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Video Demonstrates Benefits of Controlled Nucleation

Video Demonstrates Benefits of Controlled NucleationSP Scientific has broadcast a new video that demonstrates how ControLyo TM Nucleation On-demand Technology can be used to control the nucleation of a product during freezing, such that the entire product nucleates at the same time and in the same way.

Using an example of freeze drying samples in vials the video ( illustrates how ControLyoTM Technology enables the freezing step to be much more repeatable and allows potentially greater control over cycle optimization.

SP Scientific has signed a license agreement with Praxair, Inc. to utilize Praxair's ControLyoTM Nucleation On-demand Technology, which provides pharmaceutical and biotechnology companies with precise control over the freeze-drying process for drug developmental efforts.

This breakthrough technology was developed to specifically control the freezing step of lyophilization.  Freeze drying (also known as lyophilization) is a method of drying products whereby the material is frozen (made chemically inactive) and then placed under vacuum while energy, in the form of heat, is added so that the ice sublimates (goes directly from a solid to a vapour without entering the liquid stage) thus rendering the product stable at elevated temperatures.  Until now, the freezing step of lyophilization was uncontrolled due to the random nature of the nucleation or crystal-forming process. Praxair's new ControLyoTM technology now makes nucleation control a reality by regulating the nucleation temperature to within 1°C of its freezing point.  The results are improved product uniformity, quality and yield.

For further information please contact SP Scientific on +1-845-255-5000 / +44-1473-240000 or email

SP Scientific ( is a leading manufacturer of laboratory-to-production scale freeze dryers / lyophilizers, centrifugal evaporators and concentrators, thermal control system and glassware washers. The company sells its products under well-known brands including VirTis®, FTSTM, Genevac® and Hotpack®, SP Scientific has ISO 9001:2008 registered production facilities in the USA and Europe.



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