AMSBIO has introduced new cell lines and controls for Programmed Cell Death Protein 1 (PD-1) research, and to test inhibitors of the PD-1 / PD-L1 pathway.

The binding of PD-1, a receptor expressed on activated T-cells, to its ligands (PD-L1 and PD-L2) negatively regulates immune responses. PD-1 ligands are highly expressed in many cancers, and their interaction inhibits T-cell activity allowing cancer cells to escape immune surveillance. The PD-1: PD-Ligands pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

A PD-1 / NFAT Reporter - Jurkat Cell Line is now available for applications including screening for activators or inhibitors of PD-1 signaling in a cellular context and also for characterizing the biological activity of PD-1 and its interactions with ligands.

AMSBIO has also introduced the accompanying TCR activator / PD-L1 - CHO Recombinant Cell line that is purpose designed for screening for activators or inhibitors of PD-1 signaling as well as screening PD-L1 antibodies for their binding affinity.

The functionality of the cell lines was validated using a PD-1:PD-L1 cell-based assay and expression of human PD-1 or PD-L1 in the cell lines was confirmed by Western blotting.

AMSBIO offers a wide range of purified, soluble immunoreceptors involved in key immunosignaling pathways. Additionally, the company offer a number of assay kits that can be used to screen for inhibitors of protein-protein interaction, as well as neutralizing antibodies to serve as positive controls for inhibition. 

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO is able to draw upon in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. Widely acknowledged as an expert in cell culture, AMSBIO partners with clients in tailoring cell systems to enhance organoid and spheroid type screening outcomes from a technological and cost-effective perspective.

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