Follow us...

 

Search News Archives

News Channels

 

New Laboratory Products

Lab News

What's going on at Lab Innovations

Research & Case Studies

Microscopy | Image Analysis

Separation Science

Brochures & Literature

Videos

Events | Webinars

 

 

Conferences | Events

BMG LABTECH Reports Success from a Recent Australian Research Council Linkage Grant

publication date: Jul 10, 2015
 | 
author/source: BMG LABTECH

The grant is targeted towards developing new technological approaches enabling academics, biotech and pharmaceutical companies to discover novel treatments for a range of disorders.

 Luminescence measurementsA major outcome of the grant has been published recently in Nature Methods (Stoddart et al., 2015).

The paper entitled “Application of BRET to monitor ligand binding to GPCRs” demonstrates for the first time the principle of real time ligand binding to G Protein-Coupled Receptors (GPCRs), the single most important family of drug targets, using Bioluminescence Resonance Energy Transfer (BRET). In effect, the BRET technique has been shown to be an alternative to radio ligand binding experiments and extends researchers’ capability to allow assessment of real time binding kinetics in live cells. This adds to the established capability of BRET to monitor protein-protein interactions in real time in live cells, further enhancing biologists’ and pharmacologists’ insights into real time cellular processes.

The project combines the knowledge and expertise of the laboratories of Associate Professor Kevin Pfleger of The University of Western Australia/Harry Perkins Institute of Medical Research and Professor Stephen Hill of The University of Nottingham (UK) who are leaders in BRET and fluorescence technology development respectively. Promega Corporation (USA) with its latest proprietary reagents and developmental know how, and BMG LABTECH the leading high-throughput microplate reader instrumentation with its associated expertise complement the team. All BRET measurements shown in the paper were performed on BMG LABTECH’s multimode microplate readers CLARIOstar® and PHERAstar FS . BMG LABTECH Australia placed both readers at disposal of the group to support the grant.

Both microplate readers are qualified for all Luminescence measurements. Equipped with BMG LABTECH’s LVF monochromatorTM technology the CLARIOstar® allows continuously adjustable bandwidths from 8 to 100 nm. The PHERAstar FS comes with assay-optimized optic modules and the fastest read times.


more about BMG labtech


more news from BMG labtech


 


If you have not logged into the website then please enter your details below.



 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd

 


Promotions

 

Media Partners