Pauline Carnell, Senior Application Scientist at Malvern Instruments, will present a paper at ISEV 2014 discussing ‘The practical use of nanoparticle tracking analysis (NTA) to characterise extracellular vesicles in general and when using fluorescence markers’.

Malvern Instruments brings a new addition to Pittcon in 2014, exhibiting NanoSight Nanoparticle Tracking Analysis (NTA) systems within its growing portfolio of analytical solutions for industry and academia.

Pittcon 2014 is Malvern’s first major exposition in the US since acquiring NanoSight in September 2013, a move which resulted in the addition of NTA to Malvern’s technologies for particle sizing and counting at the nanoscale. NTA systems will be on show alongside the Zetasizer Nano and the new Viscotek SEC-MALS 20 GPC/SEC detector.  Also on the Malvern booth is the Mastersizer 3000 laser diffraction particle size analyzer featuring new software....

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used to study extracellular vesicles in the research laboratories of Dr Gregory Gores of the Mayo Clinic in Rochester, Minnesota.

The Gores Laboratory of the Mayo Clinic does basic research into liver disease. One of the main research areas of interest is lipotoxicity and its role in development of nonalcoholic steatohepatitis, a common feature of metabolic syndrome or obesity. The group has developed the hypothesis that lipotoxicity induces the release of extracellular vesicles (exosomes and microvesicles) from the liver cells. They speculate that these extracellular vesicles are involved in immune cell recruitment and activation, resulting in liver inflammation...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, has been used to demonstrate the product performance of BD Medical - Pharmaceutical Systems' novel cross-linked silicone coating,BD XSi™, used in BD's prefillable syringe BD Neopak XSi™

Silicone oil is commonly used as a lubricant coating in prefilled syringes (PFS) and is becoming one of the most highly discussed topics in the PFS market, particularly for developers of highly sensitive biotech drugs. In specific biological drug cases, unexpected drug-container interactions have been reported that were potentially attributed to or potentially associated with sub-visible particles generated from the lubricating silicone layer...

NanoSight reports on how the University of Cordoba has applied Nanoparticle Tracking Analysis, NTA, to improve the understanding of the behaviour of silver colloids used in the development of sustainable nanomaterials.

Dr Rafael Luque is a research member in the Department of Organic Chemistry on the Campus de Rabanales of the University of Cordoba in Spain. The main research goals of his team include the preparation of nanoparticle systems for potential utilization as catalysts and in other applications (e.g. antimicrobial and photocatalytic activities). They are focused on the design of various nanomaterials for a broad range of applications...

Silicone oil is commonly used as a lubricant coating in prefilled syringes (PFS) and is becoming one of the most highly discussed topics in the PFS market, particularly for developers of highly sensitive biotech drugs.

In specific biological drug cases, unexpected drug-container interactions have been reported that were potentially attributed to or potentially associated with sub-visible particles generated from the lubricating silicone layer. These could lead to “solution inspection” concerns or even compatibility concern. Sebastien Jouffray is Core Team leader in the R&D Product Development Group at BD Medical – Pharmaceutical Systems....

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used at French company, Santen SAS, to use different nanoemulsions for applications in the treatment of the human eye.

Santen is a Japanese pharmaceutical company specializing in the development and manufacturing of ophthalmic products. Santen's products are available all over Europe and the company is the leading manufacturer of ophthalmic products in Northern Europe. Santen SAS, located in France, is the innovation center of Santen Pharmaceuticals. This is where the company incubates high technology projects...

Malvern Instruments Ltd (Malvern, UK), a leading global provider of instrumentation and expertise for materials and biophysical characterization, has acquired nanoparticle characterization company NanoSight Ltd (Amesbury, UK). The acquisition was completed on Friday 27 September 2013.

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used in the Faculty of Chemistry of the Jagiellonian University for the characterization of catalytic materials used in environmental applications such as N₂O decomposition and soot oxidation.

Dr Pawel Stelmachowski is an assistant professor in the Materials and Surface Chemistry Group at the Jagiellonian University in Krakow. "UJ," as it is known, is Poland's oldest university having been founded in the mid-fourteenth century. The Group's research goals are the design, development and optimisation of catalytic materials. These are used mainly for environmental applications such as N₂O decomposition and soot oxidation. The phase cooperation of crystallites of different sizes and deposition of active phase on monolithic supports requires sizing and characterization measurements and this is why NTA was chosen...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used at St George's, University of London, to explore extracellular vesicles as a potential source of biomarkers, by identifying proteins or peptides differentially expressed between healthy subjects and patients with rare inherited diseases.

St George's, University of London, is the UK's only independent medical and healthcare higher education institution. Dr Bridget Bax is a senior research fellow in the Clinical Sciences Division where the main focus of her group's research is to improve the understanding of the pathogenic mechanisms of rare inherited diseases and to develop novel therapies for translation into the clinical setting. One of their major areas of interest is the identification and validation of biomarkers in patients with the rare and fatal disease mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)...

NanoSight, world-leading providers of unique nanoparticle characterization technology, announces that more than 800 third party publications citing their Nanoparticle Tracking Analysis (NTA) methodology have been published, and reflect on the significance of this powerful third party endorsement.

May 2013 saw publication of the 800th peer-reviewed paper citing NTA. It was written by Mark Davis and his group at Caltech: "Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor." It was published in the Proceedings of the National Academy of Sciences of the United States of America....

NanoSight announces the release of a new NS500 instrument with a Dynamic Light Scattering (DLS) module, which will take the lower size limit of detection down to around 4 nm in diameter.

NanoSight is pleased to announce the launch of the first DLS-enabled version of their widely-used NS500 instrument. For the first time these two powerful and complementary techniques come together in one instrument, designated NanoSight NS500^+DLS. This gives all the benefit of NTA in high resolution sizing, with DLS extending the lower detection limit to 4 nm...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used at the University of Wyoming in the characterization of the physical and interfacial properties of manufactured nano materials.

Dr Jonathan Brant is leader of the group, "Interfaces in the Environment: membranes, particles and nanotechnology" in the College of Engineering and Applied Science at the University of Wyoming. The group focuses on problems associated with physicochemical processes in engineered and natural environmental systems. Understanding and ultimately controlling the many complex mechanisms that occur at environmental interfaces may resolve many of these problems...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being applied in the Chemical Engineering Department of the California Institute of Technology to study nanoparticle-based therapeutics being developed for the treatment of illnesses such as dementia and Alzheimer's.

The central theme of the Mark E Davis research group at Caltech is the use of chemical engineering concepts (synthetic chemistry and analytical engineering problem solving) to answer important fundamental questions in the physical and life sciences. Current research entails designs for the synthesis of inorganic and hybrid, organic-inorganic materials for catalysis and biocompatible materials for the delivery of macromolecular therapeutics...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being implemented for the further characterization of natural colloids (inorganic and organic) at the Institute of Water Resources and Water Supply at the Technical University Hamburg-Harburg in Germany.

Inorganic and organic colloids are widespread in aquatic systems, where they influence many water quality treatment processes. Until recently there was a lack of an adequate analysis technique to measure the size fraction below 1000 nm. The research group of Professor Mathias Ernst of the Institute of Water Resources and Water Supply at the Technical University Hamburg-Harburg has adopted the use of NanoSight's NTA technique to provide new insights into water quality...

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used in the research project "Engineering of Biomolecules" at the Lorraine University, based in Nancy.

Dr Jordane Jasniewski works at the Laboratory of Biomolecules Engineering (LIBio) at Lorraine University, Nancy, and teaches in Food Chemistry at ENSAIA, an engineering school. He is a member of the research team working on the engineering of biomolecules to understand their structure and function to help develop new molecular architectures, to be applied in the areas of foods & agrichemicals, nutrition, pharmacology and cosmetics...

NanoSight announces that Particle Technology Labs, PTL, has established cGMP compliance for Nanoparticle Tracking Analysis, NTA, and this is now available on a contract basis to the pharmaceutical industry.

PTL is the leading particle characterization research and advisory company in the United States, providing assistance to a wide range of industries. Nanoparticle Tracking Analysis, NTA, has been adopted for both research-based projects and as a quality control tool for regulated industries. PTL’s NanoSight LM10-HSB instrument is certified cGMP as of June 4, 2013. cGMP refers to the Current Good Manufacturing Practice regulations enforced by the US Food and Drug Administration (FDA)...

FREE NanoSight Webinar on the use of Nanoparticle Tracking Analysis in Drug Delivery Research.

NanoSight, leading manufacturers of unique nanoparticle characterization technology, address the challenges of nanoparticle control and analysis in the latest of their popular webinar program. On Thursday 6th June, NanoSight hosted a webinar to look at how Nanoparticle Tracking Analysis (NTA) is used to as a characterization tool during the development of drug delivery systems. During the webinar NanoSight.....

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used in the development of a method to estimate the purity of vesicle preparations by comparing the ratio of nano-vesicle counts to protein concentration. This work is reported by Dr Aled Clayton of the School of Medicine at Cardiff University in an original research article published in the Journal of Extracellular Vesicles.

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is used to help with the characterization of polymeric nanoparticles synthesized as drug carrier systems. This work is being carried out at Saarland University, Saarbrücken in Germany by Dr Christian Ruge and his colleagues

NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is used in the work of Dr Ilya Kurochkin of Lomonosov Moscow State University in the development of new bioanalytical systems for environmental and biomedical monitoring

NanoSight, providers of unique nanoparticle tracking analysis technology (NTA) welcomes the publication of the European Commission report listing methods currently available for measurement of Nanomaterials, as defined by the EU in 2011

NanoSight, leading manufacturers of unique nanoparticle characterization technology, reports on the breakthrough cancer metastasis research of Dr. Hector Peinado Selgas and Dr. David Lyden's research team from Weill Cornell Medical College

NanoSight, leading manufacturers of unique nanoparticle characterization technology, reports on the work of Principal Scientist Dr Damian Marshall and his colleagues at LGC as they develop new methods for characterizing new nanoscale reference materials