Search News Archives
Follow us on
Conferences | Events
Media Partners
Cresset BioMolecular Discovery Ltd

Cresset BioMolecular Discovery Ltd

Cresset BioMolecular Discovery Ltd

Products

Contact Cresset BioMolecular Discovery Ltd


If you have not logged into the website then please enter your details below.

All articles from Cresset BioMolecular Discovery Ltd

  Cancer Research UK Manchester Institute Enhances Toolkit for Computational and Medicinal Chemists with Flare for Structure-Based Drug Design

Electrostatic Complementarity TM maps and scoresCresset, innovative provider of software and contract research services for small molecule discovery and design, is pleased to announce that Cancer Research UK Manchester Institute(CRUK MI), has licensed Flare for fresh insights into structure-based drug design. “Putting easy-to use and visually driven structure-based design software in the hands of our medicinal chemists will empower them to deliver the next generation of cancer therapeutics more efficiently,” says Professor Caroline Springer

 

  Flare™ V2 Heralds Next Generation of Structure-Based Design with Electrostatic Complementarity™ Scoring and New Python® API

Flare V2 makes advanced structure-based design techniquesCresset, innovative provider of software for molecular discovery, is pleased to announce the release of Flare V2. Introducing major enhancements to ligand design and activity prediction in a modern, extensible, scriptable interface, Flare V2 raises the bar in structure-based design....

 

  Cresset User Group Meeting 2018 to Showcase New Science, Customer Case studies and Hands-On Software Workshops

Cresset User GroupCresset, innovative provider of outstanding software for molecular discovery, is pleased to announce the scientific program for its User Group Meeting on 21st – 22nd June in Cambridge, UK. Leading chemists from industry and academia will present scientific case studies and insights into how computational chemistry has helped transform their research...

 

  Proximagen Enhances Medicinal Chemists’ Toolkit with Flare for Structure-Based Design

cressetCresset is pleased to announce that Proximagen, a drug discovery and development company, has licensed Flare.

“Flare will give our medicinal chemistry team rapid, hands-on access to structure-based design capabilities” says Dr Ed Savory, Head of Exploratory Research, Proximagen. “When combined with our use of Cresset’s Forge for SAR and design, and Spark for R-group exploration and scaffold hopping...

 

  Cresset Releases Flare: Powerful Structure-Based Design Application with Outstanding New Methods for Protein-Ligand Systems

Cresset announces the release of Flare, an intuitive desktop application that provides outstanding new methods for understanding protein-ligand systems. 

Flare LaunchFlare enhances Cresset’s existing excellent product range focused on ligand-based design, and becomes their first product explicitly designed to support structure-based design....

 

  Cresset Applications Licensed by Shiv Nadar University, India, to Teach Computational Chemists of the Future

Cresset announces that the Shiv Nadar University, India, has licensed the following applications to educate the computational chemist of the future: Forge - powerful ligand-focused workbench for SAR and design; and Spark - scaffold hopping application for progressing through lead optimization faster.

cresset“Cresset actively supports academic research by providing flexible licensing terms,” says Dr David Bardsley, Commercial Director at Cresset. “We are delighted that Shiv Nadar University, India, joined the growing number of academics who are using our applications globally....

 

  Scientific program and workshops announced for The Cresset User Group Meeting, 29th – 30th June 2017, Cambridge, UK

Cresset, innovative provider of software and contract research services for small molecule discovery and design, announces full line-up for The Cresset User Group Meeting, 29th – 30th June 2017 in Cambridge, UK.

cressetThe scientific program on 29th June 2017 features speakers from 4 continents. Cresset scientists will present ‘New Insights for Structure-based Design with Flare’, ‘Peeking into the Heart of New Cresset Science’ and ‘What’s New in Ligand-based Design’....

 

  Cresset Signs Strategic Alliance Agreement to Speed up Drug Design

Cresset, innovative provider of software and contract research services for small molecule discovery and design, signs three-way strategic agreement to speed up drug design.

Cresset British-Chinese three-way agreement partnersDr David Bardsley, Commercial Director, Cresset visited the School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China to sign a strategic cooperation agreement for drug design technology, developed within the Research Centre for Drug Discovery (RCDD)....

 

  Cresset Corporate Rebrand Reflects New Structure for Growing Company

Cresset, innovative provider of software and contract research services for small molecule discovery and design, is pleased to announce a corporate rebrand, reflecting a new structure for this growing business.

cresset“Cresset has grown dramatically since I joined as CEO in 2010, with a tripling of annual income over this period” says Dr Robert Scoffin, CEO of Cresset. “This new visual identity formalizes our structure into three divisions, reflecting the markets we serve and creating the conditions for even greater future growth....

 

  BASF Crop Protection Choose Cresset Software for Small Molecule Discovery and Design

Cresset is pleased to announce that BASF Crop Protection has invested in a global license giving their agrochemical researchers in Germany and India access to computational chemistry tools.

cresset“Cresset software had previously been subject to an exclusivity agreement with a leading agrochemical company,” explains Dr David Bardsley, Commercial Director at Cresset. “Now our software is available across this industry we are experiencing a surge of interest from agrochemical companies keen to take advantage of our novel techniques...

 

  New Spark eMolecules Reagent Databases Enable Researchers to Tie Bioisosteric Replacement Ideas to Reagent Availability

New Spark eMolecules reagent databases enable researchers to tie bioisosteric replacement ideas to reagent availability

New Spark eMolecules reagent databasesSynergy between technologies speeds up drug optimization cycle. Cresset, innovative provider of software and contract research services for small molecule discovery and design, is pleased to announce the release of the new Spark reagent databases based on available compounds from eMolecules. This will enable researchers to use Spark to find the best R-groups for their projects, whilst also enabling a close...

 

  SAI Life Sciences Limited, India, Licenses Cresset Molecular Design Tools to Advance Customer Projects

Cresset, an innovative provider of software and contract research services for small molecule discovery and design, is pleased to announce that SAI Life Sciences, a CDMO service provider with headquarters in Hyderabad India, has licensed several Cresset molecular design tools to advance their customer projects.

Detailed molecular design in Torch with Activity Miner“We are pleased to associate with Cresset and have licensed cresset tools (Torch with Activity Miner, Spark), as the best tools to help our medicinal chemists design and optimize new drug candidates for our innovator clients,” says Sarma BVNBS, Vice President of Medicinal Chemistry at SAI Life Sciences. “We will be using Torch and Activity Miner to gain new insights into our SAR data, while Spark will help us to...

 

  Dr Robert Scoffin, CEO of Cresset, Awarded Fellowship of Royal Society of Chemistry

Cresset, innovative provider of software and discovery services for small molecule discovery and design, is pleased to announce that Cresset’s CEO, Dr Robert Scoffin, has been awarded a Fellowship of the Royal Society of Chemistry.

Rob ScoffinDr Robert Scoffin FRSC, is an expert in the fields of molecular modeling and cheminformatics. He joined Cresset as CEO in 2010. His previous roles include CEO of Amedis a...nd VP, Europe at CambridgeSoft. He also heads up Re-Pharm, an early stage discovery company which uses Cresset software to assess compounds for repurposing. His DPhil is in Chemistry from the University of Oxford. Dr Scoffin joins

 

  Cresset Discovery Services Provides Computer-Aided Drug Design to Medicines for Malaria Venture

Cresset Discovery Services, provider of contract research services for early phase discovery, and Medicines for Malaria Venture (MMV), have entered into a collaborative agreement to use computer-aided drug discovery to identify back-up compounds for a recently discovered molecule in MMV’s portfolio.

/custom/Putative binding site for the proposed target molecule.png“Cresset Discovery Services offer expertise in computational chemistry,” says Dr James Duffy, Associate Director, Drug Discovery, MMV. “We look forward to working with them to identify a back-up compound for one of our promising projects.” “Our experts in computational biology and computational chemistry are ideally placed to solve high impact problems in drug discovery such as the identification of back-up compounds...

 

  Cresset’s Innovative Clustering Method Used to Assess 3D Similarity of 1.5 Million BioBlocks Structures

Cresset Discovery Services, provider of contract research services for early phase discovery, has developed an innovative clustering method that made it possible to assess the 3D similarity across BioBlocks’ virtual database of over 1.5 million fragments.

3D similarity-based clustering workflowCresset’s work enabled BioBlocks, a collaborative medicinal chemistry company, to design new fragment libraries with maximal coverage of 3D chemical space. “Our goal was to help BioBlocks to build the maximum 3D diversity into small libraries of fragments from a starting pool of over a million compounds,” explains Dr Mark Mackey, CSO of Cresset. “Existing techniques would have required an unfeasible amount of computing...

 

  Cancer Therapeutics Cooperative Research Centre chooses Blaze for Virtual Screening

Cresset, innovative provider of software and contract research services for small molecule discovery and design, is pleased to announce that Cancer Therapeutics CRC (CTx), a collaborative partnership of leading research institutes, universities and biotechnology companies in Australia, has licensed the virtual screening software Blaze for cancer research.

Blaze workflow Blaze will be used to run virtual screening projects to translate Australia’s innovative research discoveries into new cancer drugs. “Cresset’s Blaze virtual screening platform was the obvious choice for us as it has a proven track record,” says Warwick Tong, Chief Executive Officer at CTx. “With access to a super computer at the Commonwealth Scientific and Industrial Research Organization (CSIRO) we now have the capability to run virtual...

 

  Fragments and Conformations from the CCDC’s Cambridge Structural Database Accessible Through Cresset’s Spark

Cresset, innovative provider of software and services for small molecule discovery and design, announces the release of the new Spark CSD Fragment Database derived from the Cambridge Crystallographic Data Centre’s (CCDC) Cambridge Structural Database (CSD).

cresset“Spark replaces fragments of molecules with biologically equivalent alternatives,” explains Dr Robert Scoffin at Cresset. “It is ideal for scaffold hopping, moving to clear IP, replacing R-groups and growing or linking fragments. This new database of fragments from the CSD means that Spark’s results contain chemical replacements that have experimentally validated chemistry and known conformations. This gives them a higher chance of a smooth...

 

  Cresset to Distribute COSMOlogic Scientific Software in North America: Combined Software Ranges Cover Wide Areas of Chemical Research

Cresset, innovative provider of software and services for small molecule discovery and design, is pleased to announce that they will be distributing COSMOlogic software in North America alongside the existing Cresset software range.

CressetThe COSMOlogic software provides in-depth analysis of fluid property and is very widely used in synthetic chemistry and chemical engineering. Cresset software focuses on the properties of small molecules and is widely used in synthetic chemistry and pharmaceutical discovery. Together, the two software ranges offer solutions across all aspects of chemical research, from discovery to scale-up and into product manufacturing. “We are delighted to be representing COSMOlogic in...

 

  F2G License Cresset’s Forge to Complement Successful Consulting Projects

Cresset, innovative provider of computational chemistry software and services, is pleased to announce that F2G, a UK biotech focusing on the discovery and development of novel compounds to treat life threatening fungal diseases, has chosen to license Cresset’s Forge software to help them develop the next generation of antifungal agents.

cressetForge is a powerful ligand focused workbench for molecular design, SAR analysis, QSAR and more; Forge enables users to better understand the properties and activities of their existing molecules, and to design improved compounds. “F2G have used Cresset’s consulting services for over two years,” says Dr Graham Sibley, Head of Chemistry at F2G. “Through the work presented to us I was particularly impressed with the data management and...

 

  Mercachem Choose Cresset’s Torch and Spark Molecule Design Software to Support their Growing Medicinal Chemistry Service Business

Cresset, innovative provider of computational chemistry software and services, is pleased to announce that Mercachem, a leading European contract research organization, has chosen Cresset’s Torch and Spark software to support their growing medicinal chemistry service business.

Spark showing the result of a bioisosteric replaceTorch is a molecular design and SAR analysis application. Spark is a powerful bioisosteric replacement tool which is excellent for generating new chemical ideas for your project. “Mercachem delivers outstanding discovery and medicinal chemistry on a contract basis to global clients,” says Dr Gerhard Müller, Senior Vice President Medicinal Chemistry at Mercachem. “Computational tools are an essential part of our workflow and...

 

  Re-Pharm Uses Cresset’s Forge to Identify Novel Activity for an Existing Drug

Cresset, innovative provider of computational chemistry software and services, announces that its drug discovery arm Re-Pharm Ltd has used Forge to identify novel anti-inflammatory activity for an existing drug, which is widely prescribed for other non-inflammatory conditions.

CressetRe-Pharm was searching for drugs to be re-purposed against a new enzyme target. Using known ligands and a crystal structure as a starting point, they used Cresset’s Forge to build computational templates to match any compounds likely to be active at the new target. The results were screened and RP0217 was identified as an effective new anti-inflammatory agent. Re-Pharm has filed patents on RP0217 for a variety of disease indications...

 

  Field Based Chemistry North America and Europe

Cresset, innovative provider of computational chemistry software and services, announces its annual user meetings, ‘Field Based Chemistry North America’ and ‘Field Based Chemistry Europe’.

cressetBoth meetings combine scientific presentations, product updates, and news on the latest Cresset research. There are also free expert training sessions for Cresset products at each meeting. The North America meeting takes place on June 11th, 2014 in Cambridge, MA, USA. Presentations will be given by Novartis, Retrophin, Harvard Medical School, leading academics and Cresset scientists...

 

  Rapidly explore available chemistry space in Spark V10.2

The new radial plots are an intuitive way of ranking Spark’s suggestions on multiple physicochemical properties.

The new radial plots are an intuitive way of ranking Spark’s suggestions on multiple physicochemical properties.

Cresset, innovative provider of chemistry software and services, announces the release of Spark V10.2.  This release enhances Spark’s capabilities in the lead optimization phase of a drug discovery program by recommending new molecules to make from the immediately accessible chemistry space. Spark is a powerful tool for generating novel and diverse structures for your project....

 

  Cresset grows scientific team and relocates to offices in Cambridge Cluster

Cresset, innovative provider of chemistry software and services, relocates today to offices near Cambridge. The move reflects Cresset’s growth and a desire to be close to the Cambridge Cluster. The new office is based in Litlington, Cambridgeshire and serves as the company’s global headquarters. 

Cresset's free trial demo poster

“Cresset’s scientific team is one of our major assets”, says Dr Robert Scoffin, Cresset’s CEO.  “Our recent growth has seen us strengthen our scientific consulting team, our technical group and our sales staff.  This move represents an on-going investment in our people and our intention to continue to recruit the best scientific minds over the coming years.” Dr Scoffin adds, “Our new office environment will enable us to continue to deliver Cresset’s powerful combination of outstanding chemistry software and high value consulting services for drug discovery research...

 

  Victrix CMCC chooses Cresset's software for drug discovery consulting projects to give insight into molecular activity

Under a new agreement, Victrix CMCC will use Cresset’s software for their computational chemistry consulting projects. Cresset’s Spark, Forge and Torch software will help Victrix clients to carry out structure based drug design projects and build predictive 3D SAR models for lead identification.

Cresset Software

“Victrix is very pleased to be able to offer our clients access to Cresset's software,” says Dr Adam Kallel, CSO of Victrix.  “Cresset’s field based software significantly expands our ability to help clients with programmes that have little or no structural information.” Dr Kallel adds, “I have been a believer in field based methodology since I began work in the pharmaceutical industry and I was an early adopter of the Cresset technology.  I believe the XED force field that underlies Cresset’s software provides the ability to model molecules and their molecular fields in a way that is as close to high level quantum mechanics as possible, giving valuable insights into structure reactivity relationships...

 

  Cresset seeks partners for beta testing of groundbreaking new Activity Miner

At Field Based Chemistry Europe, Dr Tim Cheeseright presented a pre-release of Cresset’s new Activity Miner module. The groundbreaking new science in Activity Miner helps researchers optimize their leads by identifying the key 3D structural and electrostatic changes that impact molecular activity. 

New Activity Miner ModuleActivity Miner explores the structure activity landscape of a set of molecules. For each pair of molecules, the difference between them in electrostatics, shape and structure is compared to the difference in activity. A small change in structure or electrostatics that results in a large change in activity is known as an activity cliff. Conversely, large structural changes resulting in little or no change in activity indicate bioisosteres. In each case, the comparison indicates an area of interest that merits further research...

 

  Cresset’s BlazeGPU delivers fast virtual screening on affordable hardware

Cresset, innovative provider of chemistry software and services, announces the release of the GPU version of Blaze, the leading virtual screening platform. 

Cresset LogoBlazeGPU runs at 40 times the speed of Blaze using affordable consumer hardware, making this effective lead generation tool accessible to any research lab. This dramatic speed increase means that screening a database of a few million compounds can be achieved overnight using a single desktop box with 4 GPUs, rather than requiring an expensive Linux cluster...

 

  Biologically Intelligent Database Searching for Lead Identification and Patent Fortification

Cresset Completes Suite with the Release of blazeV10 for Virtual Screening

cressetCresset, innovative provider of chemistry software and services, announces the completion of its Cresset proV10 suite with the relaunch of its highly successful FieldScreen system as blazeV10 for ligand based virtual screening.  blazeV10 uses the shape and electrostatic character of known ligands to rapidly search large chemical collections for molecules with similar properties, returning diverse new leads.  This makes it a powerful tool for patent fortification and compound reprofiling....

 

  sparkV10 Chosen to Facilitate the Hit Optimization Process in ProMining Therapeutics

Cresset Group, innovative provider of chemistry software and services, announces that ProMining Therapeutics Ltd has chosen to license sparkV10 for assistance in its hit-to-lead optimization efforts

sparkV10sparkV10 is Cresset’s desktop bioisostere software tool which is used by medicinal and computational chemists for drug design. sparkV10 is an exciting and powerful way of generating novel and diverse structures.  We are delighted that ProMining, an early-stage biopharmaceutical research and development company, has chosen to work with sparkV10 for the development of small molecule drugs,” says Dr David Bardsley, Cresset’s Sales Director...

 

  Cresset Launches forgeV10 and Range of Next Generation Chemistry Software Bringing Science to the Fingertips of Computational and Medicinal Chemists

Cresset forgeV10Cresset, innovative provider of software and services for molecule designers launches forgeV10 a powerful computational suite to understand SAR and design.  forgeV10 gives computational chemists control and insight into activity data enabling the planning and direction of projects with confidence.  ForgeV10 uses the shape and electrostatic character of molecules to create qualitative and quantitative 3D models of activity that are visually stimulating and easy to communicate...

 

  Isogenica, Cresset Group and Biolauncher Secure Funding from UK’s Technology Strategy Board for a £1M project to Develop New Small Molecule Drug Platform Isogenica and Biolauncher, Cambridge UK together with Cresset Group, Welwyn Garden City UK announce funding from the Technology Strategy Board, the UK's innovation agency, for a £1M project to develop a highly-scalable approach to small molecule drug discovery.

cressetThe funding enables the consortium to develop an integrated platform to identify diverse small molecules active against drug targets using very large peptide libraries to explore chemical space. The consortia's objective is to demonstrate that this platform provides a new scalable approach to the early stage drug discovery challenges that is rapid, cost effective and applicable to intracellular, extracellular and membrane bound drug targets...

 

  Cresset Launches Flexible Chemistry Service Program: CompChem on Demand cressetCresset, innovative provider of software and services for molecule designers has launched a new service program that will enable scientists to outsource computational chemistry work at a high value daily rate. With the introduction of CompChem on Demand, Cresset's services division will now provide computational chemistry services on a daily basis, without requiring a long-term project commitment. The program allows customers to pre-pay for flexible service days,..

 

  Cresset and Optibrium Announce Technology Collaboration Cresset BioMolecular Discovery LtdInnovative software and services provider Cresset, and Optibrium, a provider of software solutions for drug discovery, today announce an agreement to collaborate on the development of next-generation platforms. The innovative companies will work together, combining unique approaches to help drug discovery projects quickly identify novel, potent compounds with a high chance of success downstream...

 

  Cresset Introduces New Support Resources for FieldStere cressetCresset has introduced a new range of support resources following the recent release of FieldStere V3.0, a key software tool aiding chemists in designing novel active molecules.  In addition to phone, email and webinar support, Cresset now introduces software tutorial videos and case studies to provide insight into the features and benefits of FieldStere...

 

  Cresset Announces Fall 2011 Design a Molecule Competition Winners DaM Comp WinnersCresset is delighted to announce the results of its Fall 2011 Design a Molecule Competition. This competition, the third in a series run by Cresset, focussed on an anti-malarial target and challenged chemists to design the most biologically similar molecule (best bioisostere) to a reference compound that was provided. Entries were ranked relative to the original bioactive/bound conformer using Cresset's FieldAlign software and then judged on synthetic tractability, drug-likeness and novelty...

 

  Cresset and Redx Pharma announce Major Drug Discovery Collaboration cressetCresset and Redx Pharma are pleased to announce that they have signed a major drug discovery collaboration. The collaboration gives Redx Pharma access to Cresset's publicly available and proprietary computational chemistry technologies for use on their portfolio of drug discovery programs. In addition Cresset will provide consulting services in the area of candidate selection across a broad range of therapeutic areas and targets...

 

  Isogenica, Biolauncher and Cresset Biomolecular Discovery forge alliance to bring powerful target-to-drugs platform to market cressetIsogenica Ltd today announced a collaborative joint venture with Biolauncher Ltd (Cambridge, UK) and Cresset Biomolecular Discovery Ltd (Welwyn Garden City, UK) to develop an innovative end-to-end therapeutic discovery platform. Under the terms of the collaboration the parties will integrate their expertise in peptide library design, evolutionary screening, next generation sequencing, state of the art structural analytics, and molecular field-based computational chemistry to identify active compounds against high-value therapeutic targets...

 

  Cresset Releases New Command-Line Applications and Workflow Components Including Free Download of its Core XED Force Field cressetCresset announces the release of a range of new command-line interfaces and free workflow components for its popular Field based molecular design tools. New command-line interfaces and workflow components have been released for FieldStere, FieldAlign and FieldView. In addition, Cresset has released a number of core tools based on its unique XED force field including XedeX, a Field based conformation hunter, and XedMin, a ligand minimizer that is available for free download...

 

  Cresset Announces a Major New Academic Access Program with Software Bursaries and Free Academic Training Licences cressetCresset is delighted to announce the launch of its major new access program for academic users of its range of chemistry software tools at the American Chemical Society (ACS) show in Anaheim from March 27-31 at booth 664. This program provides academic users with a range of ways to access Cresset's products, including a software bursary program, free training licences for academic courses as well as low cost academic group licences and free downloads for some of Cresset's products...

 

  Cresset Announces Appointment of Hulinks Inc. as Japanese Distributor cressetCresset is delighted to announce the appointment of Hulinks Inc. as distributor of its Field based chemistry software products in Japan.

 

  Cresset Introduces Newest Cloud Computing Enabled Application with FieldAlign V3.0 Cresset FieldAlign V3.0 Cresset today announced that it has released a major new version of its FieldAlign package. FieldAlign V3.0 is the latest in Cresset's new generation of "cloud enabled" applications, which support parallel, distributed computing by default. It can be deployed both as a traditional desktop application and as a command-line application distributed onto large computing servers. FieldAlign V3.0 also introduces native support for the Mac for the first time.

 

  Cresset Announces New International Sales Team Cresset today announced that it has expanded its computational chemistry software sales team in the U.S. and Europe. As a result of this growth, the company looks forward to significantly increasing its presence in the European and U.S. markets in 2011.

 

  Cresset Announces Release of Free Molecular Fields Viewer Cresset is delighted to announce the release of FieldView, its powerful new molecular Fields visualizer. FieldView is a molecular viewer/editor designed to create, modify, view and compare molecules along with their associated Field patterns and physicochemical properties. This provides a richer more informative view of how molecules behave in biological systems.

 

  Cresset Announces Appointment of Rob Scoffin as New CEO Cresset is delighted to announce the appointment of Dr Rob Scoffin as Chief Executive Officer of Cresset Group. Rob joins Cresset from CambridgeSoft where, as Vice President of European Operations, he was responsible for significant growth in CambridgeSoft's European business. Rob replaces Beatrice Leigh, who will now become non-executive Chairman of the Board.

 

  Cresset Introduces New Generation of Cloud Computing Applications with FieldStere V2.0 Cresset today announced the release of a new version of its FieldStere bioisostere generator. FieldStere delivers shorter lead optimization cycles to computational and medicinal chemists by enabling them to choose the best syntheses, to fine-tune portions of lead molecules and to scaffold hop to expand into new areas of chemical space.

 

  Cresset Establishes New Versaphor Division to Provide High-quality Desktop Products Cresset today announced that it has launched Versaphor, a new desktop applications division aimed at supplying high quality tools based on its molecular Fields technology to a range of markets, including: medicinal chemists, patent teams (internal and external counsel), pre-clinical safety teams and in-licensing teams.

 

 

Media Partners