ASIT biotech, a Belgian clinical-stage biopharmaceutical company specialized in immunotherapy products for the treatment of allergies, is publishing a new article in the prestigious science journal ALLERGY. ALLERGY is the official journal of the European Academy of Allergy and Clinical Immunology (EAACI). Its task is to promote links between fundamental research and clinical research in the fields of allergies and immunology.....
New application note gives researchers insights and guidance on maximizing HDR-mediated insertion of short fragments in CRISPR genome editing
As an advocate for the genomics age, Integrated DNA Technologies (IDT), has published a new application note on optimization of CRISPR-Cas9 for homology-directed repair (HDR) applications. Available as part of the IDT collection of CRISPR application notes and protocols, this article supports researchers using CRISPR...
FLIR Systems has published a technical article that discusses the benefits of next-generation ROIC and detector material technologies and how they are pushing the boundaries on high-speed thermal imaging of ballistic testing.
For many years, high-speed visible cameras offered the ability to stop motion on fast-moving objects and provided unique insight through slow-motion playback for high-speed applications such as ballistics, munitions and tracking applications....
Fluorescence spectroscopy is regarded as a thorough and flexible technique which can be employed to study and characterize unique materials.
Fluorescence spectroscopy is often used in the life sciences as a means of examining cells and understanding the processes taking place within them. Continual breakthrough developments in the instrumentation used for fluorescence spectroscopy, along with the ongoing availability of new fluorescent materials....
Metrohm is proud to announce an update to the application finder on its website that allows users to search application notes by industry method.
The company’s extensive library features more than 2,000 documents that apply to a variety of industries. Metrohm application notes are concise documents that present real-world instrument data to prove the feasibility of a particular measurement....
The latest software release for the Matrix Gemini Laboratory Information Management System (LIMS) from Autoscribe Informatics provides greater bulk sample registration flexibility and enhanced features for visualisation and communications for users.
These include the ability to define the location of a sampling point on an image, record a screenshot with a single button and add attachments to e-mails generated within the LIMS. These useful new features have all been introduced in response to suggestions from Matrix Gemini users....
Chromatrap® has published a new article that describes a detailed genome wide comparison of native and crosslinked chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) using the company's patented solid state spin column technology.
Chromatrap® supply high quality N-ChIP-seq and X-ChIP-seq kits. This article compares the enrichment of the histone H3K4me3 modification signal across the whole genome, from chromatin prepared by both methods (native vs cross link)....
Chromatrap® has published a new application note that demonstrates how its unique solid state patented technology provides unrivalled sensitivity allowing users to perform ChIP assays using as few as 1000 cells per immunoprecipitation.
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples with chromatin from another source. In the application note, the authors demonstrate how...
Genevac has published an informative customer article that reviews the development of a new sample preparation method using its EZ-2 centrifugal evaporator to help simplify and accelerate the detection and quantitation of algal toxins in surface water.
Due to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have been able to...
The fluorescent probe NR12S detects changes in plasma membrane cholesterol levels
The cell membrane is a bilayer of phospholipids with embedded proteins. It contains cholesterol that determines the membrane’s fluidity, permeability and activity of membrane proteins. Changes in membrane cholesterol are implicated in diseases such as Alzheimer’s and cancer, demanding its investigation....
Chromatrap® has published a new application note that demonstrates how its unique solid state patented technology provides unrivalled sensitivity allowing users to perform ChIP assays using as few as 1000 cells per immunoprecipitation.
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples...
The Biorepository at the Guy’s and St Thomas’ Bioresource stores a variety of samples, including whole blood, plasma and sera.
With some 30,000 samples from 5,200 volunteers and patients now collected, a Matrix Gemini Laboratory Information Management System (LIMS) from Autoscribe Informatics has been implemented to manage all aspects of sample handling and allow the most efficient use of freezer storage space. System actions include sample tracking, location recording and chain of custody reporting with full audit trails of all activities...
A white paper that provides evidence of the positive effects of post-curing on the reduction of cyclosiloxane contamination in silicone tubing manufacture has been publishedby Watson-Marlow Fluid Technology Group (WMFTG).
As a provider of single-use components including world-leading niche peristaltic pump and associated fluid path technologies, WMFTG demonstrates that the post-curing process significantly reduces the presence of cyclosiloxane contaminates in silicone tubing. Thereby, drug manufacturers opting to use post-cured tubing and tube assemblies, will benefit from improvements to the safety of the final drug product...
SP Scientific has published a white paper that discusses how the pharmaceutical industry and safety regulators are putting more emphasis on the importance of using external washers to remove particles from the outside of vials.
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
Genevac, market leader in solvent removal, has announced the latest version of its proprietary autostop when dry control software which allows it’s EZ-2, Rocket and HT-Series evaporators to automatically detect when the samples are dry and then shut it down - safeguarding valuable samples from potential thermal degradation.
Combined with Genevac's continuous running condensers, autostop when dry control software allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs. Until the introduction of autostop when dry control software - evaporators users had to constantly monitor or estimate the drying time for a given sample....
Merck, a leading science and technology company, has launched the CellASIC® ONIX2 Microfluidic System for advanced live cell imaging.
The system converts laboratory microscopes into powerful tools for live cell imaging to more effectively perform in-depth analysis of cellular mechanisms and behavior in a live environment....
Optibrium™ and Collaborative Drug Discovery (CDD), developers of software products and services for drug discovery and development, today announced a collaboration to integrate the StarDrop™ and CDD Vault® platforms.
This creates a seamless connection in real time between project data, securely held and managed in CDD Vault, and StarDrop’s unique compound design and optimisation capabilities. Instant access to the latest assay and compound data, with which a project team can share, interpret and model their chemistry, will lead to better decisions and shorter project timelines. CDD Vault is a hosted biological and chemical database that securely manages project data...
Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding....
Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding.....
Metrohm is pleased to present an application for the straightforward determination of the herbicide glyphosate and its primary metabolite AMPA in drinking water by ion chromatography with pulsed amperometric detection.
With a detection limit of approximately 1 µg/L, the method is sensitive enough to comply with limit values in the US, Canada, Australia, and others. A free whitepaper provides more details on the method and its application. Glyphosate and its metabolite AMPA (aminomethylphosphonic acid) are usually determined by HPLC with post-column derivatization and subsequent fluorescence detection...
Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed....
Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....
As an advocate for the genomics age, Integrated DNA Technologies (IDT), has published a new application note on optimization of CRISPR-Cas9 for homology-directed repair (HDR) applications. Available as part of the IDT collection of CRISPR application notes and protocols, this article supports researchers using CRISPR...
For many years, high-speed visible cameras offered the ability to stop motion on fast-moving objects and provided unique insight through slow-motion playback for high-speed applications such as ballistics, munitions and tracking applications....
Fluorescence spectroscopy is often used in the life sciences as a means of examining cells and understanding the processes taking place within them. Continual breakthrough developments in the instrumentation used for fluorescence spectroscopy, along with the ongoing availability of new fluorescent materials....
The company’s extensive library features more than 2,000 documents that apply to a variety of industries. Metrohm application notes are concise documents that present real-world instrument data to prove the feasibility of a particular measurement....
These include the ability to define the location of a sampling point on an image, record a screenshot with a single button and add attachments to e-mails generated within the LIMS. These useful new features have all been introduced in response to suggestions from Matrix Gemini users....
Chromatrap® supply high quality N-ChIP-seq and X-ChIP-seq kits. This article compares the enrichment of the histone H3K4me3 modification signal across the whole genome, from chromatin prepared by both methods (native vs cross link)....
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples with chromatin from another source. In the application note, the authors demonstrate how...
Due to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have been able to...
The cell membrane is a bilayer of phospholipids with embedded proteins. It contains cholesterol that determines the membrane’s fluidity, permeability and activity of membrane proteins. Changes in membrane cholesterol are implicated in diseases such as Alzheimer’s and cancer, demanding its investigation....
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples...
With some 30,000 samples from 5,200 volunteers and patients now collected, a Matrix Gemini Laboratory Information Management System (LIMS) from Autoscribe Informatics has been implemented to manage all aspects of sample handling and allow the most efficient use of freezer storage space. System actions include sample tracking, location recording and chain of custody reporting with full audit trails of all activities...
As a provider of single-use components including world-leading niche peristaltic pump and associated fluid path technologies, WMFTG demonstrates that the post-curing process significantly reduces the presence of cyclosiloxane contaminates in silicone tubing. Thereby, drug manufacturers opting to use post-cured tubing and tube assemblies, will benefit from improvements to the safety of the final drug product...
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
Combined with Genevac's continuous running condensers, autostop when dry control software allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs. Until the introduction of autostop when dry control software - evaporators users had to constantly monitor or estimate the drying time for a given sample....
The system converts laboratory microscopes into powerful tools for live cell imaging to more effectively perform in-depth analysis of cellular mechanisms and behavior in a live environment....
This creates a seamless connection in real time between project data, securely held and managed in CDD Vault, and StarDrop’s unique compound design and optimisation capabilities. Instant access to the latest assay and compound data, with which a project team can share, interpret and model their chemistry, will lead to better decisions and shorter project timelines. CDD Vault is a hosted biological and chemical database that securely manages project data...
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding....
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding.....
With a detection limit of approximately 1 µg/L, the method is sensitive enough to comply with limit values in the US, Canada, Australia, and others. A free whitepaper provides more details on the method and its application. Glyphosate and its metabolite AMPA (aminomethylphosphonic acid) are usually determined by HPLC with post-column derivatization and subsequent fluorescence detection...
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed....
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....