Search News Archives
Follow us on
Conferences | Events

Media Partners

 

Dionex Demonstrates New Method that Meets U.S. Pharmacopeia Criteria for Determination of N-Methylpyrrolidine in Cefepime

Dionex is proud to announce a new method that successfully determines N-methylpyrrolidine (NMP), a cefepime decomposition product, using an ICS-2100 system and IonPac® SCS1 column set coupled with nonsuppressed conductivity detection. Application Note 259: Determination of N-Methylpyrrolidine in Cefepime with Nonsuppressed Conductivity documents results for limit of detection, limit of quantification, linear calibration range, spike recovery, retention time Detection precision, and peak area precision determinations, thereby demonstrating that this instrumental configuration fulfills U.S. Pharmacopeia (USP) acceptance criteria for determining NMP in cefepime hydrochloride and Cefepime for Injection samples.

The cefepime antibiotic can degrade under certain thermal conditions, producing NMP, which can reduce cefepime potency and present potential toxicity to patients. The USP has proposed improved compendial methods for determining the limit of NMP in cefepime hydrochloride and Cefepime for Injection by eliminating column rinse and re-equilibration steps, thus increasing sample throughput. This new approach meets the USP proposed methods and criteria for Organic Impurities, Procedure 1 (Limit of N-Methylpyrrolidine).

Dionex (NASDAQ:DNEX) is a global leader in the manufacturing and marketing of liquid chromatography and sample preparation systems, consumables, and software for chemical analysis. The company's systems are used worldwide in environmental analysis and by the life sciences, chemical, petrochemical, food and beverage, power generation, and electronics industries. Our expertise in applications and instrumentation helps analytical scientists to evaluate and develop pharmaceuticals, establish environmental regulations, and produce better industrial products.

IonPac is a registered trademark of Dionex Corporation.



 


Popular this Month

 

Win a PIPETBOY from the new Integra summer collection!

 

Great Savings off Selected GC Columns

 

CytoSMART raises 5.2 million Euros for further product innovation and growth

 

High Volume Sample Storage in Space Efficient 96-Well Format

 

Cherwell Publishes Guide on Sterility Testing

 

Effective Removal of DMSO from Stored Samples

 

ATL Webcast: A Practical Guide to Selecting the Right LIMS

 

Genetic study reveals how gut bacteria work to keep us healthy

 

Lonza Establishes Custom Cell Biology Services to Offer Unique Manufacturing and Testing Capabilities

 

Thermo Fisher Scientific Opens Food Safety Customer Solution Center in India

 

 


 

 


 

Can't find what you are looking for?

Search by company or by product


Company Name:

Product:


 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd