Thermo Fisher Scientific has developed an on-line solid-phase extraction–high-performance liquid chromatography (SPE-HPLC) method combined with ultraviolet (UV) absorbance detection for the simple and sensitive determination of tigecycline in a cell lysate sample.
Application Note 1074:Determination of Tigecycline in a Cell Lysate demonstrates that this approach, performed on a rapid separation LC (RSLC) system controlled by data management software, detects trace amounts of tigecycline in tigecycline-treated cells, concentrations so low that they cannot be assayed using a routine HPLC-UV detection method. The prevalence of multidrug-resistant bacteria in hospitals underscores the need for...
Thermo Fisher Scientific has developed a high-performance liquid chromatography (LC) method that simplifies determination of clenbuterol, ractopamine, and phenolethanolamine in meat using on-line solid-phase extraction (SPE) and ultraviolet absorbance detection.
Application Brief (AB) 154: Rapid and Sensitive Determination of Clenbuterol, Ractopamine, and Phenolethanolamine in Meatdemonstrates that this method, performed using a dual rapid separation LC system controlled by data management software, achieves method detection limits equivalent to those obtained by mass spectrometry (MS). Additionally, this approach offers the advantages of...
The 6th Annual Next Generation Sequencing Congress is taking place on 20th & 21st November 2014 in London, UK.
It brings together over 400 senior experts to discuss crucial challenges in the next generation sequencing field. Topics covered include NGS technologies & platforms, NGS data analysis technologies & platforms, NGS for cancer drug development and NGS clinical applications & diagnostics.
Multiple myeloma (MM), a proliferation (growth) of malignant plasma cells in the bone marrow destroying bones, accounts for 10% of all hematologic malignancies.
Approximately 45.000 new cases are diagnosed each year together in the US and Europe. MM is mainly a disease of elderly people with age at diagnosis between 65-70 years. During the meeting, recently developed approaches for diagnosis and monitoring will be presented. Gene-expression-profiling to detect molecular subgroups with a different prognosis and high-throughput-sequencing to identify new genetic lesions will be discussed...
Studylog Animal Study Software Named Best of Show Finalist at the 2014 Bio-IT World Conference
Studylog Systems today announced that its Studylog Animal Study Workflow Software was named a Best of Show Finalist in the Web-Based Services and Software category at the Bio-IT World Conference & Expo 2014. Only three products were awarded this distinction, which is imparted by the Cambridge Healthtech Institute, and Studylog has the honor of being the only animal research software to be a Best of Show Finalist in the past decade....
Read MoreMagritek Releases Three new Applications Paper Illustrating the Versatility and Ease of use of the Spinsolve Benchtop NMR SpectrometerJun 5, 2014
Magritek, a leading worldwide provider of compact NMR and MRI instruments, have released three new applications notes which showcase the use of their Spinsolve Benchtop NMR Spectrometer.
Magritek has released three new applications notes to illustrate the versatility of their Spinsolve family of cost-effective benchtop NMR spectrometry solutions. Spinsolve uses standard 5 mm OD NMR test tubes, exactly the same as high field instruments, so sample handling is familiar and convenient. Spinsolve can be deployed in the lab where immediate results may now be obtained...
Cresset, innovative provider of computational chemistry software and services, announces its annual user meetings, ‘Field Based Chemistry North America’ and ‘Field Based Chemistry Europe’.
Both meetings combine scientific presentations, product updates, and news on the latest Cresset research. There are also free expert training sessions for Cresset products at each meeting. The North America meeting takes place on June 11th, 2014 in Cambridge, MA, USA. Presentations will be given by Novartis, Retrophin, Harvard Medical School, leading academics and Cresset scientists...
FFEI Life Science has successfully concluded phase I of the BiognostiX project with a symposium to share the results of this 3-year EU funded FP7 research programme.
Delegates to the event, held at the Hauser Forum, Cambridge, UK on Thursday 27 February. Led by FFEI, the BiognostiX Consortium has developed a radical new approach to performing diagnostic tests at point-of-use, with potential applications in veterinary, agri-food and human diagnostics. The BiognostiX technology uses a multiplex microfluidic platform and newly invented Immuno-Ink to deliver fast, flexible, single-use tests in a format that anyone can use...
Counter Terror Expo 2014, held on 29th and 30th April at Olympia London, proved to be as successful as ever, attended by some 8,691 industry leaders and delegations from across the world.
Firmly established as the leading international event of its kind, this year’s show – the 6th edition – saw a 10% rise in pre-registrations compared to 2013. As one visitor commented, “Counter Terror is an essential day for me. It prepares my business for the year ahead by allowing me to research new products and services as well as getting updated on new legislation...
Oxford Global are pleased to announce the return of the Pharma R&D Europe Series, the leading pharmaceutical discussion forum in Europe.
The series is made up of the following events:
15th Annual Drug Discovery Summit
6th Annual Drug Development Congress
2nd Annual Discovery Chemistry & Drug Design Congress
The first round of topics have now been confirmed for the 15th Annual Drug Discovery Summit, taking place on the 2nd & 3rd June 2014 in Geneva, Switzerland.
Oxford Global are pleased to announce the full list of speakers for the Microbiology & Infectious Diseases Congress. Taking place on 29th & 30th September in London, this event is not to be missed.
Don’t miss out on a discounted rate of £350 plus VAT, places are extremely limited
Cogent TYPE-C silica LC phases from MicroSolv Technologies have the ability to retain polar solutes at high concentrations of organic solvent by aqueous normal-phase (ANP) and non-polar compounds under reversed-phase (RP) conditions.
These columns use patented bonding technology to create a surface populated by silicon-hydride functional groups instead of silanols. The lack of surface silanols leads to fast equilibration times, excellent peak shape and extended column lifetimes for a wide range of analytes. To demonstrate the unique abilities of Cogent TYPE-C silica LC phases a wide range of application notes are available including.....
Read MoreMalvern Instruments publishes new whitepaper that explores Analytical Quality by DesignMay 23, 2014
A new whitepaper on the application of Analytical Quality by Design (AQbD) to particle size assessment has been published by Malvern Instruments.
AQbD is an innovative approach to the development and validation of analytical methods that brings the benefits of Quality by Design (QbD) to pharmaceutical analysis. Malvern’s new whitepaper, ‘Beyond SOPs – Exploring the rigor and requirements of Analytical QbD’, introduces the AQbD concept, explains the associated workflow and illustrates how to apply AQbD when developing methods for laser diffraction particle sizing. The whitepaper is freely available for download from the Malvern resource center....
Biovision, the annual forum devoted to future-oriented research in life sciences, today announces its program to bring a new level of awareness to the economic and business challenges faced by the life sciences industry.
This year the emphasis is on the need to further invest in new technologies to reach the growth potential that lies in disruptive innovation. The opening session kicks off with James Barlow, chair of technology and innovation management at Imperial College London. He focuses on the adoption, implementation and sustainability of innovation in healthcare systems. The session will then feature Robert-Jan Smits, general director of DG Research and Innovation at the European Commission, alongside other high profile delegates...
Oxford Gene Technology (OGT), The Molecular Genetics Company, has released a new application note detailing the technical evaluation of two DNA labelling kits, where OGT’s CytoSure Genomic DNA Labelling Kits were found to be quicker and more accurate than a leading alternative.
Achieving efficient and uniform labelling of both test and reference DNA samples is critical for aCGH studies, enhancing data accuracy and interpretation. By ensuring greater accuracy, OGT’s kits vastly improve the identification of breakpoints and even the smallest aberrations, providing robust and invaluable insights into the underlying cause of genetic disorders...
Thermo Fisher has developed an efficient and simple high-performance liquid chromatography (HPLC) method with ultraviolet detection for the determination of phenolic compounds (gallic acid, caffeic acid, 4-hydroxybenzoic acid, syringic acid, ferulic acid, salicylic acid, phloroglucinol, cinnamic acid, catechin, quercetin, vanillin, phloridzin, and phloretin) in apple orchard soil.
Application Note (AN) 1077: Determination of Phenolic Compounds in Apple Orchard Soil demonstrates that the entire analysis process, including sample preparation and separation for one soil sample, can be accomplished within 80 minutes using this method combined with an accelerated solvent extractor....
The dramatic improvement in outcome for children with acute lymphoblastic leukemia is one of the major achievements in hematology in the last 40 years. However, while 90% of children with this disease can now be cured, the outlook has not been so good for the less common type of childhood leukemia, acute myeloid leukemia (AML).
Although only 1 in 7 children with leukemia have AML, half of these children will die from their disease. The challenge now is to harness the new developments in genomics to improve the outcome for these children. At the 19th Congress of the European Hematology Association (EHA), we will learn about the state-of-the-art in management of childhood AML. New concepts in the way AML develops and the way AML cells 'hijack' the main sites of normal blood production within the body will be presented....
Over 70 scientists from 16 countries are due in Nottingham this week for the biennial Scientific Laboratory Show and Conference at the East Midlands Conference Centre on the University of Nottingham campus.
This is the largest gathering of leading academic and commercial scientific experts in the city for several years, for what has become an occasion of real scientific value for leading manufacturers and for visiting international delegates. The three-day event is organised by Nottingham-based Scientific Laboratory Supplies Ltd, in association with the Royal Society of Chemistry and is further recognition of the city’s growing influence in the UK’s life sciences business sector....
A new white paper from Copley Scientific provides expert guidance on how to use breathing simulators effectively when testing orally inhaled products (OIPs).
Breathing simulators are machines that mimic the inhalation and/or exhalation profile of a patient and are used increasingly in OIP testing. Copley Scientific’s white paper clearly explains where breathing simulators are specified by pharmacopoeial methods and also where their optional use is beneficial. This may be in improving understanding of product performance, for example, or to support a Quality by Design (QbD) approach...
Read MoreFreeman Technology Speakers to Present Four Papers at 7th World Congress on Particle TechnologyMay 12, 2014
Tim Freeman, Managing Director, and Dr Xiaowei Fu, Product Specialist at Freeman Technology, will deliver four oral presentations relating to aspects of powder characterisation and critical powder handling issues at the 7th World Congress on Particle Technology (WCPT7) taking place from 19-22 May 2014 in Beijing, China.
Tim Freeman is an invited speaker at the Particle Design: Formulation and Processing session, where he will present ‘A QbD Approach to Continuous Tablet Manufacture’. This talk will focus on the use of powder characterisation to measure material properties that directly correlate with the quality attributes of a finished product to support the development of continuous processes...
Approximately 45.000 new cases are diagnosed each year together in the US and Europe. MM is mainly a disease of elderly people with age at diagnosis between 65-70 years. During the meeting, recently developed approaches for diagnosis and monitoring will be presented. Gene-expression-profiling to detect molecular subgroups with a different prognosis and high-throughput-sequencing to identify new genetic lesions will be discussed...
Magritek has released three new applications notes to illustrate the versatility of their Spinsolve family of cost-effective benchtop NMR spectrometry solutions. Spinsolve uses standard 5 mm OD NMR test tubes, exactly the same as high field instruments, so sample handling is familiar and convenient. Spinsolve can be deployed in the lab where immediate results may now be obtained...
Both meetings combine scientific presentations, product updates, and news on the latest Cresset research. There are also free expert training sessions for Cresset products at each meeting. The North America meeting takes place on June 11th, 2014 in Cambridge, MA, USA. Presentations will be given by Novartis, Retrophin, Harvard Medical School, leading academics and Cresset scientists...
Delegates to the event, held at the Hauser Forum, Cambridge, UK on Thursday 27 February. Led by FFEI, the BiognostiX Consortium has developed a radical new approach to performing diagnostic tests at point-of-use, with potential applications in veterinary, agri-food and human diagnostics. The BiognostiX technology uses a multiplex microfluidic platform and newly invented Immuno-Ink to deliver fast, flexible, single-use tests in a format that anyone can use...
Firmly established as the leading international event of its kind, this year’s show – the 6th edition – saw a 10% rise in pre-registrations compared to 2013. As one visitor commented, “Counter Terror is an essential day for me. It prepares my business for the year ahead by allowing me to research new products and services as well as getting updated on new legislation...
These columns use patented bonding technology to create a surface populated by silicon-hydride functional groups instead of silanols. The lack of surface silanols leads to fast equilibration times, excellent peak shape and extended column lifetimes for a wide range of analytes. To demonstrate the unique abilities of Cogent TYPE-C silica LC phases a wide range of application notes are available including.....
AQbD is an innovative approach to the development and validation of analytical methods that brings the benefits of Quality by Design (QbD) to pharmaceutical analysis. Malvern’s new whitepaper, ‘Beyond SOPs – Exploring the rigor and requirements of Analytical QbD’, introduces the AQbD concept, explains the associated workflow and illustrates how to apply AQbD when developing methods for laser diffraction particle sizing. The whitepaper is freely available for download from the Malvern resource center....
This year the emphasis is on the need to further invest in new technologies to reach the growth potential that lies in disruptive innovation. The opening session kicks off with James Barlow, chair of technology and innovation management at Imperial College London. He focuses on the adoption, implementation and sustainability of innovation in healthcare systems. The session will then feature Robert-Jan Smits, general director of DG Research and Innovation at the European Commission, alongside other high profile delegates...
Achieving efficient and uniform labelling of both test and reference DNA samples is critical for aCGH studies, enhancing data accuracy and interpretation. By ensuring greater accuracy, OGT’s kits vastly improve the identification of breakpoints and even the smallest aberrations, providing robust and invaluable insights into the underlying cause of genetic disorders... 
Although only 1 in 7 children with leukemia have AML, half of these children will die from their disease. The challenge now is to harness the new developments in genomics to improve the outcome for these children. At the 19th Congress of the European Hematology Association (EHA), we will learn about the state-of-the-art in management of childhood AML. New concepts in the way AML develops and the way AML cells 'hijack' the main sites of normal blood production within the body will be presented....
Breathing simulators are machines that mimic the inhalation and/or exhalation profile of a patient and are used increasingly in OIP testing. Copley Scientific’s white paper clearly explains where breathing simulators are specified by pharmacopoeial methods and also where their optional use is beneficial. This may be in improving understanding of product performance, for example, or to support a Quality by Design (QbD) approach...
Tim Freeman is an invited speaker at the Particle Design: Formulation and Processing session, where he will present ‘A QbD Approach to Continuous Tablet Manufacture’. This talk will focus on the use of powder characterisation to measure material properties that directly correlate with the quality attributes of a finished product to support the development of continuous processes...