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Antibodies Enable Immunoassays to be Used in Methylation Regulation Research

publication date: Oct 30, 2015
author/source: AMSBIO

AMSBIO has launched a  unique series of monoclonal and polyclonal antibodies against S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) that allows immunoassays to be used in methylation regulation research. 

MethylationMethylation is involved in nearly every aspect of life. SAM is the sole methyl donor for a variety of methyl-transfer reactions in DNA, RNA, proteins, lipids, phosphilipids, hormones and neurotransmitters. Proper DNA methylation is essential for normal embryonic development. However, when the methyl-transferase gene is homozygously deleted, it is lethal. DNA improperly methylated has been found in many tumors. Alterations in DNA methylation patterns induce the expression of oncogenes or silence the expression of tumor-suppressor genes. 

Since SAM is an intrinsically unstable molecule, without a distinguished maximum absorption peak, traditionally the determination of its concentration in various biological fluids and tissues has been a challenging task. The new antibodies, available from AMSBIO, offer a simple, convenient immunoassay method that does not require costly instrumentation for the determination of the biological concentration of SAM, and to monitor its change and metabolic paths in the body fluids, tissues and organelles.  AMSBIO also offers other immunoassay products to determine the ratio of SAM and SAH, also known as the Methylation Index, which is widely recognized as a valuable way to evaluate the methylation status of humans and other organisms.

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO is able to draw upon in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. Widely acknowledged as an expert in cell culture, AMSBIO partners with clients in tailoring cell systems to enhance organoid and spheroid type screening outcomes from a technological and cost-effective perspective. Custom services include stable cell line production, CRISPR/Cas9 Genome Editing, lentivirus and adenovirus production, large scale protein production and a comprehensive portfolio of antibody services.

more about AMS biotechnology

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