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New Tool for Large Molecule Analysis

publication date: Mar 24, 2023
author/source: Cerno Bioscience
Figure 1. 50-nt RNA analyzed against the proposed sequence along with 6 other adducts and modifications.  Spectral Accuracy fit an excellent ~90%.



Cerno to Introduce an Innovative Mass Spec Tool for Large Molecules Analysis at Pittcon

Cerno will be introducing a groundbreaking new software product for large molecule analysis with Mass Spectrometry. Using an entirely new approach for analyzing any large molecule including peptides, oligos, and proteins, SAMMI, for Spectrally Accurate Modeling of Multiply charged Ions uses a direct analytical model based on first principles. It will analyze each and every ion of a Multiply-charged molecule to provide not only the neutral mass, but also the abundance distribution across all the charge states.   

With SAMMI, you visually observe the results in a simple, intuitive, and confident fashion. Since it is based on a robust and direct analytical model, there are no parameters to tweak, it is both simple and reliable to use. SAMMI also easily accounts for modifications and adducts and not only determines the accurate neutral mass of the unknown molecule, but also can accurately confirm the sequence/formula of the molecule as well as its adducts, modifications, impurities, and isotope labels.

SAMMI uses Spectral Accuracy to allow for the most accurate modeling of the mass spectral profiles for any given ion, regardless of the charge state. It dramatically improves the quadrupole MS results to approach the performance from a more expensive high resolution instrument. This makes it perfect not only for research, but for high throughput screening or quality control applications using robust, reliable, and more cost-effective quadrupole instruments. SAMMI works with all large molecules from small peptides to large proteins, oligonucleotides such as RNA of various lengths, and other polymers.

Best of all, SAMMI is free with the purchase or upgrade of Cerno’s award winning MassWorks software. Visit Cerno at the Pittcon 2023 on March 18-22 in Philadelphia, PA, Booth #2113, for a live demo.

Learn more on our website and see some exciting results using SAMMI


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