The Clinical and Laboratory Standards Institute (CLSI) has released a new document, Liquid Chromatography-Mass Spectrometry Methods; Approved Guideline (C62-A).
This document provides guidance to the clinical laboratorian for the reduction of interlaboratory variance and the evaluation of interferences, assay performance, and other pertinent characteristics of clinical assays. C62-A emphasizes particular areas related to assay development and presents a standardized approach for method verification that is specific to mass spectrometry (MS) technology. This document provides guidance for the development and verification of liquid...
Thermo Fisher Scientific has developed a method to analyze food and environmental matrices for the presence of alkylphenol compounds using a GC-MS/MS system with automated selected reaction monitoring (AutoSRM).
Application Note 10407: Analysis of Alkylphenols Using GC-MS/MS and Automated SRM Development demonstrates the combined analytical power of the Thermo Scientific TRACE 1310 GC, the Thermo Scientific TSQ Duo triple quadrupole mass spectrometer and the Thermo Scientific Dionex Chromeleon Chromatography Data System (CDS) software to detect and quantify alkylphenol compounds in water and solid samples....
J. G. Finneran Associates is pleased to announce the addition of QuEChers to their product offerings.
QuEChERS (pronounced “catchers”), is an acronym for Quick, Easy, Cheap, Effective, Rugged and Safe. QuEChERS offer a convenient and effective sample preparation technique for determining pesticide residues in fruit, vegetables and other foods. Finneran QuEChERS make it simple to prepare your food samples for analysis with...
Hichrom's 2015 training programme is now available, featuring courses covering every area of HPLC, UHPLC, GC and sample preparation and delivered by world-renowned experts including John Dolan, Mel Euerby, Mark Powell, Diane Turner, Alan McKeown, Geoff Pickerell, Brian Montgomery, Helen Poole, Gemma Lo and Annette Larder.
Whether you are a relative newcomer to chromatography or a seasoned veteran, you can benefit from one of our courses. In addition to the well-established and well received theoretical courses (which are available as full day training courses or short 1-2 hour seminars), a wide range of practical ‘Hands-On’ courses covering all aspects of LC, LC/MS, GC, GC/MS and sample preparation is now also available. Read MoreA New Magnetic Technology for Bioseparations and Studies of Biomolecular InteractionsNov 24, 2014
AMSBIO announces MagSi-Direct - a revolutionary technology that brings the power, simplicity, and convenience of magnetic separation to researchers involved in cell biology, protein chemistry, flow cytometry, diagnostics development and many other fields.
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to which the starting molecule has bound....
Read MoreAdvanced Selectivity Phases for Powerful UHPLC and HPLC Method DevelopmentNov 24, 2014
Advanced Chromatography Technologies’ range of Advanced Selectivity phases offers chromatographers an extremely powerful tool for UHPLC and HPLC method development.
These phases incorporate the latest developments in LC stationary phase design to provide chromatographers with more choices for alternative selectivity but without compromising stability or robustness. ACE Advanced Selectivity phases are engineered to have complementary, yet differing mechanisms of interaction with your challenging analyte samples and all phases are fully scalable, highly reproducible and give excellent peak shape...
Cleaver Scientific, a leading manufacturer of innovative electrophoresis equipment and related products for the life science market, has introduced the 5th edition of its product catalogue.
The new 2015 catalogue has been expanded to 156-pages to provide detailed information covering the company’s comprehensive range of instruments, chemicals and consumables for electrophoresis and general lab equipment for life science research. Intuitively organized into sections covering horizontal and vertical gel electrophoresis systems, blotting systems, power supplies, gel documentation apparatus, reagents, chemicals and associated general lab equipment the catalogue...
Read MoreScion Instruments is Established by Techcomp from the Acquisition of Bruker GC and GC-MS SQ AssetsNov 18, 2014
Techcomp (Holdings) Ltd. (“Techcomp”) is delighted to announce the acquisition of the ex-Varian GC and GC-MS SQ assets from Bruker Corporation (“Bruker”) and the establishment of a new business - Scion Instruments - registered in Fremont California.
The GC and GC-MS SQ systems and Compass CDS software will be supplied and managed by the existing manufacturing operations and technical support team in Fremont California. Orders for new systems, spares and software will now be accepted by Scion Instruments in all global markets. To ensure a smooth transition and continuity of operations, service will continue to be supported by Bruker local offices until further notice...
Introducing the the new maXis II™ – UHR-qTOF Mass Spectrometer
Bruker Corporation (NASDAQ: BRKR) announced today, the evolution of their maXis™ line of ultrahigh-resolution quadrupole time-of-flight (UHR-qTOF) mass spectrometers, bringing industry-leading resolution and mass accuracy to the liquid chromatography, time-of-flight MS market space. The system, announced at IBC’s 18th annual Well Characterized Biologicals Conference, is designed to deliver outstanding resolution and mass accuracy which allows for unambiguous identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies....
Read MoreGyros Launches Gyrolab Protein A Kit for Efficient Quantification of Residual Protein ANov 6, 2014
Optimized kit for use with Gyros immunoassay platform
Gyros AB, a leader in utilization of microfluidic technologies to miniaturize and automate immunoassays, today announced the launch of its Gyrolab™ Protein A Kit for use on Gyrolab xP workstation. During purification of biotherapeutics, Protein A can leach from the chromatography support and co-elute with the therapeutic antibody product. The contamination complicates subsequent analysis using immunoassays....
Thermo Fisher Scientific has developed an efficient high-performance liquid chromatography (HPLC) method with fluorescence detection for sensitive and rapid determination of benzo[a]pyrene in meat products.
This method uses on-line solid-phase extraction (SPE) for sample preparation instead of the commonly used off-line SPE method. Application Note 1093: Determination of Benzo(a)pyrene in Sausage and Preserved Ham demonstrates that this approach reduces costs associated with the SPE cartridge, labor, time, and reagents; and results are more consistent because the cleanup step is performed by automated on-line SPE rather than...
The Precision Biosystems BlotCycler™ offers an automated system for performing western blots with high sensitivity and low background noise
“The functional simplicity of the BlotCycler™ design is convincing researchers that the time for automating their western blot assays is here,” says Russ Yukhananov, Ph.D., CEO of Precision Biosystems. BlotCycler™ delivers an affordable solution for busy labs demanding reproducible results. By reducing variables from slight variations in fluid delivery, timing and washing steps, researchers can achieve standardization with a repeatable automated process...
Improved workflow using automated sample preparation for analysis of Vitamin D levels by Mass Spectrometry.
Beckman Coulter's Biomek NXp Workstation allows for reduced technician time and an improved workflow using automated sample preparation for analysis of Vitamin D levels by Mass Spectrometry. With already developed methods and applications support, you can track sample information from preparation to final MS data. Most importantly, you get the hands-off approach you need to produce precise, consistent results that help you achieve your goals...
Proteome Discoverer™ users can generate spectral libraries with Spectronaut™ software
Biognosys AG, a Swiss Proteomics Company, announced today the new release of its Spectronaut™ software for analysis of Hyper Reaction Monitoring (HRM) data that will now support spectral library generation from the Thermo Scientific™ Proteome Discoverer™ platform. From August 2013 Spectronaut™ software supports the analysis of DIA data generated on the Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer....
Thermo Fisher Scientific has developed a user-friendly tool that provides technical assistance for gas chromatography (GC) methods and applications.
Designed with the expert advice of columnist John Hinshaw, the GC Troubleshooting Guide provides a step-by-step process to easily diagnosis common symptoms. The guide combats difficulties laboratory professionals can encounter when running GC methods: high levels of noise, spiking peaks, ghost peaks, decreasing retention times, and irreproducible results. This tool—offered both as an iPad mobile application and for desktop systems...
The miVac Quattro from Genevac is the perfect workhorse sample concentrator for biological laboratories tasked with handling larger numbers of samples.
The miVac Quattro centrifugal vacuum concentrator rapidly removes a wide range of solvents, from volatile organic solvents through to DMF, including water, making it the ideal system for concentrating precious samples in applications including oligonucleotide synthesis, RNA/DNA preparation, peptide preparation, sequencing, molecular biology and ADME / toxicology research. A wide variety of high capacity rotors means that the...
The PREP series of symposia is the most recognized international conference packed with expert professionals who address key developments, issues, and hottest topics in the Preparative and Process Liquid Chromatography field.
Thermo Fisher Scientific has developed an ion chromatography (IC)-based method to simultaneously determine lithium, sodium, and calcium in lithium carbonate without handling hazardous reagents.
Application Note 1090: IC Assay for Lithium, Sodium, and Calcium in Lithium Carbonatedemonstrates accurate determinations of these three analytes by separation on a cation-exchange column and detection by suppressed conductivity. This approach offers a fast (25 minutes), simple, accurate, and robust alternative to the time-consuming assays for these three analytes in the current United States Pharmacopeia (USP) monograph...
Cleaver Scientific reports that its horizontal electrophoresis equipment is being used on the frontline of the UK fight against Ebola
The Cleaver Scientific MultiSUB electrophoresis system features in a recent ITV report on UK Government plans to step up Ebola screening of passengers arriving from West Africa at Heathrow and Gatwick airports as well as major rail terminus. At the Porton Down research centre in Wiltshire, UK - scientists are working on detecting and minimising the risk of the Ebola virus appearing in the UK. Currently researchers are analysing 10-15 blood samples / week taken from National Health Service (NHS) patients, all to date have proved negative for Ebola....
Read MoreNew Orbitrap-Based Mass Spectrometer Makes High-Resolution Accurate-Mass Analysis Widely AccessibleOct 22, 2014
Introducing the New Q Exactive Focus benchtop LC-MS/MS
Laboratories performing food and environmental testing, clinical research, forensic toxicology, pharmaceutical/biopharmaceutical measurements, and other applied analyses can now benefit from the performance of high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry using a new instrument designed for cost-per-sample-sensitive workflows. The new Thermo Scientific Q Exactive Focus LC-MS/MS is...
The fight against cancer could be aided by new technical advances in filtration and separation technology.
Porvair Filtration Group believes that the evolution of its range of sintered porous plastics can help molecular biologists and clinicians better understand the mechanisms underlying cancer and other diseases. Scientists at the Wrexham division have developed BioVyon™ porous plastic materials which can now be used in a wide variety of medical and pharmaceutical applications to offer better healthcare, improve medical knowledge and help with the diagnosis and treatment of diseases....
This document provides guidance to the clinical laboratorian for the reduction of interlaboratory variance and the evaluation of interferences, assay performance, and other pertinent characteristics of clinical assays. C62-A emphasizes particular areas related to assay development and presents a standardized approach for method verification that is specific to mass spectrometry (MS) technology. This document provides guidance for the development and verification of liquid...
QuEChERS (pronounced “catchers”), is an acronym for Quick, Easy, Cheap, Effective, Rugged and Safe. QuEChERS offer a convenient and effective sample preparation technique for determining pesticide residues in fruit, vegetables and other foods. Finneran QuEChERS make it simple to prepare your food samples for analysis with...
Whether you are a relative newcomer to chromatography or a seasoned veteran, you can benefit from one of our courses. In addition to the well-established and well received theoretical courses (which are available as full day training courses or short 1-2 hour seminars), a wide range of practical ‘Hands-On’ courses covering all aspects of LC, LC/MS, GC, GC/MS and sample preparation is now also available.
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to which the starting molecule has bound....
These phases incorporate the latest developments in LC stationary phase design to provide chromatographers with more choices for alternative selectivity but without compromising stability or robustness. ACE Advanced Selectivity phases are engineered to have complementary, yet differing mechanisms of interaction with your challenging analyte samples and all phases are fully scalable, highly reproducible and give excellent peak shape...
The GC and GC-MS SQ systems and Compass CDS software will be supplied and managed by the existing manufacturing operations and technical support team in Fremont California. Orders for new systems, spares and software will now be accepted by Scion Instruments in all global markets. To ensure a smooth transition and continuity of operations, service will continue to be supported by Bruker local offices until further notice...
Bruker Corporation (NASDAQ: BRKR) announced today, the evolution of their maXis™ line of ultrahigh-resolution quadrupole time-of-flight (UHR-qTOF) mass spectrometers, bringing industry-leading resolution and mass accuracy to the liquid chromatography, time-of-flight MS market space. The system, announced at IBC’s 18th annual Well Characterized Biologicals Conference, is designed to deliver outstanding resolution and mass accuracy which allows for unambiguous identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies....
“The functional simplicity of the BlotCycler™ design is convincing researchers that the time for automating their western blot assays is here,” says Russ Yukhananov, Ph.D., CEO of Precision Biosystems. BlotCycler™ delivers an affordable solution for busy labs demanding reproducible results. By reducing variables from slight variations in fluid delivery, timing and washing steps, researchers can achieve standardization with a repeatable automated process...
Beckman Coulter's Biomek NXp Workstation allows for reduced technician time and an improved workflow using automated sample preparation for analysis of Vitamin D levels by Mass Spectrometry. With already developed methods and applications support, you can track sample information from preparation to final MS data. Most importantly, you get the hands-off approach you need to produce precise, consistent results that help you achieve your goals...
Biognosys AG, a Swiss Proteomics Company, announced today the new release of its Spectronaut™ software for analysis of Hyper Reaction Monitoring (HRM) data that will now support spectral library generation from the Thermo Scientific™ Proteome Discoverer™ platform. From August 2013 Spectronaut™ software supports the analysis of DIA data generated on the Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer....
The miVac Quattro centrifugal vacuum concentrator rapidly removes a wide range of solvents, from volatile organic solvents through to DMF, including water, making it the ideal system for concentrating precious samples in applications including oligonucleotide synthesis, RNA/DNA preparation, peptide preparation, sequencing, molecular biology and ADME / toxicology research. A wide variety of high capacity rotors means that the...
Porvair Filtration Group believes that the evolution of its range of sintered porous plastics can help molecular biologists and clinicians better understand the mechanisms underlying cancer and other diseases. Scientists at the Wrexham division have developed BioVyon™ porous plastic materials which can now be used in a wide variety of medical and pharmaceutical applications to offer better healthcare, improve medical knowledge and help with the diagnosis and treatment of diseases....