Ion Mobility Spectrometry and REIMS Direct-from-sample Ionization Deliver Greater Clarity, Confidence and Speed to Routine LC-MS and MS Analyses

Waters Corporation (NYSE:WAT) at the 63^rd conference of the Society of Mass Spectrometry announced the introduction of new technologies and innovations for mass spectrometry, intended to give laboratories greater levels of detail for every analysis.

The introductions include the new Waters^® Vion IMS QTof Mass Spectrometer, a new bench-top tandem mass spectrometer featuring ion mobility and REIMS Research System with iKnife Sampling, combining direct-from-sample ionization with high-performance time-of-flight (ToF) mass spectrometry.

Waters also expanded its family of solid phase extraction products with the first-of-its-kind Oasis PRiME HLB and added to its portfolio of protein separation columns with the ACQUITY UPLC^® Glycoprotein BEH Amide Column for glycan analysis.    

Vion IMS QTof Mass Spectrometer

Combining the benefits of high-resolution tandem mass spectrometry and ion mobility separation in a bench top instrument, the Waters^® Vion IMS QTof Mass Spectrometer brings clarity and confidence to routine analyses. Ion mobility removes spectral interferences and generates collision cross-section (CCS) values for every ion, giving scientists more information than they can get from traditional LC-MS experiments. Waters intends to commence shipments of the Vion IMS QTof Mass Spectrometer in the second half of this year. 

“More than a decade of experience in ion mobility has gone into the design of our Vion IMS QTof instrument. For scientists involved in sample screening, metabolite identification, or classical ‘omics experiments, their ability to detect and identify all sample analytes in single analysis at the bench has reached a new level,” said Gary Harland, Director, Mass Spectrometry Product Management, Waters Division. “Regardless of how many analytes there are in a sample, and regardless of the concentrations which they are present in, Vion IMS QTof empowers laboratories to respond better to analytical challenges and succeed in meeting their scientific and business objectives.”

As routine analyses involve increasingly complex samples, scientists often rely on high-resolution mass spectrometry. However, increasing mass resolution alone does not always lead to better answers. By separating ions from one another based on their shape, mass and charge, ion mobility provides an additional dimension of separation. The selectivity of ion mobility refines spectra and allows the instrument to discriminate sample ions from chromatographically co-eluting compounds and background interferences - bringing clarity to every spectrum, and enabling the confident characterization of compounds.

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