Thermo Fisher Scientific has developed a high-resolution hydrophobic interaction chromatography (HIC) method that can separate a fusion protein from a truncated version and a structural isomer.

Application Brief 171: High-Resolution Separation of a Fusion Protein demonstrates that two different HIC columns—the Thermo Scientific^™ ProPac^™ HIC-10 column and the new MAbPac^™ HIC-10 column—can each perform this challenging separation. While the ProPac HIC-10 column is an established column for the analysis of monoclonal antibody post-translational modifications, the MAbPac^™ HIC-10 column exhibits the best performance....

Benefits of integrated formulation preparation and analytics for the development of biotherapeutics to be demonstrated in webinar sponsored by Freeslate

Wyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on...

The EZ-2 ENVI from Genevac is designed for gentle evaporation of volatile environmental samples, such as pesticides, and is proven to give excellent recovery and reproducibility.

The system is fully automated, can concentrate a number of samples at the same time and provides protection from cross contamination and bumping. Over the last 25 years, to safeguard sample integrity during rapid and safe evaporation, Genevac has pioneered the development of a range of innovations including SampleGuard temperature control, the Dri-Pure anti-bumping system and most recently the unique SampleGenie technology. The ingenious patented design of...

Thermo Fisher Scientific has developed two rapid and robust high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) methods for the accurate determination of common sugars in acid-hydrolyzed wood samples.

Application Note (AN) 1089: Determination of Carbohydrates in Acid Hydrolysates of Wood demonstrates that this approach achieves high-resolution separation of even the sugar pair rhamnose-galactose that has been challenging to resolve using existing HPAE-PAD methods. Both methods use a new polymeric column, the Thermo Scientific^™ Dionex^™ CarboPac^™ SA10-4μm column, configured with a new system, the...

Thermo Fisher Scientific has updated an ion chromatography (IC) method to more easily determine total choline (free and bound forms) in 17 samples representing all forms of infant formula, adult nutritionals, and pediatric formulas (powder, ready-to-feed products, and liquid concentrates).

Application Update (AU) 193: Choline in Infant Formula and Adult Nutritionals, a Single Laboratory Validation demonstrates that this simple yet robust approach decreases sample preparation time while accurately determining choline in these products. The method detailed in AU 193 runs on an IC system that requires only a source of degassed DI water for generation of high-purity eluent, thus simplifying operation while increasing precision and...

Built-in shock absorbers and a conical design assure improved precision and reliable performance for automated sample handling systems

MicroSolv’s Reduced Surface Activity (RSA) or low adsorbing autosampler vials are specially formulated and processed to yield a surface that exhibits extremely low levels of adsorption of basic, polar compounds and shows exceptional consistency of adsorption levels from vial to vial.

Many laboratories analyzing monoclonal antibodies (mAb) regularly encounter situations where they need alternative hydrophobic interaction chromatography (HIC) selectivity. Thermo Fisher Scientific has developed new column chemistry that separates many more of these challenging mAbs, antibody-drug conjugates (ADCs) and proteins.

Agilent Technologies, Inc. and Shimadzu Corp. has announced the release of GC instrument control for their respective Chromatography Data Systems (CDS). This provides customers in analytical laboratories with more freedom of choice when selecting a chromatography data system.

Thermo Fisher Scientific has developed a simple, efficient, sensitive, and reproducible capillary ion chromatography (IC) method for determining thiosulfate and pyrophosphate in crayfish wash powder.

Application Note 1088: Determination of Thiosulfate and Pyrophosphate in Crayfish Wash Powder demonstrates that this application is easily executed using a Reagent-Free^™ IC system capable of high-pressure IC controlled by data management software. The analyst simply adds water and samples to separate thiosulfate and pyrophosphate on a specialized anion-exchange column, the Dionex IonPac AS19 capillary column, thus...

The MiniVap™ Blowdown Sample Concentrator from Porvair Sciences is purpose designed for research and development departments that need to dry smaller numbers of individual microplates or HPLC vials. 

The compact MiniVap is simple to operate and requires minimal ongoing maintenance. To install - a MiniVap requires only connection to a gas supply and standard mains socket. Safety of operation is ensured as the CE marked unit fits into all fume cupboards. Offering manual fine control of needle depth, gas temperature and flow rate - the affordably priced MiniVap can be easily optimised to produce faster drying times than other entry level lab evaporators.  MiniVap takes just minutes to...

Magritek, a leading worldwide provider of compact NMR and MRI instruments, have demonstrated the use of their Spinsolve benchtop NMR spectrometer to perform and monitor chemical reactions on-line. 

As costs for energy and raw materials continue to rise, it becomes more critical for chemists to be able to mimic a reaction or to quantify the parameters required to produce a final product without the difficulty and expense of using production facilities. To be able to recreate a production process on a lab bench is therefore highly desirable for many chemists. The Magritek Spinsolve high-resolution benchtop NMR spectrometer is a...

Thermo Fisher Scientific, the world leader in serving science, today unveiled a new high performance liquid chromatography system designed from the ground up to provide new levels of performance, productivity and usability when used as a standalone system or with the latest mass spectrometers.

The new Thermo Scientific Vanquish UHPLC looks different from standard UHPLC systems, and there are benefits to its clean design. The monolithic case contains an instrument that combines the ruggedness of an integrated system with the flexibility and serviceability of a modular system. Vanquish stands about 25 percent lower than comparable modular stacks for safety and convenience in the laboratory...

Thermo Fisher Scientific has developed a simple, rapid, reliable, and accurate high-performance liquid chromatography (HPLC) method for the simultaneous determination of amlodipine and besylate in an amlodipine besylate drug substance.

Application Note 1087: Simultaneous Determination of Amlodipine and Its Counterion Besylate by HPLC demonstrates that this method requires only 8 minutes per analysis using a column designed for pharmaceutical analysis and ultraviolet detection. In addition, combining the analysis of the active pharmaceutical ingredient (API) and counterion into a single method saves times, reduces mobile phase consumption, and minimizes waste. Amlodipine besylate is a...

AMSBIO announces MagSi-Direct - a revolutionary technology that brings the power, simplicity, and convenience of magnetic separation to researchers involved in cell biology, protein chemistry, flow cytometry, diagnostics development and many other fields

MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads.  It is particularly suited for exploiting interactions between a biomolecule and its binding partners.  With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to...

The HT-4X evaporator from Genevac has been specifically designed for drug discovery laboratories, from medicinal chemistry through to purification and metabolism studies. 

Built to the highest specifications the HT-4X makes demanding applications routine. Corrosive vapours such as trifluoroacetic acid can be routinely removed by the standard system and optional facility is provided for fast sample lyophilisation. An innovative built-in dual chamber refrigerated condenser accelerates speed of evaporation, even for high boiling point solvents such as DMSO. In addition, efficient chamber cooling between runs protects thermally...

For precise, reproducible and error-free sieving processes

Finneran storage boxes and cell dividers are designed as an economical storage solution for cryovials, cold storage sample vials or centrifuge tubes. 

Available in white or yellow, the boxes and dividers are constructed of a sturdy, durable, cardboard with a moisture repellent coating that protects the storage box from the affects of liquid nitrogen or condensation from refrigerators or freezers. Unique chromatography sample vials, closures and accessories manufactured by J.G. Finneran Associates are available internationally from a network of laboratory dealers.....

Latest chromatography products available from Hichrom

Kromasil EternityXT UHPLC/HPLC Columns

The most efficient particle sizing in the micron range

The new Air Sizer 200 is ideal for sieving very fine dry particles, which require efficient dispersion and desagglomeration via air jet technology (e.g. electrostatic material). It is also the perfect instrument to quickly provide a sieve cut of powdered materials. The Air Sizer 200 is easy to use, extremely efficient and provides accurate and reproducible results.

The EZ-2 Elite Centrifugal Evaporator from Genevac has been designed to provide unmatched final drying of stubborn samples and fast lyophilisation of HPLC fractions

Benefiting from a high performance scroll pump, that delivers deep vacuum, the EZ-2 Elite is able to  routinely remove even very high boiling solvents such as DMSO and NMP. In addition internal heating of vapour duct and system components ensures that such challenging solvents only collect in the SpeedTrap™ condensor, and not anywhere else. The SpeedTrap condenser on the EZ-2 Elite comes the benefit of automatic defrost and drain technology.  The EZ-2 controls the SpeedTrap and...

Thermo Fisher Scientific has developed a high-performance anion-exchange chromatography with pulsed amperometric detection method, based on AOAC Official Method 2011.18, to determine free and bound myo-inositol in infant formula and adult nutritionals.

Application Note (AN) 1083: Determination of Myo-Inositol (Free and Bound as Phosphatidylinositol) in Infant Formula and Adult Nutritionalsdemonstrates a column-switching technique used to remove strongly retained carbohydrates in the sample, thereby reducing run time. Pulsed amperometric detection with a gold on polytetrafluoroethylene disposable electrode offers high sensitivity while eliminating the need for sample derivatization and electrode polishing...