Follow us...

 

Search News Archives

Channels

News

 

 

View Channel

Laboratory Products

 

 

View Channel

Special Offers and Promotions

 

Microscopy | Image Analysis

 

 

View Channel

Separation Science

 

 

View Channel

Coronavirus (COVID-19)

 

 

View Channel

Research & Case Studies

 

 

View Channel

Conferences | Events

ProteoGenix, Aseem Healthcare, and Trident Biopharm Solutions Announce a New Antibody Cocktail Effective Against Major Variants of SARS-CoV-2

publication date: Jun 16, 2022
 | 
author/source: ProteoGenix

proteogenix-aseem-healthcare-and-trident-biopharm

A partnership between antibody development experts and global healthcare providers creates a new COVID-19 treatment for immunocompromised, high-risk, and vaccine refractory individuals, effective against major variants including Omicron

ProteoGenix(market-leading antibody provider), Aseem Healthcare (global healthcare company), and Trident Biopharm Solutions (life science consultancy agency) are pleased to announce the development of a new antibody cocktail effective against major variants of SARS-CoV-2. The cocktail of four fully human neutralizing antibodies (AH-5-COV) was generated by screening the plasma of a COVID-19 survivor using ProteoGenix’s phage display platform. The new treatment is undergoing preclinical evaluation and will be ready to start clinical trials in 2 months.

"Our experience in developing immunotherapies for a wide spectrum of diseases and our contribution to the engineering of three treatments on the market, allowed us to quickly generate a broadly neutralizing antibody cocktail," said Philippe Funfrock, CEO and co-founder of ProteoGenix. "This treatment’s ability to neutralize several variants of the virus also highlights the potential of phage display technologies to create efficient therapeutics against infectious diseases."

The broadly neutralizing antibodies were sourced from the plasma samples of a COVID-19 patient who contracted and survived a severe form of the disease. A highly diverse antibody library was constructed by ProteoGenix and enriched via phage display using both SARS-CoV-2 natural human receptor (ACE2) and receptor-binding domain (RBD). Neutralizing antibodies were further developed using a combination of both traditional binding and advanced custom-made neutralization assays.

The AH-5-COV cocktail provides an accessible, stable, broadly protective, and easy-to-store treatment, particularly valuable for underserved low and middle-income countries. Besides the wild type of SARS-CoV-2, all four antibodies exhibit moderate to strong activity against variants Alpha, Beta, Gamma, Epsilon, Delta, and Omicron in live virus neutralization assays (PRNT tests). The cocktail and each antibody also outperformed other monoclonal treatments currently approved or authorized by the FDA and EMA, particularly against Omicron.

"Antibody cocktails will be crucial to reduce disease severity and hospitalization times for COVID-19," said Khelan Patel, Chief Commercial Officer at Aseem Healthcare. "Unfortunately, since the start of 2022, patients have been left with fewer treatment options after most of the currently approved mAbs have ceased to be effective against Omicron."

 

About ProteoGenix

ProteoGenix is a France-based biotech contract research organization (CRO) providing flexible end-to-end solutions for the discovery and development of life-saving biologics, precision diagnostic tools, and robust reagents for research.

 

About Aseem Healthcare

Aseem Healthcare is a global healthcare company committed to revolutionizing the availability of biologics around the world and improving patient access to next-generation biotherapeutics, vaccines, and cell/gene therapy products, by providing state-of-the-art and rapidly deployable manufacturing support.

 

About Trident Biopharm Solutions

Trident BioPharm Solutions is a boutique life science consultancy engaged in helping biopharma organizations create enterprise value, increase efficiencies, and reduce time to market.

 



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

Today's Picks

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.