Freeman Technology, a global provider of powder testing instruments, and GEA Pharma Systems, a company that specialises in the design and development of processing solutions for the pharmaceutical industry, are collaborating to advance the application of continuous wet granulation and drying technology in the pharmaceutical industry.
The work involves Freeman Technology’s FT4 Powder Rheometer® and GEA Pharma Systems’ ConsiGma™ 1 continuous granulation unit. Data from the FT4 are being used to quantify the influence of the operating conditions of the ConsiGma1 on the bulk characteristics of the granules being manufactured. These data are then correlated to attributes of the tablets, providing the link between granule and tablet properties.....
Read MoreNew whitepaper highlights impact of NGS target enrichment assay choiceDec 17, 2013
OGT provides insight on NGS enrichment optimisation
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a free whitepaper titled ‘The importance of enrichment assay choice and optimisation for confident variant detection.’ The paper investigates the main strategies employed to optimise target enrichment for next generation sequencing (NGS) assays, assisting researchers to make informed decisions when designing studies...
A new application note from Malvern Instruments explores the role of particle size and the importance of particle size measurement in optimizing the formulation of drilling muds used in oil extraction processes.
The particle size of drilling mud components exerts a significant influence on the performance of the final drilling mud product. Rapid, reliable measurement and control of particle size is especially important when tailoring drilling mud formulations for individual geological situations and drilling operations. This new publication focuses on the use of laser diffraction particle sizing for this application, exploring the steps involved and providing examples of typical data generated.....
Read MoreProtocol for Preparing Top Quality Lyophilised SamplesDec 11, 2013
Genevac has developed a protocol using its SuperCool 75 condenser
Genevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...
The launch of Malvern Instruments’ Viscotek SEC-MALS 20 chromatography detector has triggered record downloads of one of the supporting white papers ‘Static light scattering technologies for GPC/SEC explained’, underlining the enthusiasm amongst users for straightforward information on GPC/SEC analysis.
The recent addition of Viscotek SEC-MALS 20 to Malvern’s range of detectors puts the company in the unique position of being the sole provider of every commercially available light scattering technology for GPC/SEC. Customers can therefore be assured of a truly unbiased choice of detector solutions. The popular white paper is just one of a suite of educational information and application notes provided by Malvern’s specialist team to help users select the right detector for their application...
A new article detailing a round table discussion on quality by design (QbD) authored by leading industry experts including Spinnovation Biologics CEO Frederic Girard is now available online.
Entitled ‘QbD and PAT in Upstream and Downstream Processing’, the article details the fundamental principles of QbD, how it is used to improve process control, and the impact technological advances have made on QbD biopharmaceutical upstream process optimization. Originally published in the July addition of Biopharm International the full article is now available to read...
Uniqsis has published details of a mild nitration method using its FlowSyn flow chemistry system that enables short reaction times and high conversion to be achieved whilst minimising the amount of corrosive (and potentially explosive) hot nitrating mixture present in the reactor at any one time.
Nitration is an important synthetic procedure that is often difficult to control. Under continuous flow-through conditions, however, exotherms are typically well controlled and nitration can be safely performed on a large scale. Using Uniqsis’s proprietary glass static mixer/reactor chip technology - nitration can be safely performed under accelerated conditions at elevated temperature and pressure without the associated problems typically encountered in batch reactors of controlling latency periods or controlling thermal run away...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download whitepaper titled ‘When to use targeted resequencing — Choosing the right NGS method.’ The paper aims to assist researchers when planning NGS strategies by providing a detailed review of the major resequencing methods. Comparing and contrasting method suitability, the paper also examines the significant impact of data analysis, as well as time and cost considerations...
METTLER TOLEDO is pleased to present a new white paper to help those working in the Chemical, Food, Consumer Product, and Mineral industries meet the challenge of understanding, optimizing and controlling particle and droplet systems in a variety of applications including suspensions, emulsions and crystallizations.
“Best Practice for Inline Particle Size Characterization” reviews a series of real-life examples where prominent food, chemical and consumer product companies have used inline characterization methods to measure real time particle size dynamics at full-process concentration to ensure repeatable process endpoints, improve yield, and optimize product quality. Inconsistencies in solid or liquid dispersion, agglomeration or precipitation can create variability in product stability and manufacturing throughput...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download application note on combined array comparative genomic hybridisation (aCGH) and single nucleotide polymorphism (SNP) arrays.
The application note, titled ‘Detecting copy number variants and runs of homozygosity on a single array — challenges and applications’ aims to support researchers in navigating this combined approach for the simultaneous detection of copy number variations (CNVs) and runs of homozygosity (ROH). aCGH has established itself as the “gold-standard” platform for array-based CNV detection. Recent advances have enabled the combination of aCGH probes for CNV detection with probes able to detect SNPs...
Drawing upon many years’ experience of designing and supplying liquid flowmeters to meet stringent OEM specifications - Titan Enterprises has produced an informative white paper 'How to specify liquid flowmeters'.
Accurate, reliable, cost effective flow measurement is more important today than it has ever been. However the optimal liquid flowmeter varies considerably according to a wide range of operational parameters including pipe bore, flow path, liquid viscosity, particulate levels, measurement accuracy, measurement dynamic range, maintenance and target purchase price...
Porvair Sciences has announced an application note describing the excellent results achievable from a new 96-well format version of its ChromaTrap chromatin immunoprecipitation (ChIP) assay technology.
Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...
New White Paper on Pipetting Ergonomics aims to protect researchers
Pipetting is a forceful and repetitive activity, and there is a strong association between pipetting and the occurrence of repetitive motion injuries. In fact, pipetting for just over an hour a day over the course of a year is enough to put researchers at risk, and the chances increase exponentially with workload and age. A new white paper about “The Ergonomics of Pipetting” has now been published by METTLER TOLEDO...
Temperature Control for Chemical Research and Production
Precise temperature control has a significant influence on performance and quality in chemical process engineering. The Unistat range of temperature control systems ensure accurate temperatures and stable process conditions in research laboratories, pilot plants and kilolabs worldwide. The new Unistat Hybrid technology offers solutions for temperature control of large scale production reactors,enabling an affordable, partial modernisation of existing central plant cooling/heating systems.
Genevac, world leaders in solvent removal technology, has over 20 year’s experience of supplying evaporators for removal of solvents from oil, fat and fuel samples.
Oils, fats and fuels are normally isolated from natural sources using extraction or separation techniques that present the final sample in a solution of organic solvent. Before analysis such samples must be dried or concentrated. Whether extracting and recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing / conversion to biofuels, or investigating drillling test samples - oils, fuels and fats can often prove difficult to dry without using very high temperatures which may lead to loss of the more volatile fractions within the sample....
Read MoreNew Opportunities in Cancer Research Created By Extracellular MatrixMar 7, 2013
A new white paper, available from AMSBIO, discusses the latest developments in extracellular matrix (ECM) and the opportunities they offer in cancer research
At least 80% of cancers are carcinomas, or tumours of the epithelia. Traditionally, cell transformation to a cancerous stage has been evaluated by anchorage dependent growth. More recently, the role of the extracellular matrix, already established in normal epithelial biology, has come to the fore in the study of carcinomas. The extracellular matrix is largely composed of several protein families, notably laminins, collagens and fibronectin. AMSBIO's new white paper focuses on ECM proteins most relevant to cancer research and their use in the oncology field...
Read MoreMerck Millipore Publishes White Paper: Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal AntibodiesMar 1, 2013
Merck Millipore, the Life Science division of Merck, today announced the publication of a white paper, "Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal Antibodies", which describes both regulatory and technical aspects of comparability studies for the development of biosimilars
Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
Details use of flow cytometry and surface plasmon resonance to quantify binding of therapeutic monoclonal antibodies to molecules mediating cytotoxicity
Assays provide valuable preclinical data about drug properties and their physiological interactions without the need for animal experiments
Pipetting is a forceful and repetitive activity, and it is now widely accepted that there is a strong association between pipetting forces and the occurrence of developing Repetitive Strain Injuries (RSI's). In fact, pipetting for just over an hour a day over the course of a year is enough to put you at risk, and these risks tend to increase with workload and age. But for most scientists pipetting is an unavoidable daily task, so reducing or even preventing your risk of RSI should be high on your list of priorities. The best way to start protecting yourself is by ensuring you have all the correct facts and advice available about which conditions pose or increase your risk...
METTLER TOLEDO today announced the release of a white paper on the topic of gravimetric sample preparation. It compares the advantages and disadvantages of gravimetric vs. volumetric sample preparation methods, with particular reference to recognizing and acting to reduce errors associated with each step in the sample preparation workflow
Anyone working in a regulated analytical laboratory or a Quality Assurance (QA) / Quality Control (QC) environment will identify with the potentially costly and time-consuming process of investigating Out-of-Specification (OOS) results. More than 50% of OOS results in analytical workflows are reportedly caused by sample processing and operator errors. Implementing automated Gravimetric Sample Preparation and following Good Weighing Practice™ (GWP®) can help reduce data variability and OOS results.
Read MoreNew Olympus Life Science Microscopy website and QR code system offers intuitive, application-focused navigationDec 6, 2012
Interactive media for targeted and fast information access
As part of its promise to provide world-class service, Olympus has enhanced its website to guarantee comprehensive, accessible and tailored support for all customers. Based on extensive market research and customer feedback, Olympus completely redesigned its website for life science microscopy. It now offers customers an interactive resource, enabling them to navigate in an application-focused manner towards the products and services that are best suited for their individual requirements...
Read MoreNew Whitepaper Compares Gene Expression Analysis TechnologiesNov 22, 2012
Plexpress helps researchers to make an informed choice
Plexpress, developer of the innovative TRAC platform for high-throughput gene expression analysis, has released a free-to-download whitepaper entitled “Gene expression analysis: A review – high throughput multiplex gene expression analysis from discovery to in-depth investigation”. The document provides a comprehensive review of the major methods available, comparing and contrasting the various...
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The work involves Freeman Technology’s FT4 Powder Rheometer® and GEA Pharma Systems’ ConsiGma™ 1 continuous granulation unit. Data from the FT4 are being used to quantify the influence of the operating conditions of the ConsiGma1 on the bulk characteristics of the granules being manufactured. These data are then correlated to attributes of the tablets, providing the link between granule and tablet properties.....
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a free whitepaper titled ‘The importance of enrichment assay choice and optimisation for confident variant detection.’ The paper investigates the main strategies employed to optimise target enrichment for next generation sequencing (NGS) assays, assisting researchers to make informed decisions when designing studies...
Genevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...
“Best Practice for Inline Particle Size Characterization” reviews a series of real-life examples where prominent food, chemical and consumer product companies have used inline characterization methods to measure real time particle size dynamics at full-process concentration to ensure repeatable process endpoints, improve yield, and optimize product quality. Inconsistencies in solid or liquid dispersion, agglomeration or precipitation can create variability in product stability and manufacturing throughput...
Accurate, reliable, cost effective flow measurement is more important today than it has ever been. However the optimal liquid flowmeter varies considerably according to a wide range of operational parameters including pipe bore, flow path, liquid viscosity, particulate levels, measurement accuracy, measurement dynamic range, maintenance and target purchase price...
Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...
Pipetting is a forceful and repetitive activity, and there is a strong association between pipetting and the occurrence of repetitive motion injuries. In fact, pipetting for just over an hour a day over the course of a year is enough to put researchers at risk, and the chances increase exponentially with workload and age. 
Precise temperature control has a significant influence on performance and quality in chemical process engineering. The Unistat range of temperature control systems ensure accurate temperatures and stable process conditions in research laboratories, pilot plants and kilolabs worldwide. The new Unistat Hybrid technology offers solutions for temperature control of large scale production reactors,enabling an affordable, partial modernisation of existing central plant cooling/heating systems.
While the first one describes the determination of sodium for the manufacture of margarine, the second one describes the determination of sodium in soy milk.....
Oils, fats and fuels are normally isolated from natural sources using extraction or separation techniques that present the final sample in a solution of organic solvent. Before analysis such samples must be dried or concentrated. Whether extracting and recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing / conversion to biofuels, or investigating drillling test samples - oils, fuels and fats can often prove difficult to dry without using very high temperatures which may lead to loss of the more volatile fractions within the sample....
Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
Anyone working in a regulated analytical laboratory or a Quality Assurance (QA) / Quality Control (QC) environment will identify with the potentially costly and time-consuming process of investigating Out-of-Specification (OOS) results. More than 50% of OOS results in analytical workflows are reportedly caused by sample processing and operator errors. Implementing automated Gravimetric Sample Preparation and following Good Weighing Practice™ (GWP®) can help reduce data variability and OOS results.
As part of its promise to provide world-class service, Olympus has enhanced its website to guarantee comprehensive, accessible and tailored support for all customers. Based on extensive market research and customer feedback, Olympus completely redesigned its website for life science microscopy. It now offers customers an interactive resource, enabling them to navigate in an application-focused manner towards the products and services that are best suited for their individual requirements...
Plexpress, developer of the innovative TRAC platform for high-throughput gene expression analysis, has released a free-to-download whitepaper entitled “Gene expression analysis: A review – high throughput multiplex gene expression analysis from discovery to in-depth investigation”. The document provides a comprehensive review of the major methods available, comparing and contrasting the various...