Creoptix® (a Malvern Panalytical brand) is announcing the addition of two new wizards to their WAVEcontrol software to simplify and streamline workflows.

By combining the high sensitivity, throughput, and no-clog microfluidics of the WAVEsystem, with a faster, more flexible, automated approach to screening and characterization, Creoptix is accelerating biologics drug discovery and diagnostics development.

The WAVEsystem uses patented grating-coupled interferometry (GCI) technology as a powerful label-free alternative to conventional bioassays. Label-based analytics can cause issues such as altered analyte structures, non-specific binding, background noise and poor detection of weak interactions. GCI technology enables real-time affinity and kinetic measurement, with accurate binding specificity data for every type of analyte, from weak-binding fragments and small molecules to the most complex, native proteins in complex matrices.

The WAVEcontrol is the intuitive software used to operate the device and enables analysts to move from set-up to reporting in four simple steps, through an experiment design optimizer, automated set-up and flexible data evaluation, including Direct Kinetics, and customizable data reporting. The two new smart wizards being launched extend the automated capabilities of the system with:

Ligand screening – a faster, flexible way to screen and characterize antibodies. This wizard works in a Ligand Block logic with each automated block of activity including ligand capture, sample injection and surface regeneration. With an integrated Target Level function, ligand level density is automatically controlled for optimal comparison.

Calibration-free concentration analysis (CFCA) – a reliable, quick and easy calibration-free approach to the quantification of active protein concentration. This new feature is ideal for active protein characterization when a suitable calibrant is not available and when purification efficiency testing is required.

Tatiana Tiago, Product Manager at Creoptix, explains: “We wanted to create an environment where analysts could move seamlessly from sample to data in as few steps as possible, getting to the outputs they need at the touch of a button. The WAVEsystem already provides sensitivity and signal stability, fast throughput and non-clog fluidics, but we wanted to make sure that analysts could harness the analytical power of the system in an easy, flexible and automated way.”

“The new WAVEcontrol software wizards mirror the way scientists work and allow them to stay close to the ligand-analyte interaction but ensure as many tasks as possible are automated, saving time and cost, and reducing the errors that can creep in with manual processes.”

More information on how the WAVEsystem and the new smart wizards within WAVEcontrol are combining to deliver the best results for antibody screening, view our webinar, which includes a presentation from Global Access Diagnostics on how they are using the WAVEsystem and the new ligand screening functionality in lateral flow diagnostics development.

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About Creoptix

Following integration in January 2022, Creoptix is a Malvern Panalytical brand. The team is headquartered in Wädenswil at the foot of the lake of Zurich in Switzerland, with US offices in the Boston area.

Accelerate discovery

Creoptix enables life scientists to accelerate discovery by providing cutting-edge tools for molecular interaction analysis, with a focus on next-generation bioanalytical instruments for drug discovery and life sciences for both industry and academic research.

High sensitivity and resolution

Based on its proprietary biosensor, microfluidics and software technologies, the Creoptix WAVE provides exceptionally high sensitivity and resolution to study real-time biological interactions involving fragment, small molecules, peptides, membrane proteins, biologics and other molecules even in crude reaction mixtures and biofluids like undiluted serum and plasma.

Breakthrough level of kinetics analysis

The core Creoptix instrument is the WAVE. The Creoptix WAVE puts a breakthrough level of kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The system’s exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. Creoptix also offer supporting chips and software for the instrument.

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