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Copley Scientific breathes new life into inhaler testing

Breath Simulator Model BRS 3000

Copley Scientific's new Breath Simulator Model BRS 3000 delivers the flow rate, acceleration and capacity required to test metered dose inhalers (MDIs) and dry powder inhalers (DPIs) in a more patient representative manner, as well being suitable for testing nebulisers, spacers and valved holding chambers, according to the latest pharmacopoeial monographs

Designed to allow closer simulation of in vivo breathing profiles, the BRS 3000 generates flow rates up to 240 litres per minute with a maximum 25 litres per second2 acceleration rate; volume capacity is 5 litres.  Companion to the smaller BRS 2000 unit, which is designed principally for nebulisers, the BRS 3000 allows users to precisely define and apply breathing profiles that mimic those of the patient during inhaler use. This enables the exploration of DPI and MDI performance under test conditions that more accurately reflect use by specific patient groups, including different age categories or those with acutely impaired lung function. 

Both the BRS 2000 and BRS 3000 breath simulators can be configured for in vitro dose uniformity and aerodynamic particle size distribution data measurement (by cascade impaction), to apply user-defined patient profiles, rather than the fixed flow rates associated with routine testing. Each breath simulator allows the application of various different waveforms including user-defined flow rate versus time profiles. Standard sinusoidal, rectangular and triangular waveforms can also be generated with control over inhalation/exhalation ratio, breath volume, breathing duration and breaths per minute. 

With a maximum inhalation volume of approx. 1 litre, the BRS 2000 is specified for testing nebulisers under neonate, infant, child and adult tidal breathing conditions, defined in the recently updated USP Chapter 1601 and Ph.Eur. Chapter 2.9.44, and for testing in accordance with the proposed new USP Chapter* for spacers and valved holding chambers used with pressurised MDIs.  The BRS 3000, in contrast, has an inhalation volume of up to 5 litres, a higher maximum flow rate and a higher acceleration rate to meet the demands of MDI and most especially DPI testing, where delivery is driven solely by the inhalation manoeuvre of the patient.

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