapidly dry their samples without foaming, cross-contamination or loss of sample due to solvent bumping.

Series 3 HTThe unique Dri-Pure® technology works by reducing pressure in the evaporation chamber in combination with an increase in rotor speed to achieve greater g-force and carefully controlling heat flow to the sample during the pressure ramping stage. Embedded in the Genevac evaporator software and hardware, Dri-Pure works automatically...

 

  Flexible Evaporator Enhances Chiral Separation

The Genevac Rocket™ Synergy Evaporator is a powerful tool proven to accelerate traditionally difficult and time consuming chiral separation protocols.

Genevac Rocket Synergy EvaporatorIn recent years there has also been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their growing importance in the natural products, biotechnology and pharmaceutical industries.  In these preparative syntheses the chiral analytes of interest are typically separated in large volumes of solvent....

 

  Online Video Demonstration of High Throughput Evaporator

A new online video has been prepared by Genevac to provide scientists with an informative demonstration of the high throughput sample drying capabilities and intuitive operation of its Series 3 HT Evaporator range.

Series 3 HT evaporator rangeThe Series 3 HT evaporator range represents the ultimate in solvent removal technology. Incorporating high performance vacuum pump, the latest touchscreen technology and a sleek ergonomic design, a Series 3 HT evaporator makes optimising your evaporation processes effortless. Available in 6- and 12-sample holder configurations, Series 3 HT evaporators are the system of choice for high throughput...

 

  Genevac Launches New Website

A new website has been launched by Genevac that provides easily navigable access to the company’s comprehensive portfolio of evaporators and concentrators to suit almost any solvent removal application, purchasing budget or productivity requirement.

genevac new websiteLocated at www.spscientific.com/genevac - the new site offers visitors ready access to an extensive searchable library of articles, technical papers, application notes and videos in the Evaporation Insights Learning Center. Alison Wake, Genevac Product & Marketing Manager commented “We have adopted the learning center concept developed by our parent company SP Scientific who have found this information...

 

  Evaporation Insights Learning Center

Genevac announces the launch of a new website that provides easily navigable access to the company’s comprehensive portfolio of evaporators and concentrators to suit almost any solvent removal application, purchasing budget or productivity requirement.

Genevac new websiteLocated at www.spscientific.com/genevac - the new site offers visitors ready access to an extensive searchable library of articles, technical papers, application notes and videos in the Evaporation Insights Learning Center. Alison Wake, Genevac Product & Marketing Manager commented “We have adopted the learning center concept developed by our parent company SP Scientific who have found this information...

 

  Versatile Centrifugal Evaporator for Contract Research Organisations

The EZ-2 Elite centrifugal evaporator from Genevac,an evaporator of choice for large Pharma R&D, uniquely combines high performance, versatility, ease-of-use and affordability making it the perfect workhorse system for Contract Research Organisations (CRO's).

EZ-2 Elite centrifugal evaporator from GenevacThe EZ-2 Elite is designed to efficiently concentrate or completely dry samples. It is compatible with a wide selection of sample holders, enabling evaporation from common sample container formats including round-bottom flasks, tubes vials and microplates. SampleGenie™ technology combined with a FastLyo programme on the EZ-2 Elite allows HPLC fractions to be concentrated and freeze dried directly into a submission vial. This innovation...

 

  Genevac Reveals Flexible Solution for High Throughput Evaporation

Series 3 HT evaporators from Genevac provide an ideal solution for evaporation bottlenecks in high throughput medicinal chemistry, natural product and production laboratories that generate large numbers of samples for processing.

Series 3 HT evaporators from GenevacCompact in design and offering a very high capacity for a wide range of sample formats including microplates, vials, and fraction collection tubes, Series 3 HT evaporators offer the versatility and productivity to assist chemists tasked with drying large numbers of samples. The high-throughput design of a Series 3 HT evaporator allows up to 48 shallow-well microplates to be dried down at the same time, while capacity for standard 16 x 100mm fraction collector tubes is...

 

  Fast Unattended Concentration of Environmental Samples

The Rocket Synergy Evaporator from Genevac is proven to provide fast, unattended operation that significantly improves environmental laboratory productivity.

The Rocket Synergy Evaporator Developed as a result of users’ demands for an evaporator that could quickly process large-volume environmental samples in parallel without supervision, the Rocket Synergy Evaporator can concentrate or dry 18 ASE tubes or up to 6 large-volume 450 ml flasks. This enables the user to focus on other tasks, confident that the Rocket Synergy Evaporator will achieve reproducible evaporation with excellent recovery rates. In addition using Genevac’s proprietary SampleGenie™ technology in...

 

  Tools for Post Purification Sample Handling

Genevac, specialists in solvent removal, have developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.

Genevac centrifugal evaporatorFor labs undertaking purification using Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents can be simply, productively and safely carried out in a Genevac centrifugal evaporator (EZ-2, ROCKET, Rocket Synergy or HT Series III).  Where the nature of the sample being concentrated can lead to solvent bumping (e.g. natural products) - Genevac's DriPure® technology is proven to completely eliminate this troublesome and...

 

  Post Purification Sample Handling

Genevac, specialists in solvent removal, have developed a suite of proprietary technological solutions to facilitate post purification sample handling, including reformatting.

post purification sample handling For labs undertaking purification using Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents can be simply, productively and safely carried out in a Genevac centrifugal evaporator (EZ-2, ROCKET, Rocket Synergy or HT Series III).  Where the nature of the sample being concentrated can lead to solvent bumping (e.g. natural products) - Genevac's DriPure® technology is proven to completely eliminate this troublesome and...

 

  Poster Details Applications of Evaporative Crystallisation Technology

A new technical poster produced by Genevac, in conjunction with the Novartis Institute for BioMedical Research (Horsham, UK), examines the application of eXalt™ evaporative crystallisation technology to drug discovery projects.

genevaceXalt™ is a proprietary Genevac technology designed to control evaporation using restricting baffles. Using this technology multiple solvents can be screened in parallel to identify optimum crystallisation conditions for amorphous materials. In the pharmaceutical industry, physical form can pose a significant challenge for small molecule drug discovery projects transitioning between the optimisation and characterisation phases. A crystalline form...

 

  Drug Discovery Benefits from Evaporative Crystallisation Technology

A new technical poster produced by Genevac, in conjunction with the Novartis Institute for BioMedical Research (Horsham, UK), examines the application of eXalt™ evaporative crystallisation technology to drug discovery projects.

crystaleXalt™ is a proprietary Genevac technology designed to control evaporation using restricting baffles. Using this technology multiple solvents can be screened in parallel to identify optimum crystallisation conditions for amorphous materials. In the pharmaceutical industry, physical form can pose a significant challenge for small molecule drug discovery projects transitioning between the optimisation and characterisation phases. A crystalline form is desirable...

 

  Multi User Evaporator System for University Labs

Designed to concentrate or completely dry samples the EZ-2 from Genevac is the evaporator of choice for hundreds of academic groups in chemistry, pharmacology, biology, natural product and environmental science departments worldwide.

genevacBenefiting from a suite of pre-programmed methods the EZ-2 evaporator has proven highly popular in multi-user environments. Running the EZ-2 evaporator is highly intuitive.  Just load your samples, select maximum safe temperature for samples, select solvent type and hit start.  Offering true unattended operation capability the EZ-2 requires no user training, even a beginner can competently use the system within 5 minutes. Durably constructed and...

 

  Evaporator System for Academic Multi-User Environments

Designed to concentrate or completely dry samples the EZ-2 from Genevac is the evaporator of choice for hundreds of academic groups in chemistry, pharmacology, biology, natural product and environmental science departments worldwide.

EZ-2 from GenevacBenefiting from a suite of pre-programmed methods the EZ-2 evaporator has proven highly popular in multi-user environments. Running the EZ-2 evaporator is highly intuitive.  Just load your samples, select maximum safe temperature for samples, select solvent type and hit start.  Offering true unattended operation capability the EZ-2 requires no user training, even a beginner can competently use the system within 5 minutes. Durably constructed and...

 

  Compact Combination Freeze Dryer / Vacuum Concentrator

Genevac has announced that its popular miVac SpeedTrap cold trap can now be used for freeze drying or configured as a combined concentration / freeze drying workstation with a miVac vacuum concentrator.

 miVac SpeedTrapUtilising the updated miVac SpeedTrap with continuous chill mode in conjunction with the miVac Super Vacuum pump, up to 250ml of water, or other solvents such as 1,4- dioxane, may be freeze dried in a single operation. Samples to be dried are simply placed in the rotor of the miVac concentrator and dried at full vacuum. The vacuum boils the samples at below their freezing point, therefore the samples freeze and the ice sublimes away, leaving the sample as a dry powder. To reduce drying times a...

 

  Touchscreen Evaporator Simplifies Solvent Removal

The all new Series 3 HT evaporator range from Genevac represents the ultimate in solvent removal technology.

genevacpr248Incorporating new high performance vacuum pump, the latest touchscreen technology and a sleek ergonomic design makes optimising your evaporation processes effortless. New intuitive touchscreen controls enhances monitoring and review of the whole evaporation process. For popular solvent removal protocols pre-set 'Press & Go' methods makes operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex...

 

  Touchscreen Evaporator Makes Solvent Removal Effortless

The all new Series 3 HT evaporator range from Genevac represents the ultimate in solvent removal technology.

HT-12Incorporating new high performance vacuum pump, the latest touchscreen technology and a sleek ergonomic design makes optimising your evaporation processes effortless. New intuitive touchscreen controls enhances monitoring and review of the whole evaporation process. For popular solvent removal protocols pre-set 'Press & Go' methods makes operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex...

 

  Rapid Evaporation Solutions for Natural Product Extraction

Genevac reports on how their Rocket Synergy automated evaporator systems are replacing rotary evaporators as the tool of choice for rapid and sample-safe evaporation of natural product extracts.

Rocket Synergy evaporatorWorking with natural products to derive potential pharmaceutical drug candidates or to identify new flavours and fragrances has a reputation of being very difficult.  Sample collection, preparation, extraction, and drying are extremely labour intensive and not easily reproducible from a process standpoint.  The traditional bottleneck in the natural product pipeline has been the drying of solvent extracted samples. Historically natural product researchers have used rotary...

 

  Evaporative Sample Preparation for Metabolism and Toxicology Studies

Genevac has launched a web page that brings together the latest technological innovations and application advances, with links to reference papers, detailing how new fast, safe evaporative sample preparation techniques are benefiting metabolism and toxicology studies.

genevac evaporatorsVisitors to the new web page can gain an insight into how Genevac evaporators are providing fast, safe sample preparation, free from artefact, contamination or loss, from simple concentration or drying of solvent extracts from tissue samples right through to quantitative screening of workers or athletes for the presence of a drug...

 

 

  Direct Concentration of Large Sample Volumes into Vials

SampleGenie 4 is the latest version of Genevac’s unique technology for direct concentration of large sample volumes into vials, designed for use in the Rocket Synergy Evaporator.

genevac imageSampleGenie technology enables large sample volumes to be dried directly into vials, eliminating a number of time-consuming sample handling steps and the attendant risk of errors. The latest generation SampleGenie further enhances the exceptional capabilities of the original design. Accommodating sample volumes of up to 250ml, and featuring a new vial adapter insert to suit a range of vials from 12mm to 28mm diameter and up to...

 

  Versatile Evaporator for Drug Discovery

The HT-4X evaporator from Genevac has been specifically designed for drug discovery laboratories, from medicinal chemistry through to purification and metabolism studies. 

evaporatorBuilt to the highest specifications the HT-4X makes demanding applications routine. Corrosive vapours such as trifluoroacetic acid can be routinely removed by the standard system and optional facility is provided for fast sample lyophilisation. An innovative built-in dual chamber refrigerated condenser accelerates speed of evaporation, even for high boiling point solvents such as DMSO. In addition, efficient chamber cooling between runs protects thermally...

 

  High Vacuum Benchtop Solvent Evaporator

The EZ-2 Elite Centrifugal Evaporator from Genevac has been designed to provide unmatched final drying of stubborn samples and fast lyophilisation of HPLC fractions

genevacBenefiting from a high performance scroll pump, that delivers deep vacuum, the EZ-2 Elite is able to  routinely remove even very high boiling solvents such as DMSO and NMP. In addition internal heating of vapour duct and system components ensures that such challenging solvents only collect in the SpeedTrap™ condensor, and not anywhere else. The SpeedTrap condenser on the EZ-2 Elite comes the benefit of automatic defrost and drain technology.  The EZ-2 controls the SpeedTrap and...

 

  Odour Free Evaporation on Your Lab Bench

Genevac announces a proprietary “odour reduction” function for its EZ-2 evaporator which enables it to be sited on the open bench rather than taking up valuable fume hood space.

genevacMany solvent evaporators are routinely sited inside fume extraction hoods because residual solvent vapour, remaining in the chamber at the end of a run, can expose the operator to potentially harmful odours when the system is opened. The EZ-2’s Reduce Odour function automatically adds a repeated vent and vacuum cycle to the end of a method, which purges the evaporation chamber of residual solvent vapours...

 

  Genevac Consolidate Evaporator & Freeze Dryer Sales Channels in the UK

genevac
Genevac, part of SP Scientific, has appointed BioPharma Process Systems (BPS) as exclusive UK distributor for its range of evaporator systems.

Biopharma Process System have successfully distributed SP Scientific's Virtis and FTS freeze drying products for over 20 years. Ian Bailey, who has been Genevac Senior Sales Executive in the UK for over 10 years, will be transferring to BPS, taking his many years’ experience with him to his new role. Alison Wake, Marketing Manager for Genevac commented "This move will consolidate our sales channels within the UK with one experienced and successful distributor whilst maintaining the personalised product support you have come to expect from Genevac...

 

  Productive Hands Free Evaporation

For laboratories tired of having to constantly attend to multiple rotary evaporators, the  Rocket™ Evaporator from Genevac sets the benchmark for productivity and ease-of-use.

genevacprProven in hundreds of installations worldwide, the Rocket Evaporator provides truly unattended operation capability. Requiring no training even a beginner can competently use the system in less than 5 minutes.  Simply load your flasks, highlight the desired evaporation method, and press start. Inbuilt monitoring and Automatic End of Run means users are able to focus on other tasks confident that they will achieve perfect, reproducible results every time...

 

  Safe Efficient Concentration of Biological Samples

The miVac DNA is a compact concentrator from Genevac capable of safely and efficiently removing water and organic solvents from biological samples in a variety of formats including tubes, microplates and vials.

genevac

The miVac DNA system is very simple to use.  The “select & set” single control knob control enables even new users to obtain excellent results first time and every time. To improve performance there are built-in stored methods for concentration of water and water / alcohol based samples, which optimise concentration time.

 

  Safe Efficient Concentration of Biological Samples

The miVac DNA is a compact concentrator from Genevac capable of safely and efficiently removing water and organic solvents from biological samples in a variety of formats including tubes, microplates and vials.

Safe Efficient Concentration of Biological SamplesThe miVac DNA system is very simple to use.  The “select & set” single control knob control enables even new users to obtain excellent results first time and every time. To improve performance there are built-in stored methods for concentration of water and water / alcohol based samples, which optimise concentration time. The miVac DNA offers digital control of concentrator temperature and short concentration times, minimising the risk of heat damage to your samples....

 

  Drying DNA and Oligonucleotide Samples

Genevac reports on a protocol that describes a rapid, safe technique for drying oligonucleotide and DNA samples.

EZ-2 Evaporation Series

DNA and oligonucleotide samples are sensitive and care needs to be exercised during concentration. Research done at the Welcome Trust Centre for Human Genetics (UK) shows that the Genevac EZ-2 evaporator is an ideal tool for concentrating SNP and oligonucleotides in microplates when preparing samples for microarraying and for Sequenon analysis. Compared to traditional methods, using the EZ-2 evaporator is shown to significantly speed up concentration rates, eliminate potential sources of damage to samples and also improve final sample quality...

 

  Enhanced Crystallisation Control Improves Polymorph Screening

Genevac announces eXalt - an exciting new non-destructive evaporation technology developed with partners in the field of pharmaceutical small molecule crystallisation.

Enhanced Crystallisation Control Improves Polymorph Screening

eXalt has found application in labs that perform tasks including first time crystallisation of amorphous forms, recrystallisation of samples which have only a few known forms, removing a hydrate, solvent screening studies to find the most suitable conditions to take forward in development, high throughput co-crystallisation screens and studies to confirm stable isoforms. eXalt enables a wide range of solvents and multiple actives to be evaporated all at the same slow rate, and under the same conditions, giving the user unprecedented control of the crystallisation process...

 

  A Rapid Safe Technique for Drying DNA and Oligonucleotide Samples

A technical article is available from Genevac that describes a rapid, safe technique for drying oligonucleotide and DNA samples.

EZ-2 Evaporation Series

DNA and oligonucleotide samples are sensitive and care needs to be exercised during concentration. Research done at the Welcome Trust Centre for Human Genetics (UK) shows that the Genevac EZ-2 evaporator is an ideal tool for concentrating SNP and oligonucleotides in microplates when preparing samples for microarraying and for Sequenon analysis. Compared to traditional methods, using the EZ-2 evaporator is shown to significantly speed up concentration rates, eliminate potential sources of damage to samples and also improve final sample quality...

 

  Powerful Evaporator for Drug Discovery

The HT-4X centrifugal evaporator from Genevac provides optimised sample preparation capabilities for scientists working in the drug discovery environment. 

HT-4X centrifugal evaporator

Built to the highest specifications, the HT-4X makes demanding applications routine.  Corrosive vapours such as trifluoroacetic acid may be removed by the standard system and an inert purge option allows high safety evaporation of flammable solvents. In addition, the HT-4X can also be used to achieve high speed lyophilisation of HPLC fractions and solvents used for reformatting samples. The HT-4X is a high performance evaporator that combines ease of use, compactness, operational versatility and efficient sample processing...

 

  Protocol for Preparing Top Quality Lyophilised Samples

Genevac has developed a protocol using its SuperCool 75 condenser

Protocol for Preparing Top Quality Lyophilised SamplesGenevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...

 

  Avoiding Sample Loss During Evaporative Drying

Dri-Pure® technology from Genevac offers significant benefits to scientists, especially those working in synthesis and purification. 

Avoiding Sample Loss During Evaporative DryingThis innovative technology enables scientists to rapidly dry their samples without cross-contamination or loss of sample due to solvent bumping. Other methods of solvent removal tend to be very laborious or lead to unacceptable cross-contamination, Dri-Pure® running on a Genevac evaporator gives smooth, controlled solvent removal in optimum time. The patented Dri-Pure® technology is available for all current models of Genevac centrifugal evaporators, from the affordable EZ-2 through to the production-scale HT-24...

 

  Rocket 4D Receives Positive Customer Commentary

Genevac has reported very positive feedback from early adopters of their Rocket 4D – a fully automated system for automatic drying or concentration of very large volumes up to 100 litres.

Rocket 4D

Launched worldwide during the summer of 2013 – Genevac has received considerable interest, from laboratories drawn by the ease of use, automated productivity and performance of the Rocket 4D. A chemistry scale-up laboratory at a major Pharma company, running kilo scale preparative SFC, were drawn by the unattended automation offered by the Rocket 4D...

 

  Faster Drying of Deep Well Microplates

Genevac’s new generation heat transfer plates for centrifugal evaporators enable almost any deep well plate to be dried up to 50% faster than previously possible.

Heat transfer plate

Evaporation from microplates, especially deep well plates, can be extremely slow. The design of deep well plates makes it particularly difficult for an evaporator system to transfer enough heat for rapid drying, especially with higher boiling point solvents such as water or DMSO. In addition, often the wells in deep-well plates are supported above the level of the skirt and need support to prevent the plate from deforming in a centrifugal evaporator...

 

  Fully Automated Drying or Concentration of Very Large Volumes

Genevac has announced the launch of the ROCKET 4D – a fully automated system for automatic drying or concentration of very large volumes (a few to 100 litres) in one operation with no user interaction.

Rocket 4DCompact in size the ROCKET 4D allows you to dry or concentrate your samples with complete confidence as it uses proprietary vacuum technology to suppress solvent bumping and foaming – problems associated with sample loss when using large scale rotary evaporators. Rocket 4D comes as standard with a single, 5 litre 316 stainless steel vessel for drying or concentrating product. This has detachable handles and is easily lifted into and out of the evaporator. Access to the dried or concentrated product in the vessel is very easy...

 

  Routine Generation of Powder Samples from HPLC Fractions

Genevac reports that its HT Series II  Evaporator using the Fast Lyophilisation, or LyoSpeed™ process is enabling a growing number of pharmaceutical labs to routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved.

Genevac HT Series II EvaporatorWhen working with certain HPLC solvents, such as water and acetonitrile, a fully dried result can be hard to achieve due to interactions with the dissolved sample - resulting in the formation of a gum or oil. To provide a rapid, high-throughput alternative to freeze drying HPLC purification fractions - Genevac developed its proprietary fast lyophilisation (LyoSpeed™) methodology for use on the HT Series II Evaporators. While LyoSpeed™ works well for most hydrophilic samples, difficulties may arise where the sample cannot dissolve in only water...

 

  Automated Direct-to-Vial Concentration System

A series of technical papers are available from Genevac that demonstrate the advantages and benefits that their proprietary SampleGenie technology offers to chemical, environmental and food labs tasked with pooling and concentrating GC and HPLC  fractions.

SampleGenie TechnologyTraditional protocols for concentration of GC or HPLC fractions has involved drying multiple fractions in an evaporator, re-suspending pooled fractions into a single vial and then re-drying before storage and analysis.  Even with modern centrifugal evaporators such processes typically take 2-3 days to complete. The development of SampleGenie™ technology enables samples in Genevac evaporators to be concentrated, without loss of volatile components, directly into a single GC or HPLC vial eliminating the need for reformatting of samples after drying...

 

  Accelerating Isolation of Oils, Fuels and Fats from Natural Sources

Genevac, world leaders in solvent removal technology, has over 20 year’s experience of supplying evaporators for removal of solvents from oil, fat and fuel samples.

Genevac EZ-2 and Rocket EvaporatorOils, fats and fuels are normally isolated from natural sources using extraction or separation techniques that present the final sample in a solution of organic solvent. Before analysis such samples must be dried or concentrated. Whether extracting and recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing / conversion to biofuels, or investigating drillling test samples - oils, fuels and fats can often prove difficult to dry without using very high temperatures which may lead to loss of the more volatile fractions within the sample....

 

  Safe Evaporation of Acids and Organic Solvents

Genevac evaporators are robust systems designed to be resistant to the most common solvents and acids used within the chemistry laboratory, including Trifluoroacetic Acid (TFA), Dichloromethane (DCM), and Dimethyl Sulphoxide (DMSO)

genevacHowever a wide range of applications in the Pharmaceutical, Speciality / Fine Chemical, Petrochemical, Cosmetic, Electronic and Nuclear industries use acid chlorides and stronger mineral acids for routine synthesis and experimentation. For laboratories that wish to use stronger mineral acids and acid chlorides, special models of Genevac systems exist which are specifically designed to be resistant to these highly corrosive acids including acid resistant versions of Genevac's HT-4X, HT-12 and EZ-2 evaporators...

 

  Accelerating Isolation of Novel Flavour Ingredients from Nature

A technical article from Genevac is available that details how its HT-24 centrifugal evaporation system is assisting a commercial flavours and fragrance company in its quest to find and isolate novel flavour ingredients from nature

Genevac HT-24 Evaporator Natural product derived discovery of novel flavour molecules is a highly complex process. Natural product sources yield complex extracts containing many components, which often do not lend themselves to processing and analysis. Conventionally, many steps of fractionation and evaluation are necessary until a compound is obtained from natural sources at the purity required for structural analysis. In the article a state of the art fractionation process using a Sepbox® Preparative HPLC - SPE system* and a Genevac® HT-24 centrifugal evaporator is described.

 

  Robust Evaporators for Parallel Chemistry Genevac, world leaders in solvent removal technology, has over 20 year's experience of designing and supplying robust evaporators that can withstand the rigors of working in a chemical laboratory environment. 

Robust Evaporators for Parallel ChemistryWhether working in drug discovery, flavour or fragrance research, organic LED synthesis or academic research, Genevac systems are the ideal tool when faced with evaporating multiples samples in parallel. Genevac evaporators are proven in a wide range of parallel chemistry applications including removal of reaction solvents between stages of a multi-step synthesis and removal of strong acids of bases when changing salt forms...

 

  SMART Technology Accelerates Determination of Freeze Drying Product Resistance SP Scientific has written a new technical article that describes research undertaken to understand the impact of controlled nucleation temperature on freeze drying product resistance.

SMART™ Freeze Dryer technology The researchers demonstrate how SMARTTM Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments. SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles...

 

  Pilot Plant & Production Scale Freeze Drying & Lyophilisation Genevac, an SP Scientific group company, has announced that it will display its latest solutions for freeze drying, lyophilisation and evaporation at ACHEMA 2012

Advantage Plus benchtop freeze dryerVisitors to Hall 4.1, Booth N69 will have the chance to see the latest version of of the market-leading Advantage Plus benchtop freeze dryer. The Advantage Plus is a versatile system that can freeze dry bulk product or be configured for applications in stoppered vials...

 

  Optimised Evaporators for Environmental Analysis Evaporators for Environmental AnalysisGenevac, world leaders in solvent removal technologies, offers a range of evaporator systems optimised for environmental analysis. Monitoring of the environment for substances potentially harmful to health is a core activity not just for government departments but for many organisations who wish to ensure that they are not harming their staff or the environment.  Samples of air, water, soil or plant matter are routinely monitored for the presence of potentially harmful substances such as pesticides and polyaromatic hydrocarbons...

 

  DNA Sample Concentrator miVac DNA from GenevacThe miVac DNA from Genevac is designed to safely and quickly evaporate solvents from sensitive DNA, RNA and other biological samples. Delivering best-of-class performance in all aspects the miVac DNA provides scientists everything they need to safely and swiftly concentrate or dry their samples in a compact, easy-to-use benchtop unit...

 

  Evaporation without Solvent Bumping Dri-PureAvailable for use with Genevac evaporators - Dri-Pure® technology enables scientists to rapidly dry their samples without cross-contamination or loss of sample due to solvent bumping. Dri-Pure® offers significant benefits to scientists, especially those working in synthesis and purification.  Other methods of solvent removal tend to be...

 

  Sports Drug Testing Lab Accelerates Sample Preparation miVac Duo sample concentratorGenevac has announced an applications report that details how its miVac Duo sample concentrator has been used by a leading testing laboratory to develop a new sample preparation method to help curb sports doping. Recent developments in applying mass spectrometry to proteomics means that it is becoming feasible for doping laboratories to routinely detect and confirm the abuse of peptide hormones by sportsmen and women. Using mass spectrometry to detect and confirm the abuse of peptide hormones is preferred to the use of immunoassay techniques as the methodology is able to...

 

  State-of-the-Art Condenser Enhances Lyophilisation Results SuperCool 75Genevac announces the new SuperCool 75 - a state-of-the-art condenser that in conjunction with its HT-12 High Throughput Evaporator has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. Drying HPLC purification fractions, principally comprising water and acetonitrile, is a routine yet essential task in many pharmaceutical laboratories. The requirement is to dry the samples to a powder form...

 

  Compact, High Efficiency Cold Trap & Freeze Dryer Genevac its miVac SpeedTrap™ frost-free cold trap Genevac has announced a new version of its miVac SpeedTrapTM frost-free cold trap that not only provides unmatched volatile solvent recovery but now also enables freeze drying of up to 250ml of aqueous samples. The new generation SpeedTrap is suitable for use with a wide range of solvents, from volatile organic solvents through to water and even higher boiling point solvents including 1,4-dioxane, tertiary butanol, and cyclohexane.

 

  Improving chiral separation and natural product sample preparation The Genevac Rocket™ Evaporator The Genevac Rocket Evaporator is a powerful tool proven to accelerate traditionally difficult and time consuming chiral separation and natural product sample preparation tasks. The Genevac Rocket Evaporator is widely used by researchers seeking to extract functional molecules from natural sources. Typically investigations involve a primary solvent extraction of natural products that result in a large volume of crude extract...

 

  Improving Accelerated Solvent Extraction (ASE) Workflow Genevac has launched the Flip-Flop™ systemGenevac has launched the Flip-FlopTM system to improve post Accelerated Solvent Extraction (ASE®) concentration and preparation of samples. Using the special double-ended Flip-FlopTM tube - samples can be collected directly from a Dionex ASE® system. A SampleGenieTM adaptor with GC vial is then fitted. The tube is flipped over and placed into the Puck sample holder in a Genevac Rocket Evaporator and the cap removed. The samples are then concentrated directly into a GC autosampler vial...

 

  Genevac and Dionex sign worldwide distribution agreement Genevac RocketGenevac Ltd (Ipswich, UK), the solvent evaporation business of SP Industries Inc (Warminster, PA) has entered into an OEM agreement with ion chromatography (IC) specialist Dionex Corp (Sunnyvale, CA), which sees the Genevac RocketTM high speed evaporator being sold as part of Dionex accelerated solvent extraction (ASE®) instruments...

 

  Online Resource for Food & Beverage Sample Preparation Genevac LtdGenevac has announced a new web page (www.genevac.com/food) that brings together the latest technological innovations, applications advances and references for evaporation and sample concentration techniques relating to food and beverage analysis...

 

  New Benchtop Evaporator Removes Even Highest Boiling Point Solvents EZ-2 Elite Genevac has launched the EZ-2 Elite - a new addition to its popular EZ-2 evaporator range. The EZ-2 Elite is designed to remove high boiling point solvents and deliver enhanced solvent recovery thereby improving final drying of stubborn samples and enabling fast lyophilisation of HPLC fractions.

 

  Optimising, Adjusting & Controlling Evaporation Methods Optimising, Adjusting & Controlling Evaporation MethodsGenevac has announced the availability of the Winter 2010 edition of its informative technical eNewsletter. Accessible as a pdf download, the main feature of the new issue focuses upon how to optimise, adjust and control methods on modern centrifugal evaporators. Also in this edition the phenomenon known as "cryopumping" (where a condenser removes vapour from the evaporator chamber to maintain the vacuum level, thereby enabling more vapour to be removed) is discussed.

 

  Natural Product Sample Preparation Web Page Natural Product Sample Preparation Web PageGenevac has announced a new web page that brings together the latest technological innovations, applications advances and references for evaporation and sample concentration techniques relating to natural products research.

 

  Powerful High Throughput Evaporation System Genevac HT-4X centrifugal evaporation system The Genevac HT-4X centrifugal evaporation system provides the ideal solution for overcoming evaporation bottlenecks in high throughput and production laboratories. Built to the highest specifications - the HT-4X makes demanding applications routine

 

  Webpage for Evaporators, Concentrators, Freeze Dryers & Lyophilisation Systems Genevac Ltd, world leader in solvent removal technologies, has announced the launch of a dedicated new web page providing downloads of technical brochures describing the company's market leading range of products.

 

  Freeze-Dried Parenterals - Quality by Design SP Scientific, a world leader in freeze drying technology, has announced a new LyoLearn webinar that will discuss the essential elements of quality by design in formulation and process development of freeze-dried parenterals.

 

  High Capacity Biological Sample Concentrator For laboratories looking to concentrate larger numbers of biological samples presented in a range of different formats the miVac Quattro from Genevac is the perfect high capacity sample concentrator.

 

  Sample Concentration Techniques Benefit Food & Beverage Labs Genevac has announced increased use of its EZ-2 and ROCKET evaporator systems by food and beverage laboratories for applications including quality testing of beverages, pesticide analysis in fruit and vegetables and determining vitamin levels in cereals.

 

  ADME-Tox Studies Benefit from Advances in Evaporative Sample Preparation A new web page from Genevac brings together the latest technological innovations, applications advances and links to references that details how new fast, safe evaporative sample preparation techniques are benefiting metabolism and toxicology studies.

 

  Evaporative Sample Preparation for Clinical & Diagnostic Testing Genevac has announced a new online resource that brings together the latest technological innovations, applications advances and links to references that detail the current scope of evaporative sample preparation techniques as used in clinical and diagnostic testing.

 

  Video Demonstrates Evaporator Versatility & Ease of Use Genevac, world leader in evaporation and freeze drying technologies, has announced a new online video demonstrating the ease of use and market-leading operational versatility offered by its RocketTM Evaporator.

 

  Concentrating Environmental Samples Prior to Analysis For environmental laboratories it is of great benefit to concentrate samples prior to analysis to help accurately determine levels of analyte in a given sample.

 

  SP Scientific Expands German Distribution Network SP Scientific Inc. has announced an expansion in its network of specialist distributors serving the German market. The new structure will provide enhanced levels of top quality sales, service and applications support for its Genevac evaporator and concentrator products as well as FTS and Virtis freeze dryer product ranges.

 

  Optimised Systems for Concentration or Removal of Solvents Genevac Ltd, world leader in solvent removal technologies, has chosen Analytica 2010 in Munich, Germany to launch new capabilities for its ROCKET Evaporator and to display SP Industries high productivity AdVantage Plus Freeze Drying system.

 

  How To Concentrate Or Dry Samples For laboratories tasked with concentrating or drying samples in wide ranging sample formats - Genevac has presents a new online movie that demonstrates the ease of use and excellent consistent results achievable using its EZ-2 Personal Solvent Evaporator.

 

  Efficient pre-concentration of protein solutions For laboratories looking to pre-concentrate protein solutions prior to separation (size exclusion chromatography, electrophoresis) or analysis (x-ray crystallography) the miVac sample concentrator from Genevac provides a highly efficient, cost effective alternative to traditional membrane centrifugation techniques

 

  Personal Solvent Evaporator Offers Optimised Stored Methods Genevac Ltd, world leader in solvent removal technologies, has announced the launch of a new third-generation version of its popular EZ-2 personal solvent evaporator.