Earlier this month, Alfa Chemistry announced the launch of acylation reagents, a type of derivatization reagents frequently used in Gas Chromatography (GC) analysis, and other instrumental analytical scenarios.

In order to bring out the best chromatographic analysis effect, sample compounds need to meet a few criteria, for instance, high-temperature resistance and rapid transformation into the vapor state without degradation. However, if these criteria are not met, derivatization reagents generally undergo chemical modifications that rearrange or transform the original compounds, thus affording new compounds suitable for GC analysis. In most cases, derivatization serves as a procedural technique to escalate the volatility, selectivity, stability, and detectability of samples.

There are varieties of derivatization reagents, including alkylation reagents, silylation reagents, acylation reagents, fluorescent derivatization reagents, ultraviolet derivatization reagents, hydroxyl derivatization reagents, chiral derivatization reagents, amino derivatization reagents and the like. Among them, acylation reagents are of vital importance for derivatization procedures as many compounds of interest consist of the amine and/or hydroxy groups.

“Acylation can enhance the GC analytical performance due to increased analyte volatility. Acylation can also reduce the polarity of a molecule, making it more retentive in the reversed-phase HPLC applications,” said one of the senior scientists from Alfa Chemistry.

Acid anhydrides, acid halides, and reactive acyl derivatives are the three types of acylation reagents that are most commonly used in acylation reactions for chromatography, with unique characterizations and applications.

Currently, Alfa Chemistry provides the following acylation reagents that customers can reach out to for their varied research purposes.

2,2,6,6-Tetramethyl-3,5-heptanedione (CAS 1118-71-4), 1-(Trifluoroacetyl)imidazole (CAS 1546-79-8), 6,6,7,7,8,8,8-Heptafluoro-2,2-dimethyl-3,5-octanedione (CAS 17587-22-3), N-Heptafluorobutyrylimidazole (CAS 32477-35-3), Methyl trifluoromethanesulfonate (CAS 333-27-7), Heptafluorobutyric anhydride (CAS 336-59-4), Pentafluoropropionic anhydride (CAS 356-42-3), Ethyl trifluoromethanesulfonate (CAS 425-75-2), Butylboronic acid (CAS 4426-47-5), N-Methyl-bis(trifluoroacetamide) (CAS 685-27-8), N-Methyl-bis-heptafluorobutyramide (CAS 73980-71-9), (±)-α-Methoxy-α-trifluoromethylphenylacetic acid (CAS 81655-41-6), 4-Bromophenacyl trifluoromethanesulfonate (CAS 93128-04-2), etc.

“Ideally, a successful derivatization procedure should afford compounds that are readily distinguishable from starting materials and make sure that over 95 percent of the sample is derivatized.” The scientist further added.

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