Follow us...


Search News Archives





View Channel

Laboratory Products



View Channel

Separation Science



View Channel

Microscopy | Image Analysis



View Channel

IT Solutions and Laboratory Automation



View Channel


Conferences | Events

Confused about Cascade Impaction? Watch the New Animations from Copley Scientific to Improve your Understanding of Inhaled Drug Product Testing

publication date: Sep 13, 2016
author/source: Copley Scientific Limited

 vitro-in vivo

Copley Scientific, the world’s leading manufacturer and supplier of inhaler test equipment, has released two new educational animations that provide a clear, easy to understand introduction to critical aspects of inhaled product testing.

The videos, entitled ‘How does a cascade impactor work?’ and ‘System for improved in vitro-in vivo correlations (IVIVCs) of inhaled drug products’ are an excellent resource for training, for researchers new to inhaled product testing and/or those seeking enhanced testing strategies.

The size of particles delivered by an inhaled product influences where the drug deposits in the lung, affecting efficacy and is therefore considered a critical quality attribute. Uniquely, cascade impaction enables the generation of an aerodynamic particle size distribution specifically for the active pharmaceutical ingredient (API) within a formulation and is specified in the pharmacopoeias for the testing of all inhaled products. ‘How does a cascade impactor work?’ takes the viewer inside an animated cascade impactor - the Andersen Cascade Impactor (ACI) - to provide a step-by-step explanation of how it separates and collects particles for subsequent chemical analysis (typically by HPLC). In this way the animation supports the development of a robust understanding of this pivotal analytical technique, which can, at times, be a little difficult to understand.

Ensuring that data measured in the lab – in vitro – is as representative as possible of what happens to a drug in the body – in vivo – is extremely valuable for bioequivalence and further advancement of inhaled technologies. The second animation presents an optimal test set-up that delivers enhanced IVIVCs, relative to standard pharmacopoeial test methods, and explains how each key element works. Equipment highlighted includes: the breath simulator, for the application of a patient representative breath profile; the Alberta Idealised Throat (AIT) for more realistic modelling of the human throat; and the Mixing Inlet – a key piece of equipment that enables application of a variable flow rate through the inhaler, whilst maintaining a constant flow rate through the cascade impactor; in this case the Next Generation Impactor (NGI). Cascade impactors must always be operated at a constant flow rate, which has, until now, been a limitation of this methodology when considering improving IVIVCs.

more about copley scientific

more news from copley scientific


If you have not logged into the website then please enter your details below.


Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin


Request your free copies HERE




Popular this Month

Top 10 most popular articles this month



Today's Picks



Looking for a Supplier?

Search by company or by product


Company Name:






Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


Media Partners