Cogent TYPE-C silica LC phases from MicroSolv Technologies have the ability to retain polar solutes at high concentrations of organic solvent by aqueous normal-phase (ANP) and non-polar compounds under reversed-phase (RP) conditions.
These columns use patented bonding technology to create a surface populated by silicon-hydride functional groups instead of silanols. The lack of surface silanols leads to fast equilibration times, excellent peak shape and extended column lifetimes for a wide range of analytes. To demonstrate the unique abilities of Cogent TYPE-C silica LC phases a wide range of application notes are available including.....
Read MoreMalvern Instruments publishes new whitepaper that explores Analytical Quality by DesignMay 23, 2014
A new whitepaper on the application of Analytical Quality by Design (AQbD) to particle size assessment has been published by Malvern Instruments.
AQbD is an innovative approach to the development and validation of analytical methods that brings the benefits of Quality by Design (QbD) to pharmaceutical analysis. Malvern’s new whitepaper, ‘Beyond SOPs – Exploring the rigor and requirements of Analytical QbD’, introduces the AQbD concept, explains the associated workflow and illustrates how to apply AQbD when developing methods for laser diffraction particle sizing. The whitepaper is freely available for download from the Malvern resource center....
Biovision, the annual forum devoted to future-oriented research in life sciences, today announces its program to bring a new level of awareness to the economic and business challenges faced by the life sciences industry.
This year the emphasis is on the need to further invest in new technologies to reach the growth potential that lies in disruptive innovation. The opening session kicks off with James Barlow, chair of technology and innovation management at Imperial College London. He focuses on the adoption, implementation and sustainability of innovation in healthcare systems. The session will then feature Robert-Jan Smits, general director of DG Research and Innovation at the European Commission, alongside other high profile delegates...
Oxford Gene Technology (OGT), The Molecular Genetics Company, has released a new application note detailing the technical evaluation of two DNA labelling kits, where OGT’s CytoSure Genomic DNA Labelling Kits were found to be quicker and more accurate than a leading alternative.
Achieving efficient and uniform labelling of both test and reference DNA samples is critical for aCGH studies, enhancing data accuracy and interpretation. By ensuring greater accuracy, OGT’s kits vastly improve the identification of breakpoints and even the smallest aberrations, providing robust and invaluable insights into the underlying cause of genetic disorders...
Thermo Fisher has developed an efficient and simple high-performance liquid chromatography (HPLC) method with ultraviolet detection for the determination of phenolic compounds (gallic acid, caffeic acid, 4-hydroxybenzoic acid, syringic acid, ferulic acid, salicylic acid, phloroglucinol, cinnamic acid, catechin, quercetin, vanillin, phloridzin, and phloretin) in apple orchard soil.
Application Note (AN) 1077: Determination of Phenolic Compounds in Apple Orchard Soil demonstrates that the entire analysis process, including sample preparation and separation for one soil sample, can be accomplished within 80 minutes using this method combined with an accelerated solvent extractor....
The dramatic improvement in outcome for children with acute lymphoblastic leukemia is one of the major achievements in hematology in the last 40 years. However, while 90% of children with this disease can now be cured, the outlook has not been so good for the less common type of childhood leukemia, acute myeloid leukemia (AML).
Although only 1 in 7 children with leukemia have AML, half of these children will die from their disease. The challenge now is to harness the new developments in genomics to improve the outcome for these children. At the 19th Congress of the European Hematology Association (EHA), we will learn about the state-of-the-art in management of childhood AML. New concepts in the way AML develops and the way AML cells 'hijack' the main sites of normal blood production within the body will be presented....
Over 70 scientists from 16 countries are due in Nottingham this week for the biennial Scientific Laboratory Show and Conference at the East Midlands Conference Centre on the University of Nottingham campus.
This is the largest gathering of leading academic and commercial scientific experts in the city for several years, for what has become an occasion of real scientific value for leading manufacturers and for visiting international delegates. The three-day event is organised by Nottingham-based Scientific Laboratory Supplies Ltd, in association with the Royal Society of Chemistry and is further recognition of the city’s growing influence in the UK’s life sciences business sector....
A new white paper from Copley Scientific provides expert guidance on how to use breathing simulators effectively when testing orally inhaled products (OIPs).
Breathing simulators are machines that mimic the inhalation and/or exhalation profile of a patient and are used increasingly in OIP testing. Copley Scientific’s white paper clearly explains where breathing simulators are specified by pharmacopoeial methods and also where their optional use is beneficial. This may be in improving understanding of product performance, for example, or to support a Quality by Design (QbD) approach...
Read MoreFreeman Technology Speakers to Present Four Papers at 7th World Congress on Particle TechnologyMay 12, 2014
Tim Freeman, Managing Director, and Dr Xiaowei Fu, Product Specialist at Freeman Technology, will deliver four oral presentations relating to aspects of powder characterisation and critical powder handling issues at the 7th World Congress on Particle Technology (WCPT7) taking place from 19-22 May 2014 in Beijing, China.
Tim Freeman is an invited speaker at the Particle Design: Formulation and Processing session, where he will present ‘A QbD Approach to Continuous Tablet Manufacture’. This talk will focus on the use of powder characterisation to measure material properties that directly correlate with the quality attributes of a finished product to support the development of continuous processes...
Thermo Fisher Scientific has developed a method for quantitative determination of over 200 multi-residue pesticides present in a blend of herbs and spices known as “churna”and widely used in Ayurvedic medicine using gas chromatography-tandem mass spectrometry (GC-MS/MS).
Application Note 10361, Analysis of Multi-Residue Pesticides Present in Ayurvedic Churna by GC-MS/MS describes a sensitive and precise assay for the detection of pesticides. Trace levels of the multi-residue pesticides were detected in the highly complex churna extracts at concentrations as low as 2.5 ng/g. The analysis was performed using a Thermo Scientific™ TRACE™ 1310 GC coupled to a Thermo Scientific™ TSQ 8000™ triple-quadrupole GC-MS/MS.
Photonics Technology Roadshow will visit Cambridge University on 18th June, focussing on biophotonics techniques and light technologies for science and industry.
The Photonex Roadshow at Robinson College, University of Cambridge, will be a convenient and free opportunity for scientists and industrialists to attend a high level one-day conference and a 30-company exhibition. This event comprises an in-depth conference and a day-long programme of photonics tutorials focussing on latest techniques and instrumentation from leading scientists and technology experts....
Cherwell Laboratories, specialist suppliers of environmental monitoring and process validation products for the pharmaceutical and related industries will be exhibiting at the inaugural Making Pharmaceuticals event on 29th & 30th April 2014.
Making Pharmaceuticals, to be held at NMM Exhibition Centre, Birmingham is the only event in the UK dedicated to the detailed and complex issues associated with sourcing, manufacturing, outsourcing and delivering consistent pharmaceutical products to the market. Experts from Cherwell Laboratories will be available throughout the 2-day event to discuss environmental monitoring and process validation solutions to meet the specific requirements of the pharmaceutical industry.....
Thermo Fisher Scientific has released a new technical note which demonstrates the complete recovery of human hormones from drinking water.
Technical Note 148: Automated Extraction and Determination of Human Hormones in Drinking Water uses our newly released polymeric sorbent extraction cartridges (Thermo Scientific™ Dionex™ SolEx™ SPE HRPHS cartridges) on our solid-phase extraction instrument (Thermo Scientific™ Dionex™ AutoTrace 280 instrument) for the determination of human hormones. The SPE instrument can reduce solvent and labor costs by up to 90% in sample preparation...
Oxford Gene Technology (OGT), The Molecular Genetics Company, has produced a new whitepaper titled ‘Comprehensive genomic analysis – complementing sequencing with high-resolution CNV detection’.
The free, downloadable whitepaper provides researchers with an opportunity to explore the latest strategies in the genomic characterisation of complex disorders, and to discover how, when used alongside sequencing, microarrays play a vital role in delivering accurate detection of point mutations and single exon copy number aberrations. The new whitepaper explains how utilising a range of available tools builds a more complete picture of inherently complex genetic disorders...
Latest Application Note from Wyatt Technology Demonstrates How Absolute Molar Mass can be Measured Using UHPLC SEC-MALS
Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has announced the availability of a new application note which outlines the combined use of the Wyatt μDAWN™ multi-angle light scattering (MALS) detector and the Optilab® UT-rEX™ refractive index (RI) detector to measure the absolute molecular weight (or molar mass) and size of eluting species in ultra high performance liquid chromatography (UHPLC)....
Read MoreFull list of speakers for the 2nd Annual Next Generation Sequencing Data Congress AnnouncedApr 22, 2014
Oxford Global are pleased to announce the full list of speakers for the 2nd Annual Next Generation Sequencing Data Congress. Taking place on 19th & 20th May at the Copthorne Tara Kensington in London, this event is not to be missed.
Thermo Fisher Scientific has developed a rapid and reliable sample preparation procedure and ion chromatography-based method to determine the phytate hydrolysis products in dried distillers grains with solubles (DDGS).
Application Note 1070: Determination of Inositol Phosphates in Dried Distillers Grains with Solubles demonstrates the determination of 25 inositol phosphate isomers—InsP2–InsP6—in an in-house prepared reference solution. Separation is achieved in less than 42 minutes using a column designed for high-resolution separations of carbohydrates. Using this separation, inositol phosphates are determined in DDGS....
Malvern Instruments is proud to be a premier sponsor of the inaugural PEGS China meeting.
The PEGS China Protein & Antibody Engineering and Development summit is presented by Cambridge Healthtech Institute and takes place in Shanghai from 1 - 3 April 2014. Malvern is participating in both the conference and the associated exhibition, with Dr Wei Qi, Senior Scientist within Malvern’s Bioscience Development Initiative, presenting a paper on ‘Emerging techniques for therapeutic protein characterization – viscosity, stability and sub-visible particles’....
150 life scientists from 23 countries met at the VIB in Ghent
In cooperation with the Flanders Institute of Biotechnology (VIB) and Core for Life, ZEISS invited the international community of correlative microscopists for 3 days to a joint workshop at the Bioimaging Core of the VIB Inflammatory Research Centre (IRC) in Ghent, Belgium. The workshop followed the first meeting of the community at the ZEISS Microscopy Labs Munich in 2012. From 9-11 March 2014, 150 scientists from 23 countries took the opportunity to discuss the current state of the art in correlative microscopy and 3D imaging techniques....
Thermo Fisher Scientific has developed a reproducible and accurate ion chromatography (IC) method for determining monochloroacetic acid (MCAA) in carbocisteine drug substance and two monochloroacetic acid drug products, thus enabling efficient quality control of the carbocmanufacturing processisteine.
Application Note 1076: Determination of Monochloroacetic Acid in Carbocisteine demonstrates that this IC method is easily executed using a reagent-free IC system controlled by data management software. The analyst simply adds water and samples to separate and accurately determine MCAA using a hydroxide-selective anion-exchange column (Thermo Scientific™ Dionex™ IonPac™ AS11-HC column)...
These columns use patented bonding technology to create a surface populated by silicon-hydride functional groups instead of silanols. The lack of surface silanols leads to fast equilibration times, excellent peak shape and extended column lifetimes for a wide range of analytes. To demonstrate the unique abilities of Cogent TYPE-C silica LC phases a wide range of application notes are available including.....
AQbD is an innovative approach to the development and validation of analytical methods that brings the benefits of Quality by Design (QbD) to pharmaceutical analysis. Malvern’s new whitepaper, ‘Beyond SOPs – Exploring the rigor and requirements of Analytical QbD’, introduces the AQbD concept, explains the associated workflow and illustrates how to apply AQbD when developing methods for laser diffraction particle sizing. The whitepaper is freely available for download from the Malvern resource center....
This year the emphasis is on the need to further invest in new technologies to reach the growth potential that lies in disruptive innovation. The opening session kicks off with James Barlow, chair of technology and innovation management at Imperial College London. He focuses on the adoption, implementation and sustainability of innovation in healthcare systems. The session will then feature Robert-Jan Smits, general director of DG Research and Innovation at the European Commission, alongside other high profile delegates...
Achieving efficient and uniform labelling of both test and reference DNA samples is critical for aCGH studies, enhancing data accuracy and interpretation. By ensuring greater accuracy, OGT’s kits vastly improve the identification of breakpoints and even the smallest aberrations, providing robust and invaluable insights into the underlying cause of genetic disorders... 
Application Note (AN) 1077: Determination of Phenolic Compounds in Apple Orchard Soil demonstrates that the entire analysis process, including sample preparation and separation for one soil sample, can be accomplished within 80 minutes using this method combined with an accelerated solvent extractor....
Although only 1 in 7 children with leukemia have AML, half of these children will die from their disease. The challenge now is to harness the new developments in genomics to improve the outcome for these children. At the 19th Congress of the European Hematology Association (EHA), we will learn about the state-of-the-art in management of childhood AML. New concepts in the way AML develops and the way AML cells 'hijack' the main sites of normal blood production within the body will be presented....
Breathing simulators are machines that mimic the inhalation and/or exhalation profile of a patient and are used increasingly in OIP testing. Copley Scientific’s white paper clearly explains where breathing simulators are specified by pharmacopoeial methods and also where their optional use is beneficial. This may be in improving understanding of product performance, for example, or to support a Quality by Design (QbD) approach...
Tim Freeman is an invited speaker at the Particle Design: Formulation and Processing session, where he will present ‘A QbD Approach to Continuous Tablet Manufacture’. This talk will focus on the use of powder characterisation to measure material properties that directly correlate with the quality attributes of a finished product to support the development of continuous processes...
Application Note 10361, Analysis of Multi-Residue Pesticides Present in Ayurvedic Churna by GC-MS/MS describes a sensitive and precise assay for the detection of pesticides. Trace levels of the multi-residue pesticides were detected in the highly complex churna extracts at concentrations as low as 2.5 ng/g. The analysis was performed using a Thermo Scientific™ TRACE™ 1310 GC coupled to a Thermo Scientific™ TSQ 8000™ triple-quadrupole GC-MS/MS.
Making Pharmaceuticals, to be held at NMM Exhibition Centre, Birmingham is the only event in the UK dedicated to the detailed and complex issues associated with sourcing, manufacturing, outsourcing and delivering consistent pharmaceutical products to the market. Experts from Cherwell Laboratories will be available throughout the 2-day event to discuss environmental monitoring and process validation solutions to meet the specific requirements of the pharmaceutical industry.....
The free, downloadable whitepaper provides researchers with an opportunity to explore the latest strategies in the genomic characterisation of complex disorders, and to discover how, when used alongside sequencing, microarrays play a vital role in delivering accurate detection of point mutations and single exon copy number aberrations. The new whitepaper explains how utilising a range of available tools builds a more complete picture of inherently complex genetic disorders...
Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, has announced the availability of a new application note which outlines the combined use of the Wyatt μDAWN™ multi-angle light scattering (MALS) detector and the Optilab® UT-rEX™ refractive index (RI) detector to measure the absolute molecular weight (or molar mass) and size of eluting species in ultra high performance liquid chromatography (UHPLC)....
In cooperation with the Flanders Institute of Biotechnology (VIB) and Core for Life, ZEISS invited the international community of correlative microscopists for 3 days to a joint workshop at the Bioimaging Core of the VIB Inflammatory Research Centre (IRC) in Ghent, Belgium. The workshop followed the first meeting of the community at the ZEISS Microscopy Labs Munich in 2012. From 9-11 March 2014, 150 scientists from 23 countries took the opportunity to discuss the current state of the art in correlative microscopy and 3D imaging techniques....
Application Note 1076: Determination of Monochloroacetic Acid in Carbocisteine demonstrates that this IC method is easily executed using a reagent-free IC system controlled by data management software. The analyst simply adds water and samples to separate and accurately determine MCAA using a hydroxide-selective anion-exchange column (Thermo Scientific™ Dionex™ IonPac™ AS11-HC column)...