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The Advantages Of Controlled Ice Nucleation for Freeze Drying Scale-Up

LyoLearn webinar SP Scientific, a world leader in freeze drying technology, has announced a new LyoLearn webinar that will discuss the role of controlled ice nucleation in quality by design freeze drying scale-up procedures.

Chaired by Professor Michael J Pikal, Professor and Distinguished Chair, Pharmaceutical Technology at the University of Connecticut - the scope of the 27th January 2011 webinar will be to discuss controlled ice nucleation by both the ice-fog technique and the depressurization technique and to review the advantages of controlled ice nucleation.

To practice "Quality by Design", organizations must be able to scale up freeze drying results generated in the laboratory to full scale manufacturing. To do this a technique must address a number of heat and mass transfer scale up issues.  The 27th January webinar will suggest methodology for estimating the changes to a laboratory procedure that are required.

In addition the webinar will address the scale-up challenge presented by the difference in ice nucleation temperatures between the laboratory and the Class 100 environment found in manufacturing. Much greater degrees of super-cooling are typically found in manufacturing, meaning manufacturing processes run longer and run hotter than in the laboratory. Operators may minimize the freezing difference between laboratory and manufacturing by annealing in the frozen state, but perhaps the best strategy is to control the ice nucleation temperature. In this webinar the author discusses controlled ice nucleation by both the ice-fog technique and the depressurization technique and reviews the advantages of controlled ice nucleation.

SP Scientific's program of free educational webinars delivered by industry experts are devoted to freeze-drying topics, and follow a 30-minute format for the presentations with a Q&A session immediately afterwards.  To register for the January 27, 2011 webinar please visit the SP Scientific website or contact the company on +1-845-255-5000 (+44-1473-240000 in Europe).

SP Scientific is a leading manufacturer of laboratory to production scale freeze dryers / lyophilizers, centrifugal evaporators and concentrators, thermal control system and glassware washers. The company sells its products under well-known brands including VirTis®, FTSTM Genevac®, and Hotpack®. SP Scientific has ISO 9001:2008 registered production facilities in the USA and Europe.


 

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