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  Deceptively Simple SCAPE 4D Microscope Brings Major Innovation to Live Cell and Whole Animal Imaging

Andor Zyla 5.5 sCMOS camera at the heart of new technique to perform real-time 3D imaging at unprecedented spatial resolution

SCAPE system diagramAdvances in confocal, two-photon and light-sheet microscopy have rapidly advanced our understanding of cellular and subcellular structures and processes. However, live cell and whole animal imaging could be on the verge of even more breakthroughs following the publication in Nature Photonics of work by a team of Columbia University scientists....

 

  Andor Camera Brings Sound of Ancient Wind Instruments to Life

A set of 13 sixteenth century Italian wind instruments has been brought back to life thanks to the unique skills of specialist Swiss restorers and the high sensitivity and dynamic range of the Andor iKon-L CCD camera.

andorThe resulting intensely-detailed 3D models of the composite wood, metal and leather structures provided valuable information about the construction methods of the original instrument makers and were used to guide their restoration in Basel, Switzerland.....

 

  Andor iXon 860 EMCCD powers direct video recording of Cell Signalling Complexes

Albuquerque team designs unique, high-speed hyperspectral microscope to visualise membrane receptor dynamics at the molecular level in living cells                                                     

Conceptual diagram of high-speed hyperspectral microscopeA unique hyperspectral microscope (HSM) designed specifically to visualise molecular-level protein-protein interactions in living cells has been unveiled recently by the University of Albuquerque. Designed around an Andor iXon 860 high-speed EMCCD detection system to record these profoundly challenging nanometer-scale events, the microscope delivers an unprecedented combination of speed, sensitivity and spectral detection. The novel design of the HSM provides acquisition rates of 27 fps over a 28 square micrometre field of view with each pixel collecting 128 spectral channels, allowing the determination of stoichiometry and dynamics of small oligomers unmeasurable by any other technique...

 

  Andor sCMOS Camera's Speed, Resolution and Sensitivity key to Brain-wide 3D Imaging

High-speed imaging of neuronal activity across entire Brain for the first time 

Volumetric fluorescence imaging using wide-field two-photon light sculpting

Although the entire nervous system connectivity map of the nematode model organism, Caenorhabditis elegans, has been known for more than 25 years, it has not been possible to predict all functional connections underlying behaviour. Now, the Vaziri and Zimmer research groups in Vienna, Austria, have demonstrated a high-speed imaging technique that allows neuronal activity across the entire brain to be recorded simultaneously. Publishing in Nature Methods, Professor Alipasha Vaziri ascribes two key breakthroughs for their success in being the first to implement brain-wide imaging...

 

  Andor Luca-R camera sheds light on Oral Cancer

Diffuse Reflectance Imaging validated for early non-invasive detection of malignant and pre-malignant tumours

Diffuse Reflectance imaging set-up and image processingA team of Indian cancer researchers led by Dr Narayanan Subhash has developed a simple, non-invasive spectral imaging system that holds out the possibility of rapid, inexpensive mass screening for oral cancers in dental and clinical settings. Even in the hands of non-clinical staff, it is capable of real-time discrimination of healthy oral tissue from pre-malignant and malignant tissues with accuracy comparable to the gold standard histopathology of a biopsy sample....

 

  Einstein's "Spooky Action at a Distance" shown for First Time in Real-Time Imaging

Ground-breaking speed and resolution of Andor iStar ICCD camera provides instantaneous visual evidence of quantum entanglement events for the first time.

Ground-breaking speed and resolution of Andor iStar ICCD camera

Quantum Entanglement is one of the most counterintuitive features of quantum mechanics, in which the quantum states of two physically separated particles are linked. If a measurement is made that causes one particle of a pair to take on a definite value, the other particle will take the anti-correlated value instantaneously, even when separated by large distances.....

 

  Pioneering publication locates origin of Autophagosomal Membranes

Trio of Andor iXon EMCCD cameras on Revolution XD microscope make possible the simultaneous tracking of key autophagosome markers to deliver new insights into organelle biogenesis 

Three Andor iXon3 EMCCD cameras surround the Andor Revolution XD spinning disk confocal microscope inThe location of the site where autophagosomal membranes are created within the cell has been the subject of two competing models for many years. Now, a group of researchers from Osaka University led by Prof. Maho Hamasaki has located the origin of autophagosomes within the cell and shown that neither model is correct. Writing in Nature, they show that autophagosomes form at the contact site of the endoplasmic reticulum (ER) with mitochondria. Live cell imaging studies, using an Andor Revolution XD spinning disk confocal microscope equipped with three Andor iXon 3 EMCCD cameras, captured previously hidden detail...

 

  Rice Team fabricates Stable Three-Dimensional Plasmonic Nanoclusters

Andor iKon-M CCD Camera collects spectra of individual nanoclusters to demonstrate strong correlation with theoretical data

Optical properties of icosahedral clustersRecent advances in nanotechnology have created a novel breed of optically active materials fabricated from highly-structured two-dimensional arrays of noble metal nanoparticles. Now, a team from Rice University in Houston, Texas, has developed a method to manufacture stable, three-dimensional (3-D) nanoclusters that could be used to impart metamaterial optical properties into unstructured substrates such as liquids, glasses and plastics....

 

  Fundamentals of Embryo Development uncovered in Real Time

Andor Zyla high-speed cameras power novel four-lens light-sheet microscope to deliver whole embryo images in under ten seconds.

Optical set-up of the specially-designed four-lens selective plane illumination microscope showing the dual Andor Zyla sCMOS cameras
Understanding embryo development is still one of the most intriguing questions facing today's biologists. Light-sheet microscopy is rapidly gaining recognition for whole organism imaging, allowing cell growth, differentiation and morphogenesis to be studied in detail. However, compared to confocal microscopy, the amount of data generated by this new technique is approximately three thousand times greater and poses new storage and image post-processing challenges...

 

  Andor iXon 897 EMCCD Camera images 4 Bose-Einstein Condensates simultaneously

iXon EMCCD camera's exceptional low light performance opens the door to real-time implementation of atomtronics

Atom Chip Magnetic Trap setup and high resolution image acquisition with the Andor iXon 897 EMCCD CameraSince the first demonstrations of Bose-Einstein condensation in 1995, ultra-cold matter has become a fertile and lively field of study. Research around the world is establishing a high level of understanding of the underlying physics for applications, such as inertial guidance systems, atomic clocks and quantum computing. Teams are also beginning to design and build compact, low-power instrumentation for handling ultra-cold atoms...

 

  Andor iXon 897 EMCCD camera discovers two undetected stars in well-mapped globular cluster

iXon EMCCD camera's spatial resolution and high readout speed demonstrate possibility of finding more stars and planetary systems in our galaxy

iXon camera 897 SeriesWith the accelerating interest in seeking out Earth 2.0 exoplanets, the need for accurate star maps on which to base our searches only increases. However, an international team of scientists has found two previously undetected stars in a recently mapped globular cluster using the ultra-sensitive Andor iXon 897 Electron Multiplying CCD camera on the Danish 1.54m telescope at La Silla, Chile. This discovery raises the possibility that we can pinpoint more potential target planets that would be hospitable to life...

 

  Andor EMCCD camera delivers Ultrahigh Accuracy for Super Resolution Microscopy

Ultrahigh accuracy imaging modality (UAIM) technique provides more than 200% accuracy improvement compared with conventional low-light imaging

iXon camera series

Super resolution localization microscopy techniques, which allow the capture of images with a higher resolution than the diffraction limit of approx. 250 nm, are breaking new ground in our understanding of subcellular structures and the movement of individual molecules within cells. However, the positional accuracy attained by these powerful techniques has been limited by the pixelation and noise generated by CCD and EMCCD detectors...

 

  Andor custom-built CCD cameras power new search for 'super-Earths'

Twelve-strong array of ground-based telescopes equipped with specially built red-sensitive cameras to survey the sky to find transiting Neptunes and super-Earths

SuperWASPAs the worldwide race to discover Earth-like exoplanets accelerates, Andor's expertise in high-performance digital camera design and manufacture is proving crucial for many of the leading groups in the field. SuperWASP (Wide Angle Search for Planets) has proven to be one of the most successful projects, finding more than a third of all confirmed transiting planetary systems through its two telescopes, each equipped with eight Andor iKon-L cameras. Its successor, the Next Generation Transit Survey (NGTS), aims to build on those successes through a twelve-strong array of telescopes at the European Southern Observatory in Chile, equipped with custom-designed, red-sensitive CCD cameras from Andor...

 

  Non-invasive Quality Control of Cryopreserved Samples

Since the dawn of modern medicine, human biological material has been collected, stored, and used for a variety of purposes with biological integrity ensured by cryopreservation at temperatures below -137°C. These samples are almost always unique and irreplaceable but, until now, it has been impossible to quality assure the material before use to check that thermal damage has not occurred.

An operator with EuroCryo, Europe’s largest research biobankIn a recently published paper, a team from Saarland University's Biophysics and Cryotechnology department in Germany has demonstrated a powerful, Raman-scattering technique for monitoring and investigating cryopreserved samples. In particular, they confirmed unambiguously the detection of ice crystals in vitreous samples in situ at temperatures below -120°C....


 

  Feynman's double-slit experiment preserved

Detection efficiency of Andor iXon 885 low-light EMCCD camera captures fluorescent interference patterns built up by individual massive molecules at double slit grating

quantum-interferenceDescribed as the "most beautiful experiment in physics", Richard Feynman spoke of the double-slit experiment as 'the heart of quantum physics', emphasizing how the diffraction of individual particles at a grating is an unambiguous demonstration of wave-particle duality and contrary to classical physics. Matter-wave interference has been observed for almost 90 years, first for electrons, neutrons, atoms, and small molecules. The first single-electron/double-slit experiment to back-up Feynman's assertion that an individual electron itself can behave like a wave was reported by Tonomura's team in 1989....

 

  Andor Neo sCMOS cameras at core of Light Sheet Microscopy

European and US labs announce simultaneous adoption of Andor Neo sCMOS camera to power high-speed 4-axis live imaging of biological specimens

The SiMView light sheet microscope in Philipp Keller's laboratoryLaboratories in Europe and the USA have independently announced in the same issue of Nature Methods the development of new microscopes capable of imaging rapid biological processes in thick samples in unprecedented detail and ideally suited to the long-term study of live biological specimens...

 

  Non-invasive cytometric technique could eliminate need for blood samples

Andor Newton camera powers novel non-invasive probe capable of providing cell concentration and morphological data for blood in vivo

Golan_NewtonAn Israeli team has demonstrated a non-invasive technique for imaging blood cells in vivo that could eliminate the need to extract blood from many patients. Powered by the Andor Newton Electron Multiplying EMCCD camera, their high-resolution Spectrally Encoded Flow Cytometry (SEFC) probe offers primary care physicians the capability to detect directly a wide range of common medical disorders, such as anaemia and bacterial infection, and potentially life threatening conditions, including sepsis, thrombosis and sickle cell crisis...

 

  Bitplane Imaris Software to visualise effect of Neurobeachin on differentiation of synapses at Westfälische Wilhelms University of Münster Bitplane Imaris SoftwareOne of the challenges facing neuroscience researchers is understanding how nerve cells contact each other to transmit information and which proteins and mechanisms control the formation and function of these synaptic contacts. Most excitatory synapses in the brain are built on actin-rich dendritic protrusions called spines and, as numerous psychiatric and neurological diseases are accompanied by alterations of spine numbers or size, the elucidation of mechanisms that regulate formation and plasticity of spinous synapses is vital...

 

  Ultra-sensitive Andor iXon EMCCD camera proves case for hyperspectral imaging and may lead to new generation of rapid, automated cancer screening systems Andor iXonMalignant melanoma (MM), the most dangerous type of skin cancer, is caused mainly by intense episodes of UV exposure and originates in the pigment-producing melanocytes in the basal layer of the epidermis. Early detection and complete excision of the primary lesions is crucial for reducing melanoma-related deaths but current diagnostic practice is highly subjective. This leads to unnecessary surgical procedures, which are highly-invasive and expensive...

 

  Pioneering publication reports first ratiometric, single-protein red fluorescent pH sensor in live neurons pH responseThe importance that intracellular pH plays in cell biology is highlighted in a new paper published by the American Chemical Society. Written by a group of researchers from Harvard Medical School led by Professor Gary Yellen, it reports the engineering of the first ratiometric, single-protein red fluorescent sensor of pH, called pHRed, and its use to image intracellular pH in live neuronal cells...

 

  Non-invasive instrument for skin cancer screening demonstrated Andor Newton cameraNow, a joint US-Dutch team under the direction of Anita Mahadevan-Jansen, Vanderbilt University, US, has developed a non-invasive probe capable of both morphological and biochemical characterization of skin cancers. The portable instrument combines a Raman spectroscopy (RS) system with an Optical Coherence Tomography (OCT) device and enables sequential acquisition of co-registered OCT and RS data sets...

 

  St Andrew’s University researchers use laser-based near-infrared (NIR) spectroscopy to characterise whiskies and identify fakes Andor NewtonIf you can't tell your Bruichladdich from your Irn-Bru, or your Glenfiddich from your Glenmorangie, help is at hand from the physics department at St Andrews University. Praveen Ashok, Kishan Dholakia and Bavishna Praveen of the optical manipulation group have developed a microfluidic device that can not only detect counterfeit whisky samples but also characterise genuine samples by brand, age and, even, cask...

 

  Bitplane Imaris 4D Software helps the Centre for Microvascular Research understand regulation of transendothelial migration of neutrophils in vivo Andor Bitplane ImarisThe migration of neutrophils from the vascular lumen into inflamed tissues is a crucial component of the normal immune response and a significant factor in the development of inflammatory pathologies, where inappropriate inflammation contributes to tissue damage and disease progression. A decisive step in this process is the passage of the blood neutrophils through the endothelial cells lining the lumen - transendothelial migration (TEM)...

 

  Andor deep-depletion CCD camera captures advance that could speed-up introduction of stem cell therapy Andor iDus 401A-BRDD Many medical researchers believe that stem cell therapy will revolutionise the treatment of human disease and may provide treatments for many currently incurable diseases. However, one problem still to be overcome is controlling the excessive proliferation of cells with unwanted phenotypes after transplantation to prevent tissue overgrowth and tumour formation...

 

  1,000-fold Response Increase shown in Nanoantenna Arrays Andor iDus camera Andor iDus camera captures dramatic results that promise major advances for highly efficient solar energy photoelectric devices development, precise optical imaging and single molecule detection. Nanoscale antennas hold out the promise of higher resolution optical imaging of nano objects, including proteins and DNA molecules, and converting solar energy into electricity at very high efficiencies. Now, a team from the University of Illinois led by Nicholas Fang and Kimani Toussaint has demonstrated a 1,000-fold increase in the UV-Visible optical response of devices based on nanoantennas periodic arrays...

 

  Cell Receptor Recycling Mechanism Discovery opens up New Class of Therapeutic Targets Andor Revolution XD Confocal MicroscopeUsing the Andor Revolution XD Confocal Microscope for live cell studies, Prof. Puthenveedu has led an international team of researchers to elucidate how signalling receptors are recycled to the cell membrane. The discovery of the mechanism by which signalling receptors travel back to the surface of the cell after activation and internalisation opens up a new class of therapeutic targets...

 

  Cancer Research UK chooses Bitplane Imaris to identify novel role for CD169+ macrophages in activating Invariant Natural Killer T cells Cancer Research UK chooses Bitplane Imaris Lymphocyte Interaction Laboratory uses 3D/4D image visualization and analysis software to gain new insights in vivo

 

  Cancer Research UK identifies novel role for CD169+ macrophages in activating Invariant Natural Killer T cells Bitplane Imaris 3D/4D image visualization and analysis software used to gain new insights in vivo Dr Patricia Barral and her colleagues study the cellular and molecular mechanisms controlling lymphocyte activation and eventual fate. Knowledge of these processes is invaluable not only in increasing our understanding of the causes of cancer but also in the treatment and prevention of infectious and autoimmune diseases.

 

  Sub 60-second identification of MRSA and other Hospital Acquired Infections demonstrated Andor iStarAt a time of rising levels of MRSA and other hospital acquired infections, Laser Induced Breakdown Spectroscopy (LIBS) has been demonstrated to be a rapid and reliable technique for detection of life-threatening bacterial pathogen species that can be found in such medical environments. For the first time, scientists have used Chemometrics analysis of LIBS data in a blind test to successfully identify five pathogenic bacterial samples and differentiate between strains of a multiple-antibiotic-resistant species.