Alfa Chemistry, a trust-worthy chemical supplier, announces that it newly releases a portfolio of protection reagents for researchers worldwide, which will help solve one of the biggest difficulties in the multi-step synthesis of natural products.

In organic synthesis, several sites or functional groups in a molecule may react with the reactants, but only specific sites are needed for the reaction process. Thus, chemoselectivity in functional group transformations is always a critical issue that needs to be tackled.

“Efficient protection should meet several criteria. First, they should selectively and easily react with protected groups to achieve high conversion rates. Second, they should be stable throughout the whole synthesis process. Moreover, the protecting group in the protection reagents should be easily removed when not needed or when the functional group requires manipulation,” says the Marketing Chief of Alfa Chemistry.

The following protection reagents are provided by Alfa Chemistry, which are readily available, making reactions more easily handled and less contaminated.

• 2-(Trimethylsilyl)ethoxycarbonylation (Teoc) Reagents
• 9-Fluorenylmethyloxycarbonylation (Fmoc) Reagents
• Acetalization Reagents
• Acylation Reagents
• Alkoxymethylation Reagents
• Allylation Reagents
• Allyloxycarbonylation (Alloc) Reagents
• Benzylation (Bn) Reagents
• Benzyloxycarbonylation (Cbz) Reagents
• Photolabile Protection Reagents
• Silylation Reagents
• Sulfonylation Reagents
• tert-Butoxycarbonylation (Boc) Reagents
• Thioacetalization Reagents
• Trichloroethoxycarbonylation Reagents
• Tritylation (Tr) Reagents
• Other Protecting Reagents

Protection reagents have multiple applications in organic synthesis, and special focus goes to the following areas:

Carbohydrate chemistry

Protection reagents play a key role in the synthesis of complex natural products such as oligosaccharides. The DMP-group was used in the synthesis of several β-glucosamines, which has shown to be stable to certain basic and acidic reaction conditions and could be readily removed using NaOH or hydrazine.

Peptide chemistry

Protection reagents are also needed in the synthesis of peptides. Proper protection reagents manipulation strategies can maximize the yield of the desired product or allow the construction of complex peptide-based structures.

Oligonucleotide synthesis

In the chemical synthesis of natural products having phosphoric acid esters, the phosphate protection reagents should be selected.

“All chemicals provided by Alfa Chemistry are strictly QC assessed so that high quality is guaranteed. Technical documents such as COA are also provided,” the Marketing Chief further explains.

For more information about the wide offering of protection reagents at Alfa Chemistry, please visit the website.

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About Alfa Chemistry

Having established good cooperation relationships with many pharmaceutical companies, universities and research institutions, Alfa Chemistry is keenly aware of the latest research trends, and manages to meet the increasing market demand by continuously expanding and optimizing its product portfolios, including the recent release of environmental goods standards, porphyrins and phthalocyanines.

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