The future of reaction screening is here

Laboratory technology developer Technobis has released ReactALL™, an innovative benchtop multiple reactor system for medium throughput experimentation, helping scientists tap into the under-utilized nights and weekends. Available globally now, ReactALL™ uses novel integrated automated sampling technology to accelerate chemical reaction screening, optimisation, route scouting, reaction profiling and kinetics. ReactALL™ addresses the gap between high throughput and low throughput screening to provide high-quality, data rich results with low material needs.

Technobis’ new instrument, developed with scientific input from Pfizer, uses proprietary SmartCap™ technology to sample, quench and dilute directly into commercial standard HPLC (high performance liquid chromatography) vials. Reaction setup is fast, taking less than 30 minutes with ReactALL™.

The system comprises five small-scale reactors, each equipped with fully automated sampling. Representative samples are immediately quenched, diluted, and transferred to standard HPLC vials on the ReactALL™. The sample and dilution volumes are precisely controlled by the system for quantitative analysis.  Wide bore tubing and streamlined pump-free fluidics assure robust sample transfer, even for heterogeneous samples. And the novel SmartCap™ sampling technology does not pierce reactor septa, so there are no pierced holes for losing solvent. 

Accelerating in-depth chemical understanding is a key goal of the ReactALL™. Such data-rich experiments can translate to significant time saving, and thus money. Screening reactions for the best reagents, catalysts and conditions; optimising reaction yield, selectivity and impurity control; mechanistic profiling; ReactALL™ obtains high quality results early in drug development to allow chemists to draw the right conclusions, as early as possible.

“A guiding ethos at Technobis is ‘Help research succeed’”, explained John de Kok, CEO of Technobis. “ReactALL™ will transform the way chemists conduct medium throughput research and in the pharmaceutical industry, which is close to my heart, bring medicines to market faster than ever before.”

ReactALL™ possesses multiple features that enhance reaction scientists’ investigation capabilities. Colour cameras, integrable Raman spectroscopy probes, provide crucial information on physical and chemical state changes, such as dissolution and precipitation, colour changes, and much more. ReactALL™ uses overhead stirring design specifically with the aid of Computational Fluid Dynamics to closely recreate mixing properties conferred by mechanical agitators, and poorly captured by magnetic stir bars.

“It’s essential that ReactALL™ fits into the lab of the future and industry 4.0 compatibility is key there,” said Stephan van Banning, chief technology officer at Technobis. “Our software engineers have enabled interoperability with pretty much anything you might want in your workflow.”

For example, ReactALL™ could run reactions and automatically take, quench and dilute samples into HPLC vials. A pre-loaded SmartCap™ can be loaded in ReactALL™ while a robotic arm could then transport your sample vial trays to the HPLC machine. The chemist would need only 30 minutes for setting up the reactions and the next day, they already have the HPLC data.

To learn more about how ReactALL™ can help your laboratory workflow step into the future, visit the launch page

About Technobis

Technobis is a world-leading technology provider for reaction screening, solid-state research, process development and formulation. Our mission is to help research succeed! 

Since 2005, our platforms for accelerating crystallization research have been successfully developed and installed in nearly every pharmaceutical research lab in the world. With this strong global presence, we help the scientific community to drive forward the rapidly advancing pharmaceutical development space. In recent years, we have been developing new applications in agrochemical, fine chemical, (bio) fuel research, food, and personal care.

In 2024, we expanded our instrument portfolio beyond crystallization research and into the broader field of chemical process research and development. With the game changing ReactALL™ instrument, we empower process chemists across various markets to successfully optimize and further scale up their reaction experiments for production, with unprecedented efficiency. Designed by scientists, for scientists.