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New 3D Cell Invasion Assay

publication date: Feb 17, 2016
 | 
author/source: AMSBIO

invasion capacity of tumor cells

AMSBIO announces the launch of the Oris™ 3D Embedded Invasion Assay – a unique product offering quantifiable real-time analysis of cell invasion.

This new cell invasion assay is designed to enable cell movement through an extracellular matrix (ECM) in 3-Dimensions, thereby getting you as close as possible to an in vivo experiment using in vitro conditions.

The invasion capacity of tumor cells is of particular concern in cancer research, and is a first step to metastasis, the deadliest aspect of the disease. Traditionally, cell invasion assays are performed by seeding cells in a chamber and assessing invasion by counting cells that penetrate through a flat, two dimensional ECM, typically a coated porous membrane, towards a lower chamber. However, these membranes are unlike any in vivo structure, potentially compromising the physiological relevance of the assay. Moreover, traditional invasion assays are not amendable to real-time monitoring, as cells can only be viewed microscopically post-invasion through the membrane, precluding real-time analysis of changes in invasion rate and cell morphology.

Based upon patented “exclusion zone” technology which uses cells embedded in a collagen matrix - Oris™ 3D Embedded Invasion Assays from AMSBIO provide a simple, quantitative, and efficient way to monitor cell invasion and morphology changes in a more physiologically relevant microenvironment. With no artificial membranes obscuring visualization of the cells, cell invasion rates and morphology changes can be reproducibly and quantifiably measured as end-point assays or in real-time. Designed in an industry-standard 96-well plate format, the assay can be used with microscopes, plate readers and high content imaging system thereby delivering significant reductions in handling time for set up and analysis.

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized today as a leading company contributing to the acceleration of discovery through the provision of cutting-edge life science technology, products and services for research and development in the medical, nutrition, cosmetics and energy industries. AMSBIO is able to draw upon in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion and proliferation. Widely acknowledged as an expert in cell culture, AMSBIO partners with clients in tailoring cell systems to enhance organoid and spheroid type screening outcomes from a technological and cost-effective perspective.


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