JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of AFM systems in the group of Dr Bart Hoogenboom of the London Centre for Nanotechnology
Lecturer at the London Nanotechnology Centre and the Department of Physics and Astronomy, University College London, Dr Bart Hoogenboom's main research interest is where nanotechnology tools may be used to study and manipulate single biomolecules. Specifically, he applies AFM as the only instrument that provides ~1 nm spatial resolution on large biomolecules that are "alive", or in more scientific terms, they are still functional and may be studied in the natural environment, i.e. aqueous salt solution...
Read MoreMalvern Zetasizer Nano is integral to QueenSep 6, 2012
"The Zetasizer Nano ZS is an integral piece of equipment in our polymer characterization laboratory," said Daniel Krasznai, Department of Chemical Engineering, Queen's University, Kingston, Canada. "The most important features that the Zetasizer Nano ZS offers are rapidity, reproducibility, and a user-friendly interface."
Daniel Krasznai's supervisor,Dr. Michael F. Cunningham, holds the Ontario Research Chair in Green Chemistry and Engineering at Queen's University. His team focuses on the synthesis of polymer colloids using a range of dispersed free-radical polymerization techniques. Together with Dr. Niels M.B. Smeets, and fellow collaborators Dr. Pascale Champagne and Dr. Timothy F.L. McKenna, they have recently published a paper in which they use the Zetasizer Nano ZS to characterize novel core-shell materials in pure water. Read MoreBiotage Announces EVOLUTE EXPRESS 96-Well Plates; Simplified, Fast and Efficient SPE Using the Load-Wash-Elute ProcedureSep 6, 2012
Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical and medicinal chemistry, introduced EVOLUTE® EXPRESS, a novel family of 96-well plates that simplify polymer-based SPE by employing a streamlined 3-step protocol; Load-Wash-Elute
By using this novel approach and removing the conditioning and equilibration steps, necessary with traditional bio-analytical SPE procedures, processing and method development times are dramatically reduced without loss of analyte recovery or method robustness.
Read MoreAirClean Systems launches new Patriot ductless fume hoodsSep 5, 2012
AirClean Systems, the North American leader in ductless containment since 1992, announces the introduction of its newest product line
Patriot Ductless Fume Hoods. Patriot ductless hoods incorporate much of the advanced technology of AirClean's Independence fume hood with the cost effective backbone of AirClean's AC4000 folding and sliding-sash ductless fume hoods. Patriot ductless fume hoods feature the easy-to-use AirSafeTM TOUCH automatic safety controller for added operator safety. This color touchscreen controller automatically increases or decreases blower speed to maintain the user's pre-set face velocity, ensuring airflow is within standard operating parameters...
Read MoreGuaranteed Knockdown for siRNA Gene SilencingSep 3, 2012
AMSBIO has announced its new Trilencer-27 siRNA kit, that contains Dicer-Substrate duplexes, provides critical improvements over the use of traditional 21mer siRNA designs
Gene silencing through the use of RNAi has become a primary tool for characterizing gene involvement in disease states and interactive pathways. Offering genome-wide coverage against human, mouse and rat, the AMSBIO Trilencer-27 siRNA kit takes advantage of the natural processing by Dicer to produce 10-fold higher potency and specificity than shorter 21mer RNAi forms. Beneficially the 27mer dicer-substrate duplexes in the kit also evade the radar of the mammalian interferon response when expressed in mammalian cells and initiate strong and specific gene silencing...
Read MoreLow running costs for TOC with the multi N/C from Analytik Jena UKSep 3, 2012
Improvements in combustion technology have further reduced day-to-day running costs for the multi N/C® TOC analyzer from Analytik Jena UK
This high performance analytical instrument combines low-maintenance technologies for sample digestion with an environment-friendly low consumption of consumables such as gas and power, as well as robust engineering and a long service life...
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
Histone modifications caused by histone deacetylases (HDACs) are strongly related to epigenetic regulation of transcription. Determining the activity of recombinant HDAC1 using the POLARstar OPTIMA microplate reader from BMG LABTECH offers high precision and performance. Using Boc-Lys(Ac)-AMC as fluorescent substrate HDAC activity and inhibitor assays can be performed over a wide concentration range...
Read MoreTecanAug 30, 2012
Tecan has launchedthe QC Kit, a total solution for liquid handling performance verification testing on Freedom EVO® workstations
Created in collaboration with Artel - the worldwide leader in liquid handling quality assurance - the QC Kit incorporates Artel's proprietary Ratiometric PhotometryTM technology within the Freedom EVO system. It offers precision and accuracy performance verification which is fully traceable to the International System of Units (SI) - through reference standards maintained by NIST (in the US) and NPL (in the UK) - allowing direct comparison of verification testing results between different sites and instruments...
Read MoreLarge Horizontal Capacity Autoclave Saves MoneyAug 29, 2012
The Q63 autoclave from Priorclave has a larger horizontal chamber profile than found in most ‘cylindrical' machines to accommodate the requirements of those laboratories where there is tremendous variation in size of items to be sterilised
Design of the Q63 enables it to handle everything from small to taller than average items, eliminating the need to even consider purchase of a larger rectangular chamber autoclave which would obviously be more expensive to purchase and more costly to run...
Read MoreJ.G. Finneran's Molded Sealing Mats for 96-Well MicroplatesAug 28, 2012
J.G. Finneran Associates, an innovative manufacturer of sample containment products for chromatography, biotechnology and environmental analysis, offers molded Teflon/Silicone and Silicone only Sealing Mats, designed to fit standard 96-well microplates with cylindrical or tapered wells, and square wells.
The tight seal prevents sample cross contamination and the liner reseals after multiple injections thus reducing the chance of solvent evaporation. The liners are made from Teflon lined medical grade silicone which meets the requirements of U.S.P. Class VI...
Read MoreAutomating Cell-Based Microplate AssaysAug 27, 2012
PHERAstar FS with Direct Optic Bottom Reading, the Optimal Solution for Cell Based Assays
One of the most important uses for fluorescent proteins like GFP, mCherry, and mOranage is real-time monitoring of cellular processes in live cells. Now with the PHERAstar FS microplate reader, it is possible to miniaturize and increase throughput of fluorescent protein cell-based assays that were not possible before...
The costs of buying and of disposing of solvents are increasing. Recycling is an alternative. Many solvents like Acetone, Ethanol, Ethyl acetate, Hexane and others are often used and are easy to recycle. The easiest way to do this is by distillation in a rotary evaporator
The most important step is the way in which the used solvent is collected. The cleaner the collected solvent is, the better the separation. This process is already very well established in universities, where "green chemistry" is a part of the education. Depending on the impurities of the waste solvent, a purification of > 95% is possible.
Read MoreTerraSpray Rinse Station from Cole-Parmer Aug 24, 2012
Compact design fits in small spaces or on laboratory benchtops and keeps water contained-eliminating wet floors and slippery hazards from laboratories and workshops
The TerraSpray® Rinse Station from Cole-Parmer is a cost-effective choice for cleaning all styles of vessels and carboys up to 200 litres. The station connects directly to water inlet and drain-no electricity needed. Select from countertop or floor models. The countertop model cleans vessels up to 38.1 cm (15") in diameter. Operate by the hand-controlled valve on the side of the unit. The floor model cleans vessels up to 48.3 cm (19") in diameter. A foot-controlled valve on the bottom platform turns rinse on and off. Both models are easy to use with quick set-up...
Read MorePortable System for Aspiration and Disposal of Biological WasteAug 21, 2012The VACUSIP from INTEGRA provides an ideal benchtop solution for the safe aspiration and disposal of small volumes of liquid waste in clinical, molecular biology, biochemistry and microbiology labs.
With integrated vacuum pump and long-life battery the VACUSIP from INTEGRA is completely portable enabling aspiration and waste disposal where and when you need it. To optimize battery run-time, the pump automatically switches on and off according to the vacuum needed for an aspiration task. With its space saving footprint, silent operation and optimal organization, the VACUSIP is a true asset to any lab performing liquid aspiration tasks...
Read MoreAvanti J-26S High Performance Centrifuge Provides Enhanced Environmental, Safety BenefitsAug 21, 2012New 1-Litre Bottles Provide Sample Security
The newly redesigned Avanti J-26S high performance centrifuge from Beckman Coulter Life Sciences combines important environmental benefits with increased BioSafety* features. Coupling the J-26S with new 1-litre polypropylene bottles furthers sample security and extends the range of biopharmaceutical and research applications...
Read MoreEconomic Approach to Protein Precipitation Sample PreparationAug 17, 2012The CombipackTM is Porvair Sciences economic response to the growing use of protein precipitation separation techniques in chromatography labs.
Comprising four Porvair p3 protein precipitation plates and four 1ml deep well collection plates (colour coded in red or blue polypropylene) the Combipack provides all the elements you require to undertake protein precipitation separations at a very affordable price...
Read MoreAgilent Technologies Bond Elut PlexaAug 17, 2012Easy-to-use, new generation of polymeric SPE
The PlexaTMfamily of amide-free, polymeric SPE products provide a generic, sample independent route to cleaner extracts. This simple approachmeans minimal method development saving you both time and cost. The tighter control of particle size distribution elimates small fines to prevent blockage meaning Bond Elut PlexaTM can be used even with the most complex matrices...
Read MoreMore Reliability in WeighingAug 17, 2012Protection against operating errors and uncertain weighing data in regulated areas
All balances are required to deliver precise and, above all, correct results. To ensure ccuracy, users need to not only check that a balance's metrological specifications are suitable, but also that they control all parameters that influence weighing when setting up and operating a alance. Temperature fluctuations, exposure to sunlight, benchtop vibration and leveling are only a few of the conditions that can distort weight measurements and that can be monitored by an advanced weighing instrument. Incorporating numerous functions for Advanced Pharma Compliance (APC), the new Sartorius Secura laboratory balance offers a new level of security in all weighing processes.
Read MoreCopley Scientific breathes new life into inhaler testingAug 16, 2012Copley Scientific's new Breath Simulator Model BRS 3000 delivers the flow rate, acceleration and capacity required to test metered dose inhalers (MDIs) and dry powder inhalers (DPIs) in a more patient representative manner, as well being suitable for testing nebulisers, spacers and valved holding chambers, according to the latest pharmacopoeial monographs.
Designed to allow closer simulation of in vivo breathing profiles, the BRS 3000 generates flow rates up to 240 litres per minute with a maximum 25 litres per second2 acceleration rate; volume capacity is 5 litres. Companion to the smaller BRS 2000 unit, which is designed principally for nebulisers, the BRS 3000 allows users to precisely define and apply breathing profiles that mimic those of the patient during inhaler use...
Read MoreMerck Millipore Launches PureGenome Kits and Reagents for Fast and Efficient Preparation of Next Generation Sequencing LibrariesAug 15, 2012Merck Millipore, the Life Science division of Merck, today launched PureGenomeTM kits and reagents for rapid and efficient Next Generation Sequencing (NGS) sample preparation.
Enables NGS library preparation in under two hours, less hands-on time than similar kits
Delivers maximum library yields from less input DNA with minimal bias for better results
Provides higher genome coverage and more matched reads
Processes samples of virtually any biological liquid, whole tissue and tissue sections
ArcticZymes AS today announced the launch of Heat&Run®, a new RNA sample prep kit based on the company's proprietary Heat-Labile (HL) dsDNase enzyme. The heat lability and other properties of dsDNase enable Heat&Run® to overcome the assay-critical limitations of existing DNase-based techniques by rapidly and completely removing genomic DNA (gDNA) without damaging the delicate RNA. With a simple three-step mix-heat-run protocol, Heat&Run® is also designed for seemless integration into existing laboratory workflows...
Read More
An universal planned product family is available with a selection of different motors, varying housing safety classes and intelligent control of delivery volumes, covering a broad spectrum of application areas in the lab or industry...
Lecturer at the London Nanotechnology Centre and the Department of Physics and Astronomy, University College London, Dr Bart Hoogenboom's main research interest is where nanotechnology tools may be used to study and manipulate single biomolecules. Specifically, he applies AFM as the only instrument that provides ~1 nm spatial resolution on large biomolecules that are "alive", or in more scientific terms, they are still functional and may be studied in the natural environment, i.e. aqueous salt solution...
Daniel Krasznai's supervisor, Dr. Michael F. Cunningham, holds the Ontario Research Chair in Green Chemistry and Engineering at Queen's University. His team focuses on the synthesis of polymer colloids using a range of dispersed free-radical polymerization techniques. Together with Dr. Niels M.B. Smeets, and fellow collaborators Dr. Pascale Champagne and Dr. Timothy F.L. McKenna, they have recently published a paper in which they use the Zetasizer Nano ZS to characterize novel core-shell materials in pure water. 
By using this novel approach and removing the conditioning and equilibration steps, necessary with traditional bio-analytical SPE procedures, processing and method development times are dramatically reduced without loss of analyte recovery or method robustness.
Patriot Ductless Fume Hoods. Patriot ductless hoods incorporate much of the advanced technology of AirClean's Independence fume hood with the cost effective backbone of AirClean's AC4000 folding and sliding-sash ductless fume hoods. Patriot ductless fume hoods feature the easy-to-use AirSafeTM TOUCH automatic safety controller for added operator safety. This color touchscreen controller automatically increases or decreases blower speed to maintain the user's pre-set face velocity, ensuring airflow is within standard operating parameters...
This high performance analytical instrument combines low-maintenance technologies for sample digestion with an environment-friendly low consumption of consumables such as gas and power, as well as robust engineering and a long service life...
Histone modifications caused by histone deacetylases (HDACs) are strongly related to epigenetic regulation of transcription. Determining the activity of recombinant HDAC1 using the POLARstar OPTIMA microplate reader from BMG LABTECH offers high precision and performance. Using Boc-Lys(Ac)-AMC as fluorescent substrate HDAC activity and inhibitor assays can be performed over a wide concentration range...
Created in collaboration with Artel - the worldwide leader in liquid handling quality assurance - the QC Kit incorporates Artel's proprietary Ratiometric PhotometryTM technology within the Freedom EVO system. It offers precision and accuracy performance verification which is fully traceable to the International System of Units (SI) - through reference standards maintained by NIST (in the US) and NPL (in the UK) - allowing direct comparison of verification testing results between different sites and instruments...
Design of the Q63 enables it to handle everything from small to taller than average items, eliminating the need to even consider purchase of a larger rectangular chamber autoclave which would obviously be more expensive to purchase and more costly to run...
The tight seal prevents sample cross contamination and the liner reseals after multiple injections thus reducing the chance of solvent evaporation. The liners are made from Teflon lined medical grade silicone which meets the requirements of U.S.P. Class VI...
One of the most important uses for fluorescent proteins like GFP, mCherry, and mOranage is real-time monitoring of cellular processes in live cells. Now with the PHERAstar FS microplate reader, it is possible to miniaturize and increase throughput of fluorescent protein cell-based assays that were not possible before...
The most important step is the way in which the used solvent is collected. The cleaner the collected solvent is, the better the separation. This process is already very well established in universities, where "green chemistry" is a part of the education. Depending on the impurities of the waste solvent, a purification of > 95% is possible.
The TerraSpray® Rinse Station from Cole-Parmer is a cost-effective choice for cleaning all styles of vessels and carboys up to 200 litres. The station connects directly to water inlet and drain-no electricity needed. Select from countertop or floor models. The countertop model cleans vessels up to 38.1 cm (15") in diameter. Operate by the hand-controlled valve on the side of the unit. The floor model cleans vessels up to 48.3 cm (19") in diameter. A foot-controlled valve on the bottom platform turns rinse on and off. Both models are easy to use with quick set-up...
With integrated vacuum pump and long-life battery the VACUSIP from INTEGRA is completely portable enabling aspiration and waste disposal where and when you need it. To optimize battery run-time, the pump automatically switches on and off according to the vacuum needed for an aspiration task. With its space saving footprint, silent operation and optimal organization, the VACUSIP is a true asset to any lab performing liquid aspiration tasks...
The newly redesigned Avanti J-26S high performance centrifuge from Beckman Coulter Life Sciences combines important environmental benefits with increased BioSafety* features. Coupling the J-26S with new 1-litre polypropylene bottles furthers sample security and extends the range of biopharmaceutical and research applications...
Comprising four Porvair p3 protein precipitation plates and four 1ml deep well collection plates (colour coded in red or blue polypropylene) the Combipack provides all the elements you require to undertake protein precipitation separations at a very affordable price...
The PlexaTMfamily of amide-free, polymeric SPE products provide a generic, sample independent route to cleaner extracts. This simple approach means minimal method development saving you both time and cost. The tighter control of particle size distribution elimates small fines to prevent blockage meaning Bond Elut PlexaTM can be used even with the most complex matrices...
All balances are required to deliver precise and, above all, correct results. To ensure ccuracy, users need to not only check that a balance's metrological specifications are suitable, but also that they control all parameters that influence weighing when setting up and operating a alance. Temperature fluctuations, exposure to sunlight, benchtop vibration and leveling are only a few of the conditions that can distort weight measurements and that can be monitored by an advanced weighing instrument. Incorporating numerous functions for Advanced Pharma Compliance (APC), the new Sartorius Secura laboratory balance offers a new level of security in all weighing processes.
Designed to allow closer simulation of in vivo breathing profiles, the BRS 3000 generates flow rates up to 240 litres per minute with a maximum 25 litres per second2 acceleration rate; volume capacity is 5 litres. Companion to the smaller BRS 2000 unit, which is designed principally for nebulisers, the BRS 3000 allows users to precisely define and apply breathing profiles that mimic those of the patient during inhaler use...
Enables NGS library preparation in under two hours, less hands-on time than similar kits
ArcticZymes AS today announced the launch of Heat&Run®, a new RNA sample prep kit based on the company's proprietary Heat-Labile (HL) dsDNase enzyme. The heat lability and other properties of dsDNase enable Heat&Run® to overcome the assay-critical limitations of existing DNase-based techniques by rapidly and completely removing genomic DNA (gDNA) without damaging the delicate RNA. With a simple three-step mix-heat-run protocol, Heat&Run® is also designed for seemless integration into existing laboratory workflows...